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Displaying 50 of 260 results for "NTRK2"
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  1. LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR PDB

    ID: PDB:1WWB

    Description: NT-3 GROWTH FACTORS RECEPTOR (TRKB)

  2. Differential microRNA profile in frontal cortex of suicide completers compared to control ArrayExpress

    ID: E-GEOD-34120

    Description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...

  3. into genetic risk factors for Body Mass Index and Type 2 Diabetes... OmicsDI

    ID: EGAS00001001004

    Date Released:

    Description: dy mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians. To identify loci associated with BMI and T2D we undertook a genome...

  4. CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5 PDB

    ID: PDB:1HCF

    Description: NEUROTROPHIN-4, BDNF/NT-3 GROWTH FACTORS RECEPTOR

  5. Differential microRNA profile in frontal cortex of suicide completers compared to control BioProject

    ID: PRJNA149873

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...
  6. THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONS FOR ACHIEVING SELECTIVE INHIBITION PDB

    ID: PDB:4ASZ

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  7. Neurotrophic Tyrosine Kinase Receptor 1 is Epigenetically Regulated by IL-13 and Contributes to Allergic Inflammation BioProject

    ID: PRJNA247384

    Keywords: Other

    Access Type: download

  8. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580 PDB

    ID: PDB:4AT5

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  9. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429 PDB

    ID: PDB:4AT4

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  10. Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia BioProject

    ID: PRJNA255201

    Keywords: Variation

    Access Type: download

    dataset.description: shed bone marrow transplantation model. To mimick tyrosine kinase signalling we expressed a constitutively active form of the TRKA receptor tyrosine kinase (ΔTrkA) in hematopoietic progenitor cells. Mice transplanted wi...
  11. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH CPD5N PDB

    ID: PDB:4AT3

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  12. NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB PDB

    ID: PDB:2MFQ

    Description: Fibroblast growth factor receptor substrate 2, BDNF/NT-3 growth factors receptor (E.C.2.7.10.1)...

  13. Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis Dryad

    DateIssued: 02-24-2016

    Description: me to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive knowledge of the genetic control of these events, it is not understood, at the cellular level, how renal branching morphogenesis is achieved or how Ret signaling influences epithelial cell behaviors to promote this process...

  14. Expression data from Trk-overexpressing NB cell line SY5Y BioProject

    ID: PRJNA118261

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rs a good prognosis to NB patients, expression of TrkB/NTRK2 is associated with unfavorable outcome. We have transfected the neurotrophin-receptor null cell line SY5Y with either full-length TrkA or TrkB and performed transcriptional profiling to analyse ...
  15. TIE2 mutations in VM : Venous Malformation: from causative TIE2 mutations to murine model and targeted therapy BioProject

    ID: PRJEB9698

    Keywords: Other

    Access Type: download

    dataset.description: age. Activating mutations in the endothelial cell tyrosine kinase receptor TIE2 are a common cause of the lesions. VMs expand causing deformity, pain, and local intravascular coagulopathy. Despite sclerotherapy or excision, lesions often recur. Ta...
  16. Neurotrophic Tyrosine Kinase Receptor 1 is Epigenetically Regulated by IL-13 and Contributes to Allergic Inflammation ArrayExpress

    ID: E-GEOD-57637

    Description: he epigenome of the IL-13 response, we identified neurotrophic tyrosine kinase receptor 1 (NTRK1) as a major target of IL-13 in epithelial cells. Using eosinophilic esophagitis as a model system for human allergic inflammation, we found that NTRK1 was dramatically induced in inflamed esophageal biopsies, and downstream mediators of NTRK1 signaling were elevated in diseased tissue. The NTRK1 ligand nerve growth factor (NGF) was constitutively expressed in control and disease states, indicating that induction of the receptor by IL-13 limited pathway activation. In epithelial cells, NGF and IL-13 synergistically induced transcription and secretion of the key ...

