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  1. Solution NMR Structure of PH Domain of Tyrosine-protein kinase Tec from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR3504C PDB

    ID: PDB:2LUL

    Description: Tyrosine-protein kinase Tec (E.C.2.7.10.2)

  2. NMR STRUCTURE OF THE SH3 DOMAIN FROM THE TEC PROTEIN TYROSINE KINASE PDB

    ID: PDB:1GL5

    Description: TYROSINE-PROTEIN KINASE TEC (E.C.2.7.1.112)

  3. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases. PDB

    ID: PDB:3K54

    Description: Tyrosine-protein kinase BTK (E.C.2.7.10.2)

  4. The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound PDB

    ID: PDB:3GEN

    Description: Tyrosine-protein kinase BTK (E.C.2.7.10.2)

  5. Genome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs) BioProject

    ID: PRJNA267718

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Identification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo OmicsDI

    ID: E-GEOD-50555

    Date Released: 05-02-2014

    Description: propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-e...

  7. TEC_BPP1 UniProt:Swiss-Prot

    ID: Q06261

    Description: Protein tec

  8. Transcription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice ArrayExpress

    ID: E-GEOD-65617

    Description: umerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existenc...

  9. Genome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs) ArrayExpress

    ID: E-GEOD-63432

    Description: purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up- or down-regulated genes, affected by the Hipk2 gene knockout. Total RNA obtained from isolated CD80 low and CD80 high mTECs of TEC

  10. imageData: an R package that aids in processing and plotting data from a Lemna-Tec Scananalyzer Dryad

    DateIssued: 11-18-2016

    Description: s traits from imaging data produced using a Lemna-Tec Scananalyzer. Growth rates between successive imagings are obtained and those for a nominated set of intervals can also be calculated. Profile or longitudinal...

  11. Human thymic epithelial cell: untransfected control vs. scramble-siRNA transfected vs. CD49e-siRNA transfected BioProject

    ID: PRJNA119437

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: mic microenvironment the thymic epithelial cells (TEC) are crucial for the maturation of T-lymphocytes because the secretion of extracellular matrix compounds, thymic hormones and cytokines and also by cell-cell contacts which can be mediated by extracellular matrix compounds and its receptors, integrins. There is evidence that extracellular matrix molecules play a fundamental role in localizing the different thymocyte stag...
  12. Genome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs) OmicsDI

    ID: E-GEOD-63432

    Date Released: 01-10-2015

    Description: purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up- or down-regulated genes, affected by the Hipk2 gene knockout. Total RNA obtained from isolated CD80 low and CD80 high mTECs of TEC

  13. Transcription profiling by high throughput sequencing of primary cTEC, mTEClo, and mTEChi harvested from wild type and Aire-deficient mice OmicsDI

    ID: E-GEOD-65617

    Date Released: 06-27-2016

    Description: umerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existenc...

  14. Gene Expression Data from Adult and Embryo Thymic Epithelial Cells (TEC) BioProject

    ID: PRJNA321529

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Identification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo ArrayExpress

    ID: E-GEOD-50555

    Description: propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-e...

  16. Itk-sh3 PDB

    ID: PDB:2LMJ

    Description: Tyrosine-protein kinase ITK/TSK (E.C.2.7.10.2)

  17. Differential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells BioProject

    ID: PRJNA274486

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: umerous self-antigens in thymic epithelial cells (TEC) enables the elimination of self-reactive T cells. The autoimmune regulator (Aire) is the only known molecular determinant driving pGE in the thymus but the existenc...
  18. Activation of Inflammation and Metabolic Networks in Age-related Thymic Involution. BioProject

    ID: PRJNA320761

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nvironment, particularly thymic epithelial cells (TEC). We studied the pathogenic processes in chronological aging of the murine thymus. We used microarrays to elucidate the global gene expression and to identify a leading edge subset of age-associated genes in TEC. Analyses of the
  19. Escherichia coli strain:tEC : Escherichia coli strain:tEC Genome sequencing and assembly BioProject

    ID: PRJNA308525

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: E. coli strain tEC was isolated from fecal sample of mouse and has been sequenced for genome.
  20. Identification of a stable molecular signature in breast tumor endothelial cells that persists ex vivo BioProject

