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Displaying 20 of 50 results for "SOS1"
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  1. Lentiviral vector-based insertional mutagenesis identifies new clinically relevant cancer genes involved in the pathogenesis of hepatocellular carcino... OmicsDI

    ID: E-GEOD-31409

    Date Released: 01-07-2013

    Description: es. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose functions are poorly understood, and the complex Dlk1-Dio3 imprinted region which has been recently implicated in cancer and stemness. Activation of Fign or Braf and upregulation of the Dlk1-Dio3 imprinted region are functionally interconnected and m...

  2. Lentiviral vector-based insertional mutagenesis identifies new clinically relevant candidate cancer genes involved in the pathogenesis of hepatocellul... OmicsDI

    ID: E-GEOD-35986

    Date Released: 02-20-2015

    Description: es. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose functions are poorly understood, and the paternally expressed gene Rtl1 within the complex Dlk1-Dio3 imprinted region recently involved in stemness. Interestingly, Fign and Braf regulate the expression of the maternal genes of the Dlk1-Dio3 imprinted...

  3. Differential endothelial cell gene expression by African Americans versus Caucasian Americans: A possible contribution to health disparity in vascular... ArrayExpress

    ID: E-GEOD-22688

    Description: er significantly different genes were: for AA>CA, SOS1, AMFR, FGFR3; and for AACA) for 46/157 genes within that system. Conclusions: The most significant single gene changes detected for AA involved genes having substantial, known roles in endothelial biology. Biological systems analysis suggested that shear stress response, a critical regulator of endothelial function and vascular homeostasis, may be different between AA and CA. These results potentially have direct implications for the role of endothelial cells in both vascular disease (e.g., hypertension and stroke) and cancer (via angiogenesis). The present findings are consistent with our overarching hypothesis that genetic influences stemming from ancestral continent-of-origin could impact upon endothelial cell biology and thereby contribute to disparity of vascular-related disease burden amongst AA. From self-identified, healthy, 20-29 year old AA (n=21) and CA (n=17), we established cultures of blood outgrowth endothelial cells (BOEC) and applied microarray profiling. BOEC have never been exposed to in vivo influences, and ...

  4. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4US1

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  5. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URY

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  6. Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS PDB

    ID: PDB:1NVX

    Description: Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1

    gene.name: SOS1
  7. Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS PDB

    ID: PDB:1NVU

    Description: Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1

    gene.name: SOS1
  8. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URU

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  9. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URX

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  10. Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. PDB

    ID: PDB:1XDV

    Description: Son of sevenless protein homolog 1

    gene.name: SOS1
  11. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4US0

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  12. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4US2

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  13. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URW

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  14. Crystal Structure of the Histone domain of Son of Sevenless PDB

    ID: PDB:1Q9C

    Description: Son of sevenless protein homolog 1

    gene.name: SOS1
  15. Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS PDB

    ID: PDB:1NVW

    Description: Transforming protein p21/H-RAS-1, Son of sevenless protein homolog 1

    gene.name: SOS1
  16. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URZ

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  17. The crystal structure of H-Ras and SOS in complex with ligands PDB

    ID: PDB:4URV

    Description: GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1

  18. Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) PDB

    ID: PDB:1XD4

    Description: Son of sevenless protein homolog 1

    gene.name: SOS1
  19. Identification of novel potential biomarkers and signaling pathways related to otitis media induced by diesel exhaust particle in in vivo system via t... BioProject

    ID: PRJNA342703

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ied several key molecular biomarkers, CHRM1, EPO, SOS1, ESR1, CD4, and IFNA1. In conclusion, our results might ascertain related cell process and signaling interacted genes underlying DEP exposure and its effects. Moreover, the discovered biomarkers can be recognized as potential candidates for developing early diagnosis and effective treatment strategies of DEP-mediated disorders. Overall design: One-condition experiment, DEP treated mouse ear. Biological replicates: 4 replicates....
  20. Comparative proteomics and transcriptomics study of signaling network proteins across multiple normal and cancer cell lines BioProject

    ID: PRJNA320318

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n 50,000-70,000 copies per cell, but the adaptors SOS1, SOS2, and GAB1 were found at far lower levels (2,000-5,000 per cell). MAPK signaling showed saturation in all cells between 3,000-10,000 occupied EGFR, consistent with the idea that adaptors limit signaling. Our results suggest that the relative stoichiometry of core MAPK pathway proteins is very similar across different cell types, with cell-specific differences mostly restricted to variable levels of feedback regulators. The low abundance of adaptors relative to the EGFR could be responsible for previous observation of saturable signaling, endocytosis, and high affinity EGFR. Overall design: Cells grown to ~80% confluence were serum starved and processed for both RNA-Seq and proteomics anaysis, using parallel samples. A total of seven samples. RNA was extracted from duplicate 15cm plates and poled before library preparation....

Displaying 20 of 50 results for "SOS1"