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Displaying 100 of 124 results for "OXR1"
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  1. A germline mutation in human Oxidation Resistance 1 gene causes developmental delay, epilepsy and cerebellar atrophy BioProject

    ID: PRJNA341845

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway ArrayExpress

    ID: E-GEOD-65949

    Description: Purpose: The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxida...

  3. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway OmicsDI

    ID: E-GEOD-65949

    Date Released: 02-21-2015

    Description: Purpose: The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxida...

  4. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway BioProject

    ID: PRJNA275502

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. OXR1_XENLA UniProt:Swiss-Prot

    ID: B4F6Q9

    Description: Oxidation resistance protein 1 LysM GRAM Poly-Glu Poly-Gly

  6. OXR1_CYBJA UniProt:Swiss-Prot

    ID: Q6ZZF5

    Description: Oxidation resistance protein 1 TLD

  7. OXR1_BOVIN UniProt:Swiss-Prot

    ID: A5PKL1

    Description: Oxidation resistance protein 1 LysM GRAM TLD Mediates oxidative antimutato...

  8. OXR1_SCHPO UniProt:Swiss-Prot

    ID: O14284

    Description: Oxidation resistance protein 1 TLD

  9. ducing a gene expression switch toward fatty acid oxidation in SHR.Cg-Leprcp ⁄NDmcr rats... Dryad

    DateIssued: 05-12-2015

    Description: e prevention and treatment of metabolic disorders associated with energy surplus and obesity. Tang-Nai-Kang (TNK), a mixture of five herbal plant extracts, has been shown to improve abnormal glucose metabolism in patients with pre-diabetes. Here, we report the metabolic phenotype of SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated with TNK. Pre-diabetic SHR/cp rats were randomly divided into control, TN...

  10. OXR1_ASHGO UniProt:Swiss-Prot

    ID: Q755A3

    Description: Oxidation resistance protein 1 TLD

  11. OXR1_PODAS UniProt:Swiss-Prot

    ID: Q874Z5

    Description: Oxidation resistance protein 1 TLD

  12. Crystal structure of the TLDC domain of Oxidation resistance protein 2 from zebrafish PDB

    ID: PDB:4ACJ

    Description: WU\:FB25H12 PROTEIN,

  13. to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals... ArrayExpress

    ID: E-GEOD-474

    Description: It has been found that fat oxidation is reduced in the skeletal muscle of obese humans. This study aims to identify the mRNA of proteins involved in fat

  14. RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice ArrayExpress

    ID: E-GEOD-30764

    Description: mole-rat and mouse in terms of longevity, cancer resistance and adaptation to subterranean environments. Analysis of 2 mRNA samples, one pooled from 3 wild-type mice liver tissue and another pooled from 3 naked mole-rat liver tissue....

  15. OHRR_BACSU UniProt:Swiss-Prot

    ID: O34777

    Description: Organic hydroperoxide resistance transcriptional regulator HTH marR-type H-T-H motif Cysteine sulfenic acid (-SOH); alternate S-bacillithiol cysteine dis...

  16. Eicosapentaenoic acid improves metabolic switching in human myotubes ArrayExpress

    ID: E-GEOD-18589

    Description: ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR l...

  17. Transcription profiling of mouse skeletal muscle overexpressing PPARalpha ArrayExpress

    ID: E-GEOD-5777

    Description: ull mice were protected from diet-induced insulin resistance in the context of obesity. In skeletal muscle, MCK-PPARalpha mice exhibited increased fatty acid oxidation rates, diminished AMP-activated protein kinase activity, and reduced insulin-stimulated glucose uptake without alterations in the phosphorylation status of key insulin-signaling proteins. These effects on muscle glucose uptake involved transcriptional repression of the GLUT4 gene. Pharmacologic inhibition of fatty acid oxidation or mitochondrial respiratory coupling prevented the effects of PPARalpha on GLUT4 expression and glucose homeostasis. These results identify PPARalpha-driven alterations in muscle fatty acid oxidation and energetics as a potential link between obesity and the development of glucose intolerance and insulin resistance. Experiment Overall Design: RNA from two wild-type (non-transgenic (NTG)) and two PPARalpha overexpressing (MCK-PPARa) mice was analyzed. Two replicates of each are...

  18. Transcription profiling of human skeletal muscle of women with PCOS reveals reduced expression of mitochondrial oxidative metabolism genes ArrayExpress

    ID: E-GEOD-6798

    Description: ed in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). ...

  19. Expression data from rice lesion mimic mutant spotted leaf 5 (spl5) ArrayExpress

    ID: E-GEOD-61952

    Description: HR-like lesions on its leaves and shows enhanced resistance to rice blast and bacterial blight pathogens. Some genes were differentially expressed in this mutant compared with its WT control ZF802, and these genes were also associated with some import...

  20. The roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue ArrayExpress

    ID: E-GEOD-26207

    Description: major risk factor for the development of insulin resistance and type II diabetes. The nuclear receptors PPAR delta and PPAR gamma play a central role in regulating metabolism in adipose tissue...

