microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function OmicsDI

ID: E-GEOD-40708

Date Released: 09-26-2012

Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

Modulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b BioProject

ID: PRJNA170259

Keywords: Transcriptome or Gene expression

Access Type: download

microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function BioProject

ID: PRJNA174740

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice ArrayExpress

ID: E-GEOD-45789

Description: y and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneou...

microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function ArrayExpress

ID: E-GEOD-40708

Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] OmicsDI

ID: E-GEOD-45209

Date Released: 10-03-2013

Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] ArrayExpress

ID: E-GEOD-45209

Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] BioProject

ID: PRJNA193208

Keywords: Transcriptome or Gene expression

Access Type: download

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis. OmicsDI

ID: E-GEOD-63511

Date Released: 08-29-2015

Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis ArrayExpress

ID: E-GEOD-63511

Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis BioProject

ID: PRJNA268095

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA-profiling by high-throughput sequencing of colonic tissues from wild-type C57BL6/J mice with or without infection by Clost... ArrayExpress

ID: E-GEOD-39235

Description: h Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miRNA)-sequencing analysis indicated that miR-146b, miR-1940, and miR-1298 were significantly overexpressed in colons of C. difficile-infected mice Colon of uninfected and C.difficile-infected C57BL6/J WT mice were sampled at day 4 post-infection with Clostridium difficile VPI 1046...

MicroRNA-profiling by high-throughput sequencing of colonic tissues from wild-type C57BL6/J mice with or without infection by Clost... OmicsDI

ID: E-GEOD-39235

Date Released: 01-13-2015

Description: h Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miRNA)-sequencing analysis indicated that miR-146b, miR-1940, and miR-1298 were significantly overexpressed in colons of C. difficile-infected mice Colon of uninfected and C.difficile-infected C57BL6/J WT mice were sampled at day 4 post-infection with Clostridium difficile VPI 1046...

MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice OmicsDI

ID: E-GEOD-45789

Date Released: 05-13-2014

Description: y and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneou...

MicroRNA Profiling Analysis of Differences between the Melanoma of Young Adults and Older Adults BioProject

ID: PRJNA120857

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA transcriptome in weaning and sucking porcine intestines ArrayExpress

ID: E-GEOD-50500

Description: xpressed miRNAs were found between W4 and S4 (ssc-mir-146b had the largest difference and ssc-mir-215 had the highest expression level); and 22 differentially expressed miRNAs were found between W7 and S7. Sequencing miRNA results were validated using RT-qPCR. Approximately 12,819 miRNA-mRNA interactions corresponding to 4,250 target genes were predicted. The biological analyses revealed that the differentially expressed miRNAs regulated small intestinal metabolism, stressful responses, cellular and immune functions and miRNA biosynthesis in piglets. Therefore, the small intestine miRNA transcriptome was significantly different between weaning and suckling piglets; the difference varied with the number of days after weaning. six small RNA libraries from weaning piglets at 1, 4 and 7 d after weaning ...

MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice BioProject

ID: PRJNA196321

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA transcriptome in weaning and sucking porcine intestines BioProject

ID: PRJNA217780

Keywords: Transcriptome or Gene expression

Access Type: download

Altered microRNA expression and pre-mRNA splicing events reveal new mechanisms associated with early stage Mycobacterium avium subspecies p... BioProject

ID: PRJNA300273

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA profiling by array of 217 cases of chronic lymphocytic leukemia (CLL) comparing CLL-affected B-cells against normal B-cell... OmicsDI

ID: E-MTAB-1454

Date Released: 05-03-2014

Description: rentially expressed miRNAs in CLL, which included miR-193b, miR-33b*, miR-365, miR-181b and miR-196a/b among the down-regulated and miR-23a/b, miR-26a, miR-130a, miR-532 (5p and 3p) among the up-regulated miRNAs. We also investigated differences of miRNA expression related to the IGHV somatic mutation status and to deletions at 13q, 11q and 17p or trisomy 12. Little differences were detected between unmutated (UM) versus mutated (M) CLLs, although miR-29c, miR-29c* and miR-146b were st...