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  1. LIGAND BINDING DOMAIN OF HUMAN TRKB RECEPTOR PDB

    ID: PDB:1WWB

    Description: NT-3 GROWTH FACTORS RECEPTOR (TRKB)

  2. Differential microRNA profile in frontal cortex of suicide completers compared to control ArrayExpress

    ID: E-GEOD-34120

    Description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...

  3. into genetic risk factors for Body Mass Index and Type 2 Diabetes... OmicsDI

    ID: EGAS00001001004

    Date Released:

    Description: dy mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians. To identify loci associated with BMI and T2D we undertook a genome...

  4. CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5 PDB

    ID: PDB:1HCF

    Description: NEUROTROPHIN-4, BDNF/NT-3 GROWTH FACTORS RECEPTOR

  5. Differential microRNA profile in frontal cortex of suicide completers compared to control BioProject

    ID: PRJNA149873

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...
  6. THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONS FOR ACHIEVING SELECTIVE INHIBITION PDB

    ID: PDB:4ASZ

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  7. Neurotrophic Tyrosine Kinase Receptor 1 is Epigenetically Regulated by IL-13 and Contributes to Allergic Inflammation BioProject

    ID: PRJNA247384

    Keywords: Other

    Access Type: download

  8. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580 PDB

    ID: PDB:4AT5

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  9. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH EX429 PDB

    ID: PDB:4AT4

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  10. Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia BioProject

    ID: PRJNA255201

    Keywords: Variation

    Access Type: download

    dataset.description: shed bone marrow transplantation model. To mimick tyrosine kinase signalling we expressed a constitutively active form of the TRKA receptor tyrosine kinase (ΔTrkA) in hematopoietic progenitor cells. Mice transplanted wi...
  11. CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH CPD5N PDB

    ID: PDB:4AT3

    Description: BDNF/NT-3 GROWTH FACTORS RECEPTOR (E.C.2.7.10.1)

  12. NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB PDB

    ID: PDB:2MFQ

    Description: Fibroblast growth factor receptor substrate 2, BDNF/NT-3 growth factors receptor (E.C.2.7.10.1)...

  13. Data from: Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis Dryad

    DateIssued: 02-24-2016

    Description: me to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive knowledge of the genetic control of these events, it is not understood, at the cellular level, how renal branching morphogenesis is achieved or how Ret signaling influences epithelial cell behaviors to promote this process...

  14. Expression data from Trk-overexpressing NB cell line SY5Y BioProject

    ID: PRJNA118261

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rs a good prognosis to NB patients, expression of TrkB/NTRK2 is associated with unfavorable outcome. We have transfected the neurotrophin-receptor null cell line SY5Y with either full-length TrkA or TrkB and performed transcriptional profiling to analyse ...
  15. TIE2 mutations in VM : Venous Malformation: from causative TIE2 mutations to murine model and targeted therapy BioProject

    ID: PRJEB9698

    Keywords: Other

    Access Type: download

    dataset.description: age. Activating mutations in the endothelial cell tyrosine kinase receptor TIE2 are a common cause of the lesions. VMs expand causing deformity, pain, and local intravascular coagulopathy. Despite sclerotherapy or excision, lesions often recur. Ta...
  16. Neurotrophic Tyrosine Kinase Receptor 1 is Epigenetically Regulated by IL-13 and Contributes to Allergic Inflammation ArrayExpress

    ID: E-GEOD-57637

    Description: he epigenome of the IL-13 response, we identified neurotrophic tyrosine kinase receptor 1 (NTRK1) as a major target of IL-13 in epithelial cells. Using eosinophilic esophagitis as a model system for human allergic inflammation, we found that NTRK1 was dramatically induced in inflamed esophageal biopsies, and downstream mediators of NTRK1 signaling were elevated in diseased tissue. The NTRK1 ligand nerve growth factor (NGF) was constitutively expressed in control and disease states, indicating that induction of the receptor by IL-13 limited pathway activation. In epithelial cells, NGF and IL-13 synergistically induced transcription and secretion of the key ...

  17. Crystal structure of apo TrkA PDB

    ID: PDB:4F0I

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  18. Transcription profiling of mouse knockouts for Etv4 and Etv5 - plusGDNF and minusGDNF comparison using U74Av2 and 430A arrays ArrayExpress

    ID: E-GEOD-18267

    Description: GDNF signaling through the Ret receptor tyrosine kinase is critical for ureteric bud branching morphogenesis during kidney d...

