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Displaying 20 of 408 results for "THBS1"
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  1. Side population phenotype in quiescent human/murine tissue resident memory (TRM) T cells: Role of ABC transporters and NR4A1 in TRM biology ArrayExpress

    ID: E-GEOD-85074

    Description: The ability to detect and isolate human CD8 TSP (Side population), Naïve, Effector memory (EM), Central memory (CM) cells allowed us to compare the global gene expression pro...

  2. CO6_HUMAN UniProt:Swiss-Prot

    ID: P13671

    Description: Complement component C6 TSP type-1 1 TSP type-1 2 LDL-receptor class A MACPF EG...

  3. CO6_RAT UniProt:Swiss-Prot

    ID: Q811M5

    Description: Complement component C6 TSP type-1 1 TSP type-1 2 LDL-receptor class A MACPF EG...

  4. CO6_PANTR UniProt:Swiss-Prot

    ID: P61134

    Description: Complement component C6 TSP type-1 1 TSP type-1 2 LDL-receptor class A MACPF EG...

  5. Gene expression signatures and molecular markers predict response to therapy in locally advanced head and neck squamous cell carcinoma. OmicsDI

    ID: E-GEOD-23036

    Date Released: 06-10-2011

    Description: l (LRFS) and overall survival (OS). Tumor subtype 1, associated with low LRFS and OS, showed features of epithelial-mesenchymal transition and undifferentiation. It also overexpressed genes related to cell adhesion, NF-κB and integrin signalling pathways. Tumor subtype 3, associated with a high LRFS and OS, showed a high degree of differentiation and overexpressed genes located in chromosome regions 19q13 and 1q21. Tumor subtype 2, with a LRFS that was similar to subtype 3 and an OS similar to subtype 1, overexpressed genes involved in branching morphogenesis. ROC analysis identified genes associated with local recurrence and survival. Using qRT-PCR we confirmed the association of RAB25, DUOX1 and THBS1 expression with LRFS a...

  6. Gene expression profiling of side population cells of mouse thyroid before and after partial thyroidectomy ArrayExpress

    ID: E-GEOD-34513

    Description: ation (CMP) vs. thyroidectomized side population (TSP) vs. thyroidectomized main population (TMP). Biological replicates: 6 CSP, 3 CMP, 6 TSP, and 3 TMP samples....

  7. Tasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro BioProject

    ID: PRJNA117795

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ine receptor CXCR4, cytochrome P450 1A1 (CYP1A1), thrombospondin-1 (THBS1) and Lysyloxidase preprotein (LOX). To further explore the mode of action of ABR-215050, in vitro experiments with gene microarray analysis were performed using LNCaP prostate tumor cells. The array data were validated by real-time PCR (sqRT-PCR), as well as by protein expression experiments. One of the most significant differentially expressed genes after exposure to ABR-215050, was thrombospondin-1 (THBS1). Overall design: 2-color treatment vs. control microarray experiment comprising four biological replicates. Each biological replicate was hybridized with dye-swap; resulting in eight hyb...
  8. Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial ArrayExpress

    ID: E-GEOD-60331

    Description: rs ELISA’s were performed for PDGF-AA, PDGF-BB, THBS-1, IL-8, CYR61 and Ang-2. The expression of all markers was correlated with the pathological response of the patients. Results: Differences in tumoral gene expression are observed between patients with and without a pCR, with the first response group presenting a more angiogenic phenotype before start of treatment and changes in angiogenic processes after bevacizumab delivery. One dose of bevacizumab leads to a decrease in the number of pericyte covered blood vessels, a decrease in circulating PDGF-AA, PDGF-BB and Thrombospondin-1. Patients showing a pCR having less pericyte covered blood vessels, more hypoxia, and less circulating PDGF-BB compared to patients who did not have a pCR after bevacizumab treatment with chemoradiation and bevacizumab. Conclusions: The translational data demonstrate that tumors with an angiogenic expression profile respond better to bevacizumab combined with CRT and points towards a possible role for PDGF, CA-IX and pericyte covered blood vessels for the early response prediction to this treatment. Our findings suggest a role for mural cell recruitment and vessel maturation for the susceptibility of the tumor vasculature to bevacizumab treatment. Further validation of our biological observations and hypothesis generating data in randomized trials is needed. This study involves samples of p...

  9. Expression analysis of the glucose deprivation-induced human tumor cell responses ArrayExpress

    ID: E-GEOD-38583

    Description: easing the expression of angiogenesis inhibitors (THBS1, CXCL14 and CXCL10). The markers of Unfolded Protein Response (UPR) (Grp78/Bip, CHOP, ATF4, etc.) were significantly increased. The above results suggest GD may regulate angiogenesis through activation of the UPR. UM-SCC-81B cells (human oral squamous cell carcinoma cell line) were treated with glucose deprivation (GD) for 4 hours (UM-SCC-81B-GD-4) and 24 hours (UM-SCC-81B-GD24). Cells without treatment were used as a non-treatment control (UM-SCC-81B-NT). Each sample was analyzed once, i.e., without biological replicates. The expression of the genes of interest was confirmed with real-time PCR, ELISA and Western blot....

