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Displaying 20 of 45 results for "TCN2"
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  1. Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form PDB

    ID: PDB:2BBC

    Description: Transcobalamin II

  2. Structure of Cobalamin-complexed Bovine Transcobalamin in Monoclinic Crystal Form PDB

    ID: PDB:2BB6

    Description: bovine transcobalamin II

  3. Structure of Human Transcobalamin in complex with Cobalamin PDB

    ID: PDB:2BB5

    Description: Transcobalamin II

  4. E88 deletion mutant of CD320 in complex with TC2 PDB

    ID: PDB:4ZRQ

    Description: Transcobalamin-2, CD320 antigen

  5. Physiologic expression of Sf3b1K700E causes impaired erythropoieses, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation BioProject

    ID: PRJNA339149

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Over 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We...

  6. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice ArrayExpress

    ID: E-GEOD-57761

    Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...

  7. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice BioProject

    ID: PRJNA248010

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ction of the mtDNA polymerase, PolgA, and develop macrocytic anemia similar to that of patients with MDS. We observed an unexpected defect in clearance of dysfunctional mitochondria at specific stages during erythroid maturation in hematopoietic cells from aged mtDNA-mutator mice. Mechanistically, aberrant activation of mechanistic target of rapamycin signaling and phosphorylation of uncoordinated 51-like kinase (ULK) 1 in mtDNA-mutator mice resulted in proteasome mediated degradation of ULK1 and inhibition of autophagy in erythroid cells. To directly evaluate...

  8. Prevotella sp. TC2-28 : Prevotella sp. TC2-28 genome sequencing BioProject

    ID: PRJNA303336

    Keywords: genome sequencing

    Access Type: download

  9. Prevotella sp. TC2-24 : Prevotella sp. TC2-24 genome sequencing BioProject

    ID: PRJNA303337

    Keywords: genome sequencing

    Access Type: download

  10. Mycoplasma ovipneumoniae strain:TC2 : Mycoplasma ovipneumoniae strain:TC2 Genome sequencing and assembly BioProject

    ID: PRJNA253502

    Keywords: Genome sequencing and assembly

    Access Type: download

    organism.strain: TC2

  11. TC:CD320 PDB

    ID: PDB:4ZRP

    Description: Transcobalamin-2, CD320 antigen

  12. Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups ArrayExpress

    ID: E-GEOD-2912

    Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...

  13. TCO2_PONAB UniProt:Swiss-Prot

    ID: Q5REL7

    Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...

  14. TCO2_RAT UniProt:Swiss-Prot

    ID: Q9R0D6

    Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...

  15. Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature... ArrayExpress

    ID: E-MTAB-4348

    Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....

  16. Growth phase dependent gene expression and motility_3 time courses ArrayExpress

    ID: E-GEOD-3636

    Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...

  17. Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0... ArrayExpress

    ID: E-SMDB-1661

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....

  18. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection ArrayExpress

    ID: E-GEOD-3556

    Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...

  19. PRJEB16650 BioProject

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Prevotella sp. TC2-28

  20. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions BioProject

    ID: PRJNA259803

    Keywords: Transcriptome or Gene expression

    Access Type: download

Displaying 20 of 45 results for "TCN2"

bioCADDIE is supported by the National Institutes of Health through the Big Data to Knowledge, Grant 1U24AI117966-01. NIH | UCSD | DBMI

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