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Displaying 50 of 124 results for "OXR1"
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  1. A germline mutation in human Oxidation Resistance 1 gene causes developmental delay, epilepsy and cerebellar atrophy BioProject

    ID: PRJNA341845

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway ArrayExpress

    ID: E-GEOD-65949

    Description: Purpose: The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxida...

  3. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway OmicsDI

    ID: E-GEOD-65949

    Date Released: 02-21-2015

    Description: Purpose: The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxida...

  4. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway BioProject

    ID: PRJNA275502

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. OXR1_XENLA UniProt:Swiss-Prot

    ID: B4F6Q9

    Description: Oxidation resistance protein 1 LysM GRAM Poly-Glu Poly-Gly

  6. OXR1_CYBJA UniProt:Swiss-Prot

    ID: Q6ZZF5

    Description: Oxidation resistance protein 1 TLD

  7. OXR1_BOVIN UniProt:Swiss-Prot

    ID: A5PKL1

    Description: Oxidation resistance protein 1 LysM GRAM TLD Mediates oxidative antimutato...

  8. OXR1_SCHPO UniProt:Swiss-Prot

    ID: O14284

    Description: Oxidation resistance protein 1 TLD

  9. ducing a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp ⁄NDmcr rats... Dryad

    DateIssued: 05-12-2015

    Description: e prevention and treatment of metabolic disorders associated with energy surplus and obesity. Tang-Nai-Kang (TNK), a mixture of five herbal plant extracts, has been shown to improve abnormal glucose metabolism in patients with pre-diabetes. Here, we report the metabolic phenotype of SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated with TNK. Pre-diabetic SHR/cp rats were randomly divided into control, TN...

  10. OXR1_ASHGO UniProt:Swiss-Prot

    ID: Q755A3

    Description: Oxidation resistance protein 1 TLD

  11. OXR1_PODAS UniProt:Swiss-Prot

    ID: Q874Z5

    Description: Oxidation resistance protein 1 TLD

  12. Crystal structure of the TLDC domain of Oxidation resistance protein 2 from zebrafish PDB

    ID: PDB:4ACJ

    Description: WU\:FB25H12 PROTEIN,

  13. to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals... ArrayExpress

    ID: E-GEOD-474

    Description: It has been found that fat oxidation is reduced in the skeletal muscle of obese humans. This study aims to identify the mRNA of proteins involved in fat

  14. RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice ArrayExpress

    ID: E-GEOD-30764

    Description: mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments. Analysis of 2 mRNA samples, one pooled from 3 wild-type mice liver tissue and another pooled from 3 naked mole-rat liver tissue....

  15. OHRR_BACSU UniProt:Swiss-Prot

    ID: O34777

    Description: Organic hydroperoxide resistance transcriptional regulator HTH marR-type H-T-H motif Cysteine sulfenic acid (-SOH); alternate S-bacillithiol cysteine dis...

  16. Eicosapentaenoic acid improves metabolic switching in human myotubes ArrayExpress

    ID: E-GEOD-18589

    Description: ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR l...

  17. Transcription profiling of mouse skeletal muscle overexpressing PPARalpha ArrayExpress

    ID: E-GEOD-5777

    Description: ull mice were protected from diet-induced insulin resistance in the context of obesity. In skeletal muscle, MCK-PPARalpha mice exhibited increased fatty acid oxidation rates, diminished AMP-activated protein kinase activity, and reduced insulin-stimulated glucose uptake without alterations in the phosphorylation status of key insulin-signaling proteins. These effects on muscle glucose uptake involved transcriptional repression of the GLUT4 gene. Pharmacologic inhibition of fatty acid oxidation or mitochondrial respiratory coupling prevented the effects of PPARalpha on GLUT4 expression and glucose homeostasis. These results identify PPARalpha-driven alterations in muscle fatty acid oxidation and energetics as a potential link between obesity and the development of glucose intolerance and insulin resistance. Experiment Overall Design: RNA from two wild-type (non-transgenic (NTG)) and two PPARalpha overexpressing (MCK-PPARa) mice was analyzed. Two replicates of each are...

  18. Transcription profiling of human skeletal muscle of women with PCOS reveals reduced expression of mitochondrial oxidative metabolism genes ArrayExpress

    ID: E-GEOD-6798

    Description: ed in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). ...

  19. Expression data from rice lesion mimic mutant spotted leaf 5 (spl5) ArrayExpress

    ID: E-GEOD-61952

    Description: HR-like lesions on its leaves and shows enhanced resistance to rice blast and bacterial blight pathogens. Some genes were differentially expressed in this mutant compared with its WT control ZF802, and these genes were also associated with some import...

  20. The roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue ArrayExpress

    ID: E-GEOD-26207

    Description: major risk factor for the development of insulin resistance and type II diabetes. The nuclear receptors PPAR delta and PPAR gamma play a central role in regulating metabolism in adipose tissue...

