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Displaying 5 of 82 results for "RGS9"
  1. Systems biology of gene expression of bladder papilloma cells modulated by a malignant-derived extracellular matrix BioProject

    ID: PRJNA102931

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: iles of RT4 cells grown on Matriges over 12 hours-9 days timecourse. Total 5881 hypervariable (HV) genes were found to vary significantly over the time points, indicating a response to matrix change. Correlational clustering showed these HV genes fell into distinct families, predominantly genes which became highly expressed on ECM. Another cluster show genes expressed at 12 hours after grown on Matrigel and...
  2. Gene profiling studies in postnatal Mfrprd6 mutant eyes reveal differential expression of Prss56, a trypsin-like serine protease, and genes involved i... ArrayExpress

    ID: E-GEOD-53411

    Description: he expression of RPE-specific visual transduction protein, RPE65, was significantly decreased in Mfrprd6 mutants. As an indirect consequence of the primary RPE cell defect due to the Mfrprd6 mutation, retinal specific transcripts Rgr, Pde6a, GuCa1b, and Rgs9 were also significantly decreased. We also confirmed the significantly elevated levels of Prss56, a gene previously associated with myopia and open angle glaucoma. In the Mfrprd6 mutant, a progressive increase in Prss56 mRNA levels from 14- to 70-fold was observed from P7 to P21, respectively. In situ hybridization and glutamine synthetase staining of mutant eyes indirectly identified Müller glia in the inner nuclear layer of retina as the cell type expressing the Prss56 transcript. This experiment had one model term, a combination of strain and time, which consisted of four levels (B6_P0, B6_P14, Rd6_P0 and Rd6_P14). Three biological replicates were used per term level. A total of 12 Affymetrix Mouse 430v2 Arrays were used in gene expression analysis....

  3. Combined RNA-seq and Polr2a ChIP-seq Identifies Gene Targets for Transcriptional Regulation in Vasopressin-Sensitive Collecting Duct Cells ArrayExpress

    ID: E-GEOD-79573

    Description: duced changes in the abundance of the aquaporin-2 protein. Defects in the long-term regulation have been implicated in multiple water balance disorders. With the objetive to identify genes that are transcriptionally regulated in response to vasopressin in cultured mouse collecting duct cells (mpkCCD), we carried out both RNA-seq to measure all transcripts (n=9) and ChIP-seq for RNA polymerase II (Polr2a) binding along the genome (n=3). Observations were made both after 24-hr treatment wit...

  4. Effects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells ArrayExpress

    ID: E-GEOD-56819

    Description: o-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferatio...

  5. A Phase 2 Study of Tipifarnib in Large Granular Lymphocyte (LGL) Leukemia dbGaP

    ID: phs000594.v1.p1

    Description: LGL leukemia can be divided into three subsets including the following: αβ or γδT-LGL and NK-LGL leukemia. All three subtypes will...

    study.selectionCriteria: arnib previously or with other inhibitors of MAPK signaling intermediates
  6. History of allergic reactions attributed to compounds of similar chemical or biologic composition to tipifarnib. Tipifarnib is contraindicated in individuals with allergies to imidazoles such as clotrimazole, ketoconazole, miconazole, econazaole, fenticonazole, isoconazole, sulconazole, tioconazole, or terconazole. Information regarding possible drug allergies should be obtained from both patient questionnaires and past-medical records
  7. Uncontrolled concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  8. Women who are pregnant
  9. Women who are breastfeeding
  10. Women of childbearing potential who will not agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.
  11. Men who will not agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.
  12. Patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy. HIV-positive patients receiving anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with tipifarnib, but HIV-positive patients receiving no retroviral therapy may be included in the study
  13. Patients with psychiatric illness/social situations that would limit compliance with study requirements and that would prevent informed decisions regarding entry into the study are excluded from study participation
  14. Patients with γδ T LGL that are positive for iso-chromosome 7, as determined by FISH analysis
  15. ...

Displaying 5 of 82 results for "RGS9"