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  1. Crystal Structure of the Thrombospondin-1 N-terminal domain PDB

    ID: PDB:1Z78

    Description: Thrombospondin 1

  2. Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra PDB

    ID: PDB:1ZA4

    Description: Thrombospondin 1

  3. Crystal Structure of Thrombospondin-1 N-terminal Domain in P1 Form at 1.85A Resolution PDB

    ID: PDB:2ES3

    Description: Thrombospondin-1

  4. Thrombospondin 1 in a model of colorectal carcinogenesis BioProject

    ID: PRJNA259597

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution PDB

    ID: PDB:2ERF

    Description: Thrombospondin-1

  6. Crystal Structure of Thrombospondin-1 TSR Domains 2 and 3 PDB

    ID: PDB:3R6B

    Description: Thrombospondin-1

  7. Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia BioProject

    ID: PRJNA118655

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Crystal structure of the Thrombospondin-1 N-terminal domain in complex with fractionated Heparin DP10 PDB

    ID: PDB:2OUH

    Description: Thrombospondin-1

  9. The crystal structure of the Thrombospondin-1 N-terminal domain in complex with fractionated Heparin DP8 PDB

    ID: PDB:2OUJ

    Description: Thrombospondin-1

  10. Crystal Structure of the Thrombospondin-1 Type 1 Repeats PDB

    ID: PDB:1LSL

    Description: Thrombospondin 1

  11. Transcription profiling by array of wild-type or Thrombospondin 1 (TSP-1) null mouse dextran sulphate sodium (DSS)-induced ... ArrayExpress

    ID: E-GEOD-32697

    Description: Thrombospondin 1 (TSP-1) is an anti-angiogenic matricellular protein with ...

  12. Thrombospondin 1 in a model of colorectal carcinogenesis ArrayExpress

    ID: E-GEOD-60805

    Description: nflammation-induced carcinogenesis the effects of TSP-1 in induced tumors were analyzed. Mice received a single injection of azoxymethane (AOM) and multiple cycles of dextran sodium s...

  13. 299K) in complex with GDP and the human TSR1 from thrombospondin 1... PDB

    ID: PDB:5FOE

    Description: GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2, THROMBOSPONDIN-1

  14. Transcription profiling by array of wild-type or Thrombospondin 1 (TSP-1) null mouse dextran sulphate sodium (DSS)-induced ... OmicsDI

    ID: E-GEOD-32697

    Date Released: 07-03-2015

    Description: Thrombospondin 1 (TSP-1) is an anti-angiogenic matricellular protein with ...

  15. Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: genetic profile and therapeutic effects BioProject

    ID: PRJNA146891

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia ArrayExpress

    ID: E-GEOD-17556

    Description: d with a more aggressive form of atherosclerosis. Thrombospondin-1 (TSP-1), an extracellular matrix protein, is an acute phase reactant that indu...

  17. Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia OmicsDI

    ID: E-GEOD-17556

    Date Released: 06-10-2011

    Description: d with a more aggressive form of atherosclerosis. Thrombospondin-1 (TSP-1), an extracellular matrix protein, is an acute phase reactant that indu...

  18. Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells. BioProject

    ID: PRJNA96643

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. THS7A_HUMAN UniProt:Swiss-Prot

    ID: Q9UPZ6

    Description: Thrombospondin type-1 domain-containing protein 7A Extracellular Helical Cytoplasmic TSP type...

  20. Transcription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1 ArrayExpress

    ID: E-GEOD-5134

    Description: atory factors (TGFbeta, thrombospondins, CD59, IL-1 receptor antagonist, etc.) in PE cells as identified via an oligonucleotide microarray. Several thrombospondin-binding molecules were detected, and thus we focused subsequent analyses on thrombospondins. Via the conversion of latent TGFbeta to an active form that appears to be mediated by thrombospondin 1 (TSP-1), cultured iris PE and retinal PE cells induce a PE-induced Treg cell fate. After conversion, both ocular PE and PE-induced Treg cells express TSP-1. Regulatory T cell generation was amplified when the T cells also expressed TSP-1. In addition, PE-induced T...

