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Displaying 45 of 45 results for "TCN2"
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  1. Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form PDB

    ID: PDB:2BBC

    Description: Transcobalamin II

  2. Structure of Cobalamin-complexed Bovine Transcobalamin in Monoclinic Crystal Form PDB

    ID: PDB:2BB6

    Description: bovine transcobalamin II

  3. Structure of Human Transcobalamin in complex with Cobalamin PDB

    ID: PDB:2BB5

    Description: Transcobalamin II

  4. E88 deletion mutant of CD320 in complex with TC2 PDB

    ID: PDB:4ZRQ

    Description: Transcobalamin-2, CD320 antigen

  5. Physiologic expression of Sf3b1K700E causes impaired erythropoieses, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation BioProject

    ID: PRJNA339149

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Over 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We...
  6. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice ArrayExpress

    ID: E-GEOD-57761

    Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...

  7. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice BioProject

    ID: PRJNA248010

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ction of the mtDNA polymerase, PolgA, and develop macrocytic anemia similar to that of patients with MDS. We observed an unexpected defect in clearance of dysfunctional mitochondria at specific stages during erythroid maturation in hematopoietic cells from aged mtDNA-mutator mice. Mechanistically, aberrant activation of mechanistic target of rapamycin signaling and phosphorylation of uncoordinated 51-like kinase (ULK) 1 in mtDNA-mutator mice resulted in proteasome mediated degradation of ULK1 and inhibition of autophagy in erythroid cells. To directly evaluate...
  8. Prevotella sp. TC2-28 : Prevotella sp. TC2-28 genome sequencing BioProject

    ID: PRJNA303336

    Keywords: genome sequencing

    Access Type: download

  9. Prevotella sp. TC2-24 : Prevotella sp. TC2-24 genome sequencing BioProject

    ID: PRJNA303337

    Keywords: genome sequencing

    Access Type: download

  10. Mycoplasma ovipneumoniae strain:TC2 : Mycoplasma ovipneumoniae strain:TC2 Genome sequencing and assembly BioProject

    ID: PRJNA253502

    Keywords: Genome sequencing and assembly

    Access Type: download

    organism.strain: TC2
  11. TC:CD320 PDB

    ID: PDB:4ZRP

    Description: Transcobalamin-2, CD320 antigen

  12. Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups ArrayExpress

    ID: E-GEOD-2912

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...

  13. TCO2_PONAB UniProt:Swiss-Prot

    ID: Q5REL7

    Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...

  14. TCO2_RAT UniProt:Swiss-Prot

    ID: Q9R0D6

    Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...

  15. Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature... ArrayExpress

    ID: E-MTAB-4348

    Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....

  16. Growth phase dependent gene expression and motility_3 time courses ArrayExpress

    ID: E-GEOD-3636

    Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...

  17. Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0... ArrayExpress

    ID: E-SMDB-1661

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....

  18. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection ArrayExpress

    ID: E-GEOD-3556

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...

  19. PRJEB16650 BioProject

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Prevotella sp. TC2-28
  20. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions BioProject

    ID: PRJNA259803

    Keywords: Transcriptome or Gene expression

    Access Type: download

  21. PRJEB16979 BioProject

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Prevotella sp. TC2-24
  22. Growth phase dependent gene expression and motility_3 time courses BioProject

    ID: PRJNA93753

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...
  23. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. BioProject

    ID: PRJNA93633

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Keywords: time_series_design Overall design: Computed...
  24. Molecular classification of multiple myeloma BioProject

    ID: PRJNA92601

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Keywords: other Overall design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. T...
  25. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions ArrayExpress

    ID: E-GEOD-60914

    Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...

  26. Crystal Structure of Haptocorrin in Complex with Cbi PDB

    ID: PDB:4KKJ

    Description: Transcobalamin-1

  27. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions OmicsDI

    ID: E-GEOD-60914

    Date Released: 01-10-2016

    Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...

  28. Molecular classification of multiple myeloma GEMMA

    ID: 2130

    Keywords: functional genomics

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Last Updated (by provider): Dec 15 2010 Contributers: Vincenzo Callea Luigia Lombardi Daniela Intini Luca Agnelli Antonino Neri Michela Mattioli Donata Verdelli Luca Baldini Sonia Fabris Silvio Bicciato Fortunato Morabito Includes GDS1284. Update date: Oct 05 2006. Dataset description GDS1284: Analysis of CD138+ plasma cells purifi...

  29. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... ArrayExpress

    ID: E-GEOD-39683

    Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...

  30. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice OmicsDI

    ID: E-GEOD-57761

    Date Released: 04-27-2015

    Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...

  31. Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups OmicsDI

    ID: E-GEOD-2912

    Date Released: 03-27-2012

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...

  32. Collaborative Study of Genes, Nutrients and Metabolites (CSGNM) dbGaP

    ID: phs000789.v1.p1

    Description: While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand t...

    Study Types: Control Set

    disease.name: Holo transcobalamin II
  33. Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi ArrayExpress

    ID: E-GEOD-18175

    Description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...

  34. Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi BioProject

    ID: PRJNA119533

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...
  35. Proteomic analysis of integrin adhesion complex assembly OmicsDI

    ID: GPM32310025299

    Date Released:

    Description: , PXD ID: PXD002159. Experiment: 20101108 JAA FN1 tc2 1-30, file: 20101108_JAA_FN_tc2_AB17.mzml. From ProteomeXchange: {{i}} To explore the dynamics of integrin adhesion complex assembly, isolated adhesion ...

  36. Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M2Q

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  37. Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M3B

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  38. Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M29

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  39. Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli PDB

    ID: PDB:5M34

    Description: Vitamin B12-binding protein

    material.name: COB(II)INAMIDE
  40. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... BioProject

    ID: PRJNA171397

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. Overall design: This series of microarray experiments contains the gen...
  41. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. OmicsDI

    ID: E-GEOD-3556

    Date Released: 10-18-2011

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...

  42. Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0... OmicsDI

    ID: E-SMDB-1661

    Date Released: 03-27-2012

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....

  43. Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature... OmicsDI

    ID: E-MTAB-4348

    Date Released: 02-05-2016

    Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....

  44. Growth phase dependent gene expression and motility_3 time courses OmicsDI

    ID: E-GEOD-3636

    Date Released: 03-27-2012

    Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering criteria use...

  45. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... OmicsDI

    ID: E-GEOD-39683

    Date Released: 07-01-2013

    Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...


Displaying 45 of 45 results for "TCN2"