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Displaying 20 of 408 results for "THBS1"
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  1. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals. BioProject

    ID: PRJNA168100

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. aTEA 40 uM 12 hour treatment for MDA-MB-435 cells BioProject

    ID: PRJNA98075

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ein referred to as ARG (Abelson-related gene) and THBS1 which codes for thrombospondin 1, TSP-1 were chosen for further study. Keywords: Anti-cancer drug (aTEA at 40 uM 12 hour) treatment for MDA-MB-435 cells Overall design: The whole-genome cDNA microarrays were manufactured in the laboratory of Dr. Vishwanath Iyer (U.T. Austin). For the microarray experiments, MDA-MB-435 cells were cultured with 40 mM of a-TEA or ethanol control for 12 h. Messenger RNA was isolated using the FastTrack 2.0 kit (Invitrogen, Carlsbad, CA) then reverse transcribed by SuperScript II reverse transcriptase (Invitrogen) according to the manufacturersÔÇ...
  3. TSP3B_DANRE UniProt:Swiss-Prot

    ID: Q1L8P7

    Description: Thrombospondin-3b Laminin G-like EGF-like 1; calcium-binding EGF-like 2 TSP type-3 <

  4. BAI1_HUMAN UniProt:Swiss-Prot

    ID: O14514

    Description: Brain-specific angiogenesis inhibitor 1 Extracellular Helical; Name=1 Cytoplasmic Helical; Name=2 Extracellular Helical; Name=3 Cytoplasmic Helical; N...

  5. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals ArrayExpress

    ID: E-GEOD-38537

    Description: HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we...

  6. gene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients ArrayExpress

    ID: E-GEOD-33859

    Description: n activated /CD69+ blood cells selected from HTLV-1-infected patient displaying HAM-TSP disease (HTLV-1-associated myelopathy/tropical spastic paraparesis), compared to healthy blood donor /HD (biological sample provi...

  7. MLP_ACRMI UniProt:Swiss-Prot

    ID: B3EWY9

    Description: in-like protein Extracellular Helical Cytoplasmic TSP type-1 1 TSP type-1 2 TSP type-

  8. AGRB2_PONAB UniProt:Swiss-Prot

    ID: Q5R7Y0

    Description: n-coupled receptor B2 Extracellular Helical; Name=1 Cytoplasmic Helical; Name=2 Extracellular Helical; Name=3 Cytoplasmic Helical; Name=4 Extracellular Helical; Name=5 Cytoplasmic Helical; Name=6 Ex...

  9. Genes expression of cervical squamous cell carcinoma, CaSki cells, treated with or without recombinant TGF-b1 (2 ng/mL) BioProject

    ID: PRJNA246462

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: asscocited fibroblasts (CAFs) activates TGF-b via TSP-1 secretion to facilitate CSCC invade, resulting in up-regulation of pSMAD3 in CSCC cells to promote invasion. These results suggest that activation of TGF-b induced by the interaction between CSCC cells and CAFs could play a key role in the initiation of tumor spreads. Overall design: We used microarrays to clarify the changes of gene expression along with recombinant TGF-b1 treatment and to confirm whether there are any changes on genes expression related to TGF-b pathway....
  10. Identification of Cellular Genes Targeted by KSHV-Encoded MicroRNAs BioProject

    ID: PRJNA100371

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e of these genes and found that protein levels of thrombospondin 1 (THBS1) were decreased >10-fold. THBS1 has previously been reported to be down-regulated in KS lesions and has known activity as a strong tumor suppressor and anti-angiogenic factor, exerting its anti-angiogenic effect in part by activating the latent form of TGF-b. We show that reduced THBS1 expression in the presence of viral miRNAs translates into decreased TGF-b activity. These data suggest that KSHV-encoded miRNAs may contribute directly to pathogenesis by down-regulation of THBS1, a major regulator of cell adhesion, migration, and angiogenesis. Keywords: comparison, experiemental versus control Overall design: 293 cells were stably transfected with either a vector expressing 10 KHSV encoded microRNAs or empty vector control. Cells were selected through G418. 4 samples were collected for each cell line and RNA collecte...
  11. Gene expression analysis of TGF-beta signaling-disrupting gastric cancer cell line 2MLN BioProject

