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  1. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways BioProject

    ID: PRJNA237042

    Keywords: Other

    Access Type: download

  2. CRYSTAL STRUCTURE OF THE DIMERIC OCT-6 (POU3F1) POU DOMAIN BOUND TO PALINDROMIC MORE DNA PDB

    ID: PDB:2XSD

    Description: POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1/DNA Complex, 1,2-ETHANEDIOL

  3. Data from: The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways... Dryad

    DateIssued: 07-16-2014

    Description: conversion remains unclear. Here, we showed that Pou3f1 is essential for the neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimeric analysis showed that Pou3f1 knockdown leads to a markedly decreased incorporation of ESCs in the neuroectoderm. By contrast, Pou3f1-overe...

  4. ETV5 Mediated Downstream Gene Activation in Spermatogonial Stem Cells ArrayExpress

    ID: E-GEOD-30683

    Description: tv5), B-cell CLL/lymphoma 6, member B (Bcl6b) and POU domain, class-3 transcription factor-1 (Pou3f1). We reasoned that these three factors may function as a core-set of transcription factors, regulating genes responsible for maintaining the SSC population. Using transient short-interfering RNA oligonucleotides (siRNA) to individually target Etv5, Bcl6b and Pou3f1 within mouse SSC cultures, we examined changes to the global gene expression profiles associated with these transcrip...

  5. Genome-wide ChIP-seq analysis of Pou3f1 during mouse pluripotent stem cell neural fate commitment BioProject

    ID: PRJNA286774

    Keywords: Epigenomics

    Access Type: download

  6. ETV5 Mediated Downstream Gene Activation in Spermatogonial Stem Cells OmicsDI

    ID: E-GEOD-30683

    Date Released: 08-02-2011

    Description: tv5), B-cell CLL/lymphoma 6, member B (Bcl6b) and POU domain, class-3 transcription factor-1 (Pou3f1). We reasoned that these three factors may function as a core-set of transcription factors, regulating genes responsible for maintaining the SSC population. Using transient short-interfering RNA oligonucleotides (siRNA) to individually target Etv5, Bcl6b and Pou3f1 within mouse SSC cultures, we examined changes to the global gene expression profiles associated with these transcrip...

  7. PO3F2_RAT UniProt:Swiss-Prot

    ID: P56222

    Description: POU domain, class 3, transcription factor 2 POU-specific

  8. Genome-wide ChIP-seq analysis of Pou3f1 during mouse pluripotent stem cell neural fate commitment ArrayExpress

    ID: E-GEOD-69778

    Description: s, we demonstrate that the transcriptional factor Pou3f1 is an upstream activator of neural-promoting genes, and it is able to repress neural-inhibitory signals as well. Further studies revealed that Pou3f1 could directly bind neural lineage genes like Sox2 and downstream targets of neural inhibition signaling such as BMP and Wnt. Our results thus identify Pou3f1 as a critical dual-regulator of the intrinsic transcription factors and the extrinsic cellular signals during neural fate commitment. ChIP-seq assay was ultilized to characterize the targets of Pou3f1

  9. PO3F3_MOUSE UniProt:Swiss-Prot

    ID: P31361

    Description: POU domain, class 3, transcription factor 3 POU-specifi...

  10. PO3F3_XENLA UniProt:Swiss-Prot

    ID: P20914

    Description: POU domain, class 3, transcription factor 3 POU-specifi...

  11. PO3F3_PIG UniProt:Swiss-Prot

    ID: Q29087

    Description: POU domain, class 3, transcription factor 3 POU-specifi...

  12. PO2F3_XENLA UniProt:Swiss-Prot

    ID: P20912

    Description: POU domain, class 2, transcription factor 3 POU-specific

  13. PO3F4_MESAU UniProt:Swiss-Prot

    ID: Q812B1

    Description: POU domain, class 3, transcription factor 4 POU-specific

  14. Genome-wide ChIP-seq analysis of Pou3f1 during mouse pluripotent stem cell neural fate commitment OmicsDI

    ID: E-GEOD-69778

    Date Released: 11-28-2015

    Description: s, we demonstrate that the transcriptional factor Pou3f1 is an upstream activator of neural-promoting genes, and it is able to repress neural-inhibitory signals as well. Further studies revealed that Pou3f1 could directly bind neural lineage genes like Sox2 and downstream targets of neural inhibition signaling such as BMP and Wnt. Our results thus identify Pou3f1 as a critical dual-regulator of the intrinsic transcription factors and the extrinsic cellular signals during neural fate commitment. ChIP-seq assay was ultilized to characterize the targets of Pou3f1

  15. PO3F1_XENTR UniProt:Swiss-Prot

    ID: Q4QQQ7

    Description: POU domain, class 3, transcription factor 1 POU-specifi...

