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Displaying 20 of 834 results for "MAP2K1"
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  1. Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase- BioProject

    ID: PRJNA275650

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease ArrayExpress

    ID: E-GEOD-79596

    Description: eratins regulate Tslp expression in parts through MEK1/2 activation. The finding that 8 out of 17 EBS patients show elevated TSLP serum levels supports a major role of keratins in TSLP regulation. Our data identify a novel, keratin-dependent and cell-intrinsic regulation of Tslp. Elevated TSLP levels likely explain the high prevalence of pruritus in EBS and additional forms of EB, suggesting TSLP as novel biomarker for pruritus in EB. MEK1/2, in addition to calcineurin inhibitors, might be suitable drugs to treat itch in EB. Investigation was carried out using Keratin deficient keratinocytes isolated from typeI keratin mice....

  3. X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP PDB

    ID: PDB:1S9I

    Description: Dual specificity mitogen-activated protein kinase kinase 2 (E.C.2.7.1.-)...

  4. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN9

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  5. Regulation of Protein Phosphatase 4 by a MAP Kinase Cascade Controls Chemotaxis BioProject

    ID: PRJNA96885

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4ANB

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  7. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN3

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  8. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum (ER) stress response BioProject

    ID: PRJNA98299

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN2

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  10. Transcription profiling by array of HaCat cells with or without over-expression of BCL-3 ArrayExpress

    ID: E-GEOD-60551

    Description: ratinocytes. KIAA1199 expression is enhanced upon human papillomavirus (HPV) infection and is aberrantly expressed in clinical cases of cervical (pre)neoplastic lesions. Mechanistically, KIAA1199 binds Plexin A2 and protects from Semaphorin 3A-mediated cell death by promoting EGFR stability and signaling. Moreover, KIAA1199 is an EGFR-binding protein and KIAA1199 deficiency impairs EGF-dependent Src,

  11. Gene profiles of pathway interference downstream neurofibromin signaling BioProject

    ID: PRJNA171610

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ow in an inoperable location. Neurofibromin, the protein coded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to constitutive activation of RAS and mitogen-activated protein kinase (MAPK) signaling in NF1 patients’ tumors. However, therapeutic targeting of RAS and MAPK have had limited success (Kalamarides, et al., 2012).  In this study, we modulated NRAS, MEK1/2 and neurofibromin levels in MPNST cell lines and determined the global gene expression changes that were associated with each experimental...
  12. Gene regulation in a novel therapeutic approach that involves ceramide-induced apoptosis pathways BioProject

    ID: PRJNA118807

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We have used human umbilical vein endothelial cell line (HUVEC) as a model to investigate the effect of ultrasound (US) activated
  13. Extracellular Superoxide Dismutase Regulates the Expression of GTPase Guanine Nucleotide Exchange Factors (GEFs), GTPase-activating proteins (GAPs), a... BioProject

    ID: PRJNA243869

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: creased EGFR, RYK, ALK, FLT3, and EPHA10 tyrosine kinase receptor phosphorylation with consequent downstream SRC, FYN, YES, HCK, and LYN kinase activation. However, RAS pull-down experiment suggested lack of mitogen pathway stimulation that was confirmed by MEK1/2 and ERK1/2 Western blot. Interestingly, mRNA expression analysis indicated that SOD3 regulated in a dose dependent manner the expression of selected guanine nucleotide exchange factors (Rho GEF16, Ral GEF RGL1), GTPase activating proteins (ArfGAP ADAP2, Ras GAP RASAL1, RGS4), and Rho guanine nucleotide disassociation inhibitors (Rho GDI 2) therefore controlling the signal transduction through RAS GTPases to downstream signal transduction pathways. Our current data suggests a SOD3-induced activation of growth signal transduction is controlled in a dose dependent manner through GEF, GAP, and GDI. Overal...
  14. Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae PDB

    ID: PDB:2IRM

    Description: mitogen-activated protein kinase kinase

  15. Raf/MEK signatures in zebrafish liver cells BioProject

    ID: PRJNA142819

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Gene regulation in a novel therapeutic approach that involves ceramide-induced apoptosis pathways ArrayExpress

    ID: E-GEOD-17525

    Description: We have used human umbilical vein endothelial cell line (HUVEC) as a model to investigate the effect of ultrasound (US) activated

  17. CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION PDB

    ID: PDB:2C60

    Description: HUMAN MITOGEN-ACTIVATED PROTEIN KINASE

  18. Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1 PDB

    ID: PDB:5TCO

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

  19. Human Toll-Like Receptors Pathway Array Data ArrayExpress

    ID: E-GEOD-33449

    Description: ependent inflammatory signaling in HUVEC, primary human lung microvascular ECs and human monocytes. Additionally, we observed that whereas MEK1 negatively regulates TLR2 signaling in EC, MEK1 promotes TLR2 signaling in monocytes. We also noted that activation of TLR2 led to the upregulation of intracellularly expressed TLR2 and inflammatory mediators via NF-κB, JNK and p38-MAPK. Finally, we found that p38-MAPK, JNK, ERK5 and NF-κB promote the attachment of human neutrophils to lung microvascular EC that were pretreated with TLR2 agonists. This study newly ide...

  20. Deciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis BioProject

    ID: PRJNA170306

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: m of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is essentially required for eyelid closure. We used microarray to characterize the central role that MAP3K1 plays in embryonic eyelid closure. Overall design:...

Displaying 20 of 834 results for "MAP2K1"