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Displaying 10 of 45 results for "TCN2"
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  1. Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups OmicsDI

    ID: E-GEOD-2912

    Date Released: 03-27-2012

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...

  2. Collaborative Study of Genes, Nutrients and Metabolites (CSGNM) dbGaP

    ID: phs000789.v1.p1

    Description: While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand t...

    Study Types: Control Set

    disease.name: Holo transcobalamin II
  3. Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi ArrayExpress

    ID: E-GEOD-18175

    Description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...

  4. Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi BioProject

    ID: PRJNA119533

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...
  5. Proteomic analysis of integrin adhesion complex assembly OmicsDI

    ID: GPM32310025299

    Date Released:

    Description: , PXD ID: PXD002159. Experiment: 20101108 JAA FN1 tc2 1-30, file: 20101108_JAA_FN_tc2_AB17.mzml. From ProteomeXchange: {{i}} To explore the dynamics of integrin adhesion complex assembly, isolated adhesion ...

  6. Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M2Q

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  7. Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M3B

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  8. Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M29

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  9. Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M34

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  10. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... BioProject

    ID: PRJNA171397

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. Overall design: This series of microarray experiments contains the gen...

Displaying 10 of 45 results for "TCN2"