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Displaying 20 of 32 results for "NDN"
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  1. p53 Regulates Hematopoietic Stem Cell Quiescence BioProject

    ID: PRJNA110049

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: wild type and p53 null mice identified Gfi-1 and Necdin as p53 target genes and using lentiviral vectors to upregulate or knockdown the expression of these genes, we show their importance in regulating HSC quiescence. Establishing the role of p53 (and its target genes) in controlling the cell cycle entry of HSCs may lead to therapeutic strategies capable of eliminating quiescent cancer (stem) cells. Overall design: RNAs isolated from wild type, p53 -/- and p53 -/- Mef -/- LSK cells were used in oligonucleotide arrays (Affymetrix)...
  2. Neonatal and embyronic CNS of mice with maternal or paternal duplication of proximal chromosomes 7 and 15 (430B) BioProject

    ID: PRJNA113863

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: alysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. Keywords: genetic modification, developmental comparison Overall design: Eight samples were analyzed by microarray analysis using GeneChip 430B (no biological replicates). RNAs were from neonatal cortex and cerebellum, and from whole brain of 13.5 and 15.5 dpc embryos, purified from mice carrying either mat...
  3. Gene expression profile of primary cortical neurons from necdin-null mouse embryo BioProject

    ID: PRJNA268071

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. to reveal role of insulin receptor substrates and necdin... ArrayExpress

    ID: E-GEOD-2556

    Description: cordant changes in brown adipose tissue in vivo. Necdin was markedly increased in IRS-1 KO cells that could not differentiate, and knockdown of necdin restored brown adipogenesis with down-regulation of Pref-1 and Wnt10a expression. We demonstrated a necdin-E2F4 interaction repressing PPARg transcription. IRS proteins regulated necdin via a CREB dependent pathway, defining a signalling network involved in brown preadipocyte determination....

  5. Transcription profiling of mouse neonatal and embyronic CNS from animals with maternal or paternal duplication of proximal chromosomes 7 and 15 ArrayExpress

    ID: E-GEOD-12231

    Description: alysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. This SuperSeries is composed of the following subset Series:; GSE12227: Neonatal and embyronic CNS of mice with maternal or paternal duplication of proximal chromosomes 7 and 15 (430A); GSE12230: Neonatal and embyronic CNS of mice with maternal or paternal duplication of proximal chromosomes 7 and 15 (430B) ...

  6. Transcription profiling of mouse HSCs isolated from wild type and p53 null animals reveals p53 Regulates Hematopoietic Stem Cell Quiescence ArrayExpress

    ID: E-GEOD-13448

    Description: wild type and p53 null mice identified Gfi-1 and Necdin as p53 target genes and using lentiviral vectors to upregulate or knockdown the expression of these genes, we show their importance in regulating HSC quiescence. Establishing the role of p53 (and its target genes) in controlling the cell cycle entry of HSCs may lead to therapeutic strategies capable of eliminating quiescent cancer (stem) cells. Experiment Overall Design: RNAs isolated from wild type, p53 -/- and p53 -/- Mef -/- LSK cells were used in oligonucleotide arrays (Affymetrix)...

  7. Expression profiling of Ebf2- and Ebf2- stromal cells in mouse bone marrow OmicsDI

    ID: E-GEOD-51608

    Date Released: 06-03-2014

    Description: ared to the Ebf2+ cells. These include Nov, Fmod, Ndn, Dcn, Ctgf, Angiopoietin like-1(Angptl1), Fn1 and Jag1, some of which has been reported to be expressed in culture-selected MSCs. Furthermore, consistent with antigen expression analysis by FACS, the Ebf2+ cells highly expressed transcripts of Pdgfra, Pdgfrb, Sca1/Ly6a, Thy1 and Itga7 and Itgav, that have been suggested to be linked to MSCs. Nestin was mainly expressed in the Ebf2+ cells whereas it was hardly detectable in the Ebf2- cells. Altogether, molecularly, the Ebf2...

  8. Neonatal and embyronic CNS of mice with maternal or paternal duplication of proximal chromosomes 7 and 15 (430A) BioProject

    ID: PRJNA113857

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: alysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. Keywords: genetic modification, developmental comparison Overall design: Fourteen samples were analyzed by microarray analysis using GeneChip 430A: Six different biological samples were analyzed in duplicate: RNAs were from neonatal cortex and cerebellum, and from whole brain of 15.5 dpc embryos, purified ...
  9. Expression profiling of Ebf2- and Ebf2- stromal cells in mouse bone marrow BioProject

    ID: PRJNA223943

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ared to the Ebf2+ cells. These include Nov, Fmod, Ndn, Dcn, Ctgf, Angiopoietin like-1(Angptl1), Fn1 and Jag1, some of which has been reported to be expressed in culture-selected MSCs. Furthermore, consistent with antigen expression analysis by FACS, the Ebf2+ cells highly expressed transcripts of Pdgfra, Pdgfrb, Sca1/Ly6a, Thy1 and Itga7 and Itgav, that have been suggested to be linked to MSCs. Nestin was mainly expressed in the Ebf2+ cells whereas it was hardly detectable in the Ebf2- cells. Altogether, molecularly, the Ebf2...
  10. Gene-Expression Profiles in IRS Knockout Brown Preadipocytes BioProject

    ID: PRJNA92167

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cordant changes in brown adipose tissue in vivo. Necdin was markedly increased in IRS-1 KO cells that could not differentiate, and knockdown of necdin restored brown adipogenesis with down-regulation of Pref-1 and Wnt10a expression. We demonstrated a necdin-E2F4 interaction repressing PPARg transcription. IRS proteins regulated necdin via a CREB dependent pathway, defining a signalling network involved in brown preadipocyte determination. Keywords = brown fat Keywords = preadipocyte Keywords = adipogenesis Keywords = mouse Keywords: parallel sample...
  11. Necdin, a Negative Growth Regulator, is a Novel STAT3 Target Gene Down-Regulated in Human Cancer BioProject

    ID: PRJNA128649

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. 670 Retina

    Biological Entity: Amacrine cell

    Molecular Entity: Ndn


Displaying 20 of 32 results for "NDN"