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Displaying 94 of 94 results for "MYL9"
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  1. MLRM_CHICK UniProt:Swiss-Prot

    ID: P02612

    Description: Removed Myosin regulatory light chain 2, smooth

  2. EM structure of the heavy meromyosin subfragment of Chick smooth muscle Myosin with regulatory light chain in phosphorylated state PDB

    ID: PDB:3J04

    Description: Myosin-11, Myosin regulatory light chain 2

  3. MLRN_CHICK UniProt:Swiss-Prot

    ID: P24032

    Description: Removed Myosin regulatory light chain 2, smooth

  4. Yersinia enterocolitica LC20 : Yersinia enterocolitica LC20 Genome sequencing BioProject

    ID: PRJNA233451

    Keywords: genome sequencing

    Access Type: download

  5. MYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis BioProject

    ID: PRJNA136129

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. MYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis ArrayExpress

    ID: E-GEOD-26721

    Description: d metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. MYBPH inhibits assembly compete...

  7. Mus musculus strain:129 : microRNA-1 Regulates Sarcomere Formation and Suppresses Smooth Muscle Gene Expression in the Mammalian Heart BioProject

    ID: PRJNA219345

    Keywords: transcriptome

    Access Type: download

  8. MicroRNA expression in the glomerulus of C57BL/6 mice and B6.MRLc1 glomerulonephritis mice BioProject

    ID: PRJNA221629

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. E HEAVY MEROMYOSIN SUBFRAGMENT OF CHICKEN GIZZARD SMOOTH MUSCLE MYOSIN WITH REGULATORY LIGHT CHAIN IN THE DEP... PDB

    ID: PDB:1I84

    Description: SMOOTH MUSCLE MYOSIN HEAVY CHAIN/SMOOTH

  10. MicroRNA expression in the glomerulus of C57BL/6 mice and B6.MRLc1 glomerulonephritis mice ArrayExpress

    ID: E-GEOD-51209

    Description: expression was analyzed in healthy C57BL/6 and B6.MRLc1 glomerulonephritis mice. The expression of 1,135 miRNAs was examined, and up-regulated or down-regulated miRNA was determined. These results provide a basical information of molecular patholog...

  11. Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin PDB

    ID: PDB:3TS5

    Description: Myosin heavy chain, Myosin regulatory light

  12. MLR_SPISA UniProt:Swiss-Prot

    ID: P08051

    Description: Myosin regulatory light chain, smooth muscle

  13. MLRV_RABIT UniProt:Swiss-Prot

    ID: Q7M2V4

    Description: Removed Myosin regulatory light chain 2, ventricular/cardiac

  14. Phosphorylated Light Chain Domain of Scallop smooth Muscle Myosin PDB

    ID: PDB:3TUY

    Description: Myosin heavy chain, Myosin regulatory light

  15. Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation PDB

    ID: PDB:3JTD

    Description: Myosin heavy chain, striated muscle, Myosin regulatory ...

  16. Crystal structure of squid MG.ADP myosin S1 PDB

    ID: PDB:3I5F

    Description: Myosin heavy chain isoform A, Myosin regulatory

  17. Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP PDB

    ID: PDB:3DTP

    Description: Myosin-11, Myosin-7, Myosin light polypeptide 6, Myosin...

  18. MLR1_SCHPO UniProt:Swiss-Prot

    ID: Q9UUG5

    Description: Myosin regulatory light chain 1 EF-hand 1

  19. MLR_PHYPO UniProt:Swiss-Prot

    ID: P08053

    Description: Myosin regulatory light chain EF-hand 1 EF-hand

  20. MLRC_MIZYE UniProt:Swiss-Prot

    ID: P05944

    Description: Myosin regulatory light chain, striated adductor muscle...

