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  1. MeDIP-Chip of PrEC, LnCAP, and PC3 cells treated with vehicle control, sulforaphane, or 3,3’-diindolylmethane BioProject

    ID: PRJNA203286

    Keywords: Epigenomics

    Access Type: download

  2. Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n PDB

    ID: PDB:5MIM

    Description: Furin (E.C.3.4.21.75)

    dataset.keywords: proprotein convertase
  3. P300 ChIP-Seq analysis of PC3 cells treated with MnTE-2-PyP or not 24 hours prior to irradiation of 20 Gy. OmicsDI

    ID: E-GEOD-74351

    Date Released: 12-08-2015

    Description: n assay followed by Next Generation Sequencing on PC3 cells treated with or without MnTE-2-PyP one hour post-irradiation (Figure 3A). Based on the called peaks near genes, we predicted that HIF-1βand CREB transcription factors were associating DNA less in the presence of MnTE-2-PyP. DNA was ChIP-Fixed from

  4. Transcription profiling of human PC3 cells after silencing of microRNAs by seed-targeting tiny LNAs - in vitro antilet-7 ArrayExpress

    ID: E-MEXP-2804

    Description: PC3 cells transfected with LNA-antimiR's against let-7.

  5. Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone ArrayExpress

    ID: E-GEOD-14242

    Description: rements in the glycosyltransferase Galnt3 and the proprotein convertase Pcsk5. In addition, we found that the Pcsk5 and the glycosyltransferase Galnt3 were decreased in Hyp bone, suggesting that reduced post-translational processing of FGF23 may also contribute to increased Fgf23 levels in Hyp mice. With regards to mineralization, we identified additional candidates to explain the intrinsic mineralization defect in Hyp osteoblasts, including increases in the mineralization inhibitors Mgp and Thbs4, as well as increases in local pH altering factors, carbonic anhydrase 12 (Car12) and 3 (Car3) and the sodium-dependent citrate transporter (Slc13a5). These studies demonstrate the complexity of gene expression alterations in bone that accompanies inactivating Phex mutations and identify novel pathways that may coordinate Fgf23 expression and mineralization of extracellular matrix in Hyp bone. We isolated total RNAs from long bones of both WT and Hyp mice at 12 days of age. Since the RNA yields from the long bones are very low, we combined 2 bone samples with same genotype (WT or Hyp) for one RNA extraction. We will compare the difference of the gene expressions between Hyp and WT. We wil...

  6. Clonal isolates of PC3 cells overexpressing RWDD4 BioProject

    ID: PRJNA344907

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. MELK and UBE2C gene knockdown in prostate cancer cell line PC3 ArrayExpress

    ID: E-GEOD-32873

    Description: sed inhibition of MELK and UBE2C was efficient in PC3 prostate cancer cells and decreased transcriptional level down to about 30% remaining expression level. Illumina microarray experiments were done upon siRNA based knockdown 48h after transfection of PC3 cells in triplicates....

  8. Siomycin A treatment in prostate cancer cell lines PC3 and LNCaP ArrayExpress

    ID: E-GEOD-36531

    Description: . Illumina microarray experiments were done using PC3 and LNCaP cell lines treated with 0.5 microM Siomaycin A either 24h or 48h in triplicates....

  9. The network of genes regulated by Ago1 in metastatic prostate cancer PC3 OmicsDI

    ID: E-GEOD-57885

    Date Released: 05-30-2015

    Description: go1 knockdown in metastatic prostate cancer cells PC3. To this end we profiled RNA from PC3 cells 72 hours following the transfection with a scramble siRNA (siGL3) and a siRNA targeting Ago1 (siAgo1). We profiled RNA from

  10. Gene expression profiling of PC3 cells stably expressing ERbeta1 and ERbeta2 BioProject

    ID: PRJNA150907

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Gene expression profile in bone metastatic prostate cancer cell line, PC3, following growth in bone marrow conditioned medium (BMCM) ArrayExpress

    ID: E-GEOD-38714

    Description: tate cancer cells following migration to skeleton PC3 cells grown in three dimensional spheroids on hubiogel matrices were cultured for 10 days in BMCM obtained from immunocompetent C57/BL6 mouse. Total RNA was isolated from thes...

