MDM2 | bioCADDIE Data Discovery Index
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Displaying 20 of 639 results for "MDM2"
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  1. Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a MDM2 peptide PDB

    ID: PDB:2F1Y

    Description: HAUSP/USP7

  2. XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53 PDB

    ID: PDB:1YCQ

    Description: MDM2, P53

  3. Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument PDB

    ID: PDB:5LN2

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  4. The 1.25A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5045331 PDB

    ID: PDB:4J7D

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  5. The 1.9A crystal structure of humanized Xenopus Mdm2 with nutlin-3a PDB

    ID: PDB:4J3E

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  6. MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3 BioProject

    ID: PRJNA324547

    Keywords: Other

    Access Type: download

  7. crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553) PDB

    ID: PDB:4ERF

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  8. tional file 4: Table S4. of MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk... Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3683116_D3

    Release Date: 02-04-2017

    Description: Raw data; genotypes for all individuals in study. (XLSX 118 kb)

  9. co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-ME... PDB

    ID: PDB:4QO4

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  10. Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction PDB

    ID: PDB:4OQ3

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  11. Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihyd... PDB

    ID: PDB:4JVR

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  12. MDM2_HORSE UniProt:Swiss-Prot

    ID: P56951

    Description: E3 ubiquitin-protein ligase Mdm2 SWIB RanBP2-type RING-...

  13. Transcription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2 ArrayExpress

    ID: E-MTAB-5441

    Description: mcm), and carry loxP-flanked sequences of p53 and Mdm2 was performed in the presence and absence of Tamoxifen.The molecular mechanisms underlying heart failure remain poorly understood. As such, identifying the factors which effectively maintain cardiac tissue homeostasis is of great scientific and clinical import...

  14. crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-... PDB

    ID: PDB:4QOC

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  15. Transcription profiling by array of Mdm2 knock out mice ArrayExpress

    ID: E-MEXP-1431

    Description: Analyzed gene expression in 3-day old mice lacking Mdm2 in the intestine

  16. mRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification OmicsDI

    ID: E-GEOD-74755

    Date Released: 12-01-2015

    Description: es have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity via either chemical inhibitor or genetic ablation enhanced VC. HDAC1 protein, but not mRNA, was reduced in cell and animal calcification models and in human calcif...

  17. Effect of wtp53-reactivating drug RITA on HCT116 cells ArrayExpress

    ID: E-GEOD-11578

    Description: 3, its function is inactivated due to deregulated HDM2, a protein which binds to p53 and which can inhibit the transcriptional activity of p53 and induce its degradation. RITA is a low-molecular-weight compound which addresses the second group of tumours retaining functionally reactive wt p53. It was found in a screening of the National Cancer Institute (NCI) library of low-molecular-weight compounds based on its ability to selectively kill wtp53-containing cells. RITA binds directly to p53 and diplaces its main destructor Mdm2...

  18. hot springs metagenome : Hot spring sediment microbial communities from Dewar Creek, Canada - MDM2.DC4.SYBR.5.G17.S2R-29 metagenome BioProject

    ID: PRJNA364526

    Keywords: metagenome

    Access Type: download

  19. hot springs metagenome : Hot spring sediment microbial communities from Dewar Creek, Canada - MDM2.DC4.SYBR.5.J19.Thermotogae metagenome BioProject

    ID: PRJNA364534

    Keywords: metagenome

    Access Type: download

  20. hot springs metagenome : Hot spring sediment microbial communities from Dewar Creek, Canada - MDM2.DC4.SYBR.5.J14.16S negative metagenome BioProject

    ID: PRJNA364514

    Keywords: metagenome

    Access Type: download


Displaying 20 of 639 results for "MDM2"