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Displaying 20 of 834 results for "MAP2K1"
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  1. Effect of p38 MAPK inhibitor SB203580 on gene expression in monocytic THP-1 cells stimulated with HIV gp120 or LPS. OmicsDI

    ID: E-GEOD-53712

    Date Released: 01-02-2015

    Description: Human monocytic THP-1 cells were exposed to HIV envelope protein gp120 or bacterial LPS in th...

  2. B-Raf inhibitors induce epithelial differentiation in BRAF mutant colorectal cancer cells ArrayExpress

    ID: E-GEOD-50791

    Description: the BRAF proto-oncogene, which encodes the B-Raf kinase, are associated with more aggressive, less-differentiated and therapy-resistant colorectal cancers (CRC). However, the molecular mechani...

  3. Organotpyic Human Epithelial Neoplasia ArrayExpress

    ID: E-GEOD-22573

    Description: -associated genetic pathways to transform primary human epithelial cells from epidermis, oropharynx, esophagus, and cervix into genetically defined tumors within an entirely human 3-dimensional (3-D) tissue environment incorporating cell-populated stroma and intact basement membrane (BM). These engineered organotypic tissues recapitulated nat...

  4. Human Toll-Like Receptors Pathway Array Data BioProject

    ID: PRJNA148707

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Recurrent amplifications of the histone methyltransferase SETDB1 in melanoma ArrayExpress

    ID: E-GEOD-36579

    Description: The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the

  6. Small molecule inhibition of ERK dimerization prevents tumorigenesis by Ras-ERK pathway oncogenes ArrayExpress

    ID: E-GEOD-68230

    Description: About 50% of human malignancies exhibit unregulated signalling through the Ras-ERK1/2 (ERK) pathway, as a consequence of activating mutations in...

  7. Effect of 2-aryl benzimidazole (5a) on Gene Expression Profile of the Human Breast Cancer Cells BioProject

    ID: PRJNA264153

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Endothelin-1 driven proliferation of PASMC is c-fos dependent BioProject

    ID: PRJNA244323

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Transcription profiling of human monocyte subpopulations ArrayExpress

    ID: E-MEXP-2544

    Description: nctions remains poorly understood. We report that human CD14+ monocytes represent functional ortholog to mouse Ly6C+ monocytes and are responsible for phagocytosis, Reactive Oxygen Species (ROS) and cytokine production in response to a broad range of pathogen associated molecular patterns (PAMP). In contrast a discr...

  10. Co-regulation of Cxcl1 and Versican in inflammatory response in UVB induced reactive oxygen species in the skin. BioProject

    ID: PRJNA318743

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: signaling rather than conventional UV-induced p38 mitogen-activated protein kinase. Furthermore, for the initial process of differentiating inflammatory response between Ogg1(-/-) and Ogg1(+/+), we found that down-regulation of p53 along with anti-apoptotic signal was a key event in Ogg1(-/-).The results of the present study suggest suppression of skin tumor development involving UVB/ROS-induced 8-oxoG formation by targeting genes and signaling pathways. Overall design: Irradiate UVB with 10mJ/cm2 and collected each genotype (WT and Ogg1KO) MEFs following isolation of mRNA...
  11. caArray_bonda-00136: Molecular basis of age associated cytokine dysregulation in LPS stimulated macrophages ArrayExpress

    ID: E-GEOD-68580

    Description: kappaB activation were also down-regulated but IL-1 receptor-associated kinase 3, a negative regulator of this pathway, was increased in aged mice. An increase in expression of the gene for p38 mitogen-activated protein kinase (MAPK) was observed with a corresponding increase in protein expression and enzyme activity confirmed by Western blotting. Low doses of a p38 MAPK inhibitor (SB203580) enhanced proinflammatory cytokine production by Mphi and reduced IL-10 levels, indicating that increased p38 MAPK activity has a role in cytokine dysregulation in the aged mouse Mphi. bonda-00136 Assay Type: Gene Expression Provider: Affymetrix Array Designs: Mouse430_2 Organism: Mus musculus (ncbitax)...

  12. Role of Bank1 in the Secretion of IL6 and Expression of Type I Interferon Inducible Genes Through the Control of p38 Signaling and the eIF4E Translati... BioProject

    ID: PRJNA176716

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Bank1 is an adaptor protein primarily expressed in B-cells with a little understood role in B-cell signaling. Studies involving human
  13. RAS signaling in colon carcinoma: Target gene deregulation and growth control through Y-box-binding protein 1 BioProject

    ID: PRJNA119617

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Pten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells ArrayExpress

    ID: E-GEOD-34839

    Description: /AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metas...