  10. UNC5A_RAT UniProt:Swiss-Prot

    ID: O08721

    Description: lular Helical Cytoplasmic Ig-like Ig-like C2-type TSP type-1 1 TSP type-1 2 ZU5 Death Interaction with DCC Cleavage; by caspase-3 N-lin...

  11. Molecular mechanism behind the hematopoiesis-enhancing effect of SRT3025 BioProject

    ID: PRJNA259874

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ize. Among the other genes suppressed by SRT3025, Thbs1 and Fosl2 encode thrombospondin 1 and Fos-like antigen 2, respectively. Both proteins are components of the HSC niche. Overall design: The goal of this study is to investigate gene expression changes in wild-type 129 mice in response to SRT3025 treatment. The study focuses on bone marrow cKit+ Sca1+ Lin- cells (representing hematopoietic stem and progenitor cells). These cells were sorted twice by FACS to ensure the purity. Cells of interest were collected in Trizol. RNA were isolated using RNAeasy mini prep kit and mRNAs were positively selected using oligo(dT)- Dynobeads. Then RNAseq libraries were then made using Illumina TruSeq RNA Sample Prep Kit and sequeced on an Illumina HiSeq 2000 genome analyzer....
  12. CO9_ONCMY UniProt:Swiss-Prot

    ID: P06682

    Description: mplement component C9 Beta stranded Beta stranded TSP type-1 1 LDL-receptor class A MACPF EGF-like TSP type-1

  13. CO6_PONPY UniProt:Swiss-Prot

    ID: P61135

    Description: Complement component C6 TSP type-1 1 TSP type-1 2 LDL-receptor class A MACPF EG...

  14. CO6_BOVIN UniProt:Swiss-Prot

    ID: Q29RU4

    Description: Complement component C6 TSP type-1 1 TSP type-1 2 LDL-receptor class A MACPF EG...

  15. Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells ArrayExpress

    ID: E-GEOD-33443

    Description: cells treated with tomato leaves extract (TLE) in 1 hr and 48 hrs of treatment. Several of genes with p < 0.05 and fold-change cut-off <2.00 from human genome had significantly changed after the treatments. Its showed the greatest roles in cancer cells growth and were found either to b...

  16. Molecular mechanism behind the hematopoiesis-enhancing effect of SRT3025 ArrayExpress

    ID: E-GEOD-60941

    Description: ize. Among the other genes suppressed by SRT3025, Thbs1 and Fosl2 encode thrombospondin 1 and Fos-like antigen 2, respectively. Both proteins are components of the HSC niche. The goal of this study is to investigate gene expression changes in wild-type 129 mice in response to SRT3025 treatment. The study focuses on bone marrow cKit+ Sca1+ Lin- cells (representing hematopoietic stem and progenitor cells). These cells were sorted twice by FACS to ensure the purity. Cells of interest were collected in Trizol. RNA were isolated using RNAeasy mini prep kit and mRNAs were positively selected using oligo(dT)- Dynobeads. Then RNAseq libraries were then made using Illumina TruSeq RNA Sample Prep Kit and sequeced on an Illumina HiSeq 2000 genome analyzer....

  17. gene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients OmicsDI

    ID: E-GEOD-33859

    Date Released: 06-25-2012

    Description: n activated /CD69+ blood cells selected from HTLV-1-infected patient displaying HAM-TSP disease (HTLV-1-associated myelopathy/tropical spastic paraparesis), compared to healthy blood donor /HD (biological sample provi...

  18. FAS signalling in retroviral neuroinflammation BioProject

    ID: PRJNA324236

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: oration and microarray analysis in PBMC from HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) patients. Overall design: A systems analysis of HAM/TSP in vitro gene expression showed that triggering Fas receptor with agonist (but not antagonist) antibody, induces a specific gene set with a central role for NFKB ...
  19. Side population phenotype in quiescent human/murine tissue resident memory (TRM) T cells: Role of ABC transporters and NR4A1 in TRM biology BioProject

    ID: PRJNA336054

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The ability to detect and isolate human CD8 TSP (Side population), Naïve, Effector memory (EM), Central memory (CM) cells allowed us to compare the global gene expression pro...
  20. Gene expression profie of OSMF (Oral Submucous Fibrosis) tissues compared with the expression in normal oral tissues ArrayExpress

    ID: E-GEOD-20170

    Description: wn regulated genes also includes RARRES1, TGM2, THBS1, CHGB, MMP3, SPP1 and ALOX12, C4orf7 respectively. Analysis of microarray data revealed TGF-? pathway as a principal gene network involved in the development of OSF. Intriguingly, there was no regulation of CTGF and THBS1 in fibroblasts by arecoline. However, TGF-b1 treatment regulated all these genes in both epithelial and fibroblast cells. Conclusion: We demonstrate over expression of novel genes in OSF and suggest that OSF development involves TGF-b pathway in an epithelial-stromal cooperation. Targeting TGF-b signaling could be an alternate strategy to treat OSF. Two-condition experiment: 10 OSF tissues against 8 pooled normal tissues...


Displaying 20 of 408 results for "THBS1"