  21. veals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death... ArrayExpress

    ID: E-MEXP-1136

    Description: n this work the role of Isc1p in oxidative stress resistance and chronological lifespan was investigated. Loss of Isc1p resulted in a higher sensitivity to hydrogen peroxide that was associated with an increase in oxidative stress markers, namely intracellular oxidation, protein carbonylation and lipid peroxidation. Microarray analysis showed that Isc1p deficiency upregulated the iron ...

  22. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome ArrayExpress

    ID: E-GEOD-17576

    Description: high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a clust...

  23. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits ArrayExpress

    ID: E-GEOD-45159

    Description: We found a total of 24 miRNAs to be significantly associated with metabolic syndrome traits. We suggest a regulatory role for miR-204-5p which was predicted to inhibit ACACB, a key fatty acid oxidation enzyme that has been shown to play a role in regulating body fat and insulin resistance in adipose tissue. miRNA expression profiling of adipose tissue isolated from 200 humans...

  24. Transcription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin ArrayExpress

    ID: E-GEOD-11936

    Description: ccumulation of body fat and prevention of insulin resistance, besides increased mitochondrial beta-oxidation in white adipose tissue and decreased plasma lipids. ALA, EPA and DHA all belong to PUFA of n-3 series. The intestine is a gatekeeper organ for ingested lipids. To examine the potential contribution of the intestine in the beneficial effects of EPA and DHA, this study assessed gene expression changes using whole genome microarray analysis on small intestinal scrapings. The main bio...

  25. Crystal structure of MexR in oxidized state PDB

    ID: PDB:3MEX

    Description: Multidrug resistance operon repressor

  26. The roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue BioProject

    ID: PRJNA135035

    Keywords: Transcriptome or Gene expression

    Access Type: download

  27. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels ArrayExpress

    ID: E-GEOD-38590

    Description: mately contributing to the development of insulin resistance. Lipid droplet (LD)-coating proteins may control proper lipid storage in skeletal muscle. Perilipin 2 (PLIN2/ADRP) is one of the most abundantly expressed LD-coating proteins in skeletal muscle. Here we examined the role of PLIN2 in myocellular lipid handling and insulin sensitivity by investigating ...

  28. OXR1_CANGA UniProt:Swiss-Prot

    ID: Q6FSN5

    Description: Oxidation resistance protein 1 TLD

  29. Peroxisomal mdh mutant BioProject

    ID: PRJNA96839

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: somal NAD-malate dehydrogenase in fatty acid beta-oxidation, glyoxylate cycle and photorespiration. Both peroxisomal MDH genes (At2g22780 and At5g09660) have been knocked out with T-DNA insertions and a double mutant made. ...
  30. OXR1_YARLI UniProt:Swiss-Prot

    ID: Q6C443

    Description: Oxidation resistance protein 1 TLD

  31. Transcription profiling of brown adipose tissue from resistin-transgenic spontaneously hypertensive rats ArrayExpress

    ID: E-MTAB-3787

    Description: ied as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin (Retn) transgene specifically in a...

  32. OXR1_DEBHA UniProt:Swiss-Prot

    ID: Q6BJM5

    Description: Oxidation resistance protein 1 TLD

  33. Transcription profiling by array of Arabidopsis mutant for mdh ArrayExpress

    ID: E-GEOD-5641

    Description: somal NAD-malate dehydrogenase in fatty acid beta-oxidation, glyoxylate cycle and photorespiration. Both peroxisomal MDH genes (At2g22780 and At5g09660) have been knocked out with T-DNA insertions and a double mutant made. ...

  34. RNA-sequencing of healthy human skeletal myocytes ArrayExpress

    ID: E-GEOD-63887

    Description: e metabolically active and susceptible to insulin resistance, thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes and their elucidation at the systems lev...

  35. Whole blood expression profiling of obese diet-sensitive, obese diet-resistant and lean human subjects ArrayExpress

    ID: E-GEOD-18897

    Description: consistent with impaired capacity for fatty acid oxidation driven mitochondrial ATP synthesis in obese subjects who are resistant to weight loss. A total of 80 samples are analyzed. This consists of 20 lean subjects studied at one timepoint and 20 obese subjects (10 diet-sensitive and 10 diet-resistant) studied at 3 timepoints during caloric restriction (day of entry into program, week 3 into the program and week 6 into the program)...

  36. OXR1_KLULA UniProt:Swiss-Prot

    ID: Q6CMK8

    Description: Oxidation resistance protein 1 TLD

  37. OXR1_NEUCR UniProt:Swiss-Prot

    ID: Q7S4P1

    Description: Oxidation resistance protein 1 TLD

  38. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitiv... ArrayExpress

    ID: E-GEOD-43832

    Description: al muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We pr...

  39. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome OmicsDI

    ID: E-GEOD-17576

    Date Released: 04-20-2016

    Description: high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a clust...