  17. Crystal structure of apo TrkA PDB

    ID: PDB:4F0I

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  18. Transcription profiling of mouse knockouts for Etv4 and Etv5 - plusGDNF and minusGDNF comparison using U74Av2 and 430A arrays ArrayExpress

    ID: E-GEOD-18267

    Description: GDNF signaling through the Ret receptor tyrosine kinase is critical for ureteric bud branching morphogenesis during kidney d...

  19. Gene profiling of HER2 breast cancer patients treated with adjuvant trastuzumab BioProject

    ID: PRJNA254048

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The human epidermal growth factor receptor 2 (HER2) gene encodes a tyrosine kinase receptor
  20. Extracellular Superoxide Dismutase Regulates the Expression of GTPase Guanine Nucleotide Exchange Factors (GEFs), GTPase-activating proteins (GAPs), a... BioProject

    ID: PRJNA243869

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cells increased EGFR, RYK, ALK, FLT3, and EPHA10 tyrosine kinase receptor phosphorylation with consequent downstream SRC, FYN, YES, HCK, and LYN kinase activation. However, RAS pull-down experiment suggested lack of mitogen pathway stimulation that was confirmed by MEK1/2 and ERK1/2 Western blot. Interestingly, mRNA expression analysis indicated that SOD3 regulated in a dose dependent manner the expression of selected guanine nucleotide exchange factors (Rho GEF16, Ral GEF RGL1), GTPase activating proteins (ArfGAP ADAP2, Ras GAP RASAL1, RGS4), and Rho guanine nucleotide disassociation inhibitors (Rho GDI 2) therefore controlling the signal transduction through RAS GTPases to downstream signal transduction pathways. Our current data suggests a SOD3-induced activation of growth signal transduction...
  21. Gene expression study of MCF7/tet-off clones expressing different HER2 isoforms ArrayExpress

    ID: E-GEOD-68256

    Description: HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients wi...

  22. Differential microRNA profile in frontal cortex of suicide completers compared to control OmicsDI

    ID: E-GEOD-34120

    Date Released: 05-04-2014

    Description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...

  23. TrkA JM-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1-yl]acetamide PDB

    ID: PDB:5KMJ

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  24. Transcription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP9... ArrayExpress

    ID: E-GEOD-9079

    Description: in HSC expansion and self-renewal, including the tyrosine kinase receptor Flt3, the prion protein, Prnp, hepatic leukemia factor, Hlf and Jagged-2, Jag2. CONCLUSIONS: In conclusion this study has identified several novel Hox downstream target genes and provides important new leads to key regulators of the expansion and transformation of hematopoietic stem cells by Hox. Experiment Overall Design: Adult murine bone marrow cells transduced with vectors carrying ND13, NA10, ND13(N51S) or an empty GFP control vector (MIG) were isolated on the basis of GFP expression by FACS 24 hours post-transduction. Viable transduced cells were further enriched for primitive hematopoietic cells by exclusion of cells expressing linage markers (Gr-1, B220, Ter-119, CD4, CD5 and CD8) and selection for cells expressing the stem cell antigen-1 (Sca-1). Three independent experiments were performed for each of the four different conditions included in the study....

  25. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea PDB

    ID: PDB:5KMO

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  26. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB

    ID: PDB:5KMN

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  27. TIAM1_MOUSE UniProt:Swiss-Prot

    ID: Q60610

    Description: metastasis-inducing protein 1 PH 1 RBD PDZ DH PH 2 Poly-Lys Poly-Arg Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphotyrosine; by NTRK2 Phosphotyrosine Phosphoserine N-myristoyl...

