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Displaying 20 of 1,039 results for "TGFBRAP1"
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  1. Clustering of CpG islands constitutes an important determinant of the interphase chromosome 3D organization [4C-Seq] BioProject

    ID: PRJNA225863

    Keywords: Other

    Access Type: download

    dataset.description: raction with the NPRL3 anchor (anchors near TSR3, TRAP1, PPL genes). In the forth experiment (anchor GENE-Des) the anchor was placed in a gene-poor area that did not interact with the NPRL3 promoter. The libraries for all anchors were pooled and sequenced in paired-end mode with a total depth of 75 million reads. Anchor NPRL3: two replicates for HD3 and two replicates for DT40 cell lines. Other anchors (TSR3, GENE-Des, TRAP1, PPL): two replicates, pooled library...
  2. Comparison of gene expression in Wild type and T cell-specific conditional Trim28 KO in TCR stimulated and un-stimulated naive CD4 positive and T regu... ArrayExpress

    ID: E-GEOD-32224

    Description: efective IL-2 production and T cell proliferation associated with defective upregulation of cell-cycle associated proteins. Accordingly, young CKO showed T-lymphopenia. Surprisingly, Trim28 CKO mice eventually accumulated auto-reactive memory-phenotype T cells that produced inflammatory IL-17. CKO mice are also susceptible to induced auto-inflammatory disease with TH-17 dominant immune response. Loss of Trim28 showed aberrant accumulation of TH-17 and FoxP3+ T cells, two key T cells in inflammation vs. tolerance. We found CKO T cells showed a cell-extrinsic promotion of TH-17 and FoxP3+ T cell development by a mechanism involving overproduction of TGF-beta. Our study revealed unexpected roles of Trim28, a global chromatin regulator in both T cell activation and tolerance. Trim28 conditional KO mice and age-matched control mice were sacrificed, and neive CD4+ T cells (CD4+CD62+CD25-) and Treg (CD4+CD62+CD25+) were sorted. Stimulation of naive T cells was done with anti-CD3 and anti-CD28 for 13 hours. We collected quadru...

  3. T-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy ArrayExpress

    ID: E-GEOD-43077

    Description: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for t...

  4. Gene expression data from MDA-MB231 cells stably transduced with lentiviral vectors encoding a control shRNA (shscramble) or two shRNAs targeting Coco... ArrayExpress

    ID: E-GEOD-28049

    Description: we found that Coco, a secreted antagonist of TGF-beta ligands, induces solitary mammary carcinoma cells that have extravasated in the lung stroma to exit from dormancy. Mechanistic studies demonstrate that Coco awakens dormant metastasis-initiating cells by blocking stroma-derived Bone Morphogenetic Proteins. Inhibition of canonical BMP signaling reverses the commitment to differentiation of these cells and enhances their self-renewal and tumor-initiation capacity. Expression of Coco induces a discrete gene...

  5. Microarray analysis of T-cell death-associated gene 8 (TDAG8)-mediated gene expression in mouse Lewis lung carcinoma (LLC) cells ArrayExpress

    ID: E-GEOD-31776

    Description: eviously identified an extracellular pH-sensing G protein-coupled receptor T cell death associated gene 8 (TDAG8) as an extracellular pH sensor of t...

  6. Obesity study in transgenic and knockout animals OmicsDI

    ID: E-GEOD-12000

    Date Released: 05-01-2014

    Description: -enriched metabolic network module that is highly associated with metabolic traits in mice and humans. Integration of gene expression in the design and analysis of traditional F2 intercross studies allows high confidence prediction of causal genes, and identification of involved pathways and networks. This SuperSeries is composed of the following subset Series: GSE11991: Liver gene expression profiling of lipoprotein lipase heterozygous knockout mice GSE11992: Liver gene expression profiling of cytosolic malic enzyme knockout mice GSE11993: Liver gene expression profiling of zinc finger binding protein 90 (Zfp90) transgenic mice GSE11994: Liver gene expression profiling of transforming growth factor beta receptor 2 heterozygous knockout (Tgfbr2+/-) mice GSE11995: Liver gene expression profiling of comple...

  7. TRAP_STAEP UniProt:Swiss-Prot

    ID: Q8GQQ1

    Description: Signal transduction protein TRAP ABM Phosphohistidine Phosphohistidine Phosphohistidine

  8. Transcription profiling by array of HCT-116 cell lines transiently silenced with TRAP1 compared with scrumble OmicsDI

    ID: E-MTAB-2500

    Date Released: 09-19-2014

    Description: Trascription profiling analysis was performed on HCT-116 cell lines transiently silenced with TRAP1 compared with scrumble

  9. T-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy BioProject

    ID: PRJNA184349

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for t...
  10. DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma BioProject