  16. PO3F1_MOUSE UniProt:Swiss-Prot

    ID: P21952

    Description: POU domain, class 3, transcription factor 1 POU-specifi...

  17. PO3F4_XENTR UniProt:Swiss-Prot

    ID: A1L0Z1

    Description: POU domain, class 3, transcription factor 4 POU-specific

  18. P3F4B_XENLA UniProt:Swiss-Prot

    ID: Q6DJN3

    Description: POU domain, class 3, transcription factor 4-B POU-specific

  19. P3F1B_XENLA UniProt:Swiss-Prot

    ID: Q561L5

    Description: POU domain, class 3, transcription factor 1-B POU-speci...

  20. PO3F1_RAT UniProt:Swiss-Prot

    ID: P20267

    Description: POU domain, class 3, transcription factor 1 POU-specifi...

  21. PO2F3_MOUSE UniProt:Swiss-Prot

    ID: P31362

    Description: POU domain, class 2, transcription factor 3 POU-specific

  22. ETV5 Mediated Downstream Gene Activation in Spermatogonial Stem Cells BioProject

    ID: PRJNA144433

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tv5), B-cell CLL/lymphoma 6, member B (Bcl6b) and POU domain, class-3 transcription factor-1 (Pou3f1). We reasoned that these three factors may function as a core-set of transcription factors, regulating genes responsible for maintaining the SSC population. Using transient short-interfering RNA oligonucleotides (siRNA) to individually target Etv5, Bcl6b and Pou3f1 within mouse SSC cultures, we examined changes to the global gene expression profiles associated with these transcrip...
  23. Role of Pou3f1 during mouse pluripotent stem cell neural fate commitment ArrayExpress

    ID: E-GEOD-69865

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  24. Genome-wide maps of five major transcription factors in epiblast stem cells BioProject

    ID: PRJNA301044

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ChIP-seq data of ZIC2, OTX2, SOX2, POU5F1 and POU3F1 in EpiSCs Overall design: ChIP-seq using biotinylated transcription factors
  25. Genome-wide maps of five major transcription factors in epiblast stem cells ArrayExpress

    ID: E-GEOD-74636

    Description: ChIP-seq data of ZIC2, OTX2, SOX2, POU5F1 and POU3F1 in EpiSCs ChIP-seq using biotinylated transcription factors

  26. Phrenic neuronal determinants screen in M.Musculus [1] ArrayExpress

    ID: E-GEOD-45807

    Description: n FACS-sorted phrenic cells. Transcription factor Pou3f1 was identified as a major determinant of phrenic identity. Cells type individually compared to the overall expression to identify differentially expressed genes patterns...

  27. Phrenic neuronal determinants screen in M.Musculus [1] BioProject

    ID: PRJNA196414

    Keywords: Transcriptome or Gene expression

    Access Type: download

  28. sciP array data BioProject

    ID: PRJNA127479

    Keywords: Transcriptome or Gene expression

    Access Type: download

  29. Role of Pou3f1 during mouse pluripotent stem cell neural fate commitment OmicsDI

    ID: E-GEOD-69865

    Date Released: 06-21-2015

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  30. Phrenic neuron determinant gain-of-function screen in M. musculus ES cell-derived motor neurons BioProject

    ID: PRJNA196415

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ssed in FACS-sorted primary. Transcription factor Pou3f1 was identified as a major determinant of phrenic identity. Overall design: Expression in induced cell lines were compared to YFP controls, and over-representation of phrenic genes was computed for the list of differentially expressed genes in each indiced cell lines....
  31. Phrenic neuron determinant gain-of-function screen in M. musculus ES cell-derived motor neurons ArrayExpress

    ID: E-GEOD-45808

    Description: ssed in FACS-sorted primary. Transcription factor Pou3f1 was identified as a major determinant of phrenic identity. Expression in induced cell lines were compared to YFP controls, and over-representation of phrenic genes was computed for the list of differentially expressed genes in each indiced cell lines....

  32. sciP array data ArrayExpress

    ID: E-GEOD-22062

    Description: ted to S-phase. We identify the conserved protein SciP (small CtrA inhibitory protein) and show that it accumulates during G1 where it inhibits CtrA from activating target genes. The depletion of SciP from G1 cells leads to the inappropriate induction of CtrA-activated genes and, consequently, a disruption of the cell cycle. Conversely, the ectopic synthesis of SciP is sufficient to inhibit CtrA-dependent transcription, also disrupting the cell cycle. SciP bi...

