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Displaying 20 of 260 results for "NTRK2"
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  1. Crystal Structure of TrkA kinase with ligand PDB

    ID: PDB:5H3Q

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  2. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 ArrayExpress

    ID: E-NCMF-20

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB

  3. Diagnostic value of exome and whole genome sequencing in craniosynostosis BioProject

    ID: PRJEB17650

    Keywords: Other

    Access Type: download

    dataset.description: re mutated in single families, except for IL11RA (2 families). We classified the other positive diagnoses as follows: commonly mutated craniosynostosis genes with atypical presentation (EFNB1, TWIST1); other core craniosynostosis genes (CDC45, MSX2, ZIC1); genes for which mutations are only rarely associated with craniosynostosis (FBN1, HUWE1, KRAS, STAT3); and known disease genes for which a causal relationship with craniosynostosis is currently unknown (AHDC1, NTRK2). In two further families, likely novel disease genes are currently undergoing functional validation. In 5 of the 15 positive cases, the (previously unanticipated) molecular diagnosis had immediate, actionable consequences for either genetic or medical management (mutations in EFNB1, FBN1, KRAS, NTRK2, STAT3). Conclusions. This substantial genetic heterogeneity, and the mu...
  4. The structure of TrkA kinase bound to the inhibitor N-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1H-imidazol... PDB

    ID: PDB:4PMM

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  5. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder OmicsDI

    ID: E-GEOD-45756

    Date Released: 05-03-2014

    Description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...

  6. Crystal structure of TrkA in complex with PF-06273340 PDB

    ID: PDB:5JFX

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  7. Human TrkA in complex with the inhibitor AZ-23 PDB

    ID: PDB:4AOJ

    Description: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (E.C.2.7.10.1)

  8. Crystal structure of TrkA in complex with PF-05206283 PDB

    ID: PDB:5JFV

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  9. Crystal structure of TrkA in complex with PF-05247452 PDB

    ID: PDB:5JFW

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  10. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 OmicsDI

    ID: E-NCMF-20

    Date Released: 05-02-2014

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB

  11. Transcription profiling of rat RK3E and RIE cells overexpressing activated TrkB OmicsDI

    ID: E-NCMF-21

    Date Released: 05-02-2014

    Description: Overexpression of activated TrkB in RIE and RK3E cells

  12. Crystal structure of TrkA in complex with PF-00593174 PDB

    ID: PDB:5JFS

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  13. Expression array of peripheral neuro-ectodermal cell lines BioProject

    ID: PRJNA148263

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: characterized by high expression of AXL. AXL is a tyrosine kinase receptor which plays a role in the metastatic process of cancer. We hypothesized that AXL contributes to the metastasizing potential of non-NMA NBL and tested if AXL silencing diminishes malignant properties of high AXL expressing cell lines. AXL was silenced in two non-NMA NBL cell lines by using a lentiviral shRNA construct that was able to transduce these cell lines with >90% infection efficiency. AXL mRNA expression level was efficiently knocked-down resulting in a severe decrease of migration of AXL positive cell lines GI-M-EN and SH-EP-2, and decreased invasion of GI-M-EN. Morphologically, AXL knockdow...
  14. Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes BioProject

    ID: PRJNA102599

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in HSC expansion and self-renewal, including the tyrosine kinase receptor Flt3, the prion protein, Prnp, hepatic leukemia factor, Hlf and Jagged-2, Jag2. CONCLUSIONS: In conclusion this study has identified several novel Hox downstream target genes and provides important new leads to key regulators of the expansion and transformation of hematopoietic stem cells by Hox. Keywords: Leukemic vs. non-leukemic NUP98-HOX fusion genes Overall design: Adult murine bone marrow cells transduced with vectors carrying ND13, NA10, ND13(N51S) or an empty GFP control vector (MIG) were isolated on the basis of GFP expression by FACS 24 hours post-transduction. Viable transduced cells were further enriched for primitive hematopoietic cells by exclusion of cells expressing linage markers (Gr-1, B220, Ter-119, CD4, CD5 and CD8) and selection for cells expressing the stem cell antigen-1 (Sca-1). Three independent experiments were performed for each of the four different conditions included in the study....
  15. (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors PDB

    ID: PDB:4YPS

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  16. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder BioProject

    ID: PRJNA196175

    Keywords: Epigenomics

    Access Type: download

    dataset.description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...
  17. Transcription profiling of mouse adult and juvenile dura mater (bone) to explore the reossification of large calvarial defects during development OmicsDI

    ID: E-SMDB-3845

    Date Released: 05-02-2014

    Description: chain reaction confirmation of selected genes-BMP-2, BMP-4, and BMP-7; and osteopontin (OP), osteocalcin (OC), and FGFR-1-was performed. RESULTS: Juvenile dura mater expressed significantly greater amounts of BMP-2 and OP. Minimal difference in OC expression was observed between juvenile and adult dura mater. Extracellular matrix proteins (Col3a1, 5a1, 6a1, and fibronectin 1), osteoblast differentiation markers (Runx2/Cbfa1, Itm2a, and FGFR-1), and the growth factor Ptn were among other genes with greater expression in juvenile dura mater. Markers of osteoclasts (Acp5, MMP9, Ctsk) and the multiple candidate gene Ntrk2 were also expressed at higher levels in the juvenile dura mater. CONCLUSIONS: These findings suggest a more differentiated osteoprogenitor population to exist along with a greater presence of osteoclasts in the juvenile du...

  18. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] OmicsDI

    ID: E-GEOD-44832

    Date Released: 11-01-2014

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  19. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] OmicsDI

    ID: E-GEOD-44833

    Date Released: 11-03-2014

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  20. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition OmicsDI

    ID: E-GEOD-20358

    Date Released: 05-01-2014

    Description: r presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). Treatment of ovaries with NT3 resulted in a significant (P<0.01) increase in primordial follicle development (i.e. primordial to primary follicle transition). Treatment with BDNF at high doses of 100–250 ng/ml also significantly (P<0.01) increased primordial follicle development, but NGF had no effect. Immunohistochemical studies determined that NT3 was present in granulosa cells, interstitial tissue, and...


Displaying 20 of 260 results for "NTRK2"