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Displaying 48 of 48 results for "SPOP"
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  1. Mus musculus : SPOP mutant mouse model BioProject

    ID: PRJNA312504

    Keywords: raw sequence reads

    Access Type: download

  2. Effects of SPOP on gene expression in prostate cancer BioProject

    ID: PRJNA255304

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Effects of SPOP on gene expression in prostate cancer ArrayExpress

    ID: E-GEOD-59432

    Description: SPOP is a ubiquitin ligase adaptor frequently mutated in prostate cancer. It is involved in ubiquitination and degradation of subst...

  4. Effects of SPOP on gene expression in prostate cancer OmicsDI

    ID: E-GEOD-59432

    Date Released: 10-19-2014

    Description: SPOP is a ubiquitin ligase adaptor frequently mutated in prostate cancer. It is involved in ubiquitination and degradation of subst...

  5. Danio rerio : SPOP mutation leads to genomic instability in prostate cancer BioProject

    ID: PRJNA296414

    Keywords: transcriptome

    Access Type: download

  6. The SPOP-containing Complex Functions as an E3 Ligase for SETD2 to Regulate Gene-Specific H3K36me3-Coupled Alternative Splicing BioProject

    ID: PRJNA303041

    Keywords: Other

    Access Type: download

  7. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx-MacroH2ASBCpep2 PDB

    ID: PDB:3HSV

    Description: Speckle-type POZ protein, Core histone macro-H2A.1

  8. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx-CiSBC2 PDB

    ID: PDB:3HQM

    Description: Speckle-type POZ protein, Protein cubitus interruptus

  9. Crystal Structure of the Human SPOP C-terminal Domain PDB

    ID: PDB:4HS2

    Description: Speckle-type POZ protein

  10. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases:SPOPMATHx-PucSBC1_pep2 PDB

    ID: PDB:3HQL

    Description: Speckle-type POZ protein, Puckered (E.C.3.1.3.-, 3.1.3.16, 3.1.3.48)

  11. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-PucSBC1_pep1 PDB

    ID: PDB:3IVV

    Description: Speckle-type POZ protein, PucSBC1

  12. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx/BTB/3-box-PucSBC1 PDB

    ID: PDB:3HQI

    Description: Speckle-type POZ protein, PucSBC1

  13. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx/BTB/3-box-PucSBC1 PDB

    ID: PDB:3HU6

    Description: Speckle-type POZ protein, Puckered (E.C.3.1.3.-, 3.1.3.16, 3.1.3.48)

  14. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATHx-MacroH2ASBCpep1 PDB

    ID: PDB:3HQH

    Description: Speckle-type POZ protein, MacroH2A

  15. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer PDB

    ID: PDB:4O1V

    Description: Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

  16. Crystal Structure of the Human SPOP BTB Domain PDB

    ID: PDB:4J8Z

    Description: Speckle-type POZ protein

  17. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPBTB/3-box PDB

    ID: PDB:3HTM

    Description: Speckle-type POZ protein

  18. Drosophila melanogaster developmental timecourse: wild type, eve, ftz ArrayExpress

    ID: E-GEOD-14086

    Description: w role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of the Jun-kinase phosphatase Puckered thereby inducing TNF/Eiger dependent apoptosis. In humans we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinoma (RCC), the most prevalent form of kidney cancer. SPOP expression distinguished histological subtypes...

  19. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2 PDB

    ID: PDB:3IVQ

    Description: Speckle-type POZ protein, CiSBC2

  20. Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1 PDB

    ID: PDB:3IVB

    Description: Speckle-type POZ protein, Core histone macro-H2A.1

  21. Drosophila melanogaster developmental timecourse: wild type, eve, ftz OmicsDI

    ID: E-GEOD-14086

    Date Released: 05-04-2014

    Description: w role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of the Jun-kinase phosphatase Puckered thereby inducing TNF/Eiger dependent apoptosis. In humans we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinoma (RCC), the most prevalent form of kidney cancer. SPOP expression distinguished histological subtypes...

