NKX2-6 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 5 of 52 results for "NKX2-6"
i
  1. Global gene expression kinetics of early human lung development modeled by directed differentiation of human PSCs using an NKX2-1GFP iPSC reporter BioProject

    ID: PRJNA325535

    Access Type: download

  2. Sip1 in cortical interneuron migration BioProject

    ID: PRJNA152545

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We sequenced mRNA from 6 samples of FACsorted telencephalons from E14.5 Sip1|Nkx2-1 knockout and WT|Nkx2-1 control m...
  3. Suppression of Lung Adenocarcinoma Progression by Nkx2-1 OmicsDI

    ID: E-GEOD-26874

    Date Released: 01-27-2013

    Description: r types. Cross-species analysis identified the NK-2 related homeobox transcription factor Nkx2-1 (Ttf-1/Titf1) as a candidate suppressor of malignant progression. In this mouse model, Nkx2-1-negativity is pathognomonic of high-grade poorly differentiated tumours. Gain- and loss-of-function experiments in cells derived from metastatic and non-metastatic tumours demonstrated that Nkx2-1 controls tumour differentiation and limits metastatic potential in vivo. Interrogation of Nkx2-1 regulated genes, analysis of tumours at defined developmental stages, and functional complementation experiments indicate that Nkx2-1 constrains tumours in part by repressing the embryonically-restricted chromatin regulator Hmga2. While focal amplification of NKX2-1 in a fraction of human lung adenocarcinomas has focused attention on its oncogenic function6-9, our data specifically link Nkx2-1 downregulation to loss of differentiation, enhance...

  4. Nkx2.1 represses a latent gastric differentiation program in lung adenocarcinoma BioProject

    ID: PRJNA153501

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ams become dysregulated. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate o...
  5. Nkx2.1 represses a latent gastric differentiation program in lung adenocarcinoma OmicsDI

    ID: E-GEOD-36473

    Date Released: 04-22-2013

    Description: ams become dysregulated. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate o...


Displaying 5 of 52 results for "NKX2-6"