    ID: PRJNA218090

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: propagation of tumor-specific endothelial cells (TEC) allows for ex vivo functional studies and gene expression profiling of clonally-derived, well-characterized subpopulations. Using a genetically-e...
  21. Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2 PDB

    ID: PDB:3SXS

    Description: Cytoplasmic tyrosine-protein kinase BMX (E.C.2.7.10.2)

  22. Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib PDB

    ID: PDB:3SXR

    Description: Cytoplasmic tyrosine-protein kinase BMX (E.C.2.7.10.2)

  23. INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE PDB

    ID: PDB:1AWJ

    Description: ITK

    datasetDistributions.storedIn: Protein Data Bank
  24. Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK PDB

    ID: PDB:2DM0

    Description: Tyrosine-protein kinase TXK (E.C.2.7.10.2)

  25. Gene expression in thymic epithelial cells [RNA-seq] ArrayExpress

    ID: E-GEOD-53110

    Description: ted populations of mouse thymic epithelial cells (TEC). Two biological replicates of each of seven murine TEC populations were FACS sorted and sequenced....

  26. Environment analysis of the Training in Employment Courses (TEC) in ICT sector in Morocco. Figshare

    ID: doi:10.6084/M9.FIGSHARE.1190711

    Release Date: 10-02-2014

    Description:

  27. microRNA expression in thymic epithelial cells BioProject

    ID: PRJNA283357

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d. MicroRNAs (miRNAs) are important regulators of TEC genetic programs since miRNA-deficient TECs are severely defective. However, the individual miRNAs important for TEC maintenance and function and their mechanisms of action remain unknown. Here, we demonstrate that miR-205 is highly and preferentially expressed in mTECs during both thymic ontogeny and in the postnatal thymus. This distinct expression is suggestive of functional importance for TEC biology. Genetic ablation of miR-205 in TECs, however, neither revealed a role for miR-205 in TEC function during homeostatic...
  28. Gene expression in thymic epithelial cells [RNA-seq] BioProject

    ID: PRJNA230859

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ted populations of mouse thymic epithelial cells (TEC). Overall design: Two biological replicates of each of seven murine TEC populations were FACS sorted and sequenced....
  29. Gene expression in thymic epithelial cells [RNA-seq] OmicsDI

    ID: E-GEOD-53110

    Date Released: 12-10-2014

    Description: ted populations of mouse thymic epithelial cells (TEC). Two biological replicates of each of seven murine TEC populations were FACS sorted and sequenced....

  30. Expression data from tumor-associated endothelial cells of hepatocellular carcinoma ArrayExpress

    ID: E-GEOD-51401

    Description: ultured CD31+ and CD105+ tumor endothelial cells (TEC), non-tumor endothelial cells (NEC) ,remnant cells from tumor (TC) and non-tumor liver tissue (NTC)of HCC tissues from patientswere isolat...

  31. microRNA expression in thymic epithelial cells OmicsDI

    ID: E-GEOD-68674

    Date Released: 08-19-2015

    Description: d. MicroRNAs (miRNAs) are important regulators of TEC genetic programs since miRNA-deficient TECs are severely defective. However, the individual miRNAs important for TEC maintenance and function and their mechanisms of action remain unknown. Here, we demonstrate that miR-205 is highly and preferentially expressed in mTECs during both thymic ontogeny and in the postnatal thymus. This distinct expression is suggestive of functional importance for TEC biology. Genetic ablation of miR-205 in TECs, however, neither revealed a role for miR-205 in TEC function during homeostatic...

  32. Expression data from tumor-associated endothelial cells of hepatocellular carcinoma OmicsDI

    ID: E-GEOD-51401

    Date Released: 06-03-2014

    Description: ultured CD31+ and CD105+ tumor endothelial cells (TEC), non-tumor endothelial cells (NEC) ,remnant cells from tumor (TC) and non-tumor liver tissue (NTC)of HCC tissues from patientswere isolat...