  15. Inhibition of MEK and PI3K alone or in combination alters the transcriptome of the lung during TGFα-induced pulmonary fibrosis ArrayExpress

    ID: E-GEOD-52854

    Description: n of MAPK and PI3K pathways have been detected in human fibrotic lung samples, the therapeutic benefits of in vivo modulation of the MAPK and PI3K pathways in combination are unknown. Overexpression of TGFα in the lung epithelium of transgenic mice results in the formation of fibrotic lesions similar to those found in human pulmonary fibrosis, and previous work from our group shows that inhibitors of either the MAPK or PI3K pathway can alter the progression of fibrosis. In this study, we sought to determine whether simultaneous inhibition of the MAPK and PI3K signaling pathways is a more effective therapeu...

  16. Transcription profiling by array of Atlantic cod head kidney cells following exposure to viral, bacterial and polyclonal activator stress ArrayExpress

    ID: E-MTAB-1058

    Description: hemokine/Interleukin 8 (CXCL8/IL-8); interleukin -1? (IL-1?); cyclooxygenase 2 (COX2); leukocyte derived chemotaxin 2 (LECT2); LOC100698154, encoding a protein with unknown function; carboxyl-esterase 2 (CES2) and environmental biomarker cytochrome P450 1A (CYP1A). Mitogen activated protein kinase p38 (p38MAPK) and cathepsin F (CTSF) were downregulated by LPS. The antiviral responses induced by double stranded RNA (Poly I:C) clearly increased transcription of Toll like receptor 3 (TLR3) and interferon stimulating gene 15 (ISG15). The PH...

  17. Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease BioProject

    ID: PRJNA316429

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eratins regulate Tslp expression in parts through MEK1/2 activation. The finding that 8 out of 17 EBS patients show elevated TSLP serum levels supports a major role of keratins in TSLP regulation. Our data identify a novel, keratin-dependent and cell-intrinsic regulation of Tslp. Elevated TSLP levels likely explain the high prevalence of pruritus in EBS and additional forms of EB, suggesting TSLP as novel biomarker for pruritus in EB. MEK1/2, in addition to calcineurin inhibitors, might be suitable drugs to treat itch in EB. Overall design: Investigation was carried out using Keratin deficient keratinocytes isolated from typeI keratin mice....
  18. Transcript analysis in response to ozone in mice deficient in TLR4 BioProject

    ID: PRJNA124909

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: independent pathways in OuJ mice, which involves MAP kinase activation, NF-kappaB, AP-1, and KC. Microarray analyses identifiedTLR4 responsive genes for strain and time in OuJ versus HeJ mice (p<0.05). One significantly upregulated cluster of genes in OuJ were the heat shock proteins (Hspa1b; Hsp70), Hsp90ab1). Furthermore, O3-induced expression of HSP70 protein was increased in OuJ compared to HeJ mice following 24-48 h O3. Moreover, BAL polymorphonuclear leukocytes (PMN) and total protein were significantly reduced in response to O3 in Hspa1a/Hspa1btm1Dix (Hsp70-/-) compared to Hsp70+/+ mice (p<0.05). TLR4 signaling (MYD88-dependent), ERK1/2, AP-1 activity, and KC protein content were also significantly reduced after O3 exposure in Hsp70-/- compared to Hsp70+/+ mice (p<0.05). These studies suggest that HSP70 is involved in the regulation of O3-induced lung inflam...
  19. Identification and Validation of Genes with Expression Patterns Inverse to Multiple Metastasis Suppressor Genes in Breast Cancer Cell Lines ArrayExpress

    ID: E-GEOD-53668

    Description: cts of many MSGs. By gene expression profiling of human MCF7 breast carcinoma cells expressing a scrambled siRNA or siRNAs to each of 19 validated MSGs (NME1, BRMS1, CD82, CDH1, CDH2, CDH11, CASP8, MAP2K4, MAP2K6, MAP2K7, MAPK14, GSN, ARHGDIB, AKAP12, DRG1, CD44, PEBP1, RRM1, KISS1), we identified genes whose expression was significantly opposite to at least five MSGs. We used microarrays to evaluate the modification in gene expression profile after donregulation of multiple metastasis suppressors (NME1, BRMS1, CD82, CDH1, CDH2, CDH11, CASP8, MAP2K4, MAP2K6, MAP2K7, MAPK14, GSN, ARHGDIB, AKAP12, DRG1, CD44, PEBP1, RRM1, KISS1) in the breast cancer cell line, MCF7. MCF7 cell li...

  20. New insights into key genes and pathways involved in the pathogenesis of HLA-B27-associated acute anterior uveitis ArrayExpress

    ID: E-GEOD-37588

    Description: 27-positive and -negative monocytes isolated from human peripheral blood were stimulated with Vibrio cholera lipopolysaccharide (LPS). Gene expression microarrays were used to identify the differentially expressed genes, and they were analysed by a series of bioinformatics-based techniques. Gene expression microarray analysis revealed marked differences between B27-positive monocytes in the genes that are upregulated in response to LPS stimulation. Gene Ontology enrichment (GO) and pathway analysis indicated that genes participating in protein transport and folding were essential to the infl...


Displaying 20 of 834 results for "MAP2K1"