  21. THS7B_MOUSE UniProt:Swiss-Prot

    ID: Q6P4U0

    Description: Thrombospondin type-1 domain-containing protein 7B Extracellular Helical Cytoplasmic TSP type...

  22. TSP1_XENLA UniProt:Swiss-Prot

    ID: P35448

    Description: Thrombospondin-1 Laminin G-like VWFC TSP type-1 1

  23. THS7B_HUMAN UniProt:Swiss-Prot

    ID: Q9C0I4

    Description: Thrombospondin type-1 domain-containing protein 7B Extracellular Helical Cytoplasmic TSP type...

  24. TSP2_CHICK UniProt:Swiss-Prot

    ID: P35440

    Description: Thrombospondin-2 Laminin G-like VWFC TSP type-1 1 TSP t...

  25. TSP1_MOUSE UniProt:Swiss-Prot

    ID: P35441

    Description: Thrombospondin-1 Laminin G-like VWFC TSP type-1 1

  26. TSP4B_DANRE UniProt:Swiss-Prot

    ID: Q8JGW0

    Description: Thrombospondin-4-B Laminin G-like EGF-like 1; calcium-binding EGF-like 2; calcium-binding EGF-like 3

  27. TSP4_BOVIN UniProt:Swiss-Prot

    ID: Q3SWW8

    Description: Thrombospondin-4 Laminin G-like EGF-like 1 EGF-like 2; calcium-binding EGF-like 3; calcium-binding EGF-like 4

  28. TSP4_RAT UniProt:Swiss-Prot

    ID: P49744

    Description: Thrombospondin-4 Laminin G-like EGF-like 1 EGF-like 2; calcium-binding EGF-like 3; calcium-binding EGF-like 4

  29. TSP4_XENLA UniProt:Swiss-Prot

    ID: Q06441

    Description: Thrombospondin-4 Laminin G-like EGF-like 1 EGF-like 2; calcium-binding EGF-like 3; calcium-binding EGF-like 4

  30. Transcription profiling of mouse T cell response to ocular pigment epithelial cells - role of thrombospondin 1 OmicsDI

    ID: E-GEOD-5134

    Date Released: 03-27-2012

    Description: atory factors (TGFbeta, thrombospondins, CD59, IL-1 receptor antagonist, etc.) in PE cells as identified via an oligonucleotide microarray. Several thrombospondin-binding molecules were detected, and thus we focused subsequent analyses on thrombospondins. Via the conversion of latent TGFbeta to an active form that appears to be mediated by thrombospondin 1 (TSP-1), cultured iris PE and retinal PE cells induce a PE-induced Treg cell fate. After conversion, both ocular PE and PE-induced Treg cells express TSP-1. Regulatory T cell generation was amplified when the T cells also expressed TSP-1. In addition, PE-induced T...

  31. Thrombospondin 1 in a model of colorectal carcinogenesis OmicsDI

    ID: E-GEOD-60805

    Date Released: 08-28-2015

    Description: nflammation-induced carcinogenesis the effects of TSP-1 in induced tumors were analyzed. Mice received a single injection of azoxymethane (AOM) and multiple cycles of dextran sodium s...

  32. Arterial vs venous expression of genes: differences in inflammatory genes BioProject

    ID: PRJNA113631

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ctively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in ...
  33. Expression in Primary Effusion Lymphoma (PEL) BCBL-1 compared to BJAB (BL cell line) and L-428 (cHD cell line) BioProject

    ID: PRJNA94531

    Keywords: Transcriptome or Gene expression

    Access Type: download

  34. Thrombospondin-1: A Pro-Atherosclerotic Protein Augmented by Hyperglycemia GEMMA

    ID: 1348

    Keywords: functional genomics

    Description: d with a more aggressive form of atherosclerosis. Thrombospondin-1 (TSP-1), an extracellular matrix protein, is an acute phase reactant that indu...

