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Displaying 20 of 834 results for "MAP2K1"
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  1. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 10 PDB

    ID: PDB:5JGB

    Description: Mitogen-activated protein kinase kinase

  2. JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one PDB

    ID: PDB:3G9N

    Description: Mitogen-activated protein kinase 10 (E.C.2.7.11.24)

  3. JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one PDB

    ID: PDB:3G9L

    Description: Mitogen-activated protein kinase 10 (E.C.2.7.11.24)

  4. Crystal Structure of Human p38alpha complexed with SD-0006 PDB

    ID: PDB:3HL7

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

  5. Crystal structure of JNK2 complexed with BIRB796 PDB

    ID: PDB:3NPC

    Description: Mitogen-activated protein kinase 9 (E.C.2.7.11.24)

  6. The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor PDB

    ID: PDB:3GC9

    Description: Mitogen-activated protein kinase 11 (E.C.2.7.11.24)

  7. Identification of direct transcriptional targets of V600EBRAF/MEK in melanoma ArrayExpress

    ID: E-GEOD-17089

    Description: A375P melanoma cells were treated with 1uM of the MEK inhibitor PD184352 or 0.4uM of the V600EBRAF inhibitor PLX4720 for 2hr, 6hr and 24hrs. DMSO treatment for 2hr, 6hr and 24hrs se...

  8. Transcription profiling of human SkMel-28 cells growing in culture treated with the MEK inhibitor PD0325901 for 2, 8, or 24 hours time cour... ArrayExpress

    ID: E-GEOD-10088

    Description: l changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK. ...

  9. BET Bromodomain Protein BRD4 Regulates MEK Inhibitor-induced Kinome Reprogramming in Triple Negative Breast Cancer BioProject

    ID: PRJNA218091

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Crystal Structure of Human p38alpha complexed with PH-797804 PDB

    ID: PDB:3HLL

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

  11. Discovery of potent and selective covalent inhibitors of JNK PDB

    ID: PDB:3V6S

    Description: Mitogen-activated protein kinase 10 (E.C.2.7.11.24)

  12. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 11c PDB

    ID: PDB:5JGA

    Description: Mitogen-activated protein kinase kinase

  13. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 3 PDB

    ID: PDB:5GJF

    Description: Mitogen-activated protein kinase kinase

  14. Gene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts ArrayExpress

    ID: E-GEOD-76068

    Description: despite continued administration of the tyrosine kinase inhibitor (TKI) sunitinib (40 mg/kg/d p.o.). Resistance was associated with increased expression of VEGFA, EPO, IL