  40. A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome BioProject

    ID: PRJNA118525

    Keywords: Transcriptome or Gene expression

    Access Type: download

  41. Evaluation of iTRAQ and SWATH-MS for the quantification of proteins associated with insulin resistance in human duodenal biopsy samples OmicsDI

    ID: PXD001506

    Date Released: 08-26-2015

    Description: Insulin resistance (IR) is associated with increased production of triglyceride-rich lipoproteins of intestinal origin. ...

  42. Transcription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain ArrayExpress

    ID: E-GEOD-8582

    Description: Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in...

  43. Mechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing? ArrayExpress

    ID: E-GEOD-35697

    Description: lls (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its development and pathogenesis. Besides genetic susceptibility and lifestyle factors, environmental pollutants are suggested risk factors. In order to appraise the role of the th...

  44. Transcription profiling of liver from from spontaneously hypertensive rats expressing human C-reactive protein treated with salsalate ArrayExpress

    ID: E-MTAB-5079

    Description: Metabolic syndrome is associated with chronic low-grade inflammation which plays an important role in the pathogenesis of insulin resistance

  45. Next generation sequencing of Desulfovibrio vulgaris Hildenborough in the presence of Free Nitrous Acid stress ArrayExpress

    ID: E-GEOD-78834

    Description: detected by sequencing. Transcripts exhibiting ≥1 or ≤-1 fold abundance change in the presence of FNA were designated as differentially expressed. Results:The results imply that FNA exerted multiple antimicrobial effects. Growth of the culture was inhibited by FNA and significant proportions of the cells were killed during the exposure. Respiration by sulfate reduction and lactate oxidation was shut down along with ATP production when exposed to FNA. Correspondingly, decreased transcript levels of genes involved in these metabolic pathways were detected. Detoxification of FNA was evident by nitrite reduction and the genes coding both nitrite reductase (NrfA) and hydroxylamine reduct...

  46. Comparison of hepatic gene expression in response to fasting or 2 week high fat diet ArrayExpress

    ID: E-GEOD-8576

    Description: ext to visceral obesity, dyslipidemia and insulin resistance, excessive triglyceride accumulation in the liver has been implicated to play a role in the development of the metabolic syndrome. To investigate the underlying molecular changes leading to hepatic steatosis we performed microarray analysis on livers of mice eithe...

  47. AS8 : physiological and genomic traits for arsenite-oxidizing bacteria BioProject

    ID: PRJEB17872

    Keywords: Other

    Access Type: download

    dataset.description: novel species which has a capability for arsenic oxidation belonging to the Herminiimonas. The strain can be grown heterotrophically. Cells of strain AS8 were rod and stained Gram-stain-negative, and formed small beige-pigmented colonies. Strain AS8 grew in the rang...
  48. Growth inhibition of ovarian tumor-initiating cells by niclosamide ArrayExpress

    ID: E-GEOD-36259

    Description: cells, and they show stemness properties and drug resistance capacity. According gene expression profiles and mechanistic analysis, all evidences revealed niclosamide disrupted multiple metabolic pathways affecting biogenetics, biogenesis and redox regulation. These studies support niclosamide as a promising therapeutic agent for ovarian cancer. CP70sps cells were treated with niclosamide for 0, 2, 4 and 6 hours respectively, and then cells were harvest...

  49. Expression Differences in Ethanol Stress Response Between Saccharomyces cerevisiae Parent W303-1A Strain and its Two Ethanol Tolerant Mutants ArrayExpress

    ID: E-GEOD-21120

    Description: nt, differences in the expression levels of genes associated with a number of GO categories in the mutants suggest that their improved ethanol stress response is a consequence of increased mitochondrial and NADH oxidation activities, stimulating glycolysis and energy production. This leads to increased activity of energy-demanding processes associated with the production of proteins and plasma membrane components, which are necessary for acclimation to ethanol stress. It is suggested that a key function of the ethanol stress response is restoration of the NAD+/NADH redox balance, which increases glyceraldehyde-3-phosphate dehydrogenase activity, and higher glycolytic flux in the ethanol-stressed cell. Both mutants achieved this by a constitutive increase in carbon flux in the glycerol pathway as a means of increasing NADH

  50. gainst Diet and Age-Induced Adiposity and Insulin Resistance... ArrayExpress

    ID: E-GEOD-29984

    Description: increased mitochondrial biogenesis, hepatic lipid oxidation, and energy expenditure, but decreased hepatic de novo lipogenesis. Loss of mIndy activates hepatic AMPK, which induces PGC-1?, inhibits ACC-2, and reduces SREBP-1c levels. In contrast to wild- type mice, mINDY-/- mice have reduced body weight and are protected from insulin resistance that evolves with high-fat feeding and aging. These studies demonstrate that mIndy functions as a novel regulator of mammalian energy metabolism and suggest that mIndy might be a novel therapeutic target for the treatment of obesity and type 2 diabetes. An SLC13A5 knockout mouse model (mINDY-/-) was generated. The litters produced when heterozygous (KO/+) mINDY mice (mINDY+...

