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Displaying 100 of 609 results for "PCSK1"
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  1. PC1/3 DCSG sorting domain in CHAPS PDB

    ID: PDB:2KE3

    Description: Neuroendocrine convertase 1

  2. Deciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Secretomes OmicsDI

    ID: PXD001986

    Date Released: 09-15-2015

    Description: The prohormone convertase 1/3 (PC1/3) is...

  3. Deciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Cellular Extracts OmicsDI

    ID: PXD001984

    Date Released: 09-09-2015

    Description: The prohormone convertase 1/3 (PC1/3) is...

  4. PCSK6_RAT UniProt:Swiss-Prot

    ID: Q63415

    Description: Proprotein convertase subtilisin/kexin type 6 Peptidase...

  5. PCSK9_PANTR UniProt:Swiss-Prot

    ID: A8T644

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  6. PCSK9_ATEGE UniProt:Swiss-Prot

    ID: A8T6A1

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  7. PCSK9_COLGU UniProt:Swiss-Prot

    ID: A8T672

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  8. PCSK9_MACNE UniProt:Swiss-Prot

    ID: A8T662

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  9. PCSK9_LAGLA UniProt:Swiss-Prot

    ID: A8T6A6

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  10. PCSK9_SAGLB UniProt:Swiss-Prot

    ID: A8T682

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  11. PCSK9_MACMU UniProt:Swiss-Prot

    ID: A8T666

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  12. PCSK7_RAT UniProt:Swiss-Prot

    ID: Q62849

    Description: Proprotein convertase subtilisin/kexin type 7 Extracell...

  13. PCSK9_PONPY UniProt:Swiss-Prot

    ID: A8T658

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  14. PCSK9_SAIBB UniProt:Swiss-Prot

    ID: A8T695

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  15. PCSK9_PLEMO UniProt:Swiss-Prot

    ID: A8T677

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  16. PCSK9_CALJA UniProt:Swiss-Prot

    ID: A8T688

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  17. PCSK9_GORGO UniProt:Swiss-Prot

    ID: A8T650

    Description: Proprotein convertase subtilisin/kexin type 9 Peptidase...

  18. Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain PDB

    ID: PDB:1KN6

    Description: Prohormone Convertase 1 (E.C.3.4.21.93)

  19. The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9) PDB

    ID: PDB:2PMW

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  20. WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR PDB

    ID: PDB:2W2N

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  21. PCSK9-DELTAC D374A MUTANT BOUND TO WT EGF-A OF LDLR PDB

    ID: PDB:2W2P

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  22. PCSK9 J16 Fab complex PDB

    ID: PDB:3SQO

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  23. THE CRYSTAL STRUCTURE OF PCSK9 IN COMPLEX WITH 1D05 FAB PDB

    ID: PDB:2XTJ

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  24. Deciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Secretomes ProteomeXchange

    ID: PXD001986

    Instrument: Q Exactive

    Date Released: 09-15-2015

  25. PCSK9-DELTAC D374H MUTANT BOUND TO WT EGF-A OF LDLR PDB

    ID: PDB:2W2Q

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  26. Deciphering molecular consequences of the prohormone convertase 1/3 inhibition in macrophages for application in immunotherapy - Cellular Extracts ProteomeXchange

    ID: PXD001984

    Instrument: Q Exactive

    Date Released: 09-09-2015

  27. PCSK9-DELTAC D374Y MUTANT BOUND TO WT EGF-A OF LDLR PDB

    ID: PDB:2W2O

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  28. Proprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) I... ArrayExpress

    ID: E-GEOD-42070

    Description: Proprotein convertase subtilisin/kexin (PCSK) enzymes convert proproteins ...

  29. PC1/3 DCSG sorting domain structure in DPC PDB

    ID: PDB:2KDT

    Description: Neuroendocrine convertase 1 (E.C.3.4.21.93)

  30. Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody PDB

    ID: PDB:3H42

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  31. The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation PDB

    ID: PDB:3P5C

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  32. The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain PDB

    ID: PDB:2QTW

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  33. The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation PDB

    ID: PDB:3P5B

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  34. PC1/3 deficiency impacts POMC processing in human embryonic stem cell-derived hypothalamic neurons BioProject

    ID: PRJNA352463

    Keywords: Transcriptome or Gene expression

    Access Type: download

  35. WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR PDB

    ID: PDB:2W2M

    Description: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (E.C.3.4....

