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Displaying 15 of 15 results for "NRIP3"
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  1. A novel proteomic approach reveals GREB1 as an Estrogen Receptor co-factor BioProject

    ID: PRJNA177430

    Keywords: Epigenomics

    Access Type: download

  2. Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity BioProject

    ID: PRJNA230632

    Keywords: Other

    Access Type: download

  3. Genome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells BioProject

    ID: PRJNA130715

    Keywords: Epigenomics

    Access Type: download

  4. A novel proteomic approach reveals GREB1 as an Estrogen Receptor co-factor BioProject

    ID: PRJNA159713

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Integrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression] BioProject

    ID: PRJNA181135

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 1 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and SRC3 with ERα. The receptors modified each other’s transcriptional effect, and ERβ countered the proliferative drive of ERα through several novel mechanisms associated with specific binding site clusters. Our findings delineate distinct TF-coregulator assemblies that function as control nodes specifying precise patterns of gene regulation, proliferation, and metabolism, as exemplified by two of the most important nuclear hormone receptors in human breast cancer. Overall design: ...

  6. The role of RIP140 in retinoid mediated signaling BioProject

    ID: PRJNA100483

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Cell-and context-specific activities of nuclear receptors may in part be due to distinct coregulator complexes recruited to distinct subsets of target genes. RIP140 (als...

  7. Co-activator function of RIP140 for NF?B/p65-dependent cytokine gene BioProject

    ID: PRJNA108129

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a master transcriptional regulator of inflammation in multiple tissues. Genetic as well as acute deficiency of RIP140, which has been characterized as a co-repressor of various

  8. Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation [ChIP-exo] BioProject

    ID: PRJNA316983

    Keywords: Epigenomics

    Access Type: download

    dataset.description: HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to ...

  9. Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation [RNA-Seq] BioProject

    ID: PRJNA316984

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to ...

  10. Differential gene expression between human Cord blood transduced with HPIP-wt, mutant NRPID and control YFP BioProject

    ID: PRJNA121571

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: development. Previously, the ‘hematopoietic PBX interacting protein’ (HPIP) has been identified as a novel interacting partner of the TALE homeodomain protein PBX1, forming a microtubule signalling complex. Expression of HPIP has b...

  11. Nuclear receptor coactivator 1 (NCOA1) is involved in the regulation of PCa cell migration via PRKD1 BioProject

    ID: PRJNA304492

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Brain transcriptomic response to social eavesdropping in zebrafish BioProject

    ID: PRJNA286322

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ing data from both approaches, we further drafted protein interaction networks. Our results suggest that attentiveness towards conspecifics, whether interacting or not, activates pathways linked to neuronal plasticity and memory formation. The network analyses suggested that fos and jun are key players on this response, and that npas4a, nr4a1 and egr4 may also play an important role. Furthermore, specifically observing fighting interactions further triggered pathways associated to a change in the alertness status (dnajb5) and to other genes related to memory formation (btg2, npas4b), which suggests that the acquisition of eavesdropped information about social relationships activates specific processes on top of those already activated just by observing conspecifics. Overall design: 39 fish were previously subjected to one of three treatments (13 individuals per group) for 30 minutes: bystander to an interacting male conspecific dyad; bystander to two non-interacting male conspecifics; and socially isolated fish. From these, 4 representati...

  13. Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia BioProject

    ID: PRJNA329510

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: is on Affymetrix microarrays.Furthermore, the MLL-NRIP3-driven mice model was chosen for further examination.The K+G– mice BM cells were sorted from the 1st BMT of RictorΔ/Δ(MN3_R1,MN3_R2,MN3_R3) or control(MN3_C1,MN3_C2,MN3_C3), and subjected to microarray analysis on Affymetrix microarrays....

  14. Transcriptional regulatory dynamics set the stage for a coordinated metabolic and neural response to social threat in mice. [ChIP-Seq data set] BioProject

    ID: PRJNA320640

    Keywords: Epigenomics

    Access Type: download

    dataset.description: regulatory network and motif analyses revealed an interacting network of TFs correlated with differential gene expression across the tissues and time points we assayed, including the early-acting and conserved regulator of energy metabolism and development, ESRRA. Cell-type deconvolution analysis attributed the early metabolic activity implicated by our transcriptomic analysis primarily to oligodendrocytes and the developmental signal to neurons, and we confirmed the presence of ESRRA in both oligodendrocytes and neurons throughout the brain. To assess the role of this nuclear receptor as an early trigger of this coordinated response, we used chromatin immunoprecipitation to map ESRRA binding sites to a set of genes involved in metabolic regulation and enriched in challenge-associated differentially expressed genes. Together, these data support a rich model linking metabolic and neural responses to social challenge, and identify regulatory drivers with unprecedented tissue and...

  15. Transcriptional regulatory dynamics set the stage for a coordinated metabolic and neural response to social threat in mice [RNA-Seq data set] BioProject

    ID: PRJNA318643

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: regulatory network and motif analyses revealed an interacting network of TFs correlated with differential gene expression across the tissues and time points we assayed, including the early-acting and conserved regulator of energy metabolism and development, ESRRA. Cell-type deconvolution analysis attributed the early metabolic activity implicated by our transcriptomic analysis primarily to oligodendrocytes and the developmental signal to neurons, and we confirmed the presence of ESRRA in both oligodendrocytes and neurons throughout the brain. To assess the role of this nuclear receptor as an early trigger of this coordinated response, we used chromatin immunoprecipitation to map ESRRA binding sites to a set of genes involved in metabolic regulation and enriched in challenge-associated differentially expressed genes. Together, these data support a rich model linking metabolic and neural responses to social challenge, and identify regulatory drivers with unprecedented tissue and...
Displaying 15 of 15 results for "NRIP3"

bioCADDIE is supported by the National Institutes of Health through the Big Data to Knowledge, Grant 1U24AI117966-01. NIH | UCSD | DBMI

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