  19. Gene profiling of HER2 breast cancer patients treated with adjuvant trastuzumab BioProject

    ID: PRJNA254048

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The human epidermal growth factor receptor 2 (HER2) gene encodes a tyrosine kinase receptor
  20. Extracellular Superoxide Dismutase Regulates the Expression of GTPase Guanine Nucleotide Exchange Factors (GEFs), GTPase-activating proteins (GAPs), a... BioProject

    ID: PRJNA243869

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cells increased EGFR, RYK, ALK, FLT3, and EPHA10 tyrosine kinase receptor phosphorylation with consequent downstream SRC, FYN, YES, HCK, and LYN kinase activation. However, RAS pull-down experiment suggested lack of mitogen pathway stimulation that was confirmed by MEK1/2 and ERK1/2 Western blot. Interestingly, mRNA expression analysis indicated that SOD3 regulated in a dose dependent manner the expression of selected guanine nucleotide exchange factors (Rho GEF16, Ral GEF RGL1), GTPase activating proteins (ArfGAP ADAP2, Ras GAP RASAL1, RGS4), and Rho guanine nucleotide disassociation inhibitors (Rho GDI 2) therefore controlling the signal transduction through RAS GTPases to downstream signal transduction pathways. Our current data suggests a SOD3-induced activation of growth signal transduction...
  21. Gene expression study of MCF7/tet-off clones expressing different HER2 isoforms ArrayExpress

    ID: E-GEOD-68256

    Description: HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients wi...

  22. Differential microRNA profile in frontal cortex of suicide completers compared to control OmicsDI

    ID: E-GEOD-34120

    Date Released: 05-04-2014

    Description: Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly...

  23. TrkA JM-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1-yl]acetamide PDB

    ID: PDB:5KMJ

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  24. Transcription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP9... ArrayExpress

    ID: E-GEOD-9079

    Description: in HSC expansion and self-renewal, including the tyrosine kinase receptor Flt3, the prion protein, Prnp, hepatic leukemia factor, Hlf and Jagged-2, Jag2. CONCLUSIONS: In conclusion this study has identified several novel Hox downstream target genes and provides important new leads to key regulators of the expansion and transformation of hematopoietic stem cells by Hox. Experiment Overall Design: Adult murine bone marrow cells transduced with vectors carrying ND13, NA10, ND13(N51S) or an empty GFP control vector (MIG) were isolated on the basis of GFP expression by FACS 24 hours post-transduction. Viable transduced cells were further enriched for primitive hematopoietic cells by exclusion of cells expressing linage markers (Gr-1, B220, Ter-119, CD4, CD5 and CD8) and selection for cells expressing the stem cell antigen-1 (Sca-1). Three independent experiments were performed for each of the four different conditions included in the study....

  25. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea PDB

    ID: PDB:5KMO

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  26. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB

    ID: PDB:5KMN

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  27. TIAM1_MOUSE UniProt:Swiss-Prot

    ID: Q60610

    Description: metastasis-inducing protein 1 PH 1 RBD PDZ DH PH 2 Poly-Lys Poly-Arg Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphotyrosine; by NTRK2 Phosphotyrosine Phosphoserine N-myristoyl...

  28. TrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea PDB

    ID: PDB:5KML

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  29. The structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea PDB

    ID: PDB:4PMP

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  30. The structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2 PDB

    ID: PDB:4PMS

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  31. TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1-naphthyl)urea PDB

    ID: PDB:5KMM

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  32. Expression array of peripheral neuro-ectodermal cell lines ArrayExpress

    ID: E-GEOD-33903

    Description: characterized by high expression of AXL. AXL is a tyrosine kinase receptor which plays a role in the metastatic process of cancer. We hypothesized that AXL contributes to the metastasizing potential of non-NMA NBL and tested if AXL silencing diminishes malignant properties of high AXL expressing cell lines. AXL was silenced in two non-NMA NBL cell lines by using a lentiviral shRNA construct that was able to transduce these cell lines with >90% infection efficiency. AXL mRNA expression level was efficiently knocked-down resulting in a severe decrease of migration of AXL positive cell lines GI-M-EN and SH-EP-2, and decreased invasion of GI-M-EN. Morphologically, AXL knockdow...

  33. TrkA JM-kinase with 2-fluoro-{N}-[2-(4-fluorophenyl)-6-methyl-3-pyridyl]-4-(trifluoromethyl)benzamide PDB

    ID: PDB:5KMK

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  34. Twist, Snail and Zeb1 targets in the context of TrkB OmicsDI

    ID: E-MTAB-456

    Date Released: 05-03-2014

    Description: RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1

  35. Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models PDB

    ID: PDB:3V5Q

    Description: NT-3 growth factor receptor (E.C.2.7.10.1)

  36. TrkA JM-kinase with 1-(9{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea PDB

    ID: PDB:5KMI

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  37. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder ArrayExpress

    ID: E-GEOD-45756

    Description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...

