R9BP_CHICK UniProt:Swiss-Prot

ID: Q6XK22

Description: Regulator of G-protein signaling 9-binding

Striatal microRNA controls cocaine intake through CREB signalling ArrayExpress

ID: E-GEOD-21901

Description: iption factor CREB (cAMP response element-binding protein) is considered a core regulator of cocaine reward. We show that miR-212 controls responsiveness to cocaine by dramatically amplifying striatal CREB signaling. This action occurs through miR-212-enhanced Raf-1 activity, resulting in adenylyl cyclase sensitization and increased expression of the essential CREB co-activator TORC (Transducer of Regulated CREB; also known as CRTC). Our findings suggest that striatal miR-212 signaling plays a key role in vulnerability to addiction, and that noncoding RNAs such as the miRNAs may serve as novel targets for the development of anti-addiction therapeutics. To identify potential targets for miR-212, we transfected cells with a vector to overexpress miR-212 or an empty vector. We then analyzed profiled gene ex...

Striatal microRNA controls cocaine intake through CREB signalling BioProject

ID: PRJNA126865

Keywords: Transcriptome or Gene expression

Access Type: download

RGS9_TAMST UniProt:Swiss-Prot

ID: Q80ZD1

Description: Regulator of G-protein signaling 9 DEP G

R9BP_BOVIN UniProt:Swiss-Prot

ID: Q8MJG0

Description: Regulator of G-protein signaling 9-binding