  51. Transcriptomics analysis of biopolymer (medium chain length polyhydroxyalkanoate) producing strain P.putida LS46 cultured with biodiesel derived waste... ArrayExpress

    ID: E-GEOD-65029

    Description: es of copAB, which are usually involved in copper resistance and tolerance to other monovalent heavy metals. A local gene relocation was observed in cluster 1 consisting cusABC and copAB relative to the KT2440 type strain according to the phylogenetic and gene neighbourhood analyses on various P. putida strains. P. putida LS46 also contains 11 putative MerR family regulators, which sense various environmental stimuli including heavy metals. MerR-1 is an ortholog of the copper response regulator of other gram-negative bacteria, and was highly up-regulated in waste glycerol cultures. Finally, a number of genes involved in cell responses to high extra-cellular Na+ concentrations, and genes of the fatty acid beta-oxidation pathway were up-regulated in waste glycerol cultures Major results from objective b): Regardless to the type of substrates, up-regulation of two mcl-PHA synthase (PhaC1 and PhaC2), and two phasin proteins (PhaF and PhaI) are the most common genotype under mcl-PHA production conditions. PhaG and possible PhaJ4 connect fatty acid de novo synthesis to mcl-PHA in waste glycerol culture. Interestingly, expression of gene, fabZ, in production of unsaturated fatty acid from fatty acid de novo synthesis was only observed in waste glycerol culture. On the other hand, PhaJ1 and PhaJ4 derived mcl-PHA production via fatty acid beta-oxidation was observed under waste fatty acid culture. These results would help to explain observed different production kinetics and monomer distribution of the polymer. Although under active mcl-PHA produc...

  52. Transcriptomics analysis of biopolymer (medium chain length polyhydroxyalkanoate) producing strain P.putida LS46 cultured with biodiesel derived waste... BioProject

    ID: PRJNA272731

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: es of copAB, which are usually involved in copper resistance and tolerance to other monovalent heavy metals. A local gene relocation was observed in cluster 1 consisting cusABC and copAB relative to the KT2440 type strain according to the phylogenetic and gene neighbourhood analyses on various P. putida strains. P. putida LS46 also contains 11 putative MerR family regulators, which sense various environmental stimuli including heavy metals. MerR-1 is an ortholog of the copper response regulator of other gram-negative bacteria, and was highly up-regulated in waste glycerol cultures. Finally, a number of genes involved in cell responses to high extra-cellular Na+ concentrations, and genes of the fatty acid beta-oxidation pathway were up-regulated in waste glycerol cultures Major results from objective b): Regardless to the type of substrates, up-regulation of two mcl-PHA synthase (PhaC1 and PhaC2), and two phasin proteins (PhaF and PhaI) are the most common genotype under mcl-PHA production conditions. PhaG and possible PhaJ4 connect fatty acid de novo synthesis to mcl-PHA in waste glycerol culture. Interestingly, expression of gene, fabZ, in production of unsaturated fatty acid from fatty acid de novo synthesis was only observed in waste glycerol culture. On the other hand, PhaJ1 and PhaJ4 derived mcl-PHA production via fatty acid beta-oxidation was observed under waste fatty acid culture. These results would help to explain observed different production kinetics and monomer distribution of the polymer. Although under active mcl-PHA produc...
  53. Transcription profiling of lung carcinoma and brain glioblastoma cells were analalyzed, with microarrays run both for control and treatment with dichl... ArrayExpress

    ID: E-GEOD-6014

    Description: ncers (aerobic glycolysis) might confer apoptosis-resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential and low expression of the K+ channe...

  54. Transcription profiling by array of virulent and avirulent Entamoeba histolytica in hyperoxic conditions or normal oxygen conditions ArrayExpress

    ID: E-MTAB-1207

    Description: attention have received the mechanisms of oxygen resistance and its relationship with pathogenicity and virulence. In this work we compared the ability of virulent E. histolytica, non virulent E. histolytica and non pathogenic E. dispar to survive under physiological oxygen concentrations. Also, the effect of hyperoxia on the transcriptome, the oxygen reduction pathway, iron-sulfur protein oxidation, protein carbonylation and complement resistance was analyzed. Our results showed that a low oxygen reduction capacity plus high complement susceptibility contribute to the inability of E. dispar to survive during the early tissue invasion. On the other hand, under hyperoxia, the non virulent E. histolytica phenot...

  55. Muscle gene expression patterns in pigs with divergent phenotypes for fatness traits ArrayExpress

    ID: E-GEOD-19275

    Description: ingly, several genes which enhanced fatty acid β-oxidation and favoured insulin signalling and glucose uptake were upregulated in the fattest animals, indicating that the events leading to peripheral insulin resistance in humans with increased levels of intramuscular fat and obesity do not take place in these pigs. Moreover, neither was detected the well-characterised low-grade inflammatory state observed in overweighed humans. Conclusion: As a whole, our data suggest that selection for increasing intramuscular fat content in pigs would lead to a shift but not a disruption of the metabolic homeostasis of muscle cells. Future studies on the post-translational changes affecting protein activity or expression as well as information about protein location within the cell would be needed to fully understand how lipid deposition affects muscle physiology in pigs. 68 gluteus medius samples form 68 animals belonging to two groups of 34 animals each: HIGH group had higher carcass, plasma and muscle fat content; LOW group had lower carcass, plasma and muscle fat content...