  35. ATS19_HUMAN UniProt:Swiss-Prot

    ID: Q8TE59

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 19 Peptidase M12B Disintegrin TSP type-1 1

  36. ATS19_MOUSE UniProt:Swiss-Prot

    ID: P59509

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 19 Peptidase M12B Disintegrin TSP type-1 1

  37. Gene expression profiling in patients infected with HTLV-1: Identification of ATL and HAM/TSP-specific genetic profiles BioProject

    ID: PRJNA120489

    Keywords: Transcriptome or Gene expression

    Access Type: download

  38. The effect of milk accumulation on gene expression in bovine mammary gland ArrayExpress

    ID: E-GEOD-27840

    Description: ) in a half-udder milk stasis experiment. On day 1 of the experiment, cows were milked at 0430 h and at 1430 h, only right udder halves were milked. Mammary biopsies were obtained from both udder halves on day 2 of the experiment at 0500 h, immediately after right udder halves were milked and 12 h since left udder halves had last been milked. Using Affymetrix GeneChip® Bovin...

  39. The effect of milk accumulation on gene expression in bovine mammary gland BioProject

    ID: PRJNA138037

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ) in a half-udder milk stasis experiment. On day 1 of the experiment, cows were milked at 0430 h and at 1430 h, only right udder halves were milked. Mammary biopsies were obtained from both udder halves on day 2 of the experiment at 0500 h, immediately after right udder halves were milked and 12 h since left udder halves had last been milked. Using Affymetrix GeneChip® Bovin...
  40. ATS2_MOUSE UniProt:Swiss-Prot

    ID: Q8C9W3

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 2 Peptidase M12B Disintegrin TSP type-1 1 <

  41. ATS2_HUMAN UniProt:Swiss-Prot

    ID: O95450

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 2 Peptidase M12B Disintegrin TSP type-1 1 <

  42. ATS2_BOVIN UniProt:Swiss-Prot

    ID: P79331

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 2 Peptidase M12B Disintegrin TSP type-1 1 <

  43. Trascriptional profiling of angiogenic inhibitors BioProject

    ID: PRJNA91225

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ression profiles following treatment with either: 1. recombinant interferon-alpha (IFN-alpha); 2. pigment epithelium derived factor (PEDF); 3. all trans-retinoic acid (RA); 4. thrombospondin 1 (TSP-1); 5. TNP-470 (TNP-470); 6. endostatin (ENDO); 7. angiostatin (ANGIO). To ensure that cDNA products were proportional to the initial gene expression pattern, 33P-lab...
  44. Arterial vs venous expression of genes: differences in inflammatory genes ArrayExpress

    ID: E-GEOD-12255

    Description: ctively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in ...

  45. SSPO_RAT UniProt:Swiss-Prot

    ID: Q700K0

    Description: SCO-spondin EMI VWFD 1 TIL 1 VWFD 2 TIL 2 VWFD 3 TIL 3 LDL-receptor class A 1 LDL-receptor class A 2 LDL-receptor ...

  46. ARP_EUGGR UniProt:Swiss-Prot

    ID: Q04732

    Description: Or 23 Calcium-binding acidic-repeat protein TSP type-3 1 TSP type-3 2 TSP type-3 3 TSP type-3 4

  47. SSPO_CHICK UniProt:Swiss-Prot

    ID: Q2PC93

    Description: SCO-spondin EMI VWFD 1 TIL 1 VWFC 1 VWFD 2 TIL 2 VWFC 2 VWFD 3 TIL 3 LDL-receptor class A 1 LDL...

  48. Arterial vs venous expression of genes: differences in inflammatory genes GEMMA

    ID: 1418

    Keywords: functional genomics

    Description: ctively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in ...