  36. Crystal Structure of PCSK9 PDB

    ID: PDB:2P4E

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  37. Crystal structure of PCSK9(53-451) with Adnectin PDB

    ID: PDB:4OV6

    Description: Proprotein convertase subtilisin/kexin type 9, Adnectin

  38. PCSK9 in complex with LDLR peptide PDB

    ID: PDB:4NE9

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  39. An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo PDB

    ID: PDB:4K8R

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  40. PCSK9:EGFA (pH 7.4) PDB

    ID: PDB:3GCX

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  41. PCSK9:EGF-A complex PDB

    ID: PDB:3BPS

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  42. PCSK9(deltaCRD) in complex with phage-derived inhibitory peptide 2-8 PDB

    ID: PDB:4NMX

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  43. PCSK9:EGFA(H306Y) PDB

    ID: PDB:3GCW

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  44. The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor PDB

    ID: PDB:3M0C

    Description: Proprotein convertase subtilisin/kexin type 9 (E.C.3.4....

  45. NEC1_BOVIN UniProt:Swiss-Prot

    ID: Q9GLR1

    Description: Neuroendocrine convertase 1 Peptidase S8 Charge relay system Charge relay system Charge relay...

  46. GLUC_OCTDE UniProt:Swiss-Prot

    ID: P22890

    Description: tide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 Cleavage; by PCSK2 Cleavage; by <

  47. CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN PDB

    ID: PDB:1P8J

    Description: Furin (E.C.3.4.21.75)

  48. GLUC_MESAU UniProt:Swiss-Prot

    ID: P01273

    Description: tide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 Cleavage; by PCSK2 Cleavage; by <

  49. GLUC_CAVPO UniProt:Swiss-Prot

    ID: P05110

    Description: tide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 Cleavage; by PCSK2 Cleavage; by <

  50. The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor. PDB

    ID: PDB:2ID4

    Description: Kexin (E.C.3.4.21.61), Ac-RERK-CMK inhibitor

  51. Molecular consequences of proprotein convertase 1/3 inhibition in macrophages for application to cancer immunotherapy: a proteomic study OmicsDI

    ID: GPM32310023533

    Date Released:

    Description: ublished as part of Mol Cell Proteomics. 2015 Sep 1 . From the Abstract: {{i}} ... Here, we investigated the intracellular impact of the down-regulation of the proprotein convertase 1/

  52. The 2.2 A crystal structure of Kex2 protease in complex with Ac-Arg-Glu-Lys-boroArg peptidyl boronic acid inhibitor PDB

    ID: PDB:1R64

    Description: Kexin (E.C.3.4.21.61)/Ac-Arg-Glu-Lys-boroArg peptide inhibitor

  53. GLUC_SHEEP UniProt:Swiss-Prot

    ID: Q8MJ25

    Description: tide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 Cleavage; by PCSK2 Cleavage; by <

  54. GLUC_RAT UniProt:Swiss-Prot

    ID: P06883

    Description: tide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 Cleavage; by PCSK2 Cleavage; by <

  55. SPXN_BOVIN UniProt:Swiss-Prot

    ID: Q0VC44

    Description: Spexin Spexin-1 Spexin-2 Cleavage; by prohormone convertase 2 Cleavage; by prohormone

  56. SPXN_MOUSE UniProt:Swiss-Prot

    ID: D3Z752

    Description: Spexin Spexin-1 Spexin-2 Cleavage; by prohormone convertase 2 Cleavage; by prohormone

  57. Data from: Pleiotropy in the melanocortin system: expression levels of this system are associated with melanogenesis and pigmentation in the tawny owl... Dryad

    DateIssued: 08-21-2014

    Description: belonging to the melanocortin system (MC1R, POMC, PC1/3, PC2 and the antagonist ASIP), which have many pleiotropic effects, are associated with melanogenesis (through variation in the expression of the genes MITF, SLC7A11, TYR, TYRP1) and in turn melanin-based coloration. We considered the tawny owl (Strix aluco) because individuals vary continuously from light to dark reddish, and thus, colour variation is likely to stem from differences in the l...

  58. Transcription profiling by array of wild type and Pcsk5 Vcc mutant mouse embryos ArrayExpress

    ID: E-TABM-443

    Description: poplasia. It results from a C470R mutation in the proprotein convertase PCSK5 (PC5/6, SPC6) that fails to complement a null allele, which also has a similar phenotype. The mutation ablates a predicted disulfide bond in the P domain, and results in reduced secretion, abnormal cellular localisation, and loss of proprotein convertase activity. We analysed whole genome gene expression in a mouse line carrying ENU...