  38. Gene expression study of MCF7/tet-off clones expressing different HER2 isoforms BioProject

    ID: PRJNA282141

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer patients wi...
  39. Twist, Snail and Zeb1 targets in the context of TrkB ArrayExpress

    ID: E-MTAB-456

    Description: RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1

  40. Transcription profiling of rat RK3E and RIE cells overexpressing activated TrkB ArrayExpress

    ID: E-NCMF-21

    Description: Overexpression of activated TrkB in RIE and RK3E cells

  41. Crystal Structure of TrkA kinase with ligand PDB

    ID: PDB:5H3Q

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  42. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 ArrayExpress

    ID: E-NCMF-20

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB

  43. Diagnostic value of exome and whole genome sequencing in craniosynostosis BioProject

    ID: PRJEB17650

    Keywords: Other

    Access Type: download

    dataset.description: re mutated in single families, except for IL11RA (2 families). We classified the other positive diagnoses as follows: commonly mutated craniosynostosis genes with atypical presentation (EFNB1, TWIST1); other core craniosynostosis genes (CDC45, MSX2, ZIC1); genes for which mutations are only rarely associated with craniosynostosis (FBN1, HUWE1, KRAS, STAT3); and known disease genes for which a causal relationship with craniosynostosis is currently unknown (AHDC1, NTRK2). In two further families, likely novel disease genes are currently undergoing functional validation. In 5 of the 15 positive cases, the (previously unanticipated) molecular diagnosis had immediate, actionable consequences for either genetic or medical management (mutations in EFNB1, FBN1, KRAS, NTRK2, STAT3). Conclusions. This substantial genetic heterogeneity, and the mu...
  44. The structure of TrkA kinase bound to the inhibitor N-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1H-imidazol... PDB

    ID: PDB:4PMM

    Description: TRKA High affinity nerve growth factor receptor (E.C.2.7.10.1)

  45. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder OmicsDI

    ID: E-GEOD-45756

    Date Released: 05-03-2014

    Description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...

  46. Crystal structure of TrkA in complex with PF-06273340 PDB

    ID: PDB:5JFX

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  47. Human TrkA in complex with the inhibitor AZ-23 PDB

    ID: PDB:4AOJ

    Description: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (E.C.2.7.10.1)

  48. Crystal structure of TrkA in complex with PF-05206283 PDB

    ID: PDB:5JFV

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  49. Crystal structure of TrkA in complex with PF-05247452 PDB

    ID: PDB:5JFW

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  50. Transcription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1 OmicsDI

    ID: E-NCMF-20

    Date Released: 05-02-2014

    Description: Silencing of Fra-1 in RK3E cells overexpressing activated TrkB

  51. Transcription profiling of rat RK3E and RIE cells overexpressing activated TrkB OmicsDI

    ID: E-NCMF-21

    Date Released: 05-02-2014

    Description: Overexpression of activated TrkB in RIE and RK3E cells

  52. Crystal structure of TrkA in complex with PF-00593174 PDB

    ID: PDB:5JFS

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  53. Expression array of peripheral neuro-ectodermal cell lines BioProject

    ID: PRJNA148263

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: characterized by high expression of AXL. AXL is a tyrosine kinase receptor which plays a role in the metastatic process of cancer. We hypothesized that AXL contributes to the metastasizing potential of non-NMA NBL and tested if AXL silencing diminishes malignant properties of high AXL expressing cell lines. AXL was silenced in two non-NMA NBL cell lines by using a lentiviral shRNA construct that was able to transduce these cell lines with >90% infection efficiency. AXL mRNA expression level was efficiently knocked-down resulting in a severe decrease of migration of AXL positive cell lines GI-M-EN and SH-EP-2, and decreased invasion of GI-M-EN. Morphologically, AXL knockdow...
  54. Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes BioProject

    ID: PRJNA102599

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in HSC expansion and self-renewal, including the tyrosine kinase receptor Flt3, the prion protein, Prnp, hepatic leukemia factor, Hlf and Jagged-2, Jag2. CONCLUSIONS: In conclusion this study has identified several novel Hox downstream target genes and provides important new leads to key regulators of the expansion and transformation of hematopoietic stem cells by Hox. Keywords: Leukemic vs. non-leukemic NUP98-HOX fusion genes Overall design: Adult murine bone marrow cells transduced with vectors carrying ND13, NA10, ND13(N51S) or an empty GFP control vector (MIG) were isolated on the basis of GFP expression by FACS 24 hours post-transduction. Viable transduced cells were further enriched for primitive hematopoietic cells by exclusion of cells expressing linage markers (Gr-1, B220, Ter-119, CD4, CD5 and CD8) and selection for cells expressing the stem cell antigen-1 (Sca-1). Three independent experiments were performed for each of the four different conditions included in the study....
  55. (R)-2-Phenylpyrrolidine Substitute Imidazopyridazines: a New Class of Potent and Selective Pan-TRK Inhibitors PDB

    ID: PDB:4YPS

    Description: High affinity nerve growth factor receptor (E.C.2.7.10.1)

  56. Genome-wide Identification of Transcriptional Targets of RORA Reveals Direct Regulation of Multiple Genes Associated with Autism Spectrum Disorder BioProject

    ID: PRJNA196175

    Keywords: Epigenomics

    Access Type: download

    dataset.description: : We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). ...
  57. Transcription profiling of mouse adult and juvenile dura mater (bone) to explore the reossification of large calvarial defects during development OmicsDI

    ID: E-SMDB-3845

    Date Released: 05-02-2014

    Description: chain reaction confirmation of selected genes-BMP-2, BMP-4, and BMP-7; and osteopontin (OP), osteocalcin (OC), and FGFR-1-was performed. RESULTS: Juvenile dura mater expressed significantly greater amounts of BMP-2 and OP. Minimal difference in OC expression was observed between juvenile and adult dura mater. Extracellular matrix proteins (Col3a1, 5a1, 6a1, and fibronectin 1), osteoblast differentiation markers (Runx2/Cbfa1, Itm2a, and FGFR-1), and the growth factor Ptn were among other genes with greater expression in juvenile dura mater. Markers of osteoclasts (Acp5, MMP9, Ctsk) and the multiple candidate gene Ntrk2 were also expressed at higher levels in the juvenile dura mater. CONCLUSIONS: These findings suggest a more differentiated osteoprogenitor population to exist along with a greater presence of osteoclasts in the juvenile du...