  28. TrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB

    ID: PDB:5KML

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  29. The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea PDB

    ID: PDB:4PMP

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  30. The structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2 PDB

    ID: PDB:4PMS

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  31. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1-naphthyl)urea PDB

    ID: PDB:5KMM

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  32. Expression array of peripheral neuro-ectodermal cell lines ArrayExpress

    ID: E-GEOD-33903

    Description: characterized by high expression of AXL. AXL is a tyrosine kinase receptor which plays a role in the metastatic process of cancer. We hypothesized that AXL contributes to the metastasizing potential of non-NMA NBL and tested if AXL silencing diminishes malignant properties of high AXL expressing cell lines. AXL was silenced in two non-NMA NBL cell lines by using a lentiviral shRNA construct that was able to transduce these cell lines with >90% infection efficiency. AXL mRNA expression level was efficiently knocked-down resulting in a severe decrease of migration of AXL positive cell lines GI-M-EN and SH-EP-2, and decreased invasion of GI-M-EN. Morphologically, AXL knockdow...

  33. TrkA JM-kinase with 2-fluoro-{N}-[2-(4-fluorophenyl)-6-methyl-3-pyridyl]-4-(trifluoromethyl)benzamide PDB

    ID: PDB:5KMK

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  34. Twist, Snail and Zeb1 targets in the context of TrkB OmicsDI

    ID: E-MTAB-456

    Date Released: 05-03-2014

    Description: RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1

  35. Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models PDB

    ID: PDB:3V5Q

    Description: NT-3 growth factor receptor (E.C.2.7.10.1)

  36. TrkA JM-kinase with 1-(9{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea PDB

    ID: PDB:5KMI

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  37. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder ArrayExpress

    ID: E-GEOD-45756

    Description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...

  38. Gene expression study of MCF7/tet-off clones expressing different HER2 isoforms BioProject

    ID: PRJNA282141

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients wi...
  39. Twist, Snail and Zeb1 targets in the context of TrkB ArrayExpress

    ID: E-MTAB-456

    Description: RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1

  40. Transcription profiling of rat RK3E and RIE cells overexpressing activated TrkB ArrayExpress

    ID: E-NCMF-21

    Description: Overexpression of activated TrkB in RIE and RK3E cells

  41. Crystal Structure of TrkA kinase with ligand PDB

    ID: PDB:5H3Q

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  42. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 ArrayExpress

    ID: E-NCMF-20

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB

  43. Diagnostic value of exome and whole genome sequencing in craniosynostosis BioProject

    ID: PRJEB17650

    Keywords: Other

    Access Type: download

    dataset.description: re mutated in single families, except for IL11RA (2 families). We classified the other positive diagnoses as follows: commonly mutated craniosynostosis genes with atypical presentation (EFNB1, TWIST1); other core craniosynostosis genes (CDC45, MSX2, ZIC1); genes for which mutations are only rarely associated with craniosynostosis (FBN1, HUWE1, KRAS, STAT3); and known disease genes for which a causal relationship with craniosynostosis is currently unknown (AHDC1, NTRK2). In two further families, likely novel disease genes are currently undergoing functional validation. In 5 of the 15 positive cases, the (previously unanticipated) molecular diagnosis had immediate, actionable consequences for either genetic or medical management (mutations in EFNB1, FBN1, KRAS, NTRK2, STAT3). Conclusions. This substantial genetic heterogeneity, and the mu...
  44. The structure of TrkA kinase bound to the inhibitor N-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1H-imidazol... PDB

    ID: PDB:4PMM

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  45. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder OmicsDI

    ID: E-GEOD-45756

    Date Released: 05-03-2014

    Description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...

  46. Crystal structure of TrkA in complex with PF-06273340 PDB

    ID: PDB:5JFX

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  47. Human TrkA in complex with the inhibitor AZ-23 PDB

    ID: PDB:4AOJ

    Description: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (E.C.2.7.10.1)

  48. Crystal structure of TrkA in complex with PF-05206283 PDB

    ID: PDB:5JFV

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  49. Crystal structure of TrkA in complex with PF-05247452 PDB

    ID: PDB:5JFW

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  50. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 OmicsDI

    ID: E-NCMF-20

    Date Released: 05-02-2014

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB


Displaying 50 of 260 results for "NTRK2"