  21. MLR_PATSP UniProt:Swiss-Prot

    ID: P02613

    Description: Myosin regulatory light chain EF-hand 1 EF-hand

  22. MLR4_SCHPO UniProt:Swiss-Prot

    ID: Q09196

    Description: Myosin regulatory light chain cdc4 EF-hand 1 EF-hand

  23. MLRB_MIZYE UniProt:Swiss-Prot

    ID: P04112

    Description: Myosin regulatory light chain B, smooth adductor

  24. MLRV_BOVIN UniProt:Swiss-Prot

    ID: Q3SZE5

    Description: Removed Myosin regulatory light chain 2, ventricular/cardiac

  25. MLRS_BOVIN UniProt:Swiss-Prot

    ID: Q0P571

    Description: Removed Myosin regulatory light chain 2, skeletal

  26. MLRB_CHICK UniProt:Swiss-Prot

    ID: P02611

    Description: Removed Myosin regulatory light chain 2B, cardiac muscle

  27. MLRS_RABIT UniProt:Swiss-Prot

    ID: P02608

    Description: Removed Myosin regulatory light chain 2, skeletal

  28. MLR_ARGIR UniProt:Swiss-Prot

    ID: P13543

    Description: Removed Myosin regulatory light chain, striated adductor muscle...

  29. MLRA_CHICK UniProt:Swiss-Prot

    ID: P02610

    Description: Removed Myosin regulatory light chain 2A, cardiac muscle

  30. MLRS_RAT UniProt:Swiss-Prot

    ID: P04466

    Description: Removed Myosin regulatory light chain 2, skeletal

  31. MLRS_MOUSE UniProt:Swiss-Prot

    ID: P97457

    Description: Removed Myosin regulatory light chain 2, skeletal

  32. MLR_TODPA UniProt:Swiss-Prot

    ID: P08052

    Description: Myosin regulatory light chain LC-2, mantle

  33. MLRA_MIZYE UniProt:Swiss-Prot

    ID: P04113

    Description: Myosin regulatory light chain A, smooth adductor

  34. MLR_HALRO UniProt:Swiss-Prot

    ID: P07461

    Description: Myosin regulatory light chain, smooth muscle

  35. MLR_CHLNI UniProt:Swiss-Prot

    ID: P05963

    Description: Myosin regulatory light chain, striated adductor muscle...

  36. MRLCA_RAT UniProt:Swiss-Prot

    ID: P13832

    Description: Myosin regulatory light chain RLC-A EF-hand 1 EF-hand <...

  37. ML12B_BOVIN UniProt:Swiss-Prot

    ID: A4IF97

    Description: Myosin regulatory light chain 12B EF-hand 1 EF-hand

  38. MLRH_CAEEL UniProt:Swiss-Prot

    ID: Q09510

    Description: Myosin regulatory light chain EF-hand 1 EF-hand

  39. MLR2_CAEEL UniProt:Swiss-Prot

    ID: P19626

    Description: Myosin regulatory light chain 2 EF-hand 1

  40. ML12A_PONAB UniProt:Swiss-Prot

    ID: Q5RC34

    Description: Myosin regulatory light chain 12A EF-hand 1 EF-hand

  41. SCALLOP MYOSIN S1-ATPgammaS-p-PDM IN THE ACTIN-DETACHED CONFORMATION PDB

    ID: PDB:1KWO

    Description: MYOSIN HEAVY CHAIN/MYOSIN REGULATORY LIGHT

  42. Structure of nucleotide-free scallop myosin S1 PDB

    ID: PDB:1SR6

    Description: Myosin heavy chain, striated muscle, Myosin regulatory ...

  43. The crystal structure of rigor like squid myosin S1 in the absence of nucleotide PDB

    ID: PDB:3I5H

    Description: Myosin heavy chain isoform A, Myosin regulatory

  44. The crystal structure of squid myosin S1 in the presence of SO4 2- PDB

    ID: PDB:3I5I

    Description: Myosin heavy chain isoform A, Myosin regulatory

  45. SCALLOP MYOSIN S1-AMPPNP IN THE ACTIN-DETACHED CONFORMATION PDB

    ID: PDB:1KQM

    Description: MYOSIN HEAVY CHAIN/MYOSIN REGULATORY LIGHT

  46. Structure of Scallop myosin S1 reveals a novel nucleotide conformation PDB

    ID: PDB:1S5G

    Description: Myosin heavy chain, striated muscle, Myosin regulatory ...

