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Displaying 20 of 834 results for "MAP2K1"
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  1. Expression profiling of medulloblastoma BioProject

    ID: PRJNA85081

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: alpha (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors. Immunohistochemical validation on an independent set of tumors shows significant overexpression of PDGFRA in M+ tumors compared to M0 tumors. Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and MAPK3 (p44 MAPK) phosphorylation in a dose-dependent manner. Neutralizing antibodies to PDGFRA blocks MAP2K1, MAP2K2 and MAPK1/3 phosphorylation, whereas U0126, a highly specific inhibitor of MAP2K1 and MAP2K2, also blocks MAPK1/3. Both inhibit migration and prevent PDGFA-stimulated m...
  2. Crystal Structure of the complex of human mitogen activated protein kinase PDB

    ID: PDB:2NPT

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2...

  3. Additional file 2: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D9

    Release Date: 12-15-2016

    Description: Is Table S2 presenting upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 19 kb)

  4. Mek1 adopts DFG-out conformation when bound to an analog of E6201. PDB

    ID: PDB:5HZE

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  5. Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms ArrayExpress

    ID: E-GEOD-74442

    Description: known, and recurrent cooperating mutations in non-MAP kinase pathways are undefined for the histiocytic neoplasms. Through combined whole exome and transcriptome sequencing, we identified recurrent kinase fusions involving BRAF, ALK, and NTRK1, as well as recurrent, activating MAP2K1 and ARAF mutations in BRAFV600E-wildtype, non-LCH patients. In addition to MAP kinase pathway lesions, recurrently altered genes involving diverse cellular pathways were identified. Treatment of MAP2K1- and ARAF-mutated, non-LCH patients using <...

  6. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V04

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  7. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V01

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  8. Additional file 3: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D5

    Release Date: 12-15-2016

    Description: Is Table S3 presenting the top enriched pathways in upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 12 kb)

  9. Additional file 9: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D1

    Release Date: 12-15-2016

    Description: Is Table S5 presenting the top pathways for MCF7 versus HT-29. (XLSX 15 kb)

  10. Additional file 4: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D2

    Release Date: 12-15-2016

    Description: Is Table S4 presenting genes differentially expressed between positive and negative tumors. (XLSX 31 kb)

  11. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells. OmicsDI

    ID: E-GEOD-23930

    Date Released: 08-10-2015

    Description: Though mitogen activated protein kinase kinases (MKK or

  12. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array] BioProject

    ID: PRJNA217934

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit senescence by activating the expression of S-phase <...
  13. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array] ArrayExpress

    ID: E-GEOD-50517

    Description: e-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit senescence by activating the expression of S-phase <...

  14. Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase PDB

    ID: PDB:2O2V

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2...

  15. Expression profiling of medulloblastoma GEMMA

    ID: 169

    Keywords: functional genomics

    Description: alpha (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors. Immunohistochemical validation on an independent set of tumors shows significant overexpression of PDGFRA in M+ tumors compared to M0 tumors. Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and MAPK3 (p44 MAPK) phosphorylation in a dose-dependent manner. Neutralizing antibodies to PDGFRA blocks MAP2K1, MAP2K2 and MAPK1/3 phosphorylation, whereas U0126, a highly specific inhibitor of MAP2K1 and MAP2K2, also blocks MAPK1/3. Both inhibit migration and prevent PDGFA-stimulated m...

  16. Transcription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) ... ArrayExpress

    ID: E-GEOD-7215

    Description: tivation of several MAPK pathways, including p38, MEK-ERK, and JNK. Inhibition of MEK1/2 by U0126 inhibited the induction of ER stress-response genes. In addition, knockdown of the MEK1/2 and JNK1/2 expression by short interfering RNA (siRNA) effectively inhibited the induction of apoptosis and activation of caspase-3 and cleavage of PARP by FOH. However, only MEK1/2 siRNAs reduced the expression of ER stress-related genes and inhibited phosphorylation of eIF2. Our results demonstrate that FOH-induced apoptosis is coupled to ER stress and that activation of MEK1/2 is an upstream event in the FOH-induced ER stress signaling cascade. Vehicle vs. 4h FOH Signature Gene lists (Replicates 1 & 2) are linked as supplementary files to the Series record. Experiment Overall Design: H460 cells were treated for 4 hours with 250 micromolar FOH or vehicle (DMSO) in duplicate experiments. Each FOH treated sample was compared to its matched Vehicle and dye-flips were performed, resulting in 4 arrays (2 replicate sets x 2 technical replicates)....

  17. Transcription profiling by array of Arabidopsis mutant for mkk1 and/or mkk2 after treatment with BTH ArrayExpress

    ID: E-GEOD-10646

    Description: Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase ...

  18. Gene profiles of pathway interference downstream neurofibromin signaling ArrayExpress

    ID: E-GEOD-39764

    Description: ow in an inoperable location. Neurofibromin, the protein coded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to constitutive activation of RAS and mitogen-activated protein kinase (MAPK) signaling in NF1 patients’ tumors. However, therapeutic targeting of RAS and MAPK have had limited success (Kalamarides, et al., 2012).  In this study, we modulated NRAS, MEK1/2 and neurofibromin levels in MPNST cell lines and determined the global gene expression changes that were associated with each experimental...

  19. Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP PDB

    ID: PDB:3SLS

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  20. Reversible mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts ArrayExpress

    ID: E-GEOD-45222

    Description: tively active downstream kinases such as BRAF and MEK1. Using Affymetrix microarrays, we compared the transcriptional profiles of Rasless fibroblasts to those of K-Raslox (MEFs lacking only H-Ras and N-Ras). We also compared the transcriptional profile of Rasless cells with those of BRAF and MEK1-transfected Rasless cells which recovered proliferative ability. Re-entry of the Rasless cells into cell cycle progression through ectopic expression of activated BRAF or MEK1 resulted in full reversion ...


Displaying 20 of 834 results for "MAP2K1"