  21. veals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death... ArrayExpress

    ID: E-MEXP-1136

    Description: n this work the role of Isc1p in oxidative stress resistance and chronological lifespan was investigated. Loss of Isc1p resulted in a higher sensitivity to hydrogen peroxide that was associated with an increase in oxidative stress markers, namely intracellular oxidation, protein carbonylation and lipid peroxidation. Microarray analysis showed that Isc1p deficiency upregulated the iron ...

  22. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome ArrayExpress

    ID: E-GEOD-17576

    Description: high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a clust...

  23. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits ArrayExpress

    ID: E-GEOD-45159

    Description: We found a total of 24 miRNAs to be significantly associated with metabolic syndrome traits. We suggest a regulatory role for miR-204-5p which was predicted to inhibit ACACB, a key fatty acid oxidation enzyme that has been shown to play a role in regulating body fat and insulin resistance in adipose tissue. miRNA expression profiling of adipose tissue isolated from 200 humans...

  24. Transcription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin ArrayExpress

    ID: E-GEOD-11936

    Description: ccumulation of body fat and prevention of insulin resistance, besides increased mitochondrial beta-oxidation in white adipose tissue and decreased plasma lipids. ALA, EPA and DHA all belong to PUFA of n-3 series. The intestine is a gatekeeper organ for ingested lipids. To examine the potential contribution of the intestine in the beneficial effects of EPA and DHA, this study assessed gene expression changes using whole genome microarray analysis on small intestinal scrapings. The main bio...

  25. Crystal structure of MexR in oxidized state PDB

    ID: PDB:3MEX

    Description: Multidrug resistance operon repressor

  26. The roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue BioProject

    ID: PRJNA135035

    Keywords: Transcriptome or Gene expression

    Access Type: download

  27. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels ArrayExpress

    ID: E-GEOD-38590

    Description: mately contributing to the development of insulin resistance. Lipid droplet (LD)-coating proteins may control proper lipid storage in skeletal muscle. Perilipin 2 (PLIN2/ADRP) is one of the most abundantly expressed LD-coating proteins in skeletal muscle. Here we examined the role of PLIN2 in myocellular lipid handling and insulin sensitivity by investigating ...

  28. OXR1_CANGA UniProt:Swiss-Prot

    ID: Q6FSN5

    Description: Oxidation resistance protein 1 TLD

  29. Peroxisomal mdh mutant BioProject

    ID: PRJNA96839

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: somal NAD-malate dehydrogenase in fatty acid beta-oxidation, glyoxylate cycle and photorespiration. Both peroxisomal MDH genes (At2g22780 and At5g09660) have been knocked out with T-DNA insertions and a double mutant made. ...
  30. OXR1_YARLI UniProt:Swiss-Prot

    ID: Q6C443

    Description: Oxidation resistance protein 1 TLD

  31. Transcription profiling of brown adipose tissue from resistin-transgenic spontaneously hypertensive rats ArrayExpress

    ID: E-MTAB-3787

    Description: ied as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin (Retn) transgene specifically in a...

  32. OXR1_DEBHA UniProt:Swiss-Prot

    ID: Q6BJM5

    Description: Oxidation resistance protein 1 TLD

  33. Transcription profiling by array of Arabidopsis mutant for mdh ArrayExpress

    ID: E-GEOD-5641

    Description: somal NAD-malate dehydrogenase in fatty acid beta-oxidation, glyoxylate cycle and photorespiration. Both peroxisomal MDH genes (At2g22780 and At5g09660) have been knocked out with T-DNA insertions and a double mutant made. ...

  34. RNA-sequencing of healthy human skeletal myocytes ArrayExpress

    ID: E-GEOD-63887

    Description: e metabolically active and susceptible to insulin resistance, thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes and their elucidation at the systems lev...

  35. Whole blood expression profiling of obese diet-sensitive, obese diet-resistant and lean human subjects ArrayExpress

    ID: E-GEOD-18897

    Description: consistent with impaired capacity for fatty acid oxidation driven mitochondrial ATP synthesis in obese subjects who are resistant to weight loss. A total of 80 samples are analyzed. This consists of 20 lean subjects studied at one timepoint and 20 obese subjects (10 diet-sensitive and 10 diet-resistant) studied at 3 timepoints during caloric restriction (day of entry into program, week 3 into the program and week 6 into the program)...

  36. OXR1_KLULA UniProt:Swiss-Prot

    ID: Q6CMK8

    Description: Oxidation resistance protein 1 TLD

  37. OXR1_NEUCR UniProt:Swiss-Prot

    ID: Q7S4P1

    Description: Oxidation resistance protein 1 TLD

  38. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitiv... ArrayExpress

    ID: E-GEOD-43832

    Description: al muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We pr...

  39. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome OmicsDI

    ID: E-GEOD-17576

    Date Released: 04-20-2016

    Description: high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a clust...