  33. CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOF... PDB

    ID: PDB:2YC1

    Description: SINGLE CHAIN ANTIBODY FRAGMENT 9004G, BETA-MAMMAL TOXIN CN2

    dataset.creators: Canul-Tec, J.C.
  34. Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor TFB-TBOA and the allosteric inhibitor UCPH101 PDB

    ID: PDB:5MJU

    Description: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1

    dataset.creators: Canul-Tec, J.C.
  35. Crystallographic structure of 3mJL2 from the germinal line lambda 3 PDB

    ID: PDB:4AIZ

    Description: V2-17 PROTEIN

  36. Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric inhibitor UCPH101 PDB

    ID: PDB:5LLM

    Description: Human glutamate transporter EAAT1

    dataset.creators: Canul-Tec, J.C.
  37. Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-ASP PDB

    ID: PDB:5LLU

    Description: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1

    dataset.creators: Canul-Tec, J.C.
  38. Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-ASP and the allosteric inhibitor UCPH101 PDB

    ID: PDB:5LM4

    Description: Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1

    dataset.creators: Canul-Tec, J.C.
  39. Crystallographic structure of an amyloidogenic variant, 3rCW, of the germinal line lambda 3 PDB

    ID: PDB:4AJ0

    Description: GERMINAL LINE LAMBDA 3 3RCW VARIANT

    dataset.creators: Canul-Tec, J.C.
  40. AireKO vs Black6 BioProject

    ID: PRJNA92051

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: TEC (B6 vs Aire KO). Thymic epithelial cells from B6 strain and AIRE KO are compared. Keywords: repeat sample
  41. Crystallographic structure of an amyloidogenic variant, 3rC34Y, of the germinal line lambda 3 PDB

    ID: PDB:4AIX

    Description: IG LAMBDA CHAIN V-IV REGION BAU

    dataset.creators: Canul-Tec, J.C.
  42. CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOF... PDB

    ID: PDB:2YBR

    Description: SINGLE CHAIN ANTIBODY FRAGMENT 9004G, BETA-MAMMAL TOXIN CN2

    dataset.creators: Canul-Tec, J.C.
  43. microRNA expression in thymic epithelial cells ArrayExpress

    ID: E-GEOD-68674

    Description: d. MicroRNAs (miRNAs) are important regulators of TEC genetic programs since miRNA-deficient TECs are severely defective. However, the individual miRNAs important for TEC maintenance and function and their mechanisms of action remain unknown. Here, we demonstrate that miR-205 is highly and preferentially expressed in mTECs during both thymic ontogeny and in the postnatal thymus. This distinct expression is suggestive of functional importance for TEC biology. Genetic ablation of miR-205 in TECs, however, neither revealed a role for miR-205 in TEC function during homeostatic...

  44. Microvesicles derived from human mesenchymal stem cells protect against acute tubular injury BioProject

    ID: PRJNA113707

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: apoptosis resistance of tubular epithelial cells (TEC). In addition, MVs were found to accelerate in vivo the morphological and functional recovery of glycerol induced AKI in SCID mice by inducing TEC proliferation. The effect of MVs on the recovery of AKI was comparable to that of human MSC treatment. In vitro we found that the CD44 and beta1-integrin-dependent incorporation of MVs in TEC was required for their biological action. However, despite their internalization, RNase-treated MVs failed to induce in vitro apoptosis resistance and TEC proliferation, and in vivo recovery from AKI, suggesting an RNA-dependent biological effect. Microarray analysis and quantitati...
  45. FGF2_MOUSE UniProt:Swiss-Prot

    ID: P15655

    Description: tor 2 Heparin-binding Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  46. FGF2_SHEEP UniProt:Swiss-Prot

    ID: P20003

    Description: chment site; atypical Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  47. FGF2_RABIT UniProt:Swiss-Prot

    ID: P48799

    Description: tor 2 Heparin-binding Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  48. FGF2_BOVIN UniProt:Swiss-Prot

    ID: P03969

    Description: chment site; atypical Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  49. TEC fluctuation during magnetically disturbed events of April 2010 on high latitude station. Figshare

    ID: doi:10.6084/M9.FIGSHARE.1179773

    Release Date: 09-24-2014

    Description:

  50. Gene expression analysis of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human embryonic stem cells BioProject