  56. Differential gene expression in resting human skeletal muscle of sedentary and highly-trained individuals ArrayExpress

    ID: E-GEOD-9405

    Description: ning in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). ...

  57. Expression data from menadione, PERK inhibitor, or control-treated HMLE-shGFP and HMLE-Twist human mammary epithelial cells ArrayExpress

    ID: E-GEOD-59780

    Description: de-differentiated cells, Nrf2 is not activated by oxidation but rather through a non-canonical mechanism involving its phosphorylation by the ER membrane kinase PERK. In contrast, differentiated cells require oxidative damage to activate Nrf2. Constitutive PERK-Nrf2 signaling protects de-differentiated cells from chemotherapy by reducing ROS levels and increasing drug efflux. These findings are validated in therapy-resistant basal breast cancer cell lines and animal models, where inhibition of the PERK-Nrf2 signaling axis reversed the MDR of de-differentiated cancer cells. Additionally, analysis of patient tumor datasets showed that a PERK pathway signature correlates strongly with chemotherapy resistance, tumor grade, and overall survival. Collectively, these results indicate that de-differentiated cells upregulate MDR genes via PERK-Nrf2 signaling, and suggest tha...

  58. Genome-Wide Transcriptional Responses of Nitrosomonas europaea to Zinc BioProject

    ID: PRJNA100367

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: oautotroph that derives energy for growth through oxidation of ammonia and participates in the process of nitrification in global nitrogen cycling. The physiological, proteomic, and transcriptional responses of N. europaea to zinc stress we...
  59. Global transcriptional and phenotypic analyseis of Escherichia coli O157:H7 strain Xuzhou21 and its pO157_Sal cured mutant ArrayExpress

    ID: E-GEOD-44846

    Description: eq data. Seven differentially expressed genes are associated with NaDC resistance, including the adenine-specific DNA-methyltransferase gene (dam), multidrug efflux system subunit gene mdtA, hyperosmotically inducible periplasmic protein gene osmY and oxidation-reduction related genes while two differentially expressed genes (osmY and pspD) are likely to be related to resistance to osmotic pressure. A number of differentially expressed genes were virulence associated including four genes encoding T3SS effectors from the chromosome and ehxD from pO157. These findings demonstrated that the plasmid pO157_Sal affects the chromosome and pO157 genes transcription and contributes to the enhanced ability to resist stress. We conclude that pO157_Sal plays an important role in regulating global gene expression and affects virulence and adaptation of E.coli O157:H7. The total mRNA extracted from Escherichia coli O157:H7 Xuzhou21 and its plasmid cured strain Xuzhou21m were sequenced using Illumina....

  60. Induction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance BioProject

    ID: PRJNA113515

    Keywords: Transcriptome or Gene expression

    Access Type: download

  61. OXR1_ASPFU UniProt:Swiss-Prot

    ID: Q4WX99

    Description: Oxidation resistance protein 1 TLD Ser-rich

  62. Salmonid host response to Hematopoietic Necrosis virus: cellular receptors, viral control and novel pathways of defence BioProject

    ID: PRJNA99347

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: samples from five fish sampled on each of days 0, 1, 5 and 9 were analysed in the microarray study. Validation of nine of the significant genes was conducted on fish sampled on alternate days from 1 to 13 and compared to the unchallenged control sampled on day 0. The key pathways up-regulated in response to the virus included endosomal transport, type I and II interferon responses, the alternative comple...
  63. Role of small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BioProject

    ID: PRJNA101731

    Keywords: Transcriptome or Gene expression

    Access Type: download

  64. Induction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance ArrayExpress

    ID: E-GEOD-12115

    Description: ketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for

  65. Next generation sequencing of Desulfovibrio vulgaris Hildenborough in the presence of Free Nitrous Acid stress BioProject

    ID: PRJNA314088

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: detected by sequencing. Transcripts exhibiting ≥1 or ≤-1 fold abundance change in the presence of FNA were designated as differentially expressed. Results:The results imply that FNA exerted multiple antimicrobial effects. Growth of the culture was inhibited by FNA and significant proportions of the cells were killed during the exposure. Respiration by sulfate reduction and lactate oxidation was shut down along with ATP production when exposed to FNA. Correspondingly, decreased transcript levels of genes involved in these metabolic pathways were detected. Detoxification of FNA was evident by nitrite reduction and the genes coding both nitrite reductase (NrfA) and hydroxylamine reduct...
  66. Muscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using n-3 PUFA and Rosiglitazone in Dietary-Obese Mice ArrayExpress

    ID: E-GEOD-36717

    Description: Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel ...

  67. Muscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice ArrayExpress

    ID: E-GEOD-36716

    Description: Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel ...