  49. Structure of SmTSP2EC2 PDB

    ID: PDB:2M7Z

    Description: CD63-like protein Sm-TSP-2

  50. CADN_ACRMI UniProt:Swiss-Prot

    ID: B3EWZ3

    Description: sin Extracellular Helical Cytoplasmic F5/8 type C 1 TSP type-1 1 TSP type-1 2 TSP

  51. PROP_PONAB UniProt:Swiss-Prot

    ID: Q5RBP8

    Description: Properdin TSP type-1 0 TSP type-1 1 TSP type-<...

  52. ARID-DNA interactions are required for promoter occupancy by SWI/SNF BioProject

    ID: PRJNA147453

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n of ARID domain-dependent, BAF-A associations at THROMBOSPONDIN 1 (THBS1) led to the concomitant upregulation of this anti-angiogenic protein. Using a THBS1 promoter-reporter gene, we further show that BAF-A directly regulates THBS1 promoter activity in an ARID domain-dependent manner. Our data not only demonstrate that ARID-DNA interactions are physiologically relevant in higher eukaryotes, but also indicate these interactions can facilitate SWI/SNF binding to target sites in vivo. These findings support the model wherein cooperative interactions among intrinsic subunit-chromatin interaction domains and sequence-specific transcription factors drive SWI/SNF recruitment. Overall design: Four-condition experiment, wild-type vs Baf250a/Arid1a^V1...
  53. COMP_RAT UniProt:Swiss-Prot

    ID: P35444

    Description: Cartilage oligomeric matrix protein EGF-like 1 EGF-like 2; calcium-binding EGF-like 3; calcium-binding EGF-like 4 TSP type-3 1

  54. SPON1_CHICK UniProt:Swiss-Prot

    ID: Q9W770

    Description: Spondin-1 Reelin Spondin TSP type-1 1 TSP type-1

  55. Gene expression profiles of CD8+ T Lymphocytes isolated from HTLV-1 infected individuals OmicsDI

    ID: E-GEOD-26150

    Date Released: 06-02-2014

    Description: HTLV-1 is the etiologic agent of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP

  56. Gene expression profiling in patients infected with HTLV-1: Identification of ATL and HAM/TSP-specific genetic profiles OmicsDI

    ID: E-GEOD-19080

    Date Released: 05-02-2014

    Description: files of CD4+ T-cells isolated from 7 ATL, 12 HAM/TSP and 11 AC (asymptomatic carriers) to identify gene signatures that may be characteristic for these particular diseases. Using gene expression arrays, we identifie...

  57. Genes expression of cervical squamous cell carcinoma, CaSki cells, treated with or without recombinant TGF-b1 (2 ng/mL) ArrayExpress

    ID: E-GEOD-57441

    Description: asscocited fibroblasts (CAFs) activates TGF-b via TSP-1 secretion to facilitate CSCC invade, resulting in up-regulation of pSMAD3 in CSCC cells to promote invasion. These results suggest that activation of TGF-b induced by the interaction between CSCC cells and CAFs could play a key role in the initiation of tumor spreads. We used microarrays to clarify the changes of gene expression along with recombinant TGF-b1 treatment and to confirm whether there are any changes on genes expression related to TGF-b pathway....

  58. COMP_BOVIN UniProt:Swiss-Prot

    ID: P35445

    Description: Cartilage oligomeric matrix protein EGF-like 1 EGF-like 2; calcium-binding EGF-like 3; calcium-binding EGF-like 4 TSP type-3 1

  59. SEM5A_MOUSE UniProt:Swiss-Prot

    ID: Q62217

    Description: aphorin-5A Extracellular Helical Cytoplasmic Sema TSP type-1 1 TSP type-1 2 TSP type-

  60. Gene expression profiling in patients infected with HTLV-1: Identification of ATL and HAM/TSP-specific genetic profiles ArrayExpress

    ID: E-GEOD-19080

    Description: files of CD4+ T-cells isolated from 7 ATL, 12 HAM/TSP and 11 AC (asymptomatic carriers) to identify gene signatures that may be characteristic for these particular diseases. Using gene expression arrays, we identifie...