  58. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] OmicsDI

    ID: E-GEOD-44832

    Date Released: 11-01-2014

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  59. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] OmicsDI

    ID: E-GEOD-44833

    Date Released: 11-03-2014

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  60. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition OmicsDI

    ID: E-GEOD-20358

    Date Released: 05-01-2014

    Description: r presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). Treatment of ovaries with NT3 resulted in a significant (P<0.01) increase in primordial follicle development (i.e. primordial to primary follicle transition). Treatment with BDNF at high doses of 100–250 ng/ml also significantly (P<0.01) increased primordial follicle development, but NGF had no effect. Immunohistochemical studies determined that NT3 was present in granulosa cells, interstitial tissue, and...

  61. Transcription profiling of mouse adult and juvenile dura mater (bone) to explore the reossification of large calvarial defects during development ArrayExpress

    ID: E-SMDB-3845

    Description: chain reaction confirmation of selected genes-BMP-2, BMP-4, and BMP-7; and osteopontin (OP), osteocalcin (OC), and FGFR-1-was performed. RESULTS: Juvenile dura mater expressed significantly greater amounts of BMP-2 and OP. Minimal difference in OC expression was observed between juvenile and adult dura mater. Extracellular matrix proteins (Col3a1, 5a1, 6a1, and fibronectin 1), osteoblast differentiation markers (Runx2/Cbfa1, Itm2a, and FGFR-1), and the growth factor Ptn were among other genes with greater expression in juvenile dura mater. Markers of osteoclasts (Acp5, MMP9, Ctsk) and the multiple candidate gene Ntrk2 were also expressed at higher levels in the juvenile dura mater. CONCLUSIONS: These findings suggest a more differentiated osteoprogenitor population to exist along with a greater presence of osteoclasts in the juvenile du...

  62. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] ArrayExpress

    ID: E-GEOD-44832

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  63. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition ArrayExpress

    ID: E-GEOD-20358

    Description: r presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). Treatment of ovaries with NT3 resulted in a significant (P<0.01) increase in primordial follicle development (i.e. primordial to primary follicle transition). Treatment with BDNF at high doses of 100–250 ng/ml also significantly (P<0.01) increased primordial follicle development, but NGF had no effect. Immunohistochemical studies determined that NT3 was present in granulosa cells, interstitial tissue, and...

  64. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] ArrayExpress

    ID: E-GEOD-44833

    Description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....

  65. Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone BioProject

    ID: PRJNA326272

    Keywords: Transcriptome or Gene expression

    Access Type: download

  66. Comparison of Environmental and Genetic models of ADHD ArrayExpress

    ID: E-GEOD-12457

    Description: he expression levels of genes Gnal, COMT, Adrbk1, Ntrk2, Hk1, Syt11 and Csnk1a1 were altered in both the SHR rats and the PCB-exposed SD rats. Arrb2, Stx12, Aqp6, Syt1, Ddc and Pgk1 expression levels were changed only in the PCB-exposed SD rats. Genes with altered expression only in the SHRs included Oprm1, Calcyon, Calmodulin, Lhx1 and Hes6.The epigenetic genes Crebbp, Mecp2 and Hdac5 are significantly altered in both models. The data provide strong evidence that genes and environment can affect different set of genes in two different models of ADHD and yet result in the similar disease-like symptoms. The brains from 28 male rats (8 SHR, 8 Sprague-Dawley (SD) controls, 8 Wistar-Kyoto (WKY) controls, and 4 PCB-exposed SD rats) were harvested at postnatal day 55-65 and RNA was isolated from six brain regions of interest. The RNA was analyzed for differences in expression of a set of 308 probe sets interrogating 218 unique genes considered highly relevant to ADHD or epigenetic gene regulation using the Rat RAE 230 2.0 GeneChip (Affymetrix). Selected observations were confirmed by real time quantitative RT-PCR....