  68. Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression ArrayExpress

    ID: E-GEOD-25814

    Description: e involvement the thioredoxin system in radiation resistance was investigated in human lung cancer cells by a combination of ionizing radiation and specific thioredoxin reductase-inhi...

  69. Hepatic gene expression study BioProject

    ID: PRJNA110271

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: synthesis, lipotoxicity, inflammation and insulin resistance if maintained. Safflower oil increased hepatic β-oxidation, was beneficial in terms of circulating TG-rich VLDL particles, but led to reduced hepatic insulin sensitivity. The effects of safflower oil on hepatic gene expression were partly overlapping with those exerted by cocoa butter, but fewer transcripts from anabolic pathways were altered. Increased hepatic cholesterol levels and increased expression of hepatic CYP7A1 and ABCG5 mRNA, important gene products in bile acid production and cholesterol excretion, were ...
  70. Hepatic gene expression study ArrayExpress

    ID: E-GEOD-13936

    Description: synthesis, lipotoxicity, inflammation and insulin resistance if maintained. Safflower oil increased hepatic β-oxidation, was beneficial in terms of circulating TG-rich VLDL particles, but led to reduced hepatic insulin sensitivity. The effects of safflower oil on hepatic gene expression were partly overlapping with those exerted by cocoa butter, but fewer transcripts from anabolic pathways were altered. Increased hepatic cholesterol levels and increased expression of hepatic CYP7A1 and ABCG5 mRNA, important gene products in bile acid production and cholesterol excretion, were ...

  71. Transcription profiling by high throughput sequencing of tomato leaves treated with and without the DC3000 pathogen and nightly red light treatment ArrayExpress

    ID: E-GEOD-64087

    Description: this study, we observed diurnal changes in tomato resistance to Pseudomonas syringae pv. tomato DC3000 (Pto DC3000), with the greatest susceptibility before midnight. Nightly light treatment, particularly red light treatment, significantly enhanced the resistance; this effect was correlated with increased salicylic acid (SA) accumulation and defence-related gene transcription. RNA-seq analysis revealed that red light induced a set of circadian rhythm-related genes involved in the phytochrome and SA-regulated...

  72. Salmonid host response to Hematopoietic Necrosis virus: cellular receptors, viral control and novel pathways of defence ArrayExpress

    ID: E-GEOD-6924

    Description: samples from five fish sampled on each of days 0, 1, 5 and 9 were analysed in the microarray study. Validation of nine of the significant genes was conducted on fish sampled on alternate days from 1 to 13 and compared to the unchallenged control sampled on day 0. The key pathways up-regulated in response to the virus included endosomal transport, type I and II interferon responses, the alternative comple...

  73. RNA-seq analysis reveals the role of red light in resistance against Pseudomonas syringae pv. tomato DC3000 in tomato plants BioProject

    ID: PRJNA270083

    Keywords: Transcriptome or Gene expression

    Access Type: download

  74. Comparative Genomic Hybridization of Leishmania major SbIII resistant mutants and L. major WT ArrayExpress

    ID: E-GEOD-41750

    Description: ment against Leishmaniasis but in the past decade resistance has been a severe threat. We carried out short read next generation sequencing (NGS) and comparative genomic hybridization (CGH) of three independent Leishmania major antimony resistant mutants. Copy number variations were consistently detected in both NGS and CGH where several chromosomal aneuploidies were correla...

  75. Transcription profiling of poplar WRKY23 reveals a regulatory role in defense: WRKY23-overexpressor ArrayExpress

    ID: E-GEOD-16417

    Description: ra rust or mock-inoculated for assessment of rust-resistance and for gene expression profiling using the poplar Affymetrix GeneChip® to study the consequences of PtWRKY23 overexpression and underexpression. Transcriptome analysis of PtWRKY23 overexpressors revealed a significant overlap with the Melampsora-infection response. Transcriptome anal...

  76. Expression data from human skeletal muscle ArrayExpress

    ID: E-GEOD-22309

    Description: t of these traits in energy balance and substrate oxidation. We used microarrays to explore the molecular bases for individual variation in REE and fuel partitioning as reflected by RQ. We performed microarray studies in human vastus lateralis muscle biopsies from 40 healthy subjects with measured REE and RQ values. We identified genes significantly correlated with REE and RQ, respectively. Human skeletal muscle samples were biopsied from different individuals before and after insulin treatment for RNA extraction and hybridization on Affymetrix microarrays....

  77. gainst Diet and Age-Induced Adiposity and Insulin Resistance... BioProject

    ID: PRJNA140701

    Keywords: Transcriptome or Gene expression

    Access Type: download

  78. Examining the basis of isoniazid tolerance in nonreplicating Mycobacterium tuberculosis using transcriptional profiling ArrayExpress

    ID: E-BUGS-104

    Description: hase bacilli) of genes directly implicated in INH resistance could not account for the abrogation of INH killing in nongrowing bacilli. Thus, factors affecting the requirement for mycolic acids and the redox status of bacilli are likely responsible for the reduction in INH efficacy. We speculate on additional mechanisms revealed by transcriptome analysis that might account for INH tolerance. Data is also available from...