  33. Glis3 plays a crucial role in spermatogenesis [848_827] ArrayExpress

    ID: E-GEOD-70194

    Description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Testis total RNAs were purified from 4 WT and 4 Glis3KO2 at 1 week old age, and 3WT and 3 Glis3KO2 at 3 week-old age. Then the samples were applied to Agilent mouse genome chip....

  34. Oct6 promotes neural commitment via activation of neural lineage genes and inhibition of BMP/Wnt signals OmicsDI

    ID: E-GEOD-54569

    Date Released: 05-30-2014

    Description: appropriate neural conversion. Here, we show that Oct6 functions as an essential positive factor for neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimera analysis showed that Oct6 knockdown leads to markedly decreased incorporation of ESC in neuroectoderm. By contrast,

  35. Glis3 plays a crucial role in spermatogenesis [923] ArrayExpress

    ID: E-GEOD-70195

    Description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Thy1+ cells were isolated from 3 WT and 3 Glis3KO2 testis at postnatal day 4, and total RNAs were purified from them. Then the samples were applied to Agilent mouse genome chip....

  36. Oct6 promotes neural commitment via activation of neural lineage genes and inhibition of BMP/Wnt signals ArrayExpress

    ID: E-GEOD-54569

    Description: appropriate neural conversion. Here, we show that Oct6 functions as an essential positive factor for neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimera analysis showed that Oct6 knockdown leads to markedly decreased incorporation of ESC in neuroectoderm. By contrast,

  37. sciP array data OmicsDI

    ID: E-GEOD-22062

    Date Released: 05-02-2014

    Description: ted to S-phase. We identify the conserved protein SciP (small CtrA inhibitory protein) and show that it accumulates during G1 where it inhibits CtrA from activating target genes. The depletion of SciP from G1 cells leads to the inappropriate induction of CtrA-activated genes and, consequently, a disruption of the cell cycle. Conversely, the ectopic synthesis of SciP is sufficient to inhibit CtrA-dependent transcription, also disrupting the cell cycle. SciP bi...

  38. Phrenic neuronal determinants screen in M.Musculus [1] OmicsDI

    ID: E-GEOD-45807

    Date Released: 06-03-2014

    Description: n FACS-sorted phrenic cells. Transcription factor Pou3f1 was identified as a major determinant of phrenic identity. Cells type individually compared to the overall expression to identify differentially expressed genes patterns...

  39. Converting Oct6 into a pluripotency inducer by interrogating Oct4 residues BioProject

    ID: PRJNA323374

    Keywords: Transcriptome or Gene expression

    Access Type: download

  40. Glis3 plays a crucial role in spermatogenesis [848_827] BioProject

    ID: PRJNA287834

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Overall design: Testis total RNAs were purified from 4 WT and 4 Glis3KO2 at 1 week old age, and 3WT and 3 Glis3KO2 at 3 week-old age. Then the samples were applied to Agilent mouse genome chip....
  41. Glis3 plays a crucial role in spermatogenesis [923] BioProject

    ID: PRJNA287830

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Overall design: Thy1+ cells were isolated from 3 WT and 3 Glis3KO2 testis at postnatal day 4, and total RNAs were purified from them. Then the samples were applied to Agilent mouse genome chip....
  42. Phrenic neuron determinant gain-of-function screen in M. musculus ES cell-derived motor neurons OmicsDI

    ID: E-GEOD-45808

    Date Released: 10-07-2013

    Description: ssed in FACS-sorted primary. Transcription factor Pou3f1 was identified as a major determinant of phrenic identity. Expression in induced cell lines were compared to YFP controls, and over-representation of phrenic genes was computed for the list of differentially expressed genes in each indiced cell lines....

  43. GSE54569 Dryad

    DateIssued: 06-19-2014

    Description: RNA-seq was performed to examine Oct6 function in ESC neural differentiation at Day2, Day4 and Day6 after dox induction. On Day4 EB, ChIP-seq assay was ultilized to...

  44. Crystal structure of T6SS SciP/TssL from Escherichia Coli Enteroaggregative 042 PDB

    ID: PDB:3U66

    Description: Putative type VI secretion protein

  45. USA Today Poll # 1414 Dataverse

    Description: This survey covers the following issues and topics: Number of registered voters in household; voting in Presidential election; opinion of Reagan, Mond...