    ID: PRJNA243062

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g GFP were targeted to FOXN1, a gene required for TEC development. Using this FOXN1GFP/w line as a read out, we developed a reproducible protocol for generating FOXN1-GFP+ thymic endoderm cells. Transcriptional profiling and flow cytometry identified Integrin-β4 (ITGB4, CD104) and HLA-DR as markers that could be used in combination with EpCAM to selectively purify FOXN1+ TEC progenitors from differentiating cultures of unmanipulated PSCs. Human FOXN1+ TEC progenitors generated from PSCs will facilitate the study of thymus biology and are a valuable resource for future applications in regenerative medicine Overall design: Human embryonic stem cells were differentiated for 30 days using the protocol described by Soh et al, 2014. The hESCs used in this...
  51. miRNAs Expression of Mexican Patients with Breast Cancer ArrayExpress

    ID: E-GEOD-75669

    Description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. The experiments were with one color per patient, miRNAs expression profile is from a tumor sample of mexican patients with breast cancer....

  52. FGF2_RAT UniProt:Swiss-Prot

    ID: P13109

    Description: tor 2 Heparin-binding Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  53. Transcription profiling by array of thymic epithelial cells from AIRE knock-out mice ArrayExpress

    ID: E-GEOD-2515

    Description: TEC (B6 vs Aire KO). Thymic epithelial cells from B6 strain and AIRE KO are compared.

  54. Gene expression analysis of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human embryonic stem cells OmicsDI

    ID: E-GEOD-56373

    Date Released: 06-03-2014

    Description: g GFP were targeted to FOXN1, a gene required for TEC development. Using this FOXN1GFP/w line as a read out, we developed a reproducible protocol for generating FOXN1-GFP+ thymic endoderm cells. Transcriptional profiling and flow cytometry identified Integrin-β4 (ITGB4, CD104) and HLA-DR as markers that could be used in combination with EpCAM to selectively purify FOXN1+ TEC progenitors from differentiating cultures of unmanipulated PSCs. Human FOXN1+ TEC progenitors generated from PSCs will facilitate the study of thymus biology and are a valuable resource for future applications in regenerative medicine Human embryonic stem cells were differentiated for 30 days using the protocol described by Soh et al, 2014. The hESCs used in this protocol had be...

  55. Expression data from tumor-associated endothelial cells of hepatocellular carcinoma BioProject

    ID: PRJNA222897

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ultured CD31+ and CD105+ tumor endothelial cells (TEC), non-tumor endothelial cells (NEC) ,remnant cells from tumor (TC) and non-tumor liver tissue (NTC)of HCC tissues from patientswere isolat...
  56. Transcriptome sequencing of neonatal thymic epithelial cells ArrayExpress

    ID: E-GEOD-44945

    Description: te the capital role of TECs, our understanding of TEC biology is quite rudimentary. For instance, we ignore what might be the extent of divergence in the functional program of these two TECs populations. It also remains unclear why the number of TECs decreases rapidly with age, thereby leading to progressive thymic insufficiency. Methods: Systems level understanding of cell function begins with gen...

  57. Compilation and appraisal of geochronological data from the North Atlantic Igneous Province (NAIP) Figshare

    ID: doi:10.6084/M9.FIGSHARE.4159716

    Release Date: 11-01-2016

    Description: NAG-TEC Geochronological Database

  58. Gene Expression of Mexican Patients with Breast Cancer ArrayExpress

    ID: E-GEOD-75678

    Description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. The experiments were with one color per patient, gene expression profile is from a tumor sample of mexican patients with breast cancer....

  59. Gene expression analysis of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human embryonic stem cells ArrayExpress

    ID: E-GEOD-56373

    Description: g GFP were targeted to FOXN1, a gene required for TEC development. Using this FOXN1GFP/w line as a read out, we developed a reproducible protocol for generating FOXN1-GFP+ thymic endoderm cells. Transcriptional profiling and flow cytometry identified Integrin-β4 (ITGB4, CD104) and HLA-DR as markers that could be used in combination with EpCAM to selectively purify FOXN1+ TEC progenitors from differentiating cultures of unmanipulated PSCs. Human FOXN1+ TEC progenitors generated from PSCs will facilitate the study of thymus biology and are a valuable resource for future applications in regenerative medicine Human embryonic stem cells were differentiated for 30 days using the protocol described by Soh et al, 2014. The hESCs used in this protocol had be...