  47. Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor PDB

    ID: PDB:2OTG

    Description: Myosin heavy chain, Myosin regulatory light

  48. Visualizing new hinges and a potential major source of compliance in the lever arm of myosin PDB

    ID: PDB:3PN7

    Description: Myosin heavy chain, Myosin regulatory light

  49. SCALLOP MYOSIN S1-ADP-p-PDM IN THE ACTIN-DETACHED CONFORMATION PDB

    ID: PDB:1L2O

    Description: MYOSIN HEAVY CHAIN/MYOSIN REGULATORY LIGHT

  50. Crystal structure of rigor-like squid myosin S1 PDB

    ID: PDB:3I5G

    Description: Myosin heavy chain isoform A, Myosin regulatory

  51. ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE PDB

    ID: PDB:2W4T

    Description: MYOSIN HEAVY CHAIN, STRIATED MUSCLE, MYOSIN REGULATORY ...

  52. Placopecten Striated Muscle Myosin II PDB

    ID: PDB:2EC6

    Description: Myosin heavy chain, Myosin regulatory light

  53. PHYSARUM POLYCEPHALUM MYOSIN II REGULATORY DOMAIN PDB

    ID: PDB:2BL0

    Description: MAJOR PLASMODIAL MYOSIN HEAVY CHAIN (E.C.3.6.1.32), MYOSIN REGULATORY LIGHT

  54. Heavy meromyosin from Schistosoma mansoni muscle thick filament by negative stain EM PDB

    ID: PDB:3JAX

    Description: myosin 2 heavy chain, smooth muscle myosin

  55. MYL10_HUMAN UniProt:Swiss-Prot

    ID: Q9BUA6

    Description: Myosin regulatory light chain 10 EF-hand 1 EF-hand

  56. Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step PDB

    ID: PDB:2W4V

    Description: MYOSIN HEAVY CHAIN, STRIATED MUSCLE, MYOSIN REGULATORY ...

  57. Isometrically contracting insect asynchronous flight muscle quick frozen after a quick stretch step PDB

    ID: PDB:2W4W

    Description: MYOSIN HEAVY CHAIN, STRIATED MUSCLE, MYOSIN REGULATORY ...

  58. ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE PDB

    ID: PDB:2W4A

    Description: MYOSIN REGULATORY LIGHT CHAIN 2, SKELETAL

  59. Crystal structure of scallop myosin S1 in the pre-power stroke state to 2.6 Angstrom resolution: flexibility and function in the head PDB

    ID: PDB:1QVI

    Description: Myosin heavy chain, striated muscle, Myosin regulatory ...

  60. TWO HEAVY MEROMYOSIN INTERACTING-HEADS MOTIFS FLEXIBLE DOCKED INTO TARANTULA THICK FILAMENT 3D-MAP ALLOWS IN DEPTH STUDY OF INTRA- AND INTERMOLECULAR ... PDB

    ID: PDB:3JBH

    Description: MYOSIN 2 HEAVY CHAIN STRIATED MUSCLE, MYOSIN <

  61. HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOL... PDB

    ID: PDB:5TBY

    Description: Myosin-7, Myosin light chain 3, Myosin

  62. ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP PDB

    ID: PDB:2W4G

    Description: MYOSIN REGULATORY LIGHT CHAIN 2, SKELETAL

  63. ROCK induced transcriptional changes in mouse pancreatic ductal adenocarcinoma cells. : The effect of conditional activation of ROCK1 or ROCK2 in mous... BioProject

    ID: PRJEB14486

    Keywords: Other

    Access Type: download

    dataset.description: rough phosphorylation of substrates including the myosin regulatory light chain 2 (MLC2), myosin-binding subunit of the MLC phosphatase (MYPT1) and LIM kinases 1&2 (Rath and Olson 2012, Julian and Olson 2014). In addition to direct effects on the organization and dynamics of the actin cytoskeleton that impact cell morphology, ROCK-mediated cell contractility also affects gene transcription (Sanz-Moreno et al. 2011). How ROCK-mediated actomyosin contractility might contribute to pancreatic cancer by altering gene expression h...
  64. Mus musculus : Mus musculus Raw sequence reads BioProject