  61. PROP_CAVPO UniProt:Swiss-Prot

    ID: Q64181

    Description: Properdin TSP type-1 0 TSP type-1 1 TSP type-<...

  62. SPON1_RAT UniProt:Swiss-Prot

    ID: P35446

    Description: Spondin-1 Reelin Spondin TSP type-1 1 TSP type-1

  63. ATL4_RAT UniProt:Swiss-Prot

    ID: Q4FZU4

    Description: ADAMTS-like protein 4 TSP type-1 1 TSP type-1 2 TSP type-<...

  64. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals. OmicsDI

    ID: E-GEOD-38537

    Date Released: 06-02-2014

    Description: HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we...

  65. Transcription profiling of human cells stably expressing KSHV-encoded MicroRNAs ArrayExpress

    ID: E-GEOD-7554

    Description: e of these genes and found that protein levels of thrombospondin 1 (THBS1) were decreased >10-fold. THBS1 has previously been reported to be down-regulated in KS lesions and has known activity as a strong tumor suppressor and anti-angiogenic factor, exerting its anti-angiogenic effect in part by activating the latent form of TGF-b. We show that reduced THBS1 expression in the presence of viral miRNAs translates into decreased TGF-b activity. These data suggest that KSHV-encoded miRNAs may contribute directly to pathogenesis by down-regulation of THBS1, a major regulator of cell adhesion, migration, and angiogenesis. Experiment Overall Design: 293 cells were stably transfected with either a vector expressing 10 KHSV encoded microRNAs or empty vector control. Cells were selected through G418. 4 samples were collected for each cell line and RNA collected for Affymetrix microarray analysis. R...

  66. ATS8_MOUSE UniProt:Swiss-Prot

    ID: P57110

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 8 Peptidase M12B Disintegrin TSP type-1 1 <

  67. SPON1_BOVIN UniProt:Swiss-Prot

    ID: Q9GLX9

    Description: Spondin-1 Reelin Spondin TSP type-1 1 TSP type-1

  68. SEM5A_RAT UniProt:Swiss-Prot

    ID: D3ZTD8

    Description: Semaphorin-5A Helical Sema PSI TSP type-1 1 TSP type-1 2 TSP type-<...

  69. Gene expression profiles of CD8+ T Lymphocytes isolated from HTLV-1 infected individuals BioProject

    ID: PRJNA135263

    Keywords: Transcriptome or Gene expression

    Access Type: download

  70. Transcription profiling of human cells stably expressing KSHV-encoded MicroRNAs OmicsDI

    ID: E-GEOD-7554

    Date Released: 06-10-2011

    Description: e of these genes and found that protein levels of thrombospondin 1 (THBS1) were decreased >10-fold. THBS1 has previously been reported to be down-regulated in KS lesions and has known activity as a strong tumor suppressor and anti-angiogenic factor, exerting its anti-angiogenic effect in part by activating the latent form of TGF-b. We show that reduced THBS1 expression in the presence of viral miRNAs translates into decreased TGF-b activity. These data suggest that KSHV-encoded miRNAs may contribute directly to pathogenesis by down-regulation of THBS1, a major regulator of cell adhesion, migration, and angiogenesis. Experiment Overall Design: 293 cells were stably transfected with either a vector expressing 10 KHSV encoded microRNAs or empty vector control. Cells were selected through G418. 4 samples were collected for each cell line and RNA collected for Affymetrix microarray analysis. R...

  71. The effect of milk accumulation on gene expression in bovine mammary gland OmicsDI

    ID: E-GEOD-27840

    Date Released: 06-02-2014

    Description: ) in a half-udder milk stasis experiment. On day 1 of the experiment, cows were milked at 0430 h and at 1430 h, only right udder halves were milked. Mammary biopsies were obtained from both udder halves on day 2 of the experiment at 0500 h, immediately after right udder halves were milked and 12 h since left udder halves had last been milked. Using Affymetrix GeneChip® Bovin...