  40. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome BioProject

    ID: PRJNA118525

    Keywords: Transcriptome or Gene expression

    Access Type: download

  41. Evaluation of iTRAQ and SWATH-MS for the quantification of proteins associated with insulin resistance in human duodenal biopsy samples OmicsDI

    ID: PXD001506

    Date Released: 08-26-2015

    Description: Insulin resistance (IR) is associated with increased production of triglyceride-rich lipoproteins of intestinal origin. ...

  42. Transcription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain ArrayExpress

    ID: E-GEOD-8582

    Description: Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in...

  43. Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing? ArrayExpress

    ID: E-GEOD-35697

    Description: lls (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its development and pathogenesis. Besides genetic susceptibility and lifestyle factors, environmental pollutants are suggested risk factors. In order to appraise the role of the th...

  44. Transcription profiling of liver from from spontaneously hypertensive rats expressing human C-reactive protein treated with salsalate ArrayExpress

    ID: E-MTAB-5079

    Description: Metabolic syndrome is associated with chronic low-grade inflammation which plays an important role in the pathogenesis of insulin resistance

  45. Next generation sequencing of Desulfovibrio vulgaris Hildenborough in the presence of Free Nitrous Acid stress ArrayExpress

    ID: E-GEOD-78834

    Description: detected by sequencing. Transcripts exhibiting ≥1 or ≤-1 fold abundance change in the presence of FNA were designated as differentially expressed. Results:The results imply that FNA exerted multiple antimicrobial effects. Growth of the culture was inhibited by FNA and significant proportions of the cells were killed during the exposure. Respiration by sulfate reduction and lactate oxidation was shut down along with ATP production when exposed to FNA. Correspondingly, decreased transcript levels of genes involved in these metabolic pathways were detected. Detoxification of FNA was evident by nitrite reduction and the genes coding both nitrite reductase (NrfA) and hydroxylamine reduct...

  46. Comparison of hepatic gene expression in response to fasting or 2 week high fat diet ArrayExpress

    ID: E-GEOD-8576

    Description: ext to visceral obesity, dyslipidemia and insulin resistance, excessive triglyceride accumulation in the liver has been implicated to play a role in the development of the metabolic syndrome. To investigate the underlying molecular changes leading to hepatic steatosis we performed microarray analysis on livers of mice eithe...

  47. AS8 : physiological and genomic traits for arsenite-oxidizing bacteria BioProject

    ID: PRJEB17872

    Keywords: Other

    Access Type: download

    dataset.description: novel species which has a capability for arsenic oxidation belonging to the Herminiimonas. The strain can be grown heterotrophically. Cells of strain AS8 were rod and stained Gram-stain-negative, and formed small beige-pigmented colonies. Strain AS8 grew in the rang...
  48. Growth inhibition of ovarian tumor-initiating cells by niclosamide ArrayExpress

    ID: E-GEOD-36259

    Description: cells, and they show stemness properties and drug resistance capacity. According gene expression profiles and mechanistic analysis, all evidences revealed niclosamide disrupted multiple metabolic pathways affecting biogenetics, biogenesis and redox regulation. These studies support niclosamide as a promising therapeutic agent for ovarian cancer. CP70sps cells were treated with niclosamide for 0, 2, 4 and 6 hours respectively, and then cells were harvest...

  49. Expression Differences in Ethanol Stress Response Between Saccharomyces cerevisiae Parent W303-1A Strain and its Two Ethanol Tolerant Mutants ArrayExpress

    ID: E-GEOD-21120

    Description: nt, differences in the expression levels of genes associated with a number of GO categories in the mutants suggest that their improved ethanol stress response is a consequence of increased mitochondrial and NADH oxidation activities, stimulating glycolysis and energy production. This leads to increased activity of energy-demanding processes associated with the production of proteins and plasma membrane components, which are necessary for acclimation to ethanol stress. It is suggested that a key function of the ethanol stress response is restoration of the NAD+/NADH redox balance, which increases glyceraldehyde-3-phosphate dehydrogenase activity, and higher glycolytic flux in the ethanol-stressed cell. Both mutants achieved this by a constitutive increase in carbon flux in the glycerol pathway as a means of increasing NADH

  50. gainst Diet and Age-Induced Adiposity and Insulin Resistance... ArrayExpress

    ID: E-GEOD-29984

    Description: increased mitochondrial biogenesis, hepatic lipid oxidation, and energy expenditure, but decreased hepatic de novo lipogenesis. Loss of mIndy activates hepatic AMPK, which induces PGC-1?, inhibits ACC-2, and reduces SREBP-1c levels. In contrast to wild- type mice, mINDY-/- mice have reduced body weight and are protected from insulin resistance that evolves with high-fat feeding and aging. These studies demonstrate that mIndy functions as a novel regulator of mammalian energy metabolism and suggest that mIndy might be a novel therapeutic target for the treatment of obesity and type 2 diabetes. An SLC13A5 knockout mouse model (mINDY-/-) was generated. The litters produced when heterozygous (KO/+) mINDY mice (mINDY+...


Displaying 50 of 124 results for "OXR1"