  60. miRNAs Expression of Mexican Patients with Breast Cancer OmicsDI

    ID: E-GEOD-75669

    Date Released: 12-12-2015

    Description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. The experiments were with one color per patient, miRNAs expression profile is from a tumor sample of mexican patients with breast cancer....

  61. Compilation and appraisal of geochronological data from the North Atlantic Igneous Province (NAIP) Figshare

    ID: doi:10.6084/M9.FIGSHARE.4159716.V1

    Release Date: 11-01-2016

    Description: NAG-TEC Geochronological Database

  62. FGF2_PANTR UniProt:Swiss-Prot

    ID: Q5IS69

    Description: c dimethylarginine; alternate Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  63. FGF2_MONDO UniProt:Swiss-Prot

    ID: P48798

    Description: tor 2 Heparin-binding Heparin Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)...

  64. Whole transcriptome sequencing of splenic influenza-specific CD8+ T cells in wt and Notch1/2ko mice ArrayExpress

    ID: E-MTAB-2999

    Description: To more specifically determine whether the TEC program is controlled by Notch, we generated molecular definitions of TECs and MPCs by whole transcriptome sequencing of sorted...

  65. Transcriptome sequencing of neonatal thymic epithelial cells. OmicsDI

    ID: E-GEOD-44945

    Date Released: 05-03-2014

    Description: te the capital role of TECs, our understanding of TEC biology is quite rudimentary. For instance, we ignore what might be the extent of divergence in the functional program of these two TECs populations. It also remains unclear why the number of TECs decreases rapidly with age, thereby leading to progressive thymic insufficiency. Methods: Systems level understanding of cell function begins with gen...

  66. Transcription profiling by array of thymic epithelial cells from AIRE knock-out mice OmicsDI

    ID: E-GEOD-2515

    Date Released: 04-30-2015

    Description: TEC (B6 vs Aire KO). Thymic epithelial cells from B6 strain and AIRE KO are compared.

  67. Gene Expression of Mexican Patients with Breast Cancer BioProject

    ID: PRJNA305047

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. Overall design: The experiments were with one color per patient, gene expression profile is from a tumor sample of mexican patients with breast cancer....
  68. TEF-seq/NET-seq applied to factors Rpb3, Paf1, Spt6, Spt16, Cet1, Pcf11, Ssu72, Set2 ArrayExpress

    ID: E-MTAB-4568

    Description: erase II (Pol2) transcription elongation complex (TEC) is immunoprecipitated via associated transcription elongation factors (TEFs). Sequencing from the 3' end of the Pol2-associated nascent transcript shows the position of the final incorporated nucleotide giving strand-specific, single nucleotide resolution maps of the level of TEF association with Pol2 during transcr...

  69. Gene Expression of Mexican Patients with Breast Cancer OmicsDI

    ID: E-GEOD-75678

    Date Released: 12-12-2015

    Description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. The experiments were with one color per patient, gene expression profile is from a tumor sample of mexican patients with breast cancer....

  70. FGF2_CAVPO UniProt:Swiss-Prot

    ID: Q60487

    Description: c dimethylarginine; alternate Phosphotyrosine; by TEC Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) In isoform 2....

  71. Transcription profiling of mouse Itk-deficiency using CD3+ T-cells OmicsDI

    ID: E-GEOD-12464

    Date Released: 06-10-2011

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  72. Thymic Epithelial Cells with Human T cell Leukemia Virus type 1 (HTLV-1) Infected T cell supernatant (with or without supernatant) BioProject

    ID: PRJNA300884

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: jor histocompatibility complex (MHC) molecules in TEC and culminate in TCR repertoire formation. In this study, we show that TECs have the receptors for HTLV-1 entry and can be infected by cell-cell contact and cell-free virus. These cells change gene expression of anti-apoptosis, chemokine and adhesion molecules genes; however, there is no difference in antigen presentation molecules. Furthermore, HTLV-1 infected TECs can transmit the virus to a CD4 T cell lineage and CD4 T cells derived from peripheral blood of healthy donors after in vitro co-cultivation. Conjointly, our data points to the possibility that the human thymic epithelial cells must favor the HTLV-1 infection as a reservoir, transmitting the virus to maturing lymphocytes that cause the disease in the periphery. Overall design: We used non-treated Thymic Epithelial Cell (TEC) and TEC treated with non-infected T cell supernatant (CEM). We analyze three independent samples (biological replicates) for each conditions (total 2 conditions) and also technical replicates using dye-swap. In total we use 1.5 slides with 4 array in each....
  73. Transcription profiling by array of mouse cortical and medullary thymic epithelial cells ArrayExpress