  59. NEC2_RAT UniProt:Swiss-Prot

    ID: P28841

    Description: Neuroendocrine convertase 2 Peptidase S8 Charge relay system Charge relay system Charge relay system N-linked (G...

  60. NEC2_PONAB UniProt:Swiss-Prot

    ID: Q5REC2

    Description: Neuroendocrine convertase 2 Peptidase S8 Charge relay system Charge relay system Charge relay system N-linked (G...

  61. NEC1_RAT UniProt:Swiss-Prot

    ID: P28840

    Description: Neuroendocrine convertase 1 Peptidase S8 Charge relay system Charge relay system Charge relay...

  62. PCSK1_RAT UniProt:Swiss-Prot

    ID: Q9QXU9

    Description: Big PEN-LEN PEN PEN-20 Big LEN Little LEN ProSAAS(1-180) C-terminal inhibitory domain; interacts with PCSK1 Sufficient for inhibition of PCSK1...

  63. Expression profiling of mouse B1a cells with high expression of PC1 vs. those with low expression of PC1. BioProject

    ID: PRJNA170159

    Keywords: Transcriptome or Gene expression

    Access Type: download

  64. Myeloid Cell Expressed Proprotein Convertase FURIN Attenuates Inflammation BioProject

    ID: PRJNA328082

    Keywords: Transcriptome or Gene expression

    Access Type: download

  65. T cell-expressed proprotein convertase furin is essential for maintenance of peripheral tolerance BioProject

    ID: PRJNA105703

    Keywords: Transcriptome or Gene expression

    Access Type: download

  66. Clostridium butyricum strain:NEC1 : Clostridium butyricum strain:NEC1 Genome sequencing and assembly BioProject

    ID: PRJNA317196

    Keywords: genome sequencing and assembly

    Access Type: download

  67. 4 cre Fur flox/flox mice reveals T cell-expressed proprotein convertase furin is essential for maintenance of peripheral tolerance... OmicsDI

    ID: E-GEOD-11884

    Date Released: 06-10-2011

    Description: Furin is a proprotein convertase induced in activated T cells, reported to processes the anti-inflammatory cytokine TGFb-

  68. NEC2_PIG UniProt:Swiss-Prot

    ID: Q03333

    Description: Neuroendocrine convertase 2 Peptidase S8 Charge relay system Charge relay system Charge relay system N-linked (G...

  69. NEC2_BOVIN UniProt:Swiss-Prot

    ID: Q9GLR0

    Description: Neuroendocrine convertase 2 Peptidase S8 Charge relay system Charge relay system Charge relay system N-linked (G...

  70. Trepomonas sp. PC1 : Trepomonas sp. PC1 transcriptome BioProject

    ID: PRJNA288252

    Keywords: Transcriptome or Gene expression

    Access Type: download

  71. Pectobacterium carotovorum subsp. carotovorum PC1 : This strain will be used for comparative genome analysis BioProject

    ID: PRJNA31289

    Keywords: Genome sequencing

    Access Type: download

  72. 4 cre Fur flox/flox mice reveals T cell-expressed proprotein convertase furin is essential for maintenance of peripheral tolerance... ArrayExpress

    ID: E-GEOD-11884

    Description: Furin is a proprotein convertase induced in activated T cells, reported to processes the anti-inflammatory cytokine TGFb-

  73. Gene expression profile of adipocytes treated with bisphenol A or 17beta-estradiol ArrayExpress

    ID: E-GEOD-58516

    Description: n adipocytes culture medium, and insulin, in PANC-1 culture medium, were performed using ELISA assays. BPA was found to promote up-regulation of ERα and ERRγ, and down-regulation of GPR30 expression modulating estrogen signaling and following a non-linear dose-response. Microarray data analysis demonstrated that BPA increases the gene expression of pro-inflammatory cytokines and lipid metabolism-related FABP4 and CD36 in adipocytes. PCSK1 resulted the most interesting gene being down-regulated by BPA thus impairing insulin production in pancreas. BPA promotes inflammation and lipid metabolism dysregulation in adipocytes from lean children. Moreover, PCSK1 can be a key gene in BPA action modulating insulin production. Exposure to BPA in childhood may be an important risk factor in developing obesity and metabolic disorders. Three prototypic situations were analyzed (5 replication each): untreated cells (C), 10 nM BPA treated cells (BPA), 1 nM 17-beta Estradiol treated cells (ES)....