  67. Transcriptional Profile Analysis of RPGRORF15 frameshift mutation ArrayExpress

    ID: E-GEOD-19124

    Description: ptotic processes were altered at 7 weeks (CAMK2G, NTRK2, PRKCB, RALA, RBBP6, RNF41, SEPT5, SMYD3, SPP1, and TUBB2C) and 16 weeks (SLC25A5 and NKAP). Furthermore, DE genes at 7 weeks (ELOVL6, GLOD4, NDUFS4, and REEP1) and 16 weeks (SLC25A5 and TARS2) are related to mitochondrial functions. Real-time PCR of 11 genes confirmed the microarray results and showed differential expression for additional genes not on the array, such as GFAP, RHO, OPN1SW, CNGB3 and the mutated RPGR. Western blotting and IHC analysis also confirmed the high reliability of the presented transcriptomic data. Conclusions: A list of mutated genes in RPGRORF15 diseased retinas, which are likely candidates to further study their role in age-related photoreceptor degeneration diseases, is reported at different crucial ages. The results indicate that at 7 weeks a combination of non-classical anti- and pro-apoptotic genes appears to be involved in photoreceptor degeneration, whereas at both 7 and 16 weeks expression of mitochondria related genes indicates they may play a relevant role in the disease process. 3 biological replicates each for normal and XLPRA2 affected retinas were analyzed at 7 and 16 weeks of age. Each individual sample was hybridized in a reference design using a custom-made retinal cDNA microarray against brain pool to enable cross compari...

  68. after growth with retinoic acid or brain-derived neurotrophic factor and treatment with LY294002... OmicsDI

    ID: E-GEOD-9169

    Date Released: 03-22-2012

    Description: naling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehensively compared the gene expression profiles between SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E), each of which showed a different phenotype during RA-mediated di...

  69. Transcriptional Profile Analysis of RPGRORF15 frameshift mutation OmicsDI

    ID: E-GEOD-19124

    Date Released: 05-02-2014

    Description: ptotic processes were altered at 7 weeks (CAMK2G, NTRK2, PRKCB, RALA, RBBP6, RNF41, SEPT5, SMYD3, SPP1, and TUBB2C) and 16 weeks (SLC25A5 and NKAP). Furthermore, DE genes at 7 weeks (ELOVL6, GLOD4, NDUFS4, and REEP1) and 16 weeks (SLC25A5 and TARS2) are related to mitochondrial functions. Real-time PCR of 11 genes confirmed the microarray results and showed differential expression for additional genes not on the array, such as GFAP, RHO, OPN1SW, CNGB3 and the mutated RPGR. Western blotting and IHC analysis also confirmed the high reliability of the presented transcriptomic data. Conclusions: A list of mutated genes in RPGRORF15 diseased retinas, which are likely candidates to further study their role in age-related photoreceptor degeneration diseases, is reported at different crucial ages. The results indicate that at 7 weeks a combination of non-classical anti- and pro-apoptotic genes appears to be involved in photoreceptor degeneration, whereas at both 7 and 16 weeks expression of mitochondria related genes indicates they may play a relevant role in the disease process. 3 biological replicates each for normal and XLPRA2 affected retinas were analyzed at 7 and 16 weeks of age. Each individual sample was hybridized in a reference design using a custom-made retinal cDNA microarray against brain pool to enable cross compari...

  70. Comparison of Environmental and Genetic models of ADHD OmicsDI

    ID: E-GEOD-12457

    Date Released: 03-27-2012

    Description: he expression levels of genes Gnal, COMT, Adrbk1, Ntrk2, Hk1, Syt11 and Csnk1a1 were altered in both the SHR rats and the PCB-exposed SD rats. Arrb2, Stx12, Aqp6, Syt1, Ddc and Pgk1 expression levels were changed only in the PCB-exposed SD rats. Genes with altered expression only in the SHRs included Oprm1, Calcyon, Calmodulin, Lhx1 and Hes6.The epigenetic genes Crebbp, Mecp2 and Hdac5 are significantly altered in both models. The data provide strong evidence that genes and environment can affect different set of genes in two different models of ADHD and yet result in the similar disease-like symptoms. The brains from 28 male rats (8 SHR, 8 Sprague-Dawley (SD) controls, 8 Wistar-Kyoto (WKY) controls, and 4 PCB-exposed SD rats) were harvested at postnatal day 55-65 and RNA was isolated from six brain regions of interest. The RNA was analyzed for differences in expression of a set of 308 probe sets interrogating 218 unique genes considered highly relevant to ADHD or epigenetic gene regulation using the Rat RAE 230 2.0 GeneChip (Affymetrix). Selected observations were confirmed by real time quantitative RT-PCR....

  71. after growth with retinoic acid or brain-derived neurotrophic factor and treatment with LY294002... ArrayExpress

    ID: E-GEOD-9169

    Description: naling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehensively compared the gene expression profiles between SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E), each of which showed a different phenotype during RA-mediated di...

