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Displaying 20 of 804 results for "MYB"
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  1. Berry skin development in Norton grape: Distinct patterns of transcriptional regulation and flavonoid biosynthesis BioProject

    ID: PRJNA132627

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Gene expression profile (GEP) of myb-silenced CD34+ HPCs OmicsDI

    ID: E-GEOD-60299

    Date Released: 08-19-2015

    Description: cision, we profiled the miRNA and mRNA changes in myb-silenced CD34+ HPCs. mRNA and miRNA expression for each sample were profiled by Affymetrix GeneAtlas U219 strip array and Exiqon Human miRNome PCR Panel, respectively. miRNA/mRNA data were integrated by Ingenuity Pathway Analysis. The integrative analysis of miRNA/mRNA expression changes upon c-myb silencing in human CD34+ HPCs highlighted a set of 19 miRNA with 150 anticorrelated putative target mRNAs. Among the miRNAs downregulated in myb-silenced progenitors with the highest number ...

  3. Human induced pluripotent stem cell-derived macrophages share ontogeny with MYB-independent tissue-resident macrophages BioProject

    ID: PRJNA360466

    Keywords: Variation

    Access Type: download

  4. Expression profiling by array in ATLL BioProject

    ID: PRJNA167098

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. miRNA expression profile (miEP) of myb-silenced CD34+ HPCs OmicsDI

    ID: E-GEOD-60300

    Date Released: 08-19-2015

    Description: cision, we profiled the miRNA and mRNA changes in myb-silenced CD34+ HPCs. mRNA and miRNA expression for each sample were profiled by Affymetrix GeneAtlas U219 strip array and Exiqon Human miRNome PCR Panel, respectively. miRNA/mRNA data were integrated by Ingenuity Pathway Analysis. The integrative analysis of miRNA/mRNA expression changes upon c-myb silencing in human CD34+ HPCs highlighted a set of 19 miRNA with 150 anticorrelated putative target mRNAs. Among the miRNAs downregulated in myb-silenced progenitors with the highest number ...

  6. Gene expression profiling of murine MLL leukemias (whole BM) BioProject

    ID: PRJNA114577

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. APOBEC Signature Mutation Forms an Oncogenic Enhancer Upstream of LMO1 in T-ALL BioProject

    ID: PRJNA369547

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ncer pathogenesis, while clarifying mechanisms of gene regulation and identifying new targets for therapeutic intervention. Here we report a C-­to-­T single nucleotide transition that occurs as a somatic mutation in noncoding sequences 4 kb upstream of the transcriptional start site of the LMO1 oncogene in primary samples from patients with T-­cell acute lymphoblastic leukaemia. This single nucleotide alteration conforms to an APOBEC-­like cytidine deaminase mutational signature, and generates a new binding site for the MYB transcription factor, leading to the fo...
  8. MicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation OmicsDI

    ID: E-GEOD-55033

    Date Released: 09-04-2015

    Description: maturation were expanded. Further, we identified Myb as a direct target of miR-15/16 in NK cells, with Myb expression increased in immature 15aKO NK cells. Following adoptive transfer, immature 15aKO NK cells exhibited defective maturation, which was rescued by ectopic miR-15/16 expression or Myb knockdown. Moreover, Myb overexpression resulted in defective NK cell maturation. Thus, miR-15/16 regulation of Myb controls the normal NK cell maturation program. 3 technical replicates each of CD27+ 15a/16-1FKO NK cells, and CD27+ Ctrl NK cells...

  9. MicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation ArrayExpress

    ID: E-GEOD-55033

    Description: maturation were expanded. Further, we identified Myb as a direct target of miR-15/16 in NK cells, with Myb expression increased in immature 15aKO NK cells. Following adoptive transfer, immature 15aKO NK cells exhibited defective maturation, which was rescued by ectopic miR-15/16 expression or Myb knockdown. Moreover, Myb overexpression resulted in defective NK cell maturation. Thus, miR-15/16 regulation of Myb controls the normal NK cell maturation program. 3 technical replicates each of CD27+ 15a/16-1FKO NK cells, and CD27+ Ctrl NK cells...