  74. Expression profiling of mouse B1a cells with high expression of PC1 vs. those with low expression of PC1. OmicsDI

    ID: E-GEOD-39171

    Date Released: 07-17-2012

    Description: nto two groups based upon the expression level of PC1. One is PC1 high group and the other is PC1 low. To evaluate gene expression patterns that distinguished PC1 high ...

  75. Expression profiling of mouse B1a cells with high expression of PC1 vs. those with low expression of PC1 ArrayExpress

    ID: E-GEOD-39171

    Description: nto two groups based upon the expression level of PC1. One is PC1 high group and the other is PC1 low. To evaluate gene expression patterns that distinguished PC1 high ...

  76. Furin deficiency efect on T cells ArrayExpress

    ID: E-GEOD-67884

    Description: Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of pro...

  77. Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution. PDB

    ID: PDB:5JXH

    Description: Furin (E.C.3.4.21.75), 2UC-ARG-VAL-ARG-00S

  78. Structure of the proprotein convertase furin complexed to meta-guanidinomethyl-Phac-RVR-Amba in presence of EDTA PDB

    ID: PDB:5JXJ

    Description: Furin (E.C.3.4.21.75), 2UC-ARG-VAL-ARG-00S

  79. Structure of the unliganded form of the proprotein convertase furin in presence of EDTA. PDB

    ID: PDB:5JXI

    Description: Furin (E.C.3.4.21.75)

  80. Structure of the unliganded form of the proprotein convertase furin. PDB

    ID: PDB:5JXG

    Description: Furin (E.C.3.4.21.75)

  81. AGRP_BOVIN UniProt:Swiss-Prot

    ID: P56413

    Description: Agouti-related protein Agouti Interaction with melanocortin receptors Cleavage; by PCSK1

  82. AGRP_PIG UniProt:Swiss-Prot

    ID: Q9TU18

    Description: Agouti-related protein Agouti Interaction with melanocortin receptors Cleavage; by PCSK1

  83. SPXN_DANRE UniProt:Swiss-Prot

    ID: F1QQI2

    Description: Spexin Spexin-1 Cleavage; by prohormone convertase 2 Glutamine amide

  84. Gene expression profile of adipocytes treated with bisphenol A or 17beta-estradiol OmicsDI

    ID: E-GEOD-58516

    Date Released: 09-18-2015

    Description: n adipocytes culture medium, and insulin, in PANC-1 culture medium, were performed using ELISA assays. BPA was found to promote up-regulation of ERα and ERRγ, and down-regulation of GPR30 expression modulating estrogen signaling and following a non-linear dose-response. Microarray data analysis demonstrated that BPA increases the gene expression of pro-inflammatory cytokines and lipid metabolism-related FABP4 and CD36 in adipocytes. PCSK1 resulted the most interesting gene being down-regulated by BPA thus impairing insulin production in pancreas. BPA promotes inflammation and lipid metabolism dysregulation in adipocytes from lean children. Moreover, PCSK1 can be a key gene in BPA action modulating insulin production. Exposure to BPA in childhood may be an important risk factor in developing obesity and metabolic disorders. Three prototypic situations were analyzed (5 replication each): untreated cells (C), 10 nM BPA treated cells (BPA), 1 nM 17-beta Estradiol treated cells (ES)....

  85. Bacillus sp. Pc3 : Bacillus sp. Pc3 Genome sequencing BioProject

    ID: PRJNA271045

    Keywords: Genome sequencing

    Access Type: download

  86. ERG Overexpression in PC3 cells. BioProject

    ID: PRJNA140405

    Keywords: Transcriptome or Gene expression

    Access Type: download

  87. GLUC_CARAU UniProt:Swiss-Prot

    ID: P79695

    Description: Glicentin-related polypeptide Glucagon Glucagon-like peptide Cleavage; by PCSK2 Cleavage; by PCSK1

  88. Microarray analysis of PC3 prostate tumor-initiating cells (PC3 holoclones) BioProject

    ID: PRJNA227068

    Keywords: Transcriptome or Gene expression

    Access Type: download

  89. miR-145 transfected PC3 cells BioProject

    ID: PRJNA251942

    Keywords: Transcriptome or Gene expression

    Access Type: download

  90. Effects of bisphenol A on gene expression in adipocytes from lean children: association to metabolic disorders BioProject

