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Displaying 20 of 52 results for "NKX2-6"
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  1. RNAseq analysis of the colon of intestine-specific adult Nkx2.2 mutant mice ArrayExpress

    ID: E-GEOD-78902

    Description: llin-Cre (Nkx2.2int) mice versus control Methods: 2 cm of the colon (as measured after the caecum) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) with the...

  2. RNAseq analysis of the duodenum of intestine-specific adult Nkx2.2 mutant mice ArrayExpress

    ID: E-GEOD-72761

    Description: llin-Cre (Nkx2.2int) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) with the...

  3. Comparative global transcriptomic profiling of human ES and iPSs cells and their derived microdissected cardiac clusters ArrayExpress

    ID: E-GEOD-17579

    Description: S cells (1) and undifferentiated human iPS cells (2), human ES cell-derived cardiomyocytes (3) and human iPS cell-derived cardiomyocytes (4) enriched by microdissection of spontaneously contracting embryoid body outgrowths, and human fetal (5) and adult (6) heart tissue. Total RNA samples were prepared from three independent biological replicates in groups 1-4. In groups 5 and 6, single RNA probes were analyzed as three technical replicates....

  4. RNAseq analysis of the duodenum of intestine-specific adult TN mutant mice BioProject

    ID: PRJNA295013

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: N;Villin-Cre (TNint) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) wi...
  5. RNAseq analysis of the colon of intestine-specific adult Nkx2.2 mutant mice BioProject

    ID: PRJNA314335

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: llin-Cre (Nkx2.2int) mice versus control Methods: 2 cm of the colon (as measured after the caecum) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) with the...
  6. RNAseq analysis of the duodenum of intestine-specific adult SD mutant mice BioProject

    ID: PRJNA295014

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: D;Villin-Cre (SDint) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) wi...
  7. RNAseq analysis of the duodenum of intestine-specific adult Nkx2.2 mutant mice BioProject

    ID: PRJNA295015

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: llin-Cre (Nkx2.2int) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) with the...
  8. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models ArrayExpress

    ID: E-GEOD-28480

    Description: nflammation. A set of proteins regulated by Titf1/Nkx2-1, a master transcription factor in cells from the peripheral airways and a known lineage-survival oncogene in lung cancer was identified in plasmas of mouse models of lung adenocarcinoma. An EGFR network of proteins was discerned in the plasma of mice with lung tumors driven by a mutant human EGFR. Levels of these proteins returned toward baseline upon treatment with a tyrosine kinase inhibitor. Moreover, a distinct plasma signature was uncovered in the Trp53/Rb mutant small cell lung cancer model that included a set of proteins associated with neuroendocrine development. Our studies have identified novel plasma protein signatures among molecularly or histopathologically defined lung cancer subtypes. siRNA transfection experiments were performed in NCI-H3255 and HCC4019 lung adenocarcinoma cell lines using ON-TARGETplus SMARTpool small interfering RNAs (siRNAs) targeting TITF1 (L-0191...

  9. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: aCGH Arrays BioProject

    ID: PRJNA108579

    Keywords: Variation

    Access Type: download

    dataset.description: est region of recurrent amplification spanned the homeobox transcription factor TITF1 (also known as NKX2-1), previously linked to normal lung development and function. When amplified, TITF1 exhibited increased expression at both the RNA and protein level. siRNA-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis. Our findings...
  10. RNAseq analysis of the duodenum of intestine-specific adult TN mutant mice ArrayExpress

    ID: E-GEOD-72764

    Description: N;Villin-Cre (TNint) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) wi...

  11. Growth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity ArrayExpress

    ID: E-GEOD-58587

    Description: Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expre...

  12. Growth arrest of human thyroid cancer cells 8505C after inhibition of TTF-1 transcriptional activity ArrayExpress

    ID: E-GEOD-58243

    Description: Background: thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expre...

  13. Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame... ArrayExpress

    ID: E-GEOD-74736

    Description: emaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, (1)H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated component...

  14. RNAseq analysis of the duodenum of intestine-specific adult SD mutant mice ArrayExpress

    ID: E-GEOD-72762

    Description: D;Villin-Cre (SDint) mice versus control Methods: 2 cm of the duodenum (as measured from the stomach) of 6 week old control and mutant mice were dissected and total RNA extracted. Libraries were prepared from total RNA (RIN>8) wi...

  15. Comparative global transcriptomic profiling of human ES and iPSs cells and their derived microdissected cardiac clusters BioProject

    ID: PRJNA118681

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: S cells (1) and undifferentiated human iPS cells (2), human ES cell-derived cardiomyocytes (3) and human iPS cell-derived cardiomyocytes (4) enriched by microdissection of spontaneously contracting embryoid body outgrowths, and human fetal (5) and adult (6) heart tissue. Total RNA samples were prepared from three independent biological replicates in groups 1-4. In groups 5 and 6, single RNA probes were analyzed as three technical replicates....
  16. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models BioProject

    ID: PRJNA139309

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nflammation. A set of proteins regulated by Titf1/Nkx2-1, a master transcription factor in cells from the peripheral airways and a known lineage-survival oncogene in lung cancer was identified in plasmas of mouse models of lung adenocarcinoma. An EGFR network of proteins was discerned in the plasma of mice with lung tumors driven by a mutant human EGFR. Levels of these proteins returned toward baseline upon treatment with a tyrosine kinase inhibitor. Moreover, a distinct plasma signature was uncovered in the Trp53/Rb mutant small cell lung cancer model that included a set of proteins associated with neuroendocrine development. Our studies have identified novel plasma protein signatures among molecularly or histopathologically defined lung cancer subtypes. Overall design: siRNA transfection experiments were performed in NCI-H3255 and HCC4019 lung adenocarcinoma cell lines using ON-TARGETplus SMARTpool small interfering RNAs (siRNAs) targeti...
  17. Transcription profiling of human NSCLC tumor progression ArrayExpress

    ID: E-GEOD-7880

    Description: To identify genes associated with lung cancer progression, we examined gene expression profiles of tumor cells from 20 patients with primary, untreate...

  18. Transcription profiling by array of mouse lumbar spinal cord mutant for tenascin-C ArrayExpress

    ID: E-GEOD-33091

    Description: thermore, we could demonstrate an upregulation of Nk2 transcription factor related locus 2 (Nkx2.2) and its downstream target Sulfatase 1 in vivo. A dorsal expansion of Nkx2.2-positive cells within the ventral spinal cord indicates a potential progenitor cell domain shift. Moreover, Sulfatase 1 is known to regulate growth factor signalling by cleaving sulphate residues from heparan sulphate proteoglycans. Consistent with this possibility we observed changes in both Fibroblast growth factor 2 and Epidermal growth factor responsiveness of spinal cord neural precursor cells. Taken together our data clearly show that Tenascin-C promotes the astroglial lineage prog...

  19. Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame... BioProject

    ID: PRJNA301365

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: emaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, (1)H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated component...
  20. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: aCGH Arrays OmicsDI

    ID: E-GEOD-10025

    Date Released: 05-01-2014

    Description: est region of recurrent amplification spanned the homeobox transcription factor TITF1 (also known as NKX2-1), previously linked to normal lung development and function. When amplified, TITF1 exhibited increased expression at both the RNA and protein level. siRNA-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis. Our findings...


Displaying 20 of 52 results for "NKX2-6"