  72. Gene expression analysis of TGF-beta signaling-disrupting gastric cancer cell line 2MLN ArrayExpress

    ID: E-GEOD-12336

    Description: microarray analysis, we found gene expression of TSP-1, an angiogenic inhibitor, was down-regulated in dnTβRII tumors. This results suggested disruption of TGF-β signaling in diffuse-type gastric carcinoma cells leads to alteration of tumor microenvironment and acceleration of tumor growth. We generated two OCUM-2MLN-derived gastric carcinoma cell lines; 2MLN-dnTβRII, which expresses dominant negative form of TβRII, and control 2MLN-GFP, which expresses GFP. The transplanted tumors of these cell lines were subjected to gene expression analysis with Affymetrix U133 plus2 arrays....

  73. TRAP_PLAFA UniProt:Swiss-Prot

    ID: P16893

    Description: Thrombospondin-related anonymous protein Extracellular Helical Cytoplasmic VWFA TSP type-1 Ce...

  74. SPON1_XENLA UniProt:Swiss-Prot

    ID: P35447

    Description: Spondin-1 Reelin Spondin TSP type-1 1 TSP type-1

  75. THSD1_PONAB UniProt:Swiss-Prot

    ID: Q5R7R7

    Description: Thrombospondin type-1 domain-containing protein 1 Extracellular Helical Cytoplasmic

  76. ATS5_BOVIN UniProt:Swiss-Prot

    ID: Q9TT92

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 5 Peptidase M12B Disintegrin TSP type-1 Zinc; catalytic Zinc; catalytic...

  77. ATS4_PONAB UniProt:Swiss-Prot

    ID: Q5RFQ8

    Description: A disintegrin and metalloproteinase with thrombospondin motifs 4 Peptidase M12B Disintegrin TSP type-1 Spacer Cysteine switch Zinc; in...

  78. Tasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro OmicsDI

    ID: E-GEOD-17031

    Date Released: 06-02-2014

    Description: ine receptor CXCR4, cytochrome P450 1A1 (CYP1A1), thrombospondin-1 (THBS1) and Lysyloxidase preprotein (LOX). To further explore the mode of action of ABR-215050, in vitro experiments with gene microarray analysis were performed using LNCaP prostate tumor cells. The array data were validated by real-time PCR (sqRT-PCR), as well as by protein expression experiments. One of the most significant differentially expressed genes after exposure to ABR-215050, was thrombospondin-1 (THBS1). 2-color treatment vs. control microarray experiment comprising four biological replicates. Each biological replicate was hybridized with dye-swap; resulting in eight hybridizations for...

  79. SBSPO_BOVIN UniProt:Swiss-Prot

    ID: Q32L50

    Description: Somatomedin-B and thrombospondin type-1 domain-containing protein SMB TSP type-1 N-linked (G...

  80. Gene expression profiles of CD8+ T Lymphocytes isolated from HTLV-1 infected individuals ArrayExpress

    ID: E-GEOD-26150

    Description: HTLV-1 is the etiologic agent of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP

  81. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals. BioProject

    ID: PRJNA168100

    Keywords: Transcriptome or Gene expression

    Access Type: download

  82. aTEA 40 uM 12 hour treatment for MDA-MB-435 cells BioProject

    ID: PRJNA98075

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ein referred to as ARG (Abelson-related gene) and THBS1 which codes for thrombospondin 1, TSP-1 were chosen for further study. Keywords: Anti-cancer drug (aTEA at 40 uM 12 hour) treatment for MDA-MB-435 cells Overall design: The whole-genome cDNA microarrays were manufactured in the laboratory of Dr. Vishwanath Iyer (U.T. Austin). For the microarray experiments, MDA-MB-435 cells were cultured with 40 mM of a-TEA or ethanol control for 12 h. Messenger RNA was isolated using the FastTrack 2.0 kit (Invitrogen, Carlsbad, CA) then reverse transcribed by SuperScript II reverse transcriptase (Invitrogen) according to the manufacturers...
  83. TSP3B_DANRE UniProt:Swiss-Prot