  22. PRJNA381797 BioProject

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: f a polymorphic regulatory region associated with SPOP mutated prostate cancer on the transcriptome of PC-3 cells....
  23. Differentially expressed genes between SPOPmut and control in mouse prostate organoids BioProject

    ID: PRJNA374556

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: insight to the signaling pathways deregulated by SPOP mutation and determine the relevance of these models to human prostate cancer, we performed RNA-seq on SPOP mutant organoids ...
  24. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: GigaxoninBTB/3-box PDB

    ID: PDB:3HVE

    Description: Gigaxonin

  25. Drosophila melanogaster developmental timecourse: wild type, eve, ftz BioProject

    ID: PRJNA112513

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: w role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of the Jun-kinase phosphatase Puckered thereby inducing TNF/Eiger dependent apoptosis. In humans we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinoma (RCC), the most prevalent form of kidney cancer. SPOP expression distinguished histological subtypes...
  26. Crystal structure of the SPOP BTB domain complexed with the Cul3 N-terminal domain PDB

    ID: PDB:4EOZ

    Description: Speckle-type POZ protein, Cullin-3

  27. Genome-wide maps of HIF1a binding sites in ccRCC cell line under hypoxia condition ArrayExpress

    ID: E-GEOD-54327

    Description: ia conditions. Especially, we found HIF1a bind to SPOP under hypoxia condition, which was further validated. Examination of HIF1a binding sites in Caki-2 cell line under hypoxia condition...

  28. SPOP mutation ProteomeXchange

    ID: PXD005309

    Instrument: LTQ

    Date Released: 03-20-2017

  29. Homo sapiens : Homo sapiens Targeted Locus (Loci) BioProject

    ID: PRJNA357005

    Keywords: targeted loci

    Access Type: download

    dataset.description: nome alterations had been found, like mutation of SPOP, PIK3CA, and copy number variants of PTEN (10q23), NKX3.1 (8p21). For more comprehensive understand the molecular genetics of prostate cancer, we did target next generation gene sequence of 46 prostate cancer patients using a panel of 32 prost...
  30. Genome-wide maps of HIF1a binding sites in ccRCC cell line under hypoxia condition BioProject

    ID: PRJNA236347

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ia conditions. Especially, we found HIF1a bind to SPOP under hypoxia condition, which was further validated. Overall design: Examination of HIF1a binding sites in Caki-2 cell line under hypoxia condition...
  31. Solution structure of N-terminal domain of speckle-type POZ protein PDB

    ID: PDB:2CR2

    Description: Speckle-type POZ protein

    gene.name: SPOP
  32. SPOPA_XENLA UniProt:Swiss-Prot

    ID: Q7ZX06

    Description: Speckle-type POZ protein A MATH BTB Required for nuclear localization Homodimerization

    gene.name: spop-a
  33. Drosophila melanogaster developmental timecourse: wild type, eve, ftz GEMMA

    ID: 2515

    Keywords: functional genomics

    Description: w role for the ubiquitin E3 ligase complex factor SPOP. In Drosophila, the gene encoding SPOP is a target of segmentation transcription factors. Drosophila SPOP mediates degradation of the Jun-kinase phosphatase Puckered thereby inducing TNF/Eiger dependent apoptosis. In humans we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinoma (RCC), the most prevalent form of kidney cancer. SPOP expression distinguished histological subtypes...

  34. SPOPB_XENLA UniProt:Swiss-Prot

    ID: Q0IHH9

    Description: Speckle-type POZ protein B MATH BTB Required for nuclear localization Homodimerization

    gene.name: spop-b
  35. PRJEB11591 BioProject

    Keywords: Other

    Access Type: download

    dataset.description: n H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, and SPOP were identified in miFTC or FA. We identified a low frequency of fusion genes in miFTC (only one, PAX8–PPARG), but a high frequency of that in PTC (17.60%). The frequencies of BRAFV600E and H/K/NRAS mutations were substantially different in miFTC and cPTC, and those of FVPTC were intermediate between miFTC and cPTC. Gene expression analysis demonstrated three molecular subtypes regardless of their histological features, including Non–BRAF–Non–RAS (NBNR), as well as BRAF–like and RAS–like. The novel molecular subtype, NBNR, was associated with DICER1, EIF1AX, IDH1, PTEN, SOS...
  36. Prostate Cancer Genome Sequencing Project BioProject