    ID: PRJNA327913

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: rough phosphorylation of substrates including the myosin regulatory light chain 2 (MLC2), myosin-binding subunit of the MLC phosphatase (MYPT1) and LIM kinases 1&2 (Rath and Olson 2012, Julian and Olson 2014). In addition to direct effects on the organization and dynamics of the actin cytoskeleton that impact cell morphology, ROCK-mediated cell contractility also affects gene transcription (Sanz-Moreno et al. 2011). How ROCK-mediated actomyosin contractility might contribute to pancreatic cancer by altering gene expressi...
  65. The structure of rabbit skeletal muscle actomyosin rigor complex at 5.2 angstrom. PDB

    ID: PDB:5H53

    Description: Skeletal muscle myosin heavy chain MyHC-EO/IIL, Myosin regulatory

  66. Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle PDB

    ID: PDB:1M8Q

    Description: Chicken Skeletal muscle Myosin II, Chicken Skeletal muscle Myosin II Regulatory

  67. Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step PDB

    ID: PDB:2W4H

    Description: MYOSIN REGULATORY LIGHT CHAIN 2, SKELETAL

  68. Calcium-bound Scallop Myosin Regulatory Domain (Lever Arm) with Reconstituted Complete Light Chains PDB

    ID: PDB:3JVT

    Description: Calcium-free Scallop Myosin Regulatory Domain with ELC-D19A Point Mutation

  69. MLR_LUMTE UniProt:Swiss-Prot

    ID: P80164

    Description: Myosin regulatory light chain, striated muscle, 25 kDa ...

  70. MYOSIN DIGESTED BY PAPAIN PDB

    ID: PDB:1B7T

    Description: myosin heavy, regulatory light and essential light chains

  71. MLRT_RABIT UniProt:Swiss-Prot

    ID: P24732

    Description: Removed Myosin regulatory light chain 2, skeletal

  72. Crystal structure of an MMP twin carboxylate based inhibitor LC20 in complex with the MMP-9 catalytic domain PDB

    ID: PDB:4HMA

    Description: Matrix metalloproteinase-9 (E.C.3.4.24.35)

  73. Solution structure of coiled coil domain of myosin binding subunit of myosin light chain phosphatase PDB

    ID: PDB:5HUZ

    Description: Protein phosphatase 1 regulatory subunit 12A

  74. MYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis OmicsDI

    ID: E-GEOD-26721

    Date Released: 05-04-2014

    Description: d metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. MYBPH inhibits assembly compete...

  75. mMLCK-/- animals treated with SB/VILI reveals non muscle myosin light chain kinase isoform is an attractive molecular target in acute inflammatory lung ... ArrayExpress

    ID: E-GEOD-14525

    Description: or studies have highlighted the role of nonmuscle myosin light chain kinase (nmMLCK) as an essential element of inflammatory response with MYLK polymorphisms associated withwhich alters ALI susceptibility. In the present study we sought to further define nmMLCK in acute inflammatory syndromes and examined We examined nmMLCK as a molecular target involved in incre...

  76. Cell Image Library Dataset CIL:11992 CIL

    ID: 11992

    Description: TIRF time lapse of mCherry-tubulin (left), myosin-GFP (middle), and overlay (myosin in green and tubulin in red; right) in a cell with a monopolar spindle ...