    ID: E-MEXP-3214

    Description: Cortical 1.4C18 and medullary 3.10 TEC lines (mTEC) were cultured in 10% fetal bovine serum-supplemented RPMI 1640 medium at 37 ?C in a 5% CO2 atmosphere. Confluent c...

  74. Whole transcriptome sequencing of splenic influenza-specific CD8+ T cells in wt and Notch1/2ko mice BioProject

    ID: PRJEB7506

    Keywords: Other

    Access Type: download

    dataset.description: To more specifically determine whether the TEC program is controlled by Notch, we generated molecular definitions of TECs and MPCs by whole transcriptome sequencing of sorted...
  75. miRNAs Expression of Mexican Patients with Breast Cancer BioProject

    ID: PRJNA305036

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ncer. Samples obtained from the Hospital San Jose Tec de Monterrey. Overall design: The experiments were with one color per patient, miRNAs expression profile is from a tumor sample of mexican patients with breast cancer....
  76. Thymic Epithelial Cells with Human T cell Leukemia Virus type 1 (HTLV-1) Infected T cell supernatant (CEM, CIB, C91PL) BioProject

    ID: PRJNA300882

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: jor histocompatibility complex (MHC) molecules in TEC and culminate in TCR repertoire formation. In this study, we show that TECs have the receptors for HTLV-1 entry and can be infected by cell-cell contact and cell-free virus. These cells change gene expression of anti-apoptosis, chemokine and adhesion molecules genes; however, there is no difference in antigen presentation molecules. Furthermore, HTLV-1 infected TECs can transmit the virus to a CD4 T cell lineage and CD4 T cells derived from peripheral blood of healthy donors after in vitro co-cultivation. Conjointly, our data points to the possibility that the human thymic epithelial cells must favor the HTLV-1 infection as a reservoir, transmitting the virus to maturing lymphocytes that cause the disease in the periphery. Overall design: We used thymic epithelial cell (TEC) treated with non-infected T cell supernatant (CEM) and TEC treated with infected T cell supernatant (CIB or C91PL). We analyze three independent samples (biological replicates) for each conditions (total 3 conditions) and also technical replicates using dye-swap. In total we use 4.5 slides with 4 array in each....
  77. Transcription profiling of mouse Itk-deficiency using CD3+ T-cells ArrayExpress

    ID: E-GEOD-12464

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  78. Transcriptome sequencing of neonatal thymic epithelial cells. BioProject

    ID: PRJNA192590

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: te the capital role of TECs, our understanding of TEC biology is quite rudimentary. For instance, we ignore what might be the extent of divergence in the functional program of these two TECs populations. It also remains unclear why the number of TECs decreases rapidly with age, thereby leading to progressive thymic insufficiency. Methods: Systems level understanding of cell function begins with gen...
  79. Whole transcriptome sequencing of splenic influenza-specific CD8+ T cells in wt and Notch1/2ko mice OmicsDI

    ID: E-MTAB-2999

    Date Released: 10-22-2014

    Description: To more specifically determine whether the TEC program is controlled by Notch, we generated molecular definitions of TECs and MPCs by whole transcriptome sequencing of sorted...

  80. The cancer cell of origin controls EMT-related tumour heterogeneity OmicsDI

    ID: E-GEOD-70474

    Date Released: 09-01-2016

    Description: Using transcriptional and chromatin profiling of TEC and TMC populations, we identified the gene regulatory network responsible for the change in the chromatin landscape and gene expression that accompanied EMT. We also identified distinct set of genes that were epigenetically and tra...