    ID: Q1L8P7

    Description: Thrombospondin-3b Laminin G-like EGF-like 1; calcium-binding EGF-like 2 TSP type-3 <

  84. BAI1_HUMAN UniProt:Swiss-Prot

    ID: O14514

    Description: Brain-specific angiogenesis inhibitor 1 Extracellular Helical; Name=1 Cytoplasmic Helical; Name=2 Extracellular Helical; Name=3 Cytoplasmic Helical; N...

  85. IL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals ArrayExpress

    ID: E-GEOD-38537

    Description: HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we...

  86. gene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients ArrayExpress

    ID: E-GEOD-33859

    Description: n activated /CD69+ blood cells selected from HTLV-1-infected patient displaying HAM-TSP disease (HTLV-1-associated myelopathy/tropical spastic paraparesis), compared to healthy blood donor /HD (biological sample provi...

  87. MLP_ACRMI UniProt:Swiss-Prot

    ID: B3EWY9

    Description: in-like protein Extracellular Helical Cytoplasmic TSP type-1 1 TSP type-1 2 TSP type-

  88. AGRB2_PONAB UniProt:Swiss-Prot

    ID: Q5R7Y0

    Description: n-coupled receptor B2 Extracellular Helical; Name=1 Cytoplasmic Helical; Name=2 Extracellular Helical; Name=3 Cytoplasmic Helical; Name=4 Extracellular Helical; Name=5 Cytoplasmic Helical; Name=6 Ex...

  89. Genes expression of cervical squamous cell carcinoma, CaSki cells, treated with or without recombinant TGF-b1 (2 ng/mL) BioProject

    ID: PRJNA246462

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: asscocited fibroblasts (CAFs) activates TGF-b via TSP-1 secretion to facilitate CSCC invade, resulting in up-regulation of pSMAD3 in CSCC cells to promote invasion. These results suggest that activation of TGF-b induced by the interaction between CSCC cells and CAFs could play a key role in the initiation of tumor spreads. Overall design: We used microarrays to clarify the changes of gene expression along with recombinant TGF-b1 treatment and to confirm whether there are any changes on genes expression related to TGF-b pathway....
  90. Identification of Cellular Genes Targeted by KSHV-Encoded MicroRNAs BioProject

    ID: PRJNA100371

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e of these genes and found that protein levels of thrombospondin 1 (THBS1) were decreased >10-fold. THBS1 has previously been reported to be down-regulated in KS lesions and has known activity as a strong tumor suppressor and anti-angiogenic factor, exerting its anti-angiogenic effect in part by activating the latent form of TGF-b. We show that reduced THBS1 expression in the presence of viral miRNAs translates into decreased TGF-b activity. These data suggest that KSHV-encoded miRNAs may contribute directly to pathogenesis by down-regulation of THBS1, a major regulator of cell adhesion, migration, and angiogenesis. Keywords: comparison, experiemental versus control Overall design: 293 cells were stably transfected with either a vector expressing 10 KHSV encoded microRNAs or empty vector control. Cells were selected through G418. 4 samples were collected for each cell line and RNA collecte...
  91. Gene expression analysis of TGF-beta signaling-disrupting gastric cancer cell line 2MLN BioProject

    ID: PRJNA113229

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: microarray analysis, we found gene expression of TSP-1, an angiogenic inhibitor, was down-regulated in dnTβRII tumors. This results suggested disruption of TGF-β signaling in diffuse-type gastric carcinoma cells leads to alteration of tumor microenvironment and acceleration of tumor growth. Overall design: We generated two OCUM-2MLN-derived gastric carcinoma cell lines; 2MLN-dnTβRII, which expresses dominant negative form of TβRII, and control 2MLN-GFP, which expresses GFP. The transplanted tumors of these cell lines were subjected to gene expression analysis with Affymetrix U133 plus2 arrays....
  92. Comparison of Transcriptomics of Mouse Skin Derived Precursors (SKPs) and Dermal Fibroblasts by RNA-Seq BioProject

