Rictor Plays a Pivotal Role in Maintaining Quiescence as well as Stemness of Leukemia Stem Cells in MLL-Driven Leukemia ArrayExpress

ID: E-GEOD-84505

Description: is on Affymetrix microarrays.Furthermore, the MLL-NRIP3-driven mice model was chosen for further examination.The K+G– mice BM cells were sorted from the 1st BMT of RictorΔ/Δ(MN3_R1,MN3_R2,MN3_R3) or control(MN3_C1,MN3_C2,MN3_C3), and subjected to microarray analysis on Affymetrix microarrays....

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression] ArrayExpress

ID: E-GEOD-42347

Description: 1 clusters representing different chromatin-bound receptor and coregulator assemblies that could be functionally associated through enrichment analysis with distinct patterns of gene regulation and preferential coregulator usage, RIP140 with ERβ and SRC3 with ERα. The receptors modified each other’s transcriptional effect, and ERβ countered the proliferative drive of ERα through several novel mechanisms associated with specific binding site clusters. Our findings delineate distinct TF-coregulator assemblies that function as control nodes specifying precise patterns of gene regulation, proliferation, and metabolism, as exemplified by two of the most important nuclear hormone receptors in human breast cancer. MCF-7 cells expr...

Genome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells ArrayExpress

ID: E-GEOD-23792

Description: The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its...

A novel proteomic approach reveals GREB1 as an Estrogen Receptor co-factor ArrayExpress

ID: E-GEOD-41561

Description: Methods for identifying protein-protein interactions have mostly been limited to tagged exogenous expression approaches. We now establis...

A novel proteomic approach reveals GREB1 as an Estrogen Receptor co-factor ArrayExpress

ID: E-GEOD-37386

Description: Methods for identifying protein-protein interactions have mostly been limited to tagged exogenous expression approaches. We now establis...

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity ArrayExpress

ID: E-GEOD-52201

Description: onal corepressor through demethylation of histone 3 lysine 4 (H3K4), but has coactivator function on some genes through unclear mechanisms. We show that LSD1, interacting with CoREST, associates with and coactivates androgen

Co-activator function of RIP140 for NFκB/p65-dependent cytokine gene ArrayExpress

ID: E-GEOD-10386

Description: e describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a master transcriptional regulator of inflammation in multiple tissues. Genetic as well as acute deficiency of RIP140, which has been characterized as a co-repressor of various

Transcription profiling of mouse adipocytes to determine the role of RIP140 in adipocyte differentiation ArrayExpress

ID: E-MIMR-42

Description: Title: Gene Expression analysis of the role of RIP140 in adipocyte differentiation Description: RIPKO cells are mouse embryo fibroblasts (MEF) that we...

siRNA knock down of RIP140 in the presence of retinoic acid vs controls to investigate the role of RIP140 in retinoid mediated signaling ArrayExpress

ID: E-GEOD-7500

Description: Cell-and context-specific activities of nuclear receptors may in part be due to distinct coregulator complexes recruited to distinct subsets of target genes. RIP140 (als...

Nuclear receptor coactivator 1 (NCOA1) is involved in the regulation of PCa cell migration via PRKD1 ArrayExpress

ID: E-GEOD-75531

Description: rgent need of new targeting strategies in PCa, AR interacting proteins should be considered. In this study we aimed to test the effect of a long-term knockdown of NCOA1, an AR coactivator, in P...

Differential gene expression between human Cord blood transduced with HPIP-wt, mutant NRPID and control YFP ArrayExpress

ID: E-GEOD-18640

Description: development. Previously, the ‘hematopoietic PBX interacting protein’ (HPIP) has been identified as a novel interacting partner of the TALE homeodomain protein PBX1, forming a microtubule signalling complex. Expression of HPIP has b...