  79. Transcription profiling of poplar WRKY23 reveals a regulatory role in defense: WRKY23-RNAi ArrayExpress

    ID: E-GEOD-16419

    Description: ra rust or mock-inoculated for assessment of rust-resistance and for gene expression profiling using the poplar Affymetrix GeneChip® to study the consequences of PtWRKY23 overexpression and underexpression. Transcriptome analysis of PtWRKY23 overexpressors revealed a significant overlap with the Melampsora-infection response. Transcriptome anal...

  80. Transcription profiling of rice plants overexpressing OsWRKY13 ArrayExpress

    ID: E-GEOD-8380

    Description: mulating information indicates that plant disease resistance signaling pathway frequently interact with other pathways regulating developmental processes or abiotic stress responses. Ho...

  81. BET bromodomain proteins Brd2, Brd3 and Brd4 selectively regulate metabolic pathways in the pancreatic β-cell BioProject

    ID: PRJNA310350

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (50-400 nM) increases insulin secretion from INS-1 cells in a concentration dependent manner. JQ1 increases insulin content in INS-1 cells, accounting for increased secretion, in both rat and human islets. Higher concentrations of JQ1 decrease intracellular triglyceride stores in INS-1 cells, a result of increased fatty acid oxidation. Specific inhibition of both Brd2 and Brd4 enhances insulin transcription, leading to increased insulin content. Inhibition of Brd2 alone increases fatty acid oxidation. Overlapping yet discrete roles for individual BET proteins in metabolic regulation suggest new isoform-selective BET inhibitors may be useful to treat insulin resistant/diabetic patients. Results i...
  82. Hepatic gene expression study OmicsDI

    ID: E-GEOD-13936

    Date Released: 05-04-2014

    Description: synthesis, lipotoxicity, inflammation and insulin resistance if maintained. Safflower oil increased hepatic β-oxidation, was beneficial in terms of circulating TG-rich VLDL particles, but led to reduced hepatic insulin sensitivity. The effects of safflower oil on hepatic gene expression were partly overlapping with those exerted by cocoa butter, but fewer transcripts from anabolic pathways were altered. Increased hepatic cholesterol levels and increased expression of hepatic CYP7A1 and ABCG5 mRNA, important gene products in bile acid production and cholesterol excretion, were ...

  83. Nuclear TIGAR mediates an epigenetic-metabolic loop via Nrf2 for cancer therapeutics resistance ArrayExpress

    ID: E-GEOD-62613

    Description: thyltransferase NSD2 drives cancer cell and tumor resistance to therapeutics such as tamoxifen, doxorubicin, and radiation by reprogramming of glucose metabolism. NSD2 coordinately up-regulates expression of TIGAR, HK2 and G6PD and stimulates pentose phosphate pathway (PPP) production of NADPH for ROS reduction. We ...

  84. CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS PDB

    ID: PDB:2BV6

    Description: HTH-TYPE TRANSCRIPTIONAL REGULATOR MGRA

    dataset.keywords: MULTIDRUG RESISTANCE REGULATOR
  85. Crystal structure of Staphylococcus aureus CymR PDB

    ID: PDB:3T8R

    Description: Staphylococcus aureus CymR

    primaryPublication.title: Staphylococcus aureus CymR Is a New Thiol-based Oxidation-sensing Regulator of Stress Resistance and Oxidative Response....
  86. Transcription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain. OmicsDI

    ID: E-GEOD-8582

    Date Released: 03-27-2012

    Description: Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in...

  87. Crystal structure of Staphylococcus aureus CymR oxidized form PDB

    ID: PDB:3T8T

    Description: Staphylococcus aureus CymR (oxidized form)

    primaryPublication.title: Staphylococcus aureus CymR Is a New Thiol-based Oxidation-sensing Regulator of Stress Resistance and Oxidative Response....
  88. Transcription profiling by array of Arabidopsis expressing SOS1, M6PR or CBF3 under the control of the 35S promoter ArrayExpress

    ID: E-GEOD-26983

    Description: Engineered abiotic stress resistance is an important target for increasing agricultural productivity.There are concerns, however, regarding possible ecologic...

  89. Rice Gene Network Inferred from Expression Profiling of Plants Overexpressing OsWRKY13 BioProject

    ID: PRJNA101419

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: mulating information indicates that plant disease resistance signaling pathway frequently interact with other pathways regulating developmental processes or abiotic stress responses. Ho...
  90. 310 Metabolomics

    Study Name: Long-Chain Fatty Acid Combustion Rate Is Associated with Unique MetaboliteProfiles in Skeletal Muscle Mitochondria

    Grant ID: U01 DK097430-01

    Grant: NIH U24DK097154

  91. Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not ... ArrayExpress

    ID: E-GEOD-71614

    Description: ese deteriorations. We have previously shown that 3-days supplementation of combined Epigallocatechin-gallate and Resveratrol (E+R) increased energy expenditure, which was accompanied by improved metabolic flexibility after a high-fat mixed-meal (HFMM) in men. The present study aimed to investigate wheth...

