TGFBRAP1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 1,039 results for "TGFBRAP1"
i
  1. Epigenomic Evolution of Diffuse Large B-cell Relapse ArrayExpress

    ID: E-GEOD-66329

    Description: ted regulatory elements and determine a relapse–associated methylation signature converging on key pathways such as transforming growth factor beta (TGF-beta) receptor activity. We also observe decreased intra-tumor methylation heterogeneity from diagnosis to relapsed tumor samples. Relapse-free patients display lower intra-tumor methylation heterogeneity at diagnosis compared to relapsed patients in an independent validation cohort....

  2. Gene expression profiling of pancreatic cancer cell line BxPC-3 induced by PAR-2 AP ArrayExpress

    ID: E-GEOD-44827

    Description: Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor activated by trypsin and coagulant factors, ...

  3. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK ArrayExpress

    ID: E-GEOD-27597

    Description: genes whose expression levels were significantly associated with regional emphysema severity while controlling for gene expression differences between individuals. Genes increasing in expression with increasing emphysematous destruction included those involved in inflammation, such as the B-cell receptor signaling pathway, while genes decreasing in expression were enriched in tissue repair processes, including the transforming growth factor beta (TGF beta) pathway, actin organization, and integrin signaling. We found concordant differential expression of these emphysema severity-associated genes in four cross-sectional studies of COPD. Using the Connectivity Map, we identified GHK as a compound that can reverse the gene-expression signature associated with emphysematous destruction and...

  4. Array-comparative genomic hybridization by using DualChip® human cancer 1.1 arrays BioProject

    ID: PRJNA106835

    Keywords: Variation

    Access Type: download

    dataset.description: ridization. Cancer Genetics and Cytogenetics. 177(1): 20-29) and all 294 genes contained in DualChip® human cancer 1.1 arrays were present also in Agilent arrays, it has been possible to compare results obtained by the two different platforms. We assumed aCGH performed by Agilent slides as reference method to assess gene gains and losses in neuroblastoma samples. This approach allowed us to select 120 genes printed on DualChip® arrays as invariant genes (ABI2, ADAM9, ANGPT1, AREG, BAK1, BIK, BARD1, BCL2A1, BCL2L2, BMP1, CASP3, CASP8, CDH12, CFLAR, CTNNA1, CD34, CLK1, CGRRF1, COL6A1, CSF1R, CSPG2, CTGF, CXCL9, CCNA2, CCNB1, CCNG1, CCNH, CDKN1A, CDKN1C, CDKN2A, CDKN2B, CDKL1, DSP, E2F3, E2F5, EFNA1, EGF, EGR1, FASTK, FGF1, FGF2, FGFR1, FGR, FN1, GAS1, HGFAC, HMMR, IGF1R, IGFBP2, IK, IFNAR1, IFNGR1, ILK, IRF1, ITGA1, ITGA4, IL10, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6R, IL8, KDR, KISS1, LIF, MIF, MMP11, MMP14, MDH1, MAP2K1, MAP2K5, MAPK10, MAPK14, MCL1, NF2, NID1, NINJ1, NRG1, NTRK1, PGF, PDGFB, PDGFRA, PLAT, PLG, PDCD2, PPBP, PRODH, PTGES, PCDH1, PTK2, PURA, QSCN6, RIPK1, RRM1, ARHGDIA, SFRP2, SOD1, STAT1, TEK, TERT, THBS1, TIAM1, TNC, TANK, TGFA, TGFB2, XRCC6, TGFB3, TGFBR1, TMED10, TPBG, TYRO3, ERBB4, FLT4, FOS, VIL2)....
  5. Clustering of CpG islands constitutes an important determinant of the interphase chromosome 3D organization [4C-Seq] ArrayExpress

    ID: E-GEOD-51937

    Description: raction with the NPRL3 anchor (anchors near TSR3, TRAP1, PPL genes). In the forth experiment (anchor GENE-Des) the anchor was placed in a gene-poor area that did not interact with the NPRL3 promoter. The libraries for all anchors were pooled and sequenced in paired-end mode with a total depth of 75 million reads. Anchor NPRL3: two replicates for HD3 and two replicates for DT40 cell lines. Other anchors (TSR3, GENE-Des, TRAP1, PPL): two replicates, pooled library...

  6. Epigenetic events in early breast cancer ArrayExpress

    ID: E-GEOD-8007

    Description: EC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter hy...