    ID: PRJNA252814

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n adipocytes culture medium, and insulin, in PANC-1 culture medium, were performed using ELISA assays. BPA was found to promote up-regulation of ERα and ERRγ, and down-regulation of GPR30 expression modulating estrogen signaling and following a non-linear dose-response. Microarray data analysis demonstrated that BPA increases the gene expression of pro-inflammatory cytokines and lipid metabolism-related FABP4 and CD36 in adipocytes. PCSK1 resulted the most interesting gene being down-regulated by BPA thus impairing insulin production in pancreas. BPA promotes inflammation and lipid metabolism dysregulation in adipocytes from lean children. Moreover, PCSK1 can be a key gene in BPA action modulating insulin production. Exposure to BPA in childhood may be an important risk factor in developing obesity and metabolic disorders. Overall design: Three prototypic situations were analyzed (5 replication each): untreated cells (C), 10 nM BPA treated cells (BPA), 1 nM 17-β Estradiol treat...
  91. ASNase treatment in PC3 cells BioProject

    ID: PRJNA300627

    Keywords: Other

    Access Type: download

  92. Effect of U94 in Gene Expression in PC3 Cells BioProject

    ID: PRJNA90537

    Keywords: Transcriptome or Gene expression

    Access Type: download

  93. PC3 cells transfected with androgen receptor treated with various concentration of androgens BioProject

    ID: PRJNA114795

    Keywords: Transcriptome or Gene expression

    Access Type: download

  94. The network of genes regulated by Ago1 in metastatic prostate cancer PC3 BioProject

    ID: PRJNA248343

    Keywords: Transcriptome or Gene expression

    Access Type: download

  95. PC3 vs LNCaP amplified and unamplified miRNA BioProject

    ID: PRJNA94407

    Keywords: Transcriptome or Gene expression

    Access Type: download

  96. Data from: Sexual selection and experimental evolution of chemical signals in Drosophila pseudoobscura Dryad

    DateIssued: 11-06-2012

    Description: ent analysis that explained 72% of the variation. PC1 described the amount of CHs produced, PC2 the trade-off between short- and long-chain CHs and PC3 the trade-off between apparently arbitrary CHs. In both sexes, the amount of CHs produced was greater in flies from the E treatment. PC3 was also higher, indicating that sexual selection also influenced the evolution of CH composition. The sexes differed in all three PCs indicating substantial sexual dimorphism in this species, although the magnitude of this dimorphism was not increased as a result of our experimental evolution. Collectively, our work provides direct evidence that sexual selection plays an important role in the evolution of ...

  97. Microarray analysis of PC3 prostate tumor-initiating cells (PC3 holoclones) OmicsDI

    ID: E-GEOD-52161

    Date Released: 06-03-2014

    Description: rogen-independent human prostate cancer cell line PC3. RESULTS: We demonstrate that, under standard culture conditions, ~10% of PC3 cells form holoclones with cancer stem cell characteristics. These holoclones display high self-renewal capability in spheroid formation assays under low attachment and serum-free culture conditions, retain their holoclone morphology when passaged at high cell density, exhibit moderate drug resistance, and show high tumorigenicity in scid immunodeficient mice. PC3 holoclones readily form spheres, and PC3-derived spheres yield a high p...

  98. Microarray analysis of PC3 prostate tumor-initiating cells (PC3 holoclones) ArrayExpress

    ID: E-GEOD-52161

    Description: rogen-independent human prostate cancer cell line PC3. RESULTS: We demonstrate that, under standard culture conditions, ~10% of PC3 cells form holoclones with cancer stem cell characteristics. These holoclones display high self-renewal capability in spheroid formation assays under low attachment and serum-free culture conditions, retain their holoclone morphology when passaged at high cell density, exhibit moderate drug resistance, and show high tumorigenicity in scid immunodeficient mice. PC3 holoclones readily form spheres, and PC3-derived spheres yield a high p...

  99. PRIDE PXD001075 - Identification of biomarkers for PKD1 using urinary exosomes OmicsDI

    ID: MSV000079547

    Date Released:

    Description: D1 or PKD2 gene, encoding the proteins polycystin?1 (PC1) or polycystin?2 (PC2) respectively. PC1 and PC2 are secreted on urinary exosome?like vesicles (ELVs) (100nm diameter vesicles), where PC1 is present in a cleaved form and may be complexed with PC2. Label free...

  100. Gene expression profiling of the prostate cancer cell line PC3. BioProject

    ID: PRJNA319927

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 100 of 609 results for "PCSK1"