  12. Genome-wide analysis of gene expression in EMT cells induced by overexpression of PDGF-D compared with PC3 control cells ArrayExpress

    ID: E-GEOD-22764

    Description: m cell signatures. Total RNA isolated from stable PC3 Neo and PC3 PDGF-D cells....

  13. from xenograft in BALB/c 6-wk-old nude mice with PC3 prostate cancer cells stably expressing PML or a vector control after treatment of the mice with palbociclib... ArrayExpress

    ID: E-GEOD-70923

    Description: from xenograft in BALB/c 6-wk-old nude mice with PC3 prostate cancer cells stably expressing PML or a vector control after treatment of the mice with palbociclib (100mg/kg/day diluted in sodium l...

  14. Comparing gene-expression profiles between bone-metastatic vs. non bone-metastatic human prostate cancer cells BioProject

    ID: PRJNA185441

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rentially regulated in the highly bone-metastatic PC3-ML cells and their low-metastatic counterpart PC3-N cells, and the genes differentially regulated between PC3-N and PC3-N with overexpression of PDGFRa (PC3NRa). We have previously shown that DU-145 cells lack PDGFRa and fail to survive longer than three days as disseminated tumor cells after homing to the mouse bone marrow. Interestingly, and in contrast to PC3-N cells, the exogenous expression of PDGFRa did not promote metastatic bone-tropism of DU-145 cells in our model. Thus, we examined the genes that were differentially regulated between DU-145 and DU-145(Ra) and excluded them from our candidate genes. Finally, to refine our findings and compensate for PC3 and DU-145 genetic disparity, we performed a comparative analysis of the genes differential...
  15. Expression data from mouse EMT-induced and non-induced cells BioProject

    ID: PRJNA145949

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: l tubular and the mammary gland epithelial cells (PC1), or EMT-induced and non-induced cells (PC3). Undergoing EMT identifies the genes that discriminate between the renal tubular and the mammary gland epithelial cells(PC1), or EMT-induced and non-induced cells (PC3). Overall design: Affymetrix GeneChip Mouse Genome 430 2.0 Array was used to transcriptionally profile to compare mouse EMT-induced cells and non-induced cells....
  16. 14028 Promoter libraries through human PC3 tumor in nude mice BioProject

    ID: PRJNA104021

    Keywords: Other

    Access Type: download

  17. pulation mean soil depth (cm), soil moisture (%), PC1 (N, P, K), PC2 (Ca, Mg), and vegetation height (cm) in 24 populations of Primula farinosa, measured in 2008–2010.... Figshare

    ID: doi:10.6084/M9.FIGSHARE.3558621.V1

    Release Date: 09-30-2016

    Description: pulation mean soil depth (cm), soil moisture (%), PC1 (N, P, K), PC2 (Ca, Mg), and vegetation height (cm) in 24 populations of Primula farinosa, measured in 2008–2010....

  18. Fig 3. A-C) Quantification of IFN response in PC-3 and LNCaP cells Dryad

    DateIssued: 01-13-2016

    Description: This file includes the data for Figure 3 A-C. Fig. 3A includes the data for IFN-b secretion by PC3 and LnCap cells after VSV infection, as measured by ...

  19. Figure 5. Selection in temporally heterogeneous innate immune environments leads to VSV strains with differential capacities to block IFN-β productio... Dryad

    DateIssued: 01-13-2016

    Description: Figure 5. It describes the secretion of IFN-b in PC3 cells (as measured by ELISA) after infection with different strains of VSV experimentally evolved in heterogeneous innate immune environments....

  20. MiR-23b/-27b Targets in Prostate Cancer Cell Lines BioProject

    ID: PRJNA308181

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ated by miR-23b/-27b overexpression in aggressive PC3-ML cells, confirmed by antagomiR inhibition of miR-23b and miR-27b in the relatively indolent cell line LNCaP. Genes that were downregulated in

Displaying 20 of 609 results for "PCSK1"