    Data Types: image

  77. Downregulation of CK2-Beta is sufficient to drive epithelial-to-mesenchymal transition through Snail 1 induction ArrayExpress

    ID: E-GEOD-28569

    Description: ated genes, several mesenchymal genes (CDH2, FN1, MYL9, VIM) were upregulated, whereas epithelial genes such as CDH1, CDH3, CLDN1, CLDN7, OCLN, KRT5, KRT6B, COL2A1 and MUC1, were inversely turned down. The expression of the EMT-inducing transcription factors, Snail and Zeb, was also significantly up-regulated in accordance with the repression of their known target genes. While showing similar phenotypes, the genetic program of TGFβ1-treated or CK2β-depleted MCF10A cells also exhibited distinct features. These results highlight that in addition to TGFβ1-regulated genes, CK2β-depletion may affect alternative pathways. The microarray analysis was performed with RNAs isolated from parental MCF10A cells and the following MCF10A-derived cells: ΔCK2β- and TGFβ1-treated cells (2ng/ml for 72h) and each from two independent cell cultures (duplicates)....

  78. Cell Image Library Dataset CIL:11984 CIL

    ID: 11984

    Description: Time lapse of myosin GFP (left, imaged by TIRF microscopy) and mCherry tubulin (middle, imaged by epifluorescence; the spindle is close to the co...

    Data Types: image

  79. MicroRNA expression in the glomerulus of C57BL/6 mice and B6.MRLc1 glomerulonephritis mice OmicsDI

    ID: E-GEOD-51209

    Date Released: 10-04-2014

    Description: expression was analyzed in healthy C57BL/6 and B6.MRLc1 glomerulonephritis mice. The expression of 1,135 miRNAs was examined, and up-regulated or down-regulated miRNA was determined. These results provide a basical information of molecular patholog...

  80. Transcriptomics changes in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate ArrayExpress

    ID: E-GEOD-50215

    Description: ntal toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing their translation. Many studies have shown an essential role of miRNAs in regulation of gene expression during development and ESC differentiation. Thus, neural differentiation of ESC in vitro allows investigating the role of miRNAs ...

  81. Whole Adult Organism Transcriptional Profiling of Metal Exposures in Zebrafish ArrayExpress

    ID: E-GEOD-50648

    Description: ntrations corresponding to their respective 96 hr LC20, LC40 and LC60. Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal. Comparative analysis identified subsets of differentially expressed transcripts both overlapping and unique to each metal. Application of gene ontology (GO) and transcription factor enrichment algorithms revealed a number of key biological processes perturbed by metal exposures and the master transcriptional regulators mediating gene expression changes. Metal exposures differentially activated biological processes associated with ribosome biogenesis, proteosomal degradation and p53 signaling cascades, while repressing oxygen-generating pathways associated with amino acid and lipid metabolism. Despite appreciable effects on gene reg...

  82. miRNA expression profiling in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate and sodium arsenite ArrayExpress

    ID: E-GEOD-50216

    Description: ntal toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing their translation. Many studies have shown an essential role of miRNAs in regulation of gene expression during development and ESC differentiation. Thus, neural differentiation of ESC in vitro allows investigating the role of miRNAs ...

  83. Gene expression regulating the onset of heat-induced intratesticular calcification ArrayExpress

    ID: E-GEOD-53139

    Description: 6 and C57BL/6-background congenic mouse strain B6.MRLc1-(D1Mit202–D1Mit403) carrying the telomeric region of MRL-type Chr 1 (67.97–81.63 cM) at 10 days after a single scrotal heat stress of 43°C for 20 min. Heat-induced ...

  84. Cell Image Library Dataset CIL:25843 CIL

    ID: 25843

    Description: sing CCM1 medium. This movie corresponds to Fig. 1 C. and Video 1 from J Cell Biol 2011 193:381-396....

    Data Types: image

  85. Gene expression regulating the onset of heat-induced intratesticular calcification. BioProject

    ID: PRJNA230974

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 6 and C57BL/6-background congenic mouse strain B6.MRLc1-(D1Mit202–D1Mit403) carrying the telomeric region of MRL-type Chr 1 (67.97–81.63 cM) at 10 days after a single scrotal heat stress of 43°C for 20 min. Overall desig...
  86. Gene expression regulating the onset of heat-induced intratesticular calcification. OmicsDI

    ID: E-GEOD-53139

    Date Released: 08-10-2014

    Description: 6 and C57BL/6-background congenic mouse strain B6.MRLc1-(D1Mit202–D1Mit403) carrying the telomeric region of MRL-type Chr 1 (67.97–81.63 cM) at 10 days after a single scrotal heat stress of 43°C for 20 min. Heat-induced ...