    ID: PRJNA152971

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ated by the DKK effector matrix metalloproteinase 1 (MMP1). Furthermore, gene expression analyses established the ability of DKK2 to differentially regulate genes such as CXCR4, PTHrP, RUNX2, and TGFb1 that are associated with homing, invasion, and growth of cancer cells in bone tissue as well as genes important for osteolysis, including HIF1a, JAG1, IL6, and VEGF. DKK2 promoted bone infiltration and osteolysis in vivo and further analyses defined DKK2 as a key factor in osteotropic malignancy. Interestingly, in Ewing sarcoma cells, DKK2 suppression simultaneously increased the potential for neuronal differentiation while decreasing chondrogenic and osteogenic differentiation. Our results provide ...
  11. Transcriptional Profiling of Cultured, Embryonic Epicardial Cells Identifies Novel Genes and Signaling Pathways Regulated by TGFβR3 in vitro BioProject

    ID: PRJNA302322

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: - mice exhibit failed coronary vessel development associated with decreased epicardial cell invasion. Immortalized Tgfbr3-/- epicardial cells display the same defects. Tgfbr3+/+ and Tgfbr3-/- cells incubated for 72 hours with VEH or ligands known to promote inv...
  12. SIAT_HAEI8 UniProt:Swiss-Prot

    ID: Q4QP40

    Description: Sialic acid TRAP transporter permease protein SiaT Helical Helical Helical Helical Helical Helical Helical Helical Helical H...

  13. Obesity study in transgenic and knockout animals ArrayExpress

    ID: E-GEOD-12000

    Description: -enriched metabolic network module that is highly associated with metabolic traits in mice and humans. Integration of gene expression in the design and analysis of traditional F2 intercross studies allows high confidence prediction of causal genes, and identification of involved pathways and networks. This SuperSeries is composed of the following subset Series: GSE11991: Liver gene expression profiling of lipoprotein lipase heterozygous knockout mice GSE11992: Liver gene expression profiling of cytosolic malic enzyme knockout mice GSE11993: Liver gene expression profiling of zinc finger binding protein 90 (Zfp90) transgenic mice GSE11994: Liver gene expression profiling of transforming growth factor beta receptor 2 heterozygous knockout (Tgfbr2+/-) mice GSE11995: Liver gene expression profiling of comple...

  14. Sample 1 - Injection 1 Orbitrap-Ion Trap Dryad

    DateIssued: 08-01-2016

    Description: Sample 1 - Injection 2

  15. TRAP_STAES UniProt:Swiss-Prot

    ID: Q8CNR9

    Description: Signal transduction protein TRAP ABM Phosphohistidine Phosphohistidine Phosphohistidine

  16. TRAP_STAEQ UniProt:Swiss-Prot

    ID: Q5HNA3

    Description: Signal transduction protein TRAP ABM Phosphohistidine Phosphohistidine Phosphohistidine

  17. TRAP_STAAN UniProt:Swiss-Prot

    ID: Q7A4W3

    Description: Signal transduction protein TRAP ABM Phosphohistidine Phosphohistidine Phosphohistidine

  18. TRAP_ECOLI UniProt:Swiss-Prot

    ID: P41068

    Description: Protein TraP

  19. Gene expression profiling in erythroid progenitors through ontogeny BioProject

    ID: PRJNA166911

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ked to hematological system development, cellular growth and proliferation. The KITLG, EPO, GATA1, PIM1 and STAT3 genes represent the major connection points in the hematological system development linked genes. Some JAK-STAT signaling pathway-linked genes were steadily upregulated throughout ontogeny (PIM1, SOCS, MYC, PTPN11), while others were downregulated (PTPN6, PIAS, SPRED2). In addition, some JAK-STAT pathway related genes have specific expression just at certain stages of ontogeny (STATs, GRB2, CREBB). Beside continuously upregulated (AKT1, PPP2CA, CHUK, NFKB1) and downregulated (FOXO1, PDPK1, PIK3CG) genes in the PI3K-AKT signaling pathway, we also observed intermittently regulated gene expression (NFKBIA, YWHAH). Conclusions: This broad overview of gene expression in erythropoiesis revealed transcription factors with a prevalence at certain stages of ontogenesis. Finally, our results show that EPO-mediated proliferation and survival of erythroid progenitors occurs mainly through modulation of JAK-STAT pathway associated STATs, GRB2 and PIK3 genes, as well as AKT pathway- coupled NFKBIA and YWHAH genes. Overall design: Adult peripheral blood mononuclear cells were isolated from buffy coats of 3 healthy donors using Lymphocyte Separation Medium (BioWhittaker, Walkersville, MD). We washed mononuclear cells twice with Dulbecco's phosphate-buffered saline (PBS, Invitrogen Corporation, Carlsbad, CA), and CD34+ c...
  20. Trap-80-dependence of TNF-alpha-induced genes BioProject

    ID: PRJNA112709

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 1,039 results for "TGFBRAP1"