    ID: PRJNA81145

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: rized by mutation of the ubiquitin ligase subunit SPOP and copy number loss at specific genomic loci....
  37. SPOP_XENTR UniProt:Swiss-Prot

    ID: Q6P8B3

    Description: Speckle-type POZ protein MATH BTB Required for nuclear localization Homodimerization

    gene.name: spop
  38. SPOP_BOVIN UniProt:Swiss-Prot

    ID: Q0VCW1

    Description: Speckle-type POZ protein MATH BTB Required for nuclear localization Important for binding substrate proteins Important for homodimerization Important ...

    gene.name: SPOP
  39. Prostate Cancer Genome Sequencing Project BioProject

    ID: PRJNA81143

    Access Type: download

    dataset.description: rized by mutation of the ubiquitin ligase subunit SPOP and copy number loss at specific genomic loci....
  40. Homo sapiens : Homo sapiens Exome BioProject

    ID: PRJNA238157

    Keywords: exome

    Access Type: download

    dataset.description: n to be involved in the ubiquitin ligase complex (SPOP, KLHL22, TRPC4AP and RNF169). Functionally, both the CTNNB1 (G512V) and CAPRIN2 (R968H/S969C) were observed to be gain-of-functional mutations in HB. These results extend the landscape of genetic alterations in HB and highlight the dysregulation of Wnt and ubiquitin pathways in HB tumorigenesis....
  41. DAXX_CANLF UniProt:Swiss-Prot

    ID: Q5TJE1

    Description: essary for interaction with USP7 Interaction with SPOP Sumo interaction motif (SIM) Nuclear localization signal Nuclear localization signal Poly-Asp Asp/Glu-rich (acidic) Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine Phosphoserine N6-acetyllysine Phosp...

  42. DAXX_RAT UniProt:Swiss-Prot

    ID: Q8VIB2

    Description: essary for interaction with USP7 Interaction with SPOP Sumo interaction motif (SIM) Nuclear localization signal Nuclear localization signal Poly-Asp Asp/Glu-rich (acidic) Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine Phosphoserine Phosphoserine Phospho...

  43. Genome-wide maps of HIF1a binding sites in ccRCC cell line under hypoxia condition OmicsDI

    ID: E-GEOD-54327

    Date Released: 04-15-2014

    Description: ia conditions. Especially, we found HIF1a bind to SPOP under hypoxia condition, which was further validated. Examination of HIF1a binding sites in Caki-2 cell line under hypoxia condition...

  44. DAXX_CHLAE UniProt:Swiss-Prot

    ID: O18805

    Description: essary for interaction with USP7 Interaction with SPOP Sumo interaction motif (SIM) Nuclear localization signal Nuclear localization signal Poly-Asp Asp/Glu-rich (acidic) Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphothreonine Phosphoserine Phosphoserine N6-acetyllysine Phosp...

  45. Prostate Cancer Genome Sequencing Project OmicsDI

    ID: phs000447.v1.p1

    Date Released:

    Description: rized by mutation of the ubiquitin ligase subunit SPOP and copy number loss at specific genomic loci.

    ...

  46. Prostate Cancer Genome Sequencing Project dbGaP

    ID: phs000447.v1.p1

    Description: rized by mutation of the ubiquitin ligase subunit SPOP and copy number loss at specific genomic loci....

    Study Types: Case Set

  47. Probing the effect of promoters on noise in gene expression using thousands of designed sequences ArrayExpress

    ID: E-GEOD-55346

    Description: Genetically identical cells exhibit large variability (noise) in gene expression, with important consequences for cellular function. Although the amou...

  48. Probing the effect of promoters on noise in gene expression using thousands of designed sequences BioProject

    ID: PRJNA239368

    Keywords: Other

    Access Type: download


Displaying 48 of 48 results for "SPOP"