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Displaying 19 of 19 results for "TCN2"
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  1. NM_000355.3(TCN2):c.927_930delTCTG (p.Cys309Trpfs) AND Transcobalamin II deficiency ClinVar

  2. NM_000355.3(TCN2):c.776G>C (p.Arg259Pro) AND TCN2 POLYMORPHISM ClinVar

    Type: Variation

    Species: human

  3. NM_000355.3(TCN2):c.626C>G (p.Ser209Ter) AND Transcobalamin II deficiency ClinVar

    Type: Variation

    Species: human

  4. Physiologic expression of Sf3b1K700E causes impaired erythropoieses, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation BioProject

    ID: PRJNA339149

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Over 80% of patients with the refractory anemia with ring sideroblasts subtype of myelodysplastic syndrome (MDS) have mutations in Splicing Factor 3B, Subunit 1 (SF3B1). We...

  5. NM_000355.3(TCN2):c.427+2T>G AND Transcolabamin II deficiency ClinVar

    Type: Variation

    Species: human

  6. NM_000355.3(TCN2):c.580+624A>T AND Transcolabamin II deficiency ClinVar

    Type: Variation

    Species: human

  7. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice BioProject

    ID: PRJNA248010

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ction of the mtDNA polymerase, PolgA, and develop macrocytic anemia similar to that of patients with MDS. We observed an unexpected defect in clearance of dysfunctional mitochondria at specific stages during erythroid maturation in hematopoietic cells from aged mtDNA-mutator mice. Mechanistically, aberrant activation of mechanistic target of rapamycin signaling and phosphorylation of uncoordinated 51-like kinase (ULK) 1 in mtDNA-mutator mice resulted in proteasome mediated degradation of ULK1 and inhibition of autophagy in erythroid cells. To directly evaluate...

  8. TCN2, 2,152-BP DEL AND 4-BP INS AND Transcolabamin II deficiency ClinVar

    Type: Variation

    Species: human

  9. Prevotella sp. TC2-28 : Prevotella sp. TC2-28 genome sequencing BioProject

    ID: PRJNA303336

    Keywords: genome sequencing

    Access Type: download

  10. Prevotella sp. TC2-24 : Prevotella sp. TC2-24 genome sequencing BioProject

    ID: PRJNA303337

    Keywords: genome sequencing

    Access Type: download

  11. Mycoplasma ovipneumoniae strain:TC2 : Mycoplasma ovipneumoniae strain:TC2 Genome sequencing and assembly BioProject

    ID: PRJNA253502

    Keywords: Genome sequencing and assembly

    Access Type: download

    organism.strain: TC2

  12. PRJEB16650 BioProject

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Prevotella sp. TC2-28

  13. Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions BioProject

    ID: PRJNA259803

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. PRJEB16979 BioProject

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Prevotella sp. TC2-24

  15. Growth phase dependent gene expression and motility_3 time courses BioProject

    ID: PRJNA93753

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering cr...

  16. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. BioProject

    ID: PRJNA93633

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Keywords: time_series_design Overall design: Computed...

  17. Molecular classification of multiple myeloma BioProject

    ID: PRJNA92601

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Keywords: other Overall design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. T...

  18. Transcriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi BioProject

    ID: PRJNA119533

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigenes was quantified with 27k rat oligonucleotide arrays in each of the four replicas of all control and infected RNA samples. Considering changes >1.5-fold and p-val<0.05, the Tulahuen strain was the most disruptive to host transcriptome, with (17% sig...

  19. Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip... BioProject

    ID: PRJNA171397

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. Overall design: This series of microarray experiments contains the gen...
Displaying 19 of 19 results for "TCN2"

bioCADDIE is supported by the National Institutes of Health through the Big Data to Knowledge, Grant 1U24AI117966-01. NIH | UCSD | DBMI

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