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Displaying 35 of 35 results for "MIR146B"
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  1. microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function OmicsDI

    ID: E-GEOD-40708

    Date Released: 09-26-2012

    Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

  2. Modulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b BioProject

    ID: PRJNA170259

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function BioProject

    ID: PRJNA174740

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice ArrayExpress

    ID: E-GEOD-45789

    Description: y and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneou...

  5. microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function ArrayExpress

    ID: E-GEOD-40708

    Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

  6. MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] OmicsDI

    ID: E-GEOD-45209

    Date Released: 10-03-2013

    Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

  7. MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] ArrayExpress

    ID: E-GEOD-45209

    Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

  8. MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] BioProject

    ID: PRJNA193208

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis. OmicsDI

    ID: E-GEOD-63511

    Date Released: 08-29-2015

    Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...

  10. The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis ArrayExpress

    ID: E-GEOD-63511

    Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...

  11. The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis BioProject

    ID: PRJNA268095

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. MicroRNA-profiling by high-throughput sequencing of colonic tissues from wild-type C57BL6/J mice with or without infection by Clost... ArrayExpress

    ID: E-GEOD-39235

    Description: h Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miRNA)-sequencing analysis indicated that miR-146b, miR-1940, and miR-1298 were significantly overexpressed in colons of C. difficile-infected mice Colon of uninfected and C.difficile-infected C57BL6/J WT mice were sampled at day 4 post-infection with Clostridium difficile VPI 1046...

  13. MicroRNA-profiling by high-throughput sequencing of colonic tissues from wild-type C57BL6/J mice with or without infection by Clost... OmicsDI

    ID: E-GEOD-39235

    Date Released: 01-13-2015

    Description: h Clostridium difficile strain VPI 10463 RESULTS: MicroRNA (miRNA)-sequencing analysis indicated that miR-146b, miR-1940, and miR-1298 were significantly overexpressed in colons of C. difficile-infected mice Colon of uninfected and C.difficile-infected C57BL6/J WT mice were sampled at day 4 post-infection with Clostridium difficile VPI 1046...

  14. MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice OmicsDI

    ID: E-GEOD-45789

    Date Released: 05-13-2014

    Description: y and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneou...

  15. MicroRNA Profiling Analysis of Differences between the Melanoma of Young Adults and Older Adults BioProject

    ID: PRJNA120857

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. MicroRNA transcriptome in weaning and sucking porcine intestines ArrayExpress

    ID: E-GEOD-50500

    Description: xpressed miRNAs were found between W4 and S4 (ssc-mir-146b had the largest difference and ssc-mir-215 had the highest expression level); and 22 differentially expressed miRNAs were found between W7 and S7. Sequencing miRNA results were validated using RT-qPCR. Approximately 12,819 miRNA-mRNA interactions corresponding to 4,250 target genes were predicted. The biological analyses revealed that the differentially expressed miRNAs regulated small intestinal metabolism, stressful responses, cellular and immune functions and miRNA biosynthesis in piglets. Therefore, the small intestine miRNA transcriptome was significantly different between weaning and suckling piglets; the difference varied with the number of days after weaning. six small RNA libraries from weaning piglets at 1, 4 and 7 d after weaning ...

  17. MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice BioProject

    ID: PRJNA196321

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. MicroRNA transcriptome in weaning and sucking porcine intestines BioProject

    ID: PRJNA217780

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. Altered microRNA expression and pre-mRNA splicing events reveal new mechanisms associated with early stage Mycobacterium avium subspecies p... BioProject

    ID: PRJNA300273

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. MicroRNA profiling by array of 217 cases of chronic lymphocytic leukemia (CLL) comparing CLL-affected B-cells against normal B-cell... OmicsDI

    ID: E-MTAB-1454

    Date Released: 05-03-2014

    Description: rentially expressed miRNAs in CLL, which included miR-193b, miR-33b*, miR-365, miR-181b and miR-196a/b among the down-regulated and miR-23a/b, miR-26a, miR-130a, miR-532 (5p and 3p) among the up-regulated miRNAs. We also investigated differences of miRNA expression related to the IGHV somatic mutation status and to deletions at 13q, 11q and 17p or trisomy 12. Little differences were detected between unmutated (UM) versus mutated (M) CLLs, although miR-29c, miR-29c* and miR-146b were st...