  92. Genomic responses to arsenic in Synechocystis BioProject

    ID: PRJNA223267

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ure: arsenite [AsIII] and arsenate [AsV]. Arsenic resistance in Synechocystis sp. strain PCC 6803 is mediated by the arsBHC operon and two additional arsenate reductases encoded by the arsI1 and arsI2 genes. Here we describe the genome-wide responses in response to the presence of a...
  93. Comparative Genomic Hybridization of Leishmania major SbIII resistant mutants and L. major WT BioProject

    ID: PRJNA178109

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ment against Leishmaniasis but in the past decade resistance has been a severe threat. We carried out short read next generation sequencing (NGS) and comparative genomic hybridization (CGH) of three independent Leishmania major antimony resistant mutants. Copy number variations were consistently detected in both NGS and CGH where several chromosomal aneuploidies were correla...
  94. PRJEB3102 BioProject

    Keywords: Other

    Access Type: download

    dataset.description: ment against Leishmaniasis but in the past decade resistance has been a severe threat. We carried out short read next generation sequencing (NGS) and comparative genomic hybridization (CGH) of three independent Leishmania ma...
  95. Paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis BioProject

    ID: PRJNA128355

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -2,3-dioxygenase that also contributes to quinone resistance. Inactivation of both paralogs, CatR and YodB, results in full derepression of catDE transcription. DNA-binding assays and promoter mutagenesis studies showed that CatR protects two inverted repeats with the consensus sequence TTAC-N5-GTAA overlapping the -35 promoter region (BS1) and the transcriptional start site (BS2). The BS1 operator was required for binding of YodB in vitro. CatR and YodB share the conserved N-terminal Cys residue that is essent...
  96. Genomic responses to arsenic in Synechocystis ArrayExpress

    ID: E-GEOD-51383

    Description: ure: arsenite [AsIII] and arsenate [AsV]. Arsenic resistance in Synechocystis sp. strain PCC 6803 is mediated by the arsBHC operon and two additional arsenate reductases encoded by the arsI1 and arsI2 genes. Here we describe the genome-wide responses in response to the presence of a...

  97. Gene Expression Study in WT and ATF4 KO embryonic neurons ArrayExpress

    ID: E-GEOD-10470

    Description: n in oxidative stress-induced gene expression and resistance to oxidative death. ATF4 knockout mice experienced significantly smaller infarcts and improved behavioral recovery as compared to wild-type mice subjected to the same reductions in blood flow in a rodent model of stroke. ATF4 modulates an early, upstream event in the death pathway, as resistance to oxidative death by ATF4 deletion was associated with decreased consumption of the antioxidant glutathione. Restoration of ATF4 protein in knockout neurons was sufficient to restore sensitivity to oxidative death and to reaccelerate loss of glutathione. Together, these findings establish ATF4 as a redox-regulated, pro-death transcriptional ...

  98. Golovinomyces orontii time course with Col-0 and eds16-1 BioProject

    ID: PRJNA109387

    Keywords: Transcriptome or Gene expression

    Access Type: download

  99. Next generation sequencing based transcriptomic analysis of oxidative stress response in Bifidobacterium longum BBMN68 ArrayExpress

    ID: E-GEOD-65320

    Description: F and then the class III RNR NrdDG. The increased resistance to oxygen and hydrogen peroxide conferred by NADH oxidase was confirmed by its heterogeneous overexpression in B. longum strain NCC2705. In addition, cell-membrane and cell-wall compositions were modified, probably by an increase in cyclopropane fatty acids and a decrease in polysaccharides, respectively, resulting in improved cell hydrophobicity and autoaggregation; this subsequently reduced the permeation of dissolved oxygen into the cell. Taken together, the proposed cell model of B. longum responses to oxygen stress suggests that this bacterium employs a complex molecular defense mechanism against oxygen-induced stresses. Whole mRNA profiles of B. longum BBMN68 grown in the absence or presence of 3% oxygen were generated using AB SOLiD technology and differentially expressed genes were analyzed....

  100. Transcription profiling by array of Arabidopsis mutant for eds16 after infection with Golovinomyces orontii ArrayExpress

    ID: E-GEOD-13739

    Description: ng homotypic fusion of ER and Golgi membranes, ER-associated protein degradation, cell cycle progression, and apoptosis. Future work will elucidate the functional role of the novel regulator PUX2 in PM resistance. Experiment Overall Design: Arabidopsis whole leaves were harvested at 6h, 1 day, 3 days, 5 days and 7 days after Golovinomyces orontii infection for RNA extraction and hybridization to Affymetrix Arabidopsis ATH1 microarrays. Gene expression profiles were obtained for wild type Columbia-0 and enhanced disease susceptibility mutant eds16-1, a null isochorismate synthase 1 (At1g74710) mutant. In parallel, uninfected samples were collected at 0 hr and 7days from wild type and mutant plants. The experiment includes 4 biological replicates....


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