microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function OmicsDI

ID: E-GEOD-40708

Date Released: 09-26-2012

Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

Modulation of mucosal immune responses to Clostridium difficile by peroxisome proliferator-activated receptor γ and microRNA-146b BioProject

ID: PRJNA170259

Keywords: Transcriptome or Gene expression

Access Type: download

microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function BioProject

ID: PRJNA174740

Keywords: Transcriptome or Gene expression

Access Type: download

MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice ArrayExpress

ID: E-GEOD-45789

Description: y and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneou...

microRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function ArrayExpress

ID: E-GEOD-40708

Description: ear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] OmicsDI

ID: E-GEOD-45209

Date Released: 10-03-2013

Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] ArrayExpress

ID: E-GEOD-45209

Description: an in vivo system to investigate the role of the microRNA-146 family (consisting of 2 members miR-146a and miR-146b) in the innate immune response to S...

MicroRNA-146 function in the innate immune response of zebrafish embryos to Salmonella typhimurium infection [RNA-seq] BioProject

ID: PRJNA193208

Keywords: Transcriptome or Gene expression

Access Type: download

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis. OmicsDI

ID: E-GEOD-63511

Date Released: 08-29-2015

Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells During Carcinogenesis ArrayExpress

ID: E-GEOD-63511

Description: PTC. The integrated analyses identified a master microRNA regulatory network in PTC that is involved in essential biological processes such as thyroid differentiation. As both mature products of miR-146b (miR-146b-5p and -3p) were among the most abundant upregulated in tumors, we unveil their target genes and found that miR-146b-3p specifically binds to the 3`UTR of PAX8 and NIS, leading to an impaired translation of the proteins and subsequently decreasing the iodide uptake of the cells. Furthermore, we show that mir-146b and PAX8 regulate each other, describing a novel regulatory circuit that determines the differentiated phenotype of PTC. In conclusion, our integrative genomic analysis uncovers the target genes of two of the most upregulated miRNAs and highlights the importanc...