  21. PPARG and microRNA-146 in mucosal immune responses to C. difficile ImmPort

    ID: SDY100

    Description: een and colonic lamina propria of mice with CDAD. MicroRNA (miRNA)-sequencing analysis and RT-PCR validation indicated that miR-146b was significantly overexpressed in colons of C. difficile-infected mice. We next developed a computational model that predicts the upregulation of miR-146b, downregulation of the PPAR gamma co-activator NCOA4, and PPAR gamma, leading to upregulation of IL-17. Treatment of C. difficile-infected mice with the PPAR gamma agonist pioglitazone ameliorated colitis and suppressed pro-inflammatory gene expression. In conclusion, our data indicates that miRNA-146b and PPAR gamma may be implicated in the regulation of Th17 responses and colitis in C. difficile-infected mice....

  22. MicroRNA profiling by array of 217 cases of chronic lymphocytic leukemia (CLL) comparing CLL-affected B-cells against normal B-cell... ArrayExpress

    ID: E-MTAB-1454

    Description: rentially expressed miRNAs in CLL, which included miR-193b, miR-33b*, miR-365, miR-181b and miR-196a/b among the down-regulated and miR-23a/b, miR-26a, miR-130a, miR-532 (5p and 3p) among the up-regulated miRNAs. We also investigated differences of miRNA expression related to the IGHV somatic mutation status and to deletions at 13q, 11q and 17p or trisomy 12. Little differences were detected between unmutated (UM) versus mutated (M) CLLs, although miR-29c, miR-29c* and miR-146b were st...

  23. Aberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes BioProject

    ID: PRJNA124197

    Keywords: Transcriptome or Gene expression

    Access Type: download

  24. Human Corneal microRNA Expression Profile in Fungal Keratitis BioProject

    ID: PRJNA272148

    Keywords: Transcriptome or Gene expression

    Access Type: download

  25. MicroRNA transcriptome in weaning and sucking porcine intestines OmicsDI

    ID: E-GEOD-50500

    Date Released: 09-07-2014

    Description: xpressed miRNAs were found between W4 and S4 (ssc-mir-146b had the largest difference and ssc-mir-215 had the highest expression level); and 22 differentially expressed miRNAs were found between W7 and S7. Sequencing miRNA results were validated using RT-qPCR. Approximately 12,819 miRNA-mRNA interactions corresponding to 4,250 target genes were predicted. The biological analyses revealed that the differentially expressed miRNAs regulated small intestinal metabolism, stressful responses, cellular and immune functions and miRNA biosynthesis in piglets. Therefore, the small intestine miRNA transcriptome was significantly different between weaning and suckling piglets; the difference varied with the number of days after weaning. six small RNA libraries from weaning piglets at 1, 4 and 7 d after weaning ...

  26. Human Corneal microRNA Expression Profile in Fungal Keratitis OmicsDI

    ID: E-GEOD-64843

    Date Released: 07-28-2016

    Description: lect target genes were further analysed by Q-PCR. MiR-21-5p, miR-223-3p, miR-146b-5p, miR-155-5p, miR-511-5p were found to be involved in inflammatory and immune responses, regulating Toll like receptor signaling pathways, which is of particular interest. MiR-451a with an increased expression in keratitis may have a role in wound healing by targeting Macrophage Migration Inhibitory Factor (MIF). Further, we highlighted that Neurotrophin signaling pathway may play a role in wound healing process. One novel miRNA was also detected in cornea. In conclusion, several miRNAs with high expression in fungal keratitis corneas point towards their role in regulation of pathogenesis. Further insights in understanding miRNAs role in wound healing and inflammation may help design new therapeutic strategies. Control and fungal keratitis, human corneal miRNA profiles were generated using IlluminaHiseq1000 platform...

  27. New global miRSeq analysis of “miRNome”: the example of PTC and nodal metastases BioProject

    ID: PRJNA248083

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: urrence and mortality. In our study, we performed microRNA deep sequencing (miRSeq) of 3 PTC, their matching normal tissues and nodal metastases and designed a new bioinformatic framework to analyze variations of the different aspects of the miRNome: expression profile, isomiRs and non-templated additions distributions, mutation or A-to-I RNA-editing. Furthermore, we validated our results using qRT-PCR on independent samples from 14 patients and using the collection of miRSeq data from The Cancer Geno...
  28. MicroRNA analysis of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhance... BioProject

    ID: PRJNA253809

    Keywords: Transcriptome or Gene expression

    Access Type: download

  29. miRNA expression profiling in liver of juvenile and egg-laying hens BioProject

