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  1. Expression data from neurotrophin transgenic mice BioProject

    ID: PRJNA191107

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition BioProject

    ID: PRJNA125449

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Comparison of SCG expression profiles from Bax null versus NGF-Bax double null mice BioProject

    ID: PRJNA107953

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), which, through the receptor p75, can k...
  4. Genome-wide identification of Bcl11b gene targets BioProject

    ID: PRJNA144713

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: leukemia/lymphoma 11B (Bcl11b) is a transcription factor showing predominant expression in the striatum. To date, there are no known gene targets of Bcl11b in the nervous system. Here, w...
  5. Protective gene expression changes elicited by an inherited defect in photoreceptor structure. BioProject

    ID: PRJNA149405

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Interestingly, this response was accompanied by neurotrophic factor upregulation. We hypothesize that activation of Egr1 and neurotrophic factors represents a protective immune mechanism, contributing to the characteristically slow retinal degeneration of the rds mouse model. Overall design: We had two conditions WT and Rds-KO at 4 different time points: postnatal (P) 6, P9, P14 and P21....
  6. Porcine IVM GDNF BioProject

    ID: PRJNA179274

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Treatment of oocytes derived from large (4-6 mm; LG) or small (>3 mm; SM) follicles with glial cell line-derived neurotrophic factor (...
  7. Exercise-mimetic AICAR transiently benefits brain function BioProject

    ID: PRJNA271402

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cts of running and administration of AMPK agonist 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR, 500 mg/kg), for 3, 7 or 14 days in one-month-old male C57BL/6J mice, on muscle AMPK signaling. At the time-points where we observed equivalent running- and AICAR-induced muscle pAMPK levels (7 and 14 days), cell proliferation, synaptic plasticity and gene expression, as well as markers of oxidative stress and inflammation in the dentate gyrus (DG) of the hippocampus and lateral ento...
  8. Transcriptomes of Clostridium novyi-NT BioProject

    ID: PRJNA97561

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Effect of neurotrophin p75 receptor (p75NTR) on angiogenesis BioProject

    ID: PRJNA103899

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Hsp70 and a Novel Axis of Type 1 Interferon-Dependent Antiviral Immunity in the Measles Virus-Infected Brain BioProject

    ID: PRJNA179489

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: f brains from transgenic (TG) and non-transgenic (NT) mice 5 days after infection identified type 1 interferon (IFN) signaling and macrophage activation/antigen presentation as the main differences linked to survival. The pivotal role for type 1 IFN in hsp70-mediated protection was demonstrated in mice with a genetically disrupted type 1 IFN receptor (IFNAR-/-), where IFNAR-/- eliminated the difference in survival between TG and NT mice. Brain macrophages, not neurons, are the predominant source of type 1 IFN in the virus-infected brain, and in vitro studies provided a mechanistic basis by which MeV-infected neurons can induce IFN-β in uninfected microglia in an hsp70-de...
  11. GDNF and anxiety BioProject

    ID: PRJNA238850

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: ce the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. This is the first demonstration of a significant association between the GDNF gene and mood characteristics... (for more see dbGaP study page.)...
  12. Homo sapiens : GDNF and anxiety BioProject

    ID: PRJNA238849

    Access Type: download

    dataset.description: ce the effect of the rs3812047 A allele as a risk factor of anxiety was more pronounced in males. This is the first demonstration of a significant association between the GDNF gene and mood characteristics... (for more see dbGaP study page.)...
  13. Identification of a neuronal gene expression signature: Role of cell-cycle arrest in murine neuronal differentiation in vitro BioProject