  87. Downregulation of CK2-Beta is sufficient to drive epithelial-to-mesenchymal transition through Snail 1 induction BioProject

    ID: PRJNA139141

    Keywords: Transcriptome or Gene expression

    Access Type: download

  88. Downregulation of CK2-Beta is sufficient to drive epithelial-to-mesenchymal transition through Snail 1 induction OmicsDI

    ID: E-GEOD-28569

    Date Released: 05-03-2014

    Description: ated genes, several mesenchymal genes (CDH2, FN1, MYL9, VIM) were upregulated, whereas epithelial genes such as CDH1, CDH3, CLDN1, CLDN7, OCLN, KRT5, KRT6B, COL2A1 and MUC1, were inversely turned down. The expression of the EMT-inducing transcription factors, Snail and Zeb, was also significantly up-regulated in accordance with the repression of their known target genes. While showing similar phenotypes, the genetic program of TGFβ1-treated or CK2β-depleted MCF10A cells also exhibited distinct features. These results highlight that in addition to TGFβ1-regulated genes, CK2β-depletion may affect alternative pathways. The microarray analysis was performed with RNAs isolated from parental MCF10A cells and the following MCF10A-derived cells: ΔCK2β- and TGFβ1-treated cells (2ng/ml for 72h) and each from two independent cell cultures (duplicates)....

  89. Genome-wide transcriptional analysis of HT1080 cells stably transfected with PTK7 constructs ArrayExpress

    ID: E-GEOD-53340

    Description: egulated by proteolysis. Ubiquitous membrane type-1 matrix metalloproteinase (MT1-MMP), arguably the primary enzyme in pericellular proteolysis and cancer cell migration, cleaves the PKP621↓LI sequence in the seventh Ig-like domain of membrane PTK7 and this cleavage results in the liberation of the N-terminal soluble PTK7 fragment (sPTK7). MT1-MMP proteolysis is followed by the cleavage of the C-terminal residual portion of PTK7 by ADAMs, including ADAM17. The ectodomain shedding is a prerequisite for the intramembrane cleavage of PTK7 by γ-secretase. This cleavage releases the C-terminal cytoplasmic tail fragment of PTK7, which is then either degraded by the proteasome or transported to the nucleus.The limited pre-existing data suggest that the full-length membrane PTK7 and its proteolytic products cause an opposing effect on the efficiency of cell migration. Thus, the continuing presence of the full-length membrane PTK7 on the plasma membrane down-regulated the myosin light chain (MLC) phosphorylation (a downstream event of the Wnt/PCP pathway) and, in agreement, reduced migration efficiency of fibrosarcoma HT1080 cells. MT1-MMP proteolysis of PTK7 reversed th...

  90. Whole Adult Organism Transcriptional Profiling of Metal Exposures in Zebrafish BioProject

    ID: PRJNA218201

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ntrations corresponding to their respective 96 hr LC20, LC40 and LC60. Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal. Comparative analysis identified subsets of differentially expressed transcripts both overlapping and unique to each metal. Application of gene ontology (GO) and transcription factor enrichment algorithms revealed a number of key biological processes perturbed by metal exposures and the master transcriptional regulators mediating gene expression changes. Metal exposures differentially activated biological processes associated with ribosome biogenesis, proteosomal degradation and p53 signaling cascades, while repressing oxygen-generating pathways associated with amino acid and lipid metabolism. Despite appreciable effects on gene reg...
  91. Genome-wide transcriptional analysis of HT1080 cells stably transfected with PTK7 constructs BioProject