  72. NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR PDB

    ID: PDB:1WWC

    Description: NT-3 GROWTH FACTOR RECEPTOR TRKC

  73. NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR PDB

    ID: PDB:1WWA

    Description: NERVE GROWTH FACTOR RECEPTOR TRKA

  74. Gene expression during neuronal differentiation in two subtypes of SH-SY5Y BioProject

    ID: PRJNA102729

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: naling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehensively compared the gene expression profiles between SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E), each of which showed a different phenotype during RA-mediated di...
  75. Differential gene expression between juvenile and adult dura mater BioProject

    ID: PRJNA97407

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: chain reaction confirmation of selected genes-BMP-2, BMP-4, and BMP-7; and osteopontin (OP), osteocalcin (OC), and FGFR-1-was performed. : Juvenile dura mater expressed significantly greater amounts of BMP-2 and OP. Minimal difference in OC expression was observed between juvenile and adult dura mater. Extracellular matrix proteins (Col3a1, 5a1, 6a1, and fibronectin 1), osteoblast differentiation markers (Runx2/Cbfa1, Itm2a, and FGFR-1), and the growth factor Ptn were among other genes with greater expression in juvenile dura mater. Markers of osteoclasts (Acp5, MMP9, Ctsk) and the multiple candidate gene Ntrk2 were also expressed at higher levels in the juvenile dura mater. CONCLUSIONS: These findings suggest a more differentiated osteoprogenitor population to exist along with a greater presence of osteoclasts in the juvenile dura mate...
  76. Addiction and Reward-related Genes Show Altered Expression in the Postpartum Nucleus Accumbens BioProject

    ID: PRJNA263594

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , Arc, Homer2, Creb1, Grm3, Fosb, Gabrb3, Adra2a, Ntrk2, Cry1, Penk, Cartpt, Adcy1, Npy1r, Htr1a, Drd1a, Gria1, and Pdyn. ToppCluster analysis found maternal NAC expression profile to be significantly enriched for genes related to the drug action of nicotine, ketamine, and dronabinol. Pathway analysis indicated postpartum NAC as enriched for RNA processing, CNS development/differentiation, and transcriptional regulation. Weighted Gene Coexpression Network Analysis identified possible networks for transcription factors, including Nr1d1, Per2, Fosb, Egr1, and Nr4a1. The postpartum state involves increased risk for mental health disorders and MSET analysis indicated postpartum NAC to be enriched for genes related to depression, bipolar disorder, and schizophrenia. Mental health related genes included: Fabp7, Grm3, Penk, and Nr1d1. We confirmed via quantitative PCR Nr1d1, Per2, Grm3, Penk, Drd1a, and Pdyn. This study indicates for the firs...
  77. Identification of four subtypes of Triple Negative Breast Cancer (TNBC) by genomic profiling BioProject

    ID: PRJNA306943

    Keywords: Variation

    Access Type: download

    dataset.description: ative breast cancers (TNBCs), which lack estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), comp...
  78. Transcriptional Profile Analysis of RPGRORF15 frameshift mutation BioProject

    ID: PRJNA120739

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ptotic processes were altered at 7 weeks (CAMK2G, NTRK2, PRKCB, RALA, RBBP6, RNF41, SEPT5, SMYD3, SPP1, and TUBB2C) and 16 weeks (SLC25A5 and NKAP). Furthermore, DE genes at 7 weeks (ELOVL6, GLOD4, NDUFS4, and REEP1) and 16 weeks (SLC25A5 and TARS2) are related to mitochondrial functions. Real-time PCR of 11 genes confirmed the microarray results and showed differential expression for additional genes not on the array, such as GFAP, RHO, OPN1SW, CNGB3 and the mutated RPGR. Western blotting and IHC analysis also confirmed the high reliability of the presented transcriptomic data. Conclusions: A list of mutated genes in RPGRORF15 diseased retinas, which are likely candidates to further study their role in age-related photoreceptor degeneration diseases, is reported at different crucial ages. The results indicate that at 7 weeks a combination of non-classical anti- and pro-apoptotic genes appears to be involved in photoreceptor degeneration, whereas at both 7 and 16 weeks expression of mitochondria related genes indicates they may play a relevant role in the disease process. Overall design: 3 biological replicates each for normal and XLPRA2 affected retinas were analyzed at 7 and 16 weeks of age. Each individual sample was hybridized in a reference design using a custom-made retinal cDNA microarray against brain pool to enab...
  79. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] BioProject

    ID: PRJNA192569

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....
  80. Altered Gene Expression Profile of Microvascular Endothelium in Placentas from IUGR/Preeclamptic Pregnancies BioProject

    ID: PRJNA135785

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: entially regulated in all 6 IUGR cases. BTNL9 and NTRK2 transcripts were upregulated and SAA1, GNAS and SLAMF1 transcripts were downregulated as relative to the preterm controls. These changes were validated by Real time PCR in the PlMEC samples. This novel study is the first to identify endothelial candidate genes that may play a role in the villous hypoplasia of severe IUGR. This work advances our understanding of the molecular defects in placental microvascular endothelial cells in normal and pathologic pregnancies. Overall design: Three normal control placentas were compared against endothelial cells isolated from IUGR, IUGR and preeclampsia and normal pregancies. In this way enrichment of endothelial genes could be determined as well as changes in the expression pattern of endothelial genes due to different pathologies....
  81. Comparison of Environmental and Genetic models of ADHD GEMMA

    ID: 1168

    Keywords: functional genomics

    Description: he expression levels of genes Gnal, COMT, Adrbk1, Ntrk2, Hk1, Syt11 and Csnk1a1 were altered in both the SHR rats and the PCB-exposed SD rats. Arrb2, Stx12, Aqp6, Syt1, Ddc and Pgk1 expression levels were changed only in the PCB-exposed SD rats. Genes with altered expression only in the SHRs included Oprm1, Calcyon, Calmodulin, Lhx1 and Hes6.The epigenetic genes Crebbp, Mecp2 and Hdac5 are significantly altered in both models. The data provide strong evidence that genes and environment can affect different set of genes in two different models of ADHD and yet result in the similar disease-like symptoms. Last Updated (by provider): Mar 15 2009 Contributers: Stephen V Faraone Terje Sagvolden David F Berger Frank A Middleton John P Lombardo Tania DasBanerjee...

