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Displaying 20 of 408 results for "THBS1"
  1. Expression data from peritoneal biopsies of patients with encapsulating peritoneal sclerosis, patients undergoing first implantation of a peritoneal d... ArrayExpress

    ID: E-GEOD-62928

    Description: elevated expression of genes encoding sulfatase1, thrombospondin 1, fibronectin 1 and alpha smooth muscle actin, among many others, while in EPS and PD tissues mRNAs encoding leptin and retinol-binding protein 4 were markedly down-regulated, compared to Uremic group patients. Immunolocalization of Collagen 1 alpha 1 revealed that Col1a1 protein was predominantly expressed in the submesothelial compact zone of EPS patient peritoneal samples, whereas PD patient peritoneal samples exhibited homogenous Col1a1 staining throughout the tissue samples. The results are compatible with the hypothesis that encapsulating peritoneal sclerosis is a distinct pathological process from the simple peritoneal fibrosis that accompanies all PD treatment. Total RNA was isolated from frozen peritoneal biopsy specimens obtained at time of surgery. RNA was hybridized to Affymetrix arrays, and analyzed. Select transcripts were subjected to validation by rt-pcr and by immunodetection....

  2. Microarray analysis to identify Egfr-responsive genes ArrayExpress

    ID: E-GEOD-34872

    Description: ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) gene, to the pathway. Sulf1 showed a strong genetic interaction with the neuregulin-like ligand vein (vn) and may influence binding of Vn to heparan-sulfated proteoglycans (HSPGs). Genetic evidence also shows that CG4096 functions by modulating activity of the Egfr ligands. The substrate(s) and how ligand activity is affected are unknown, but interestingly vertebrate EGF ligands are regulated by a related ADAMTS protein. We conclude Sulf1 and CG4096 are negative feedback regulators of Egfr signaling that function in the extracellular space to influence ligand activity. 3 replicates each of wing disc samples in which EGFR dominant negative (EGFR-DN) or EGFR activated (EGFR-TOP) transgenes were expressed with the 71B-Gal4 driver....

  3. Data from: Long-term data reveal patterns and controls on streamwater chemistry in a forested stream: Walker Branch, Tennessee Dryad

    DateIssued: 08-21-2015

    Description: 2+ and SO42-) or nutrients (NH4+, NO3-, SRP, TSN, TSP, and DOC). Geochemical solutes are predominantly controlled by discharge and long-term changes in catchment hydrology have led to significant trends in the concentrations and fluxes of these solutes. Further, trends in geochemical solute concentrations indicate shifting soil flowpath contributions to streamflow generation through time, with deep groundwater having a greater proportional contribution in recent years. Despite dramatic changes in watershed runoff, there were no trends in inorganic nutrient concentrations (NH4+, NO3-, and SRP). While most nutrients entering the watershed are retained, stream fluxes of nutrient solutes have declined significantly as a result of decreasing runoff. Nutrient concentrations in...

  4. Comparison of 2 ADAMTS metalloproteases in closure of mouse palate - versican proteolysis in regulating palatal mesenchyme proliferation BioProject

    ID: PRJNA126117

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: disintegrin-like and metalloprotease domain with thrombospondin type-1 motif), ADAMTS20 and ADAMTS9, in palatogenesis. Adamts20 mutations cause the mouse white spotting mutant belted (bt), whereas Adamts9 is essential for survival beyond 7.5 days of gestation (...
  5. Integrated Network and Microarray Analysis to Identify New Biomarkers in Ischemic Heart Disease BioProject

    ID: PRJNA105803

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: biomarkers, Vascular Endothelial Growth Factor B, thrombospondin-1 and placental growth factor are all related to angiogenesis, a natural process that favors the revascularization of the heart after MI and prevents the occurrence of HF. Therefore, combined network and microarray analysis allows a systematic and less biased approach to biomarker discovery. Overall design: The 32 patients of this study were divided in 2 groups corresponding to the extreme quartiles of FE values. The first group are the patients with low Ejection fraction and the second group are the patients with high ejection fraction. Blood sample: 2.5 mL harvested in PAXgene® Blood RNA tubes (Pr...
  6. Functional analysis of exon 2 of p130Cas in fibroblasts derived from exon 2-specific knockout mice. BioProject

    ID: PRJNA101375

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: or-4 (CXCR4), CC Chemokine Receptor-5 (CCR5), and thrombospondin 4, which are implicated in cell motility and adhesion. These results define the role of Cas SH3-encoding exon in cell motility, FAK/Cas/CrkII complex formation, recruitment of Cas to focal adhesions, and regulation of cell adhesion-associated gene expression in primary fibroblasts. Keywords: SH3-encoding exon, p130Cas Overall design: RNA samples extracted from Cas exon 2+/+, Cas exon 2+/∆, and Cas exon 2∆/∆ fibroblasts (12.5dpc, two embryos for each genotype) were labeled and hybridized on Affymetrix microarray. Gene expression patterns of Cas exon 2∆/∆ fibroblasts were compared with those of Cas exon 2+/+ and Cas exon 2+/∆ cells....
  7. Divergent and Convergent Effects on Gene Expression and Function in Acute versus Chronic Endothelial Activation BioProject

    ID: PRJNA94527

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cells. In addition, the anti-angiogenic genes PAI-1 and thrombospondin were upregulated only in acutely activated endothelium, consistent with reduced angiogenic activity observed in acute versus chronically activated endothelial cells in vitro. These data suggest that continuous activation of endothelial cells leads to specific expression and functional changes, consistent with alterations observed in dysfunctional endothelium exposed to or involved in chronic inflammation. Keywords: Expression profiling Overall design: This experiment compares the response of endothelial cells from newborn mice that were either stably transfected with a non-cleavable transmembrane mutant form of murine TNFalpha, or treated with soluble TNFalpha (20ng/ml) for 4 hours. Each treatment was compared to mock-transfected control cells. Four replicates for each condition were used. Five micrograms of total RNA was assayed per Genechip using standard Affymetrix protocols....
  8. Transcription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to del... ArrayExpress

    ID: E-GEOD-3589

    Description: r of EC that binds to protease-activated receptor 1 (PAR-1). Following application of stringent filters 37 LTD4-upregulated genes were identified (> 2.5fold stimulation). Surprisingly, most of the LTD4-regulated genes were also induced by thrombin and expression of cysLT2-R- and PAR-1-regulated genes strongly correlated (Pearson correlation coefficient: r = 0.90). Moreover, LTD4 + thrombin, when added together, augmented expression of LTD4- or thrombin-stimulated genes (Wilcoxon signed rank test: p < 0.01). Prominently induced genes that may play roles in vascular injury were studied in detail: Early growth response (EGR) and nuclear receptor subfamily 4 group A; E-selectin; CXC ligand 2; interleukin 8 (IL-8); a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1

Displaying 20 of 408 results for "THBS1"