    ID: PRJNA130049

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: y significant enrichment of genes in the ephrin, neurotrophin, CDK5 and actin pathways which control multiple neuronal-specific functions. Furthermore, genes involved in cell cycle were among the most significantly changed in PN. In order to better understand the role of cell cycle arrest in mediating NSCs differentiation, we blocked the cell cycle of NSCs with Mitomycin C (MMC) and examined cellular morphology and gene expression signatures. Although these MMC-treated NSCs displayed a neuronal morphology and expressed some neuronal differentiation marker genes, their gene expression patterns was very different from primary neurons. We conclude that: 1) Fully differentiated primary neurons display a specific neuronal gene expression signature; 2) cell-cycle block in NSC does not induce the formation of fully differentiated neurons; 3) Cytokines such as IFN, TNF, TGF and IL are part of normal NSC function and/or physiology; 4) Signaling pathways of ephrin, neurotrophin, CDK5 and actin, related to major neuronal features, are dynamica...
  14. Osmotic Loading of Human Intervertebral Disc Cells BioProject

    ID: PRJNA90703

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 00 μg/ml streptomycin, and 1 μg/ml Fungizone at 5% CO2 and 37° C. After 24 h, the cell culture medium was removed via pipette and exchanged for one of three osmotically active solutions, representing iso-osmotic, hyper-osmotic and hypo-osmotic media [12, 23, 34]. The iso-osmotic solution consisted of a defined cell culture medium (Ham’s F-12 with supplements as described above; 293 mOsm/kg H2O). The hypo-osmotic solution consisted of the same cell culture media diluted with de-ionized water to a final osmolarity of 250 mOsm/kg H2O. The hyper-osmotic solution consisted of the same cell culture media supplemented with sucrose to a final osmolarity of 450 mOsm/kg H20. The osmolarity of all solution formulations was determined using a freezing-point osmometer (Advanced Laboratory Wide Range 3W2, Advanced Instrument, Needham Heights, MA) as described previously [12]. Cell-alginate beads were cultured for a 4 hour period under one of these conditions, after which the ...
  15. GDNF-Regulated Gene Expression in Cultures of Rat Spermatogonial Stem Cells BioProject

    ID: PRJNA116669

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tures for 18 hours followed by replacement for 2, 4, and 8 hours. Gene expression was studied using microarray profiling prior to GDNF withdrawal, after GDNF withdrawal, and after 2, 4, and 8 hours of GDNF replacement. 3 replicate samples from each timepoint were analyzed....
  16. Arabidopsis thaliana : Genome-Wide Identification of Small RNAs that Are Independent of DCL Proteins in Arabidopsis BioProject

    ID: PRJNA291944

    Keywords: epigenomics

    Access Type: download

    dataset.description: DNA methylation directed by 24-nucleotide (nt) small interfering RNAs (siRNAs) plays critical roles in gene regulation and transposon silencing in Arabidopsis. Twenty-four-
  17. GDNF-regulated gene expression in cultured mouse spermatogonial stem cells BioProject

    ID: PRJNA95745

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 6 day old male mice. GDNF is the essential growth factor regulating mouse spermatogonial stem cell self-renewal. Using a serum-free chemically defined culture system that supports mouse spermatogonial stem cell self-renewal for extended periods of time, GDNF-regulated genes were identified using microarr...
  18. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] BioProject

    ID: PRJNA192570

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ssociated signalling, cell adhesion molecules and neurotrophin signalling pathways during neuronal maturation. Long non-coding RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming ...
  19. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] BioProject

    ID: PRJNA192569

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ssociated signalling, cell adhesion molecules and neurotrophin signalling pathways during neuronal maturation. Long non-coding RNAs associated with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming ...
  20. Ago-bound miRNAs and pre-miRNAs : Profiling Argonaute-bound miRNAs and pre-miRNAs from Mouse Embryonic Fibroblasts BioProject

    ID: PRJEB6756

    Keywords: Other

    Access Type: download

    dataset.description: To Profile Argonaute-bound miRNAs and pre-miRNAs, 5'-end radiolabeled RNAs from anti-Ago IPs were resolved on a 10% denaturing PAGE gel. Gel slices containing 20-30 nt

Displaying 20 of 97 results for "NTF4"