TCN2 | bioCADDIE Data Discovery Index

Displaying 45 of 45 results for "TCN2"

Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form PDB

ID: PDB:2BBC

Description: Transcobalamin II
Structure of Cobalamin-complexed Bovine Transcobalamin in Monoclinic Crystal Form PDB

ID: PDB:2BB6

Description: bovine transcobalamin II
Structure of Human Transcobalamin in complex with Cobalamin PDB

ID: PDB:2BB5

Description: Transcobalamin II
E88 deletion mutant of CD320 in complex with TC2 PDB

ID: PDB:4ZRQ

Description: Transcobalamin-2, CD320 antigen
Physiologic expression of Sf3b1K700E causes impaired erythropoieses, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation BioProject

ID: PRJNA339149

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: Over 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We...
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice ArrayExpress

ID: E-GEOD-57761

Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice BioProject

ID: PRJNA248010

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: ction of the mtDNA polymerase, PolgA, and develop macrocytic anemia similar to that of patients with MDS. We observed an unexpected defect in clearance of dysfunctional mitochondria at specific stages during erythroid maturation in hematopoietic cells from aged mtDNA-mutator mice. Mechanistically, aberrant activation of mechanistic target of rapamycin signaling and phosphorylation of uncoordinated 51-like kinase (ULK) 1 in mtDNA-mutator mice resulted in proteasome mediated degradation of ULK1 and inhibition of autophagy in erythroid cells. To directly evaluate...
Prevotella sp. TC2-28 : Prevotella sp. TC2-28 genome sequencing BioProject

ID: PRJNA303336

Keywords: genome sequencing

Access Type: download
Prevotella sp. TC2-24 : Prevotella sp. TC2-24 genome sequencing BioProject

ID: PRJNA303337

Keywords: genome sequencing

Access Type: download
Mycoplasma ovipneumoniae strain:TC2 : Mycoplasma ovipneumoniae strain:TC2 Genome sequencing and assembly BioProject

ID: PRJNA253502

Keywords: Genome sequencing and assembly

Access Type: download
organism.strain: TC2
TC:CD320 PDB

ID: PDB:4ZRP

Description: Transcobalamin-2, CD320 antigen
Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups ArrayExpress

ID: E-GEOD-2912

Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...
TCO2_PONAB UniProt:Swiss-Prot

ID: Q5REL7

Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...
TCO2_RAT UniProt:Swiss-Prot

ID: Q9R0D6

Description: Transcobalamin-2 Cobalamin binding Cobalamin binding Cobalamin binding Cobalt (cobalamin axial ligand) Cobalamin Cobalamin Cobalami...
Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature... ArrayExpress

ID: E-MTAB-4348

Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....
Growth phase dependent gene expression and motility_3 time courses ArrayExpress

ID: E-GEOD-3636

Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...
Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0... ArrayExpress

ID: E-SMDB-1661

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection ArrayExpress

ID: E-GEOD-3556

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...
PRJEB16650 BioProject

Keywords: Genome sequencing and assembly

Access Type: download
dataset.description: Prevotella sp. TC2-28
Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions BioProject

ID: PRJNA259803

Keywords: Transcriptome or Gene expression

Access Type: download
PRJEB16979 BioProject

Keywords: Genome sequencing and assembly

Access Type: download
dataset.description: Prevotella sp. TC2-24
Growth phase dependent gene expression and motility_3 time courses BioProject

ID: PRJNA93753

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. BioProject

ID: PRJNA93633

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Keywords: time_series_design Overall design: Computed...
Molecular classification of multiple myeloma BioProject

ID: PRJNA92601

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Keywords: other Overall design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. T...
Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions ArrayExpress

ID: E-GEOD-60914

Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...
Crystal Structure of Haptocorrin in Complex with Cbi PDB

ID: PDB:4KKJ

Description: Transcobalamin-1
Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions OmicsDI

ID: E-GEOD-60914

Date Released: 01-10-2016

Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...
Molecular classification of multiple myeloma GEMMA

ID: 2130

Keywords: functional genomics

Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Last Updated (by provider): Dec 15 2010 Contributers: Vincenzo Callea Luigia Lombardi Daniela Intini Luca Agnelli Antonino Neri Michela Mattioli Donata Verdelli Luca Baldini Sonia Fabris Silvio Bicciato Fortunato Morabito Includes GDS1284. Update date: Oct 05 2006. Dataset description GDS1284: Analysis of CD138+ plasma cells purifi...
Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... ArrayExpress

ID: E-GEOD-39683

Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice OmicsDI

ID: E-GEOD-57761

Date Released: 04-27-2015

Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...
Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups OmicsDI

ID: E-GEOD-2912

Date Released: 03-27-2012

Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...
Collaborative Study of Genes, Nutrients and Metabolites (CSGNM) dbGaP

ID: phs000789.v1.p1

Description: While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand t...

Study Types: Control Set
disease.name: Holo transcobalamin II
Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi ArrayExpress

ID: E-GEOD-18175

Description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...
Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi BioProject

ID: PRJNA119533

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...
Proteomic analysis of integrin adhesion complex assembly OmicsDI

ID: GPM32310025299

Date Released:

Description: , PXD ID: PXD002159. Experiment: 20101108 JAA FN1 tc2 1-30, file: 20101108_JAA_FN_tc2_AB17.mzml. From ProteomeXchange: {{i}} To explore the dynamics of integrin adhesion complex assembly, isolated adhesion ...
Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli PDB

ID: PDB:5M2Q

Description: Vitamin B12-binding protein
material.name: COB(II)INAMIDE
Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli PDB

ID: PDB:5M3B

Description: Vitamin B12-binding protein
material.name: COB(II)INAMIDE
Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli PDB

ID: PDB:5M29

Description: Vitamin B12-binding protein
material.name: COB(II)INAMIDE
Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli PDB

ID: PDB:5M34

Description: Vitamin B12-binding protein
material.name: COB(II)INAMIDE
Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... BioProject

ID: PRJNA171397

Keywords: Transcriptome or Gene expression

Access Type: download
dataset.description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. Overall design: This series of microarray experiments contains the gen...
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. OmicsDI

ID: E-GEOD-3556

Date Released: 10-18-2011

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...
Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0... OmicsDI

ID: E-SMDB-1661

Date Released: 03-27-2012

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....
Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature... OmicsDI

ID: E-MTAB-4348

Date Released: 02-05-2016

Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....
Growth phase dependent gene expression and motility_3 time courses OmicsDI

ID: E-GEOD-3636

Date Released: 03-27-2012

Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering criteria use...
Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... OmicsDI

ID: E-GEOD-39683

Date Released: 07-01-2013

Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...

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TCN2(data)

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Synonyms

transcobalamin II
D22S750
TC2
TCN2
D22S676

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