  81. Endothelial inhibition of the glycolytic activator PFKFB3 induces tumor vessel normalization, impairs metastasis and improves chemotherapy ArrayExpress

    ID: E-MTAB-4842

    Description: kade treatment improved chemotherapy. Considering TEC metabolism for anti-cancer treatment might thus merit further attention....

  82. Transcription profiling of mouse Itk-deficienct CD3+, CD4+ and CD8+ T cells ArrayExpress

    ID: E-GEOD-12465

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  83. TEF-seq/NET-seq applied to factors Rpb3, Spt6, Spt16, Cet1, Paf1, Pcf11, Ssu72, Set2. BioProject

    ID: PRJEB15871

    Keywords: Other

    Access Type: download

    dataset.description: erase II (Pol2) transcription elongation complex (TEC) is immunoprecipitated via associated transcription elongation factors (TEFs). Sequencing from the 3' end of the Pol2-associated nascent transcript shows the position of the final incorporated nucleotide giving strand-specific, single nucleotide resolution maps of TEFs associated with Pol2 during transcrip...
  84. Transcription profiling by array of mouse cortical and medullary thymic epithelial cells OmicsDI

    ID: E-MEXP-3214

    Date Released: 05-16-2013

    Description: Cortical 1.4C18 and medullary 3.10 TEC lines (mTEC) were cultured in 10% fetal bovine serum-supplemented RPMI 1640 medium at 37 ?C in a 5% CO2 atmosphere. Confluent c...

  85. Gene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177) ArrayExpress

    ID: E-GEOD-69766

    Description: omparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymocytes at the respective developmental stages. Total RNA extracted from FACS-sorted primary mouse thymocytes. CD4/8 double positive (DP) thymocytes, CD4 single positive (CD4 SP) thymocytes and CD8 single positive (CD8 SP) thymocytes were FACS-sorted from conditional knock...

  86. Gene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177) BioProject

    ID: PRJNA286738

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: omparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymocytes at the respective developmental stages. Overall design: Total RNA extracted from FACS-sorted primary mouse thymocytes. CD4/8 double positive (DP) thymocytes, CD4 single positive (CD4 SP) thymocytes and CD8 single positive (CD8 SP) thymocytes were FACS-sorted from c...
  87. Gene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177) OmicsDI

    ID: E-GEOD-69766

    Date Released: 12-02-2015

    Description: omparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymocytes at the respective developmental stages. Total RNA extracted from FACS-sorted primary mouse thymocytes. CD4/8 double positive (DP) thymocytes, CD4 single positive (CD4 SP) thymocytes and CD8 single positive (CD8 SP) thymocytes were FACS-sorted from conditional knock...

  88. Transcription profiling of mouse Itk-deficienct CD3+, CD4+ and CD8+ T cells OmicsDI

    ID: E-GEOD-12465

    Date Released: 06-10-2011

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  89. TEF-seq applied to transcription elongation factors Rpb3, Spt6, Spt16, Cet1, Nrd1, Paf1, Pcf11, Ssu72, Set2, Isw1, Yra1. (Rpb3 TEF-seq is the same as ... BioProject

    ID: PRJEB13094

    Keywords: Other

    Access Type: download

    dataset.description: erase II (Pol2) transcription elongation complex (TEC) is immunoprecipitated via associated transcription elongation factors (TEFs). Sequencing from the 3' end of the Pol2-associated nascent transcript shows the position of the final incorporated nucleotide giving strand-specific, single nucleotide resolution maps of TEFs associated with Pol2 during transcrip...
  90. Genome-wide omparism of Terc deficient ntESCs BioProject

    ID: PRJNA264831

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: clone pups by tetraploid embryo complementation (TEC), the most stringent test of naïve pluripotency. These data suggest that SCNT could offer a powerful tool to reprogram telomeres and to discover the factors for robust restoration of telomeres and pluripotency of telomerase haplo-insufficient somatic cells. Overall design: RNAs from Terc+/+, +/- and -/- contain 3 biological repeatsin each group....
  91. Transcriptional signatures of Itk-deficiency using CD3+ T-cells BioProject

    ID: PRJNA114225

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...
  92. ENDOTHELIAL INHIBITION OF THE GLYCOLYTIC ACTIVATOR PFKFB3 INDUCES TUMOR VESSEL NORMALIZATION, IMPAIRS METASTASIS AND IMPROVES CHEMOTHERAPY BioProject