    ID: PRJNA231748

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: egulated by proteolysis. Ubiquitous membrane type-1 matrix metalloproteinase (MT1-MMP), arguably the primary enzyme in pericellular proteolysis and cancer cell migration, cleaves the PKP621↓LI sequence in the seventh Ig-like domain of membrane PTK7 and this cleavage results in the liberation of the N-terminal soluble PTK7 fragment (sPTK7). MT1-MMP proteolysis is followed by the cleavage of the C-terminal residual portion of PTK7 by ADAMs, including ADAM17. The ectodomain shedding is a prerequisite for the intramembrane cleavage of PTK7 by γ-secretase. This cleavage releases the C-terminal cytoplasmic tail fragment of PTK7, which is then either degraded by the proteasome or transported to the nucleus.The limited pre-existing data suggest that the full-length membrane PTK7 and its proteolytic products cause an opposing effect on the efficiency of cell migration. Thus, the continuing presence of the full-length membrane PTK7 on the plasma membrane down-regulated the myosin light chain (MLC) phosphorylation (a downstream event of the Wnt/PCP pathway) and, in agreement, reduced migration efficiency of fibrosarcoma HT1080 cells. MT1-MMP proteolysis of PTK7 reversed th...
  92. Inducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression ArrayExpress

    ID: E-GEOD-12576

    Description: f PrPC. Down-regulation of the MEF2C gene, a key regulatory transcriptional factor muscle development and remodeling of adult muscles in response to physiologic and pathologic signals, may contribute to the centrally placed nuclei in the skeletal muscles. Significantly, up-regulation of genes involved in p53 signaling and the induction of p53 protein, suggest a central role for this molecule in the myopathy. Several p53-regulated genes involved in cell cycle arrest (CDNK1A, GADD45a and GADD45b) and apoptosis (BAK1, PMAIP1, BBC3, and BAX) are induced. We suggest that PrPC over-expression in skeletal muscles, possibly in response to accumulation of a cytotoxic truncated form of PrP, causes a primary myopathy involving the induction of p53-dependent pathways. Wild type (WT), PrP-null (KO), and Tg(HQK) mice were fed food pellets either lacking or containing 6g doxycycline (Dox)/kg food to induce PrPC expression. Skeletal muscles from the quadriceps of hind legs were removed a...

  93. Inducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression BioProject

    ID: PRJNA112625

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: f PrPC. Down-regulation of the MEF2C gene, a key regulatory transcriptional factor muscle development and remodeling of adult muscles in response to physiologic and pathologic signals, may contribute to the centrally placed nuclei in the skeletal muscles. Significantly, up-regulation of genes involved in p53 signaling and the induction of p53 protein, suggest a central role for this molecule in the myopathy. Several p53-regulated genes involved in cell cycle arrest (CDNK1A, GADD45a and GADD45b) and apoptosis (BAK1, PMAIP1, BBC3, and BAX) are induced. We suggest that PrPC over-expression in skeletal muscles, possibly in response to accumulation of a cytotoxic truncated form of PrP, causes a primary myopathy involving the induction of p53-dependent pathways. Overall design: Wild type (WT), PrP-null (KO), and Tg(HQK) mice were fed food pellets either lacking or containing 6g doxycycline (Dox)/kg food to induce PrPC expression. Skeletal muscles from the quadriceps of hind legs...
  94. Whole Adult Organism Transcriptional Profiling of Metal Exposures in Zebrafish OmicsDI

    ID: E-GEOD-50648

    Date Released: 06-14-2014

    Description: ntrations corresponding to their respective 96 hr LC20, LC40 and LC60. Histopathology was performed on a subset of metal-exposed zebrafish to phenotypically anchor transcriptional changes associated with each metal. Comparative analysis identified subsets of differentially expressed transcripts both overlapping and unique to each metal. Application of gene ontology (GO) and transcription factor enrichment algorithms revealed a number of key biological processes perturbed by metal exposures and the master transcriptional regulators mediating gene expression changes. Metal exposures differentially activated biological processes associated with ribosome biogenesis, proteosomal degradation and p53 signaling cascades, while repressing oxygen-generating pathways associated with amino acid and lipid metabolism. Despite appreciable effects on gene reg...


Displaying 94 of 94 results for "MYL9"