  82. Gene expression during neuronal differentiation in two subtypes of SH-SY5Y GEMMA

    ID: 1882

    Keywords: functional genomics

    Description: naling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehensively compared the gene expression profiles between SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y-E), each of which showed a different phenotype during RA-mediated di...

  83. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] BioProject

    ID: PRJNA192570

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development....
  84. Comparison of Environmental and Genetic models of ADHD BioProject

    ID: PRJNA113019

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he expression levels of genes Gnal, COMT, Adrbk1, Ntrk2, Hk1, Syt11 and Csnk1a1 were altered in both the SHR rats and the PCB-exposed SD rats. Arrb2, Stx12, Aqp6, Syt1, Ddc and Pgk1 expression levels were changed only in the PCB-exposed SD rats. Genes with altered expression only in the SHRs included Oprm1, Calcyon, Calmodulin, Lhx1 and Hes6.The epigenetic genes Crebbp, Mecp2 and Hdac5 are significantly altered in both models. The data provide strong evidence that genes and environment can affect different set of genes in two different models of ADHD and yet result in the similar disease-like symptoms. Overall design: The brains from 28 male rats (8 SHR, 8 Sprague-Dawley (SD) controls, 8 Wistar-Kyoto (WKY) controls, and 4 PCB-exposed SD rats) were harvested at postnatal day 55-65 and RNA was isolated from six brain regions of interest. The RNA was analyzed for differences in expression of a set of 308 probe sets interrogating 218 unique genes considered highly relevant to ADHD or epigenetic gene regulation using the Rat RAE 230 2.0 GeneChip (Affymetrix). Selected observations were confirmed by real time quantitative RT-PCR....
  85. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition BioProject

    ID: PRJNA125449

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: r presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). Treatment of ovaries with NT3 resulted in a significant (P<0.01) increase in primordial follicle development (i.e. primordial to primary follicle transition). Treatment with BDNF at high doses of 100–250 ng/ml also significantly (P<0.01) increased primordial follicle development, but NGF had no effect. Immunohistochemical studies determined that NT3 was present in granulosa cells, interstitial tissue, and...
  86. Expression data from neurotrophin transgenic mice OmicsDI

    ID: E-GEOD-44734

    Date Released: 06-02-2014

    Description: s unclear. In the gustatory system, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles but exert their effects through the same receptors (TrkB and p75). Using genome wide expression analysis, we determined that BDNF and NT4 also regulat...

  87. Expression data from neurotrophin transgenic mice ArrayExpress

    ID: E-GEOD-44734

    Description: s unclear. In the gustatory system, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles but exert their effects through the same receptors (TrkB and p75). Using genome wide expression analysis, we determined that BDNF and NT4 also regulat...

  88. Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity OmicsDI

    ID: E-GEOD-26836

    Date Released: 06-26-2012

    Description: esulted in increases in hippocampal brain-derived neurotrophic factor protein as well as increased tyrosine phosphorylation of its cognate receptor (TrkB). These results indicate that amitriptyline has significant beneficial actions in aged and damaged AD brains and that it shows promise as a tolerable novel therapeutic for the treatment of AD. Male 3xTgAD mice, 14 months of age, were maintained on a 12hr light dark cycle in pathogen free conditions. Animals received food and water ad libitum. The test group received 100ug/g body weight amitriptyline-hydrochloride per os in their drinking water (Sigma-Aldrich, St. Louis MO) for 4 months (n = 15), and the control group received water (n = 15). The Hippocampus and Cortex were removed from 3 replicates of each group and RNA purification was done using glass bead disruption followed by the RNEasy Mini Kit (Qiagen, Valencia, CA) according to the manufacturer's instructions. The RNA was examined for quantity and quality using an Agilent Bioanalyzer 2100 (Agilent Technologies, Palo Alto, CA). The samples were hybridized to Illumina's SentrixMouse Ref-8 v2. Expression BeadChips (Illumina, San Diego, CA)....