    ID: PRJEB14511

    Keywords: Other

    Access Type: download

    dataset.description: kade treatment improved chemotherapy. Considering TEC metabolism for anti-cancer treatment might thus merit further attention....
  93. Transcriptional signatures of Itk-deficiency using CD3+, CD4+ and CD8+ T-cells BioProject

    ID: PRJNA114227

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...
  94. Transcriptional signatures of Itk-deficiency using CD3+ T-cells GEMMA

    ID: 1317

    Keywords: functional genomics

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  95. The cancer cell of origin controls EMT-related tumour heterogeneity ArrayExpress

    ID: E-GEOD-70474

    Description: Using transcriptional and chromatin profiling of TEC and TMC populations, we identified the gene regulatory network responsible for the change in the chromatin landscape and gene expression that accompanied EMT. We also identified distinct set of genes that were epigenetically and tra...

  96. Role of IL-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) in mast cell response to lipopolysaccharide (LPS) OmicsDI

    ID: E-GEOD-64287

    Date Released: 11-28-2015

    Description: NF-α plays an essential role to initiate sepsis. Tec family non-receptor tyrosine kinases ITK and BTK regulate mast cell-derived TNF-α in response to allergic antigen, but their role in LPS-induced TNF-α production by mast cells and r...

  97. Transcriptional signatures of Itk-deficiency using CD3+, CD4+ and CD8+ T-cells GEMMA

    ID: 1316

    Keywords: functional genomics

    Description: The Tec-family kinase Itk plays an important role during T-cell activation and function, and controls also conventio...

  98. Nanotoxicogenomic study of ZnO and TiO2 responses (Affymetrix) ArrayExpress

    ID: E-GEOD-39330

    Description: articles used in the study: ZnO-1 commercial (IBU-tec advanced materials AG), ZnO-2 (mandelic acid coated ZnO-1), ZnO-3 (mercaptopropyl-trimethoxysilane coated ZnO-1), ZnO-4 (methoxyl coated ZnO), ZnO-5 (diethylene glycol modified ZnO) and ZnO-9 (folic acid modified ZnO). Detailed particle production and characterization data can be found from the articles: Buerki-Thurnherr et al. 2012 Nanotoxicology and Tuomela et al. Altogether 71 samples were analyzed: 3 biological replicates of HMDM samples (untreated control, 10ug/ml of ZnO-1, 6 and 24 hours), 3 biological replicates of MDDC samples (untreated control, 6 and 24 hours), 7 biological replicates of MDDC samples (10ug/ml of ZnO-1, 24 hours), 3 replicates of Jurkat cells (untreated control, 10ug/ml of ZnO-1, 6 and 24 hours), 3 replicates of Jurkat cells (untreated control, 10ug/ml of ZnO-2, ZnO-3, ZnO-5 or ZnO-9, or 10, 25, 50 or 100ug/ml of ZnO-4, 24 hours)....

  99. Oncorhynchus mykiss : Nucleated erythrocytes can play more than one tune BioProject

    ID: PRJNA79833

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ic induced shift in the global trout erythrocyte (tEC) transcript profile and uncovered diverse cohorts of mRNAs related to multiple physiological systems including the endocrine, reproductive and immune systems. Further characterization of erythrocyte responses show a leukocyte-like activation profile and post-transcriptional regulation of induced mRNAs. Conditioned media obtained from poly (I:C) activated tECs contain bioactive, temperature-labile, molecules that modulate the trout macrophage anti-viral response suggesting a functional role for the erythrocyte in the...
  100. Sex hormones have pervasive effects on thymic epithelial cells BioProject

    ID: PRJNA278151

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n parallel, we analyzed variations in the size of TEC subsets in those three groups between 1 and 12 months of age. We report that sex hormones have pervasive effects on the transcriptome of TECs: the number of differentially expressed genes was 1,440 in cTECs and 1,783 in mTECs. Sexual dimorphism was particularly conspicuous in cTECs. Male cTECs displayed low proliferation rates that correlated with low expression of Foxn1 and its main targets. Furthermore, male cTECs expressed relativel...

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