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Displaying 5 of 45 results for "TCN2"
  1. Crystal Structure of Haptocorrin in Complex with Cbi PDB

    ID: PDB:4KKJ

    Description: Transcobalamin-1

  2. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions OmicsDI

    ID: E-GEOD-60914

    Date Released: 01-10-2016

    Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...

  3. Molecular classification of multiple myeloma GEMMA

    ID: 2130

    Keywords: functional genomics

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Last Updated (by provider): Dec 15 2010 Contributers: Vincenzo Callea Luigia Lombardi Daniela Intini Luca Agnelli Antonino Neri Michela Mattioli Donata Verdelli Luca Baldini Sonia Fabris Silvio Bicciato Fortunato Morabito Includes GDS1284. Update date: Oct 05 2006. Dataset description GDS1284: Analysis of CD138+ plasma cells purifi...

  4. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... ArrayExpress

    ID: E-GEOD-39683

    Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...

  5. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice OmicsDI

    ID: E-GEOD-57761

    Date Released: 04-27-2015

    Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...

Displaying 5 of 45 results for "TCN2"