  10. Effect of HIV infection on co-stimulatory capacity of dendritic cells ArrayExpress

    ID: E-GEOD-21017

    Description: CD86 by DCs at the mRNA level irrespective of the viral subtype or the mode in DC-HIV interaction. The microarray experiments were performed to understand the changes in the transcription factor profile of HIV infected DCs which may in turn lead to reduced CD80/CD86 expression as well as the effect of HIV infection on other co-stimulatory molecules on DCs. The data suggests that TFs NFKB1, NFKB2, REL and MYB may be responsible for the observed ...

  11. CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3 PDB

    ID: PDB:1H8A

    Description: CAAT/ENHANCER BINDING PROTEIN BETA, MYB TRANSFORMING PROTEIN

  12. Affymetrix SNP 6.0 array data for gastric adenocarcinoma and some matched normals BioProject

    ID: PRJNA311521

    Keywords: Variation

    Access Type: download

    dataset.description: stric adenocarcinoma such as the tumor suppressor gene SMARCA4 and proto-oncogene MYB, and additionally refined the boundaries of known significant regions. We found only slight differences in the overall copy number patterns between Asian and Western gastric adenocarcinoma patients indicating that the disease is fundamentally similar in both populations and the divergent clinical outcomes cannot be ascribed to different underlying SCNAs. The 111 copy number profiles contained in this archive are the previously unpublished portion of our study. Overall design: Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from 78 cancer DNAs derived from primary tissues, as well as from DNA obtained from 37 normal ...
  13. ChIP-Seq of TAL1 and its regulatory partners in T-ALL cells ArrayExpress

    ID: E-GEOD-29180

    Description: and that the TAL1 complex directly activates the MYB oncogene, forming a feed-forward positive regulatory loop that further promotes the TAL1-regulated oncogenic program. one of the cirtical downstream targets in this circuitry is the TRIB2 gene, which is oppositely regulated by TAL1 and HEB/E2A, and is essential for the survival of T-ALL cells. Human T-ALL cells were cross-linked with formaldehyde for 20 min. DNA was enriched by chromatin immunoprecipitation (ChIP) and analyzed by Solexa sequencing. A sample of whole cell extract (WCE) was sequenced and used as the background to de...

  14. Solution Structure of Mouse Hypothetical Gene (2610100B20Rik) Product Homologous to Myb DNA-binding Domain PDB

    ID: PDB:1UG2

    Description: 2610100B20Rik gene product

  15. Transcriptome sequencing of K-562 cells BioProject

    ID: PRJNA336493

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTC... ArrayExpress

    ID: E-GEOD-34770

    Description: Histone modifcations and CTCF binding at the c-myb locus were compared in cell lines with c-myb expressing, which are m...

  17. Berry skin development in Norton grape: Distinct patterns of transcriptional regulation and flavonoid biosynthesis OmicsDI

    ID: E-GEOD-24561

    Date Released: 06-10-2011

    Description: acids in the ripening berries in comparison with V. vinifera varieties such as Cabernet Sauvignon. Furthermore, Norton berries develop a remarkably high level of resistance to most fungal pathogens while Cabernet Sauvignon berries remain susceptible to those pathogens. The distinct characteristics of Norton and Cabernet Sauvignon merit a comprehensive analysis of transcriptional regulation and metabolite pathways. Results: A microarray study was conducted on transcriptome changes of Norton berry ski...

  18. Gene expression profile (GEP) of miR-486-3p overexpressing CD34+ HPCs ArrayExpress

    ID: E-GEOD-60298

    Description: The transcription factor c-Myb plays a key role in human primary CD34+ hematopoietic progenitor cells (HPCs) lineage choice, by enhancing...

  19. MYB1_PHYPA UniProt:Swiss-Prot

    ID: P80074

    Description: Myb-related protein Pp1 HTH myb-type H-T-H motif

  20. Gene expression profile (GEP) of miR-486-3p overexpressing CD34+ HPCs BioProject

    ID: PRJNA257986

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 804 results for "MYB"