  89. Effect of neurotrophin p75 receptor (p75NTR) on angiogenesis OmicsDI

    ID: E-GEOD-9910

    Date Released: 03-27-2012

    Description: tes angiogenesis and EC survival, via tropomyosin kinase trkA and trkB receptors. A different p75NTR receptor of NTs, which belongs to the TNF-alfa receptor

  90. Effect of neurotrophin p75 receptor (p75NTR) on angiogenesis ArrayExpress

    ID: E-GEOD-9910

    Description: tes angiogenesis and EC survival, via tropomyosin kinase trkA and trkB receptors. A different p75NTR receptor of NTs, which belongs to the TNF-alfa receptor

  91. Expression data from neurotrophin transgenic mice BioProject

    ID: PRJNA191107

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s unclear. In the gustatory system, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles but exert their effects through the same receptors (TrkB and p75). Using genome wide expression analysis, we determined that BDNF and NT4 also regulat...
  92. Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity ArrayExpress

    ID: E-GEOD-26836

    Description: esulted in increases in hippocampal brain-derived neurotrophic factor protein as well as increased tyrosine phosphorylation of its cognate receptor (TrkB). These results indicate that amitriptyline has significant beneficial actions in aged and damaged AD brains and that it shows promise as a tolerable novel therapeutic for the treatment of AD. Male 3xTgAD mice, 14 months of age, were maintained on a 12hr light dark cycle in pathogen free conditions. Animals received food and water ad libitum. The test group received 100ug/g body weight amitriptyline-hydrochloride per os in their drinking water (Sigma-Aldrich, St. Louis MO) for 4 months (n = 15), and the control group received water (n = 15). The Hippocampus and Cortex were removed from 3 replicates of each group and RNA purification was done using glass bead disruption followed by the RNEasy Mini Kit (Qiagen, Valencia, CA) according to the manufacturer's instructions. The RNA was examined for quantity and quality using an Agilent Bioanalyzer 2100 (Agilent Technologies, Palo Alto, CA). The samples were hybridized to Illumina's SentrixMouse Ref-8 v2. Expression BeadChips (Illumina, San Diego, CA)....

  93. pCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsa... OmicsDI

    ID: E-GEOD-38223

    Date Released: 06-11-2012

    Description: g 15 h sessions for 8 d and were euthanized after 2 h, 24 h, or 1 month of abstinence. Compared to yoked saline control, METH self-administration induced increases in the mRNA expression of the transcription factors, c-fos and fosb, the neurotrophic factor, Bdnf, and of the synaptic protein, synaptophysin (Syp) at 2 h after cessation of drug exposure. METH self-administration also caused changes in FosB, BDNF and TrkB protein levels, with increases at 2 and 24 h but decreases observed after 1 month of drug abstinence. Importantly, METH exposure caused increases in the levels of H3K4me3 and pCREB after 2 and 24 h of abstinence. Chromatin immunoprecipitation followed by qPCR was used to clarify the role of thes...

  94. pCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsa... ArrayExpress

    ID: E-GEOD-38223

    Description: g 15 h sessions for 8 d and were euthanized after 2 h, 24 h, or 1 month of abstinence. Compared to yoked saline control, METH self-administration induced increases in the mRNA expression of the transcription factors, c-fos and fosb, the neurotrophic factor, Bdnf, and of the synaptic protein, synaptophysin (Syp) at 2 h after cessation of drug exposure. METH self-administration also caused changes in FosB, BDNF and TrkB protein levels, with increases at 2 and 24 h but decreases observed after 1 month of drug abstinence. Importantly, METH exposure caused increases in the levels of H3K4me3 and pCREB after 2 and 24 h of abstinence. Chromatin immunoprecipitation followed by qPCR was used to clarify the role of thes...

  95. Effect of neurotrophin p75 receptor (p75NTR) on angiogenesis BioProject

    ID: PRJNA103899

    Keywords: Transcriptome or Gene expression

    Access Type: download

  96. Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer’s disease mice is associated with neurogenesis and neurotrophic activity BioProject

    ID: PRJNA136045

    Keywords: Transcriptome or Gene expression

    Access Type: download

  97. pCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsa... BioProject

    ID: PRJNA167457

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g 15 h sessions for 8 d and were euthanized after 2 h, 24 h, or 1 month of abstinence. Compared to yoked saline control, METH self-administration induced increases in the mRNA expression of the transcription factors, c-fos and fosb, the neurotrophic factor, Bdnf, and of the synaptic protein, synaptophysin (Syp) at 2 h after cessation of drug exposure. METH self-administration also caused changes in FosB, BDNF and TrkB protein levels, with increases at 2 and 24 h but decreases observed after 1 month of drug abstinence. Importantly, METH exposure caused increases in the levels of H3K4me3 and pCREB after 2 and 24 h of abstinence. Chromatin immunoprecipitation followed by qPCR was used to clarify the role of thes...
  98. BMS-536924 KINOMEscan LINCS

    Data Type: Binding Protein binding profile

    Assay: KINOMEscan kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1098

    protein.name: JAK1(Kin.Dom.2)
  99. ALW-II-49-7 KINOMEscan LINCS

    Data Type: Binding Protein binding profile

    Assay: KINOMEscan kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1036

    protein.name: JAK1(Kin.Dom.2)
  100. GDC-0941 KINOMEscan LINCS

    Data Type: Binding Protein binding profile

    Assay: KINOMEscan kinase-small molecule binding assay

    Biological Process: Small molecule metabolic process

    ID: LDS-1046

    protein.name: GCN2(Kin.Dom.2,S808G)

Displaying 100 of 260 results for "NTRK2"