    ID: PRJNA299589

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ) in egg-laying physiological stage. Among these, miR-22-3p has the highest abundant expression, and miR-146b-5p has the highest fold-change. Additionally, 19 of the 71 novel miRNAs was significantly expressed. Furthermore, 648 putative target genes of the SDE miRNAs were obtained, and among these, FADS1, FADS2, ELOVL6, ACSL5, etc which are lipid metabolism related critical regulators are targeted by some SDE miRNAs. Gene Ontology (GO) analyses to the putative target genes of all the SDE miRNAs...
  30. Human Corneal microRNA Expression Profile in Fungal Keratitis ArrayExpress

    ID: E-GEOD-64843

    Description: lect target genes were further analysed by Q-PCR. MiR-21-5p, miR-223-3p, miR-146b-5p, miR-155-5p, miR-511-5p were found to be involved in inflammatory and immune responses, regulating Toll like receptor signaling pathways, which is of particular interest. MiR-451a with an increased expression in keratitis may have a role in wound healing by targeting Macrophage Migration Inhibitory Factor (MIF). Further, we highlighted that Neurotrophin signaling pathway may play a role in wound healing process. One novel miRNA was also detected in cornea. In conclusion, several miRNAs with high expression in fungal keratitis corneas point towards their role in regulation of pathogenesis. Further insights in understanding miRNAs role in wound healing and inflammation may help design new therapeutic strategies. Control and fungal keratitis, human corneal miRNA profiles were generated using IlluminaHiseq1000 platform...

  31. Paired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients ArrayExpress

    ID: E-GEOD-13937

    Description: enrolled in 3 distinct cohorts. In ADC patients, miR-21, miR-194, miR-293, and miR-223 expression was elevated, while miR-375 and miR-203 expression was reduced in cancerous tissue compared to non-cancerous tissue. Increased levels of miR-192 and miR-194 were observed in Barrett’s associated compared to sporadic ADC cancerous tissue. In SCC patients, miR-21, miR-181b, miR-155, and miR-146b expression was elevated while miR

  32. Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study OmicsDI

    ID: E-GEOD-54213

    Date Released: 06-03-2014

    Description: compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion, despite a serious drawback attributed to the small sample size, we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by μG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis, Inc., HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated, feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41, EA 47, EA45, and EA155 that were exposed to LPS for 4 hours. Samples EA123, EA165, EA127, EA126 were exposed to LPS for 8Hrs. Samples EA33, EA 125, EA79 and EA 39 were controls in this experiment....

  33. Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study ArrayExpress

    ID: E-GEOD-54213

    Description: compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion, despite a serious drawback attributed to the small sample size, we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by μG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis, Inc., HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated, feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41, EA 47, EA45, and EA155 that were exposed to LPS for 4 hours. Samples EA123, EA165, EA127, EA126 were exposed to LPS for 8Hrs. Samples EA33, EA 125, EA79 and EA 39 were controls in this experiment....

  34. Homo sapiens : High-throughput analysis of miRNA expression profile in Hepatocellular Carcinoma using Next Generation Sequencing BioProject

    ID: PRJDB2795

    Keywords: Other

    Access Type: download

    dataset.description: was alsoestablished by microarray (Agilent human microRNA microarray Rel 14.0) andmicroarray data was analyzed by GeneSpring GX10.0.2 (Agilent).Results:The average of total sequencing reads was over 2.2 million and thesequencing reads that were mapped on human genome sequence, wasapproximately 57%. Using 10 HCC templates, the correlation of miRNAsexpressions between NGS and microarray was examined. The averagecorrelation logarithmic index of miRNA expressions was 0.613. Thesubtraction of correlation logarithmic index in miRNA expression level was0.587. As a result of investigating the same sample plural times, thereproducibility miRNA expressions was 0.976. The expression level of 8miRNAs (miR-10a-5p, miR-122-5p, miR-146b-5p, miR-148a-3p, miR-192-5p,miR-22-3p, miR-26a-5p, and miR-27b-3p) in non-tumor tissue was higher thanthat in HCC (p<0.05). The e...
  35. Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study BioProject

    ID: PRJNA237328

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion, despite a serious drawback attributed to the small sample size, we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by μG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. Overall design: We identified the CCM of Tissue Genesis, Inc., HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated, feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41, EA 47, EA45, and EA155 that were exposed to LPS for 4 hours. Samples EA123, EA165, EA127, EA126 were exposed to LPS for 8Hrs. Samples EA33, EA 125, EA79 and EA 39 were controls in this experiment....

Displaying 35 of 35 results for "MIR146B"