    ID: PRJNA113229

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: microarray analysis, we found gene expression of TSP-1, an angiogenic inhibitor, was down-regulated in dnT╬▓RII tumors. This results suggested disruption of TGF-╬▓ signaling in diffuse-type gastric carcinoma cells leads to alteration of tumor microenvironment and acceleration of tumor growth. Overall design: We generated two OCUM-2MLN-derived gastric carcinoma cell lines; 2MLN-dnT╬▓RII, which expresses dominant negative form of T╬▓RII, and control 2MLN-GFP, which expresses GFP. The transplanted tumors of these cell lines were subjected to gene expression analysis with Affymetrix U133 plus2 arrays....
  12. Comparison of Transcriptomics of Mouse Skin Derived Precursors (SKPs) and Dermal Fibroblasts by RNA-Seq BioProject

    ID: PRJNA236120

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: significantly up-regulated genes Wnt4, Wisp2 and Tsp-1 and the down-regulated genes Retn, Slitrk1, Klk6, Agtr2, Ivl, Msx1, IL15, Atp6v0d2, Kcne1l and Thbs4 might play important roles in the transition of SKPs to fibroblasts. KEGG analysis showed that DEGs were significantly enriched in the TGF-╬▓ signaling pathway, Wnt signaling pathway and Notch signaling pathway, which have been previously proven to regulate the differentiation and self-renewal of various stem cells. These identified DEGs and pathways could facilitate further investigations of the detailed molecular mechanisms, making it possible to take advantage of the potential therapeutic applications of SKPs in skin repair in the future. Overall design: Examination of 2 cell types (SKPs and fibroblasts)....
  13. ECT_ACRMI UniProt:Swiss-Prot

    ID: B3EWZ8

    Description: Ectin TSP type-1 1 TSP type-1 2 SCP

  14. SEN34_NEUCR UniProt:Swiss-Prot

    ID: Q7SAK9

    Description: Probable tRNA-splicing endonuclease subunit tsp-4

  15. Gene expression profiling of MT-2 cells treated with interferon-alpha and ascorbic acid (dose response) OmicsDI

    ID: E-GEOD-34572

    Date Released: 06-26-2012

    Description: Background: Clear guidelines for therapy of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-...

  16. Tasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro ArrayExpress

    ID: E-GEOD-17031

    Description: ine receptor CXCR4, cytochrome P450 1A1 (CYP1A1), thrombospondin-1 (THBS1) and Lysyloxidase preprotein (LOX). To further explore the mode of action of ABR-215050, in vitro experiments with gene microarray analysis were performed using LNCaP prostate tumor cells. The array data were validated by real-time PCR (sqRT-PCR), as well as by protein expression experiments. One of the most significant differentially expressed genes after exposure to ABR-215050, was thrombospondin-1 (THBS1). 2-color treatment vs. control microarray experiment comprising four biological replicates. Each biological replicate was hybridized with dye-swap; resulting in eight hybridizations for...

  17. gene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients BioProject

    ID: PRJNA148365

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. Arterial vs venous expression of genes: differences in inflammatory genes OmicsDI

    ID: E-GEOD-12255

    Date Released: 03-27-2012

    Description: ctively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in ...

  19. THSD1_BOVIN UniProt:Swiss-Prot

    ID: Q5BIR3

    Description: Thrombospondin type-1 domain-containing protein 1 Extracellular Helical Cytoplasmic

  20. SEN2_NEUCR UniProt:Swiss-Prot

    ID: Q9P6Y2

    Description: Probable tRNA-splicing endonuclease subunit tsp-2


Displaying 20 of 408 results for "THBS1"