  7. A Human Model of Cerebral Amyloid Angiopathy Using Neural Crest-Derived Vascular Smooth Muscle Cells ArrayExpress

    ID: E-GEOD-55173

    Description: myloid angiopathy (CAA), characterised by amyloid-beta (Aβ) deposits in the walls of intracerebral and leptomeningeal arteries, is evident in a majority of Alzheimer’s disease patients and aged people. Here, we leverage on human pluripotent stem cells to generate vascular smooth mu...

  8. To study the genomic changes in senescent porcine coronary arterial endothelial cells by multiple passaging in vitro BioProject

    ID: PRJNA102429

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rterial endothelial cells until passage four. The protein presence of endothelial nitric oxide synthase, cyclic GMP levels [basal and during stimulation (bradykinin and A23187)], were reduced. The mRNA expression level was measured by microarray assays. Genes related to oxidative stress [superoxide dismutase (MnSOD), glutathione peroxidase 3, glutathione S-transferase M1] were downregulated, extracellular matrix components (type III collagen, thrombospondin 1 and 3, transforming
  9. Exercise-induced modification of skeletal muscle transcriptome in Arabian horses BioProject

    ID: PRJNA349176

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: es expressed in muscle tissue and are potentially associated with exercise adaptation in Arabian horses. Methods: Whole transcriptomes between three time points of muscle tissue collection were compared: T0 (untrained horses), ...
  10. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation BioProject

    ID: PRJNA304150

    Keywords: Other

    Access Type: download

  11. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation ArrayExpress

    ID: E-GEOD-75247

    Description: enomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, including mitochondrial chaperonins, to promote mitochondrial proteostasis. While misfolded mitochondrial matrix-localized ornithine trans...

  12. Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma (HT-HG_U133A) BioProject

    ID: PRJNA108143

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion as well as MYC and AKT activation, and S3 was associated with hepatocyte differentiation. Functional studies indicated that the WNT pathway activation signature characteristic of S1 tumors was not simply the result of beta-catenin mutation but rather was the result of transforming growth factor-beta activation, thus representing a new mechanism of WNT pathway activation in HCC. These experiments establish the first consensus classification framework for HCC based on gene expression profiles and highlight the power of integrating multiple data sets to define a robust molecular taxonomy of the disease. Overall design: Four hepatocellular carcinoma (HCC) cell line samples treated or untreated by TGF-beta...
  13. Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries ArrayExpress

    ID: E-GEOD-49920

    Description: a (LTH) during pregnancy can lead to intrauterine growth restriction with reduced body/brain weight, dysregulation of cerebral blood flow (CBF), and other problems in humans and rodents. In contrast, sheep appear to undergo relati...

  14. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 11c PDB

    ID: PDB:5JGA

    Description: Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding

  15. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 10 PDB

    ID: PDB:5JGB

    Description: Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding

  16. Structure of TRAP1 fragment PDB

    ID: PDB:5HPH

    Description: Heat shock protein 75 kDa, mitochondrial

  17. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 12 PDB

    ID: PDB:5JGD

    Description: Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding

  18. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation ArrayExpress

    ID: E-GEOD-75410

    Description: enomes. In C. elegans, the mitochondrial unfolded protein response (UPRmt) senses matrix protein misfolding and induces a program of nuclear gene expression, including mitochondrial chaperonins, to promote mitochondrial proteostasis. While misfolded mitochondrial matrix-localized ornithine trans...

  19. Gene Expression of ApoE Null and ApoE Null/RAGE Diabetic and Non-diabetic Mice ArrayExpress

    ID: E-GEOD-15729

    Description: The multi-ligand Receptor for AGE (RAGE) contributes to atherosclerosis in apolipoprotein (ApoE) null mice in both the non-diabetic and diabetic sta...

  20. Gene expression profiling in true interval breast cancer reveals overactivation of mTOR signalling pathway ArrayExpress

    ID: E-GEOD-47108

    Description: aimed to identify biological markers that may be associated with the emergence of symptomatic breast cancer in the screening interval. Material and Methods: An unsupervised exploratory gene expression profile analysis was performed among 10 samples (discovery set, TIBC=5 and SDBC=5) using Affymetrix Human Gene 1.0 ST arrays and interpreted by Ingenuity Pathway Analysis. Differential expression of selected genes was confirmed in validation series of 91 patients (TIBC=12 and SDBC=79) by immunohistochemistry and 24 patients (TIBC=8 and SDBC=16) by RT-qPCR, expanding the analysis to other genes in same pathway (mTOR, 4E-BP1, eIF-4G and S6). Results: Exploratory gene expression analysis identified 1...


Displaying 20 of 1,039 results for "TGFBRAP1"