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Displaying 20 of 639 results for "MDM2"
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  1. Nanostring microRNA microarry analysis of p53 and Mdm2 knockout mouse hearts compared to vehicle-injected negative controls ArrayExpress

    ID: E-MTAB-5531

    Description: e have previously shown that inactivating the p53/Mdm2 tumor suppressor circuitry, specifically in the heart (using the Cre-loxP recombination system of bacteriophage P1), can allow differentiated CMs to regain proliferative capacity, through an upregulation of factors involved in cell cycle re-entry. These factors are repressed in quiescent CMs, in part through the action of microRNAs (miRNAs). Notably, knockout of either p53 or Mdm2 individually was insufficient to promote CM proliferation. Therefore, we hypot...

  2. Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid... PDB

    ID: PDB:4JWR

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  3. Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid PDB

    ID: PDB:4JVE

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  4. crystal structure of MDM2 (17-111) in complex with compound 23 PDB

    ID: PDB:4ERE

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  5. Co-crystal Structure of MDM2 in Complex with AM-7209 PDB

    ID: PDB:4WT2

    Description: E3 UBIQUITIN-PROTEIN LIGASE MDM2 (E.C.6.3.2.-)

  6. Targeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy ArrayExpress

    ID: E-GEOD-62855

    Description: eptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the interaction region of the MDM4 and MDM2 proteins, thereby interfering with the coopeartivy function of the proteins in the regulation of p53. This peptide is indeed able to specifically activate p53 and to cause apoptotis in different cancer cell lines and tumor growth inhibition in xenograft models. Three ...

  7. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1289844.V4

    Release Date: 03-10-2016

    Description:

  8. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1289844.V2

    Release Date: 03-10-2016

    Description:

  9. co-crystal structure of MDM2 (17-111) in complex with compound 25 PDB

    ID: PDB:4OAS

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  10. mRNA expression profile in vascular smooth muscle cells (VSMCs) after inducing calcification ArrayExpress

    ID: E-GEOD-74755

    Description: es have yet to be elucidated. Here we report that MDM2-induced polyubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity via either chemical inhibitor or genetic ablation enhanced VC. HDAC1 protein, but not mRNA, was reduced in cell and animal calcification models and in human calcif...

  11. MTBP_XENLA UniProt:Swiss-Prot

    ID: Q6NRW0

    Description: Mdm2-binding protein

  12. MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53 PDB

    ID: PDB:1YCR

    Description: MDM2, P53

  13. Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor PDB

    ID: PDB:3TPX

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), D-pepti...

  14. Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one PDB

    ID: PDB:4JV7

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  15. Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one PDB

    ID: PDB:4JV9

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  16. Co-Crystal Structure of MDM2 with Inhibitor Compound 4 PDB

    ID: PDB:4ODE

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  17. The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction PDB

    ID: PDB:4DIJ

    Description: E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)

  18. Structural Convergence of Unstructured p53 Family Transactivation Domains in MDM2 Recognition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1289844.V1

    Release Date: 03-10-2016

    Description:

  19. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition Figshare

    ID: doi:10.6084/M9.FIGSHARE.1289844

    Release Date: 03-10-2016

    Description:

  20. Structure of the stapled peptide YS-01 bound to MDM2 PDB

    ID: PDB:4UE1

    Description: E3 UBIQUITIN-PROTEIN LIGASE MDM2 (E.C.6.3.2.-), YS-01


Displaying 20 of 639 results for "MDM2"