    ID: PRJNA236120

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: significantly up-regulated genes Wnt4, Wisp2 and Tsp-1 and the down-regulated genes Retn, Slitrk1, Klk6, Agtr2, Ivl, Msx1, IL15, Atp6v0d2, Kcne1l and Thbs4 might play important roles in the transition of SKPs to fibroblasts. KEGG analysis showed that DEGs were significantly enriched in the TGF-β signaling pathway, Wnt signaling pathway and Notch signaling pathway, which have been previously proven to regulate the differentiation and self-renewal of various stem cells. These identified DEGs and pathways could facilitate further investigations of the detailed molecular mechanisms, making it possible to take advantage of the potential therapeutic applications of SKPs in skin repair in the future. Overall design: Examination of 2 cell types (SKPs and fibroblasts)....
  93. ECT_ACRMI UniProt:Swiss-Prot

    ID: B3EWZ8

    Description: Ectin TSP type-1 1 TSP type-1 2 SCP

  94. SEN34_NEUCR UniProt:Swiss-Prot

    ID: Q7SAK9

    Description: Probable tRNA-splicing endonuclease subunit tsp-4

  95. Gene expression profiling of MT-2 cells treated with interferon-alpha and ascorbic acid (dose response) OmicsDI

    ID: E-GEOD-34572

    Date Released: 06-26-2012

    Description: Background: Clear guidelines for therapy of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-...

  96. Tasquinimod, a Quinoline-3-Carboxamide Anti-Angiogenic Agent, treated Prostate Cancer Cell Line in-vivo and in-vitro ArrayExpress

    ID: E-GEOD-17031

    Description: ine receptor CXCR4, cytochrome P450 1A1 (CYP1A1), thrombospondin-1 (THBS1) and Lysyloxidase preprotein (LOX). To further explore the mode of action of ABR-215050, in vitro experiments with gene microarray analysis were performed using LNCaP prostate tumor cells. The array data were validated by real-time PCR (sqRT-PCR), as well as by protein expression experiments. One of the most significant differentially expressed genes after exposure to ABR-215050, was thrombospondin-1 (THBS1). 2-color treatment vs. control microarray experiment comprising four biological replicates. Each biological replicate was hybridized with dye-swap; resulting in eight hybridizations for...

  97. gene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients BioProject

    ID: PRJNA148365

    Keywords: Transcriptome or Gene expression

    Access Type: download

  98. Arterial vs venous expression of genes: differences in inflammatory genes OmicsDI

    ID: E-GEOD-12255

    Date Released: 03-27-2012

    Description: ctively. Expression of mRNA for thrombospondins (TSP-1, 2, 4) was greater than 5-fold higher in veins vs arteries. The most prominent gene expression difference between the normal aorta and vena cava was pancreatitis associated protein (PAP1), a protein with anti-inflammatory functions that was 64-fold higher in vena cava vs aorta. Higher mRNA expression of TSP-1, TSP-2, TSP-4 and PAP1 in vena cava vs aorta was confirmed with real time RT-PCR. Importantly, immunohistochemical analysis of blood vessels sections qualitatively confirmed a higher expression of proteins in vena cava vs aorta. These studies report a difference in ...

  99. THSD1_BOVIN UniProt:Swiss-Prot

    ID: Q5BIR3

    Description: Thrombospondin type-1 domain-containing protein 1 Extracellular Helical Cytoplasmic

  100. SEN2_NEUCR UniProt:Swiss-Prot

    ID: Q9P6Y2

    Description: Probable tRNA-splicing endonuclease subunit tsp-2


Displaying 100 of 408 results for "THBS1"