    Person: USA Today

    Release Date: 09-01-2007

    dataset.ID: hdl:1902.4/USUSATY1984-OCT6
  46. Glis3 plays a crucial role in spermatogenesis [923] OmicsDI

    ID: E-GEOD-70195

    Date Released: 07-11-2016

    Description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Thy1+ cells were isolated from 3 WT and 3 Glis3KO2 testis at postnatal day 4, and total RNAs were purified from them. Then the samples were applied to Agilent mouse genome chip....

  47. Glis3 plays a crucial role in spermatogenesis [848_827] OmicsDI

    ID: E-GEOD-70194

    Date Released: 07-01-2016

    Description: ermatogonial cells was significantly decreased in 1-week-old Glis3KO2 testis. These included a set of GDNF-dependent genes, such as Etv5, Bcl6b, Lhx1, Brachyury, Id4, and Pou3f1, and GDNF-independent genes, such as FoxO1, Oct4, and Zbtb16. Impairment of the nuclear localization of FoxO1 may be in part responsible for the reduced expression of Ret, Lhx1, and Sall4 in Glis3KO2 testis. Our study identifies Glis3 as a novel and critical regulator of early stages of spermatogenesis. Testis total RNAs were purified from 4 WT and 4 Glis3KO2 at 1 week old age, and 3WT and 3 Glis3KO2 at 3 week-old age. Then the samples were applied to Agilent mouse genome chip....

  48. Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells BioProject

    ID: PRJNA286988

    Keywords: Epigenomics

    Access Type: download

  49. microarray screening duiring ES neural differentiation Dryad

    DateIssued: 06-19-2014

    Description: Microarray was performed to screen the genes differentially expressed during mESC neural differentiation in serum-free medium.

    dataset.keywords: Oct6
  50. Rank-optimal Weighting Procedure and Replication Data for: How to be best in the OECD Better Life Index? Dataverse

    Description: al weights for a given data matrix using the free SCIP optimization suite. Rank-optimal weights are weights which are used to make a weighted sum of all columns such that the value in a particular row achieves the highest possible ra...

    Person: Lorenz, Jan Brauer, Christoph Lorenz, Dirk A.

    Release Date: 07-30-2015

  51. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [timecourse] ArrayExpress

    ID: E-GEOD-57364

    Description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...

  52. Stationary phase stimulon and CspC regulon ArrayExpress

    ID: E-GEOD-61726

    Description: required for the expression of the essential gene sciP, the ECF sigma factor sigU, as well as of the genes for the glyoxylate cycle enzymes and for oxidative stress response. Two and three replicates were performed to determine the stationary phase stimulon and CspC regulon, respectively. Each replicate was conducted with an independent biological sample....

  53. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [mapping] ArrayExpress

    ID: E-GEOD-57365

    Description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...

  54. Stationary phase stimulon and CspC regulon OmicsDI

    ID: E-GEOD-61726

    Date Released: 08-29-2015

    Description: required for the expression of the essential gene sciP, the ECF sigma factor sigU, as well as of the genes for the glyoxylate cycle enzymes and for oxidative stress response. Two and three replicates were performed to determine the stationary phase stimulon and CspC regulon, respectively. Each replicate was conducted with an independent biological sample....

  55. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [timecourse] OmicsDI

    ID: E-GEOD-57364

    Date Released: 12-10-2014

    Description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...

  56. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [mapping] OmicsDI

    ID: E-GEOD-57365

    Date Released: 12-10-2014

    Description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...

  57. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [mapping] BioProject

    ID: PRJNA246338

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...
  58. Stationary phase stimulon and CspC regulon BioProject

    ID: PRJNA261960

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: required for the expression of the essential gene sciP, the ECF sigma factor sigU, as well as of the genes for the glyoxylate cycle enzymes and for oxidative stress response. Overall design: Two and three replicates were performed to determine the stationary phase stimulon and CspC regulon, respectively. Each replicate was conducted with an independent biological sample....
  59. The Global Landscape of Transcription Initiation During the Caulobacter Cell Cycle [timecourse] BioProject

    ID: PRJNA246337

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of 4 transcription factors (DnaA, GcrA, CtrA, and SciP) and a DNA methyltransferase (CcrM). Using a modified global 5’ RACE protocol we mapped 2,726 transcriptional start sites (TSS) in the 4mb Caulobacter genome and identified 586 cell cycle-regulated TSS. The core cell cycle circuit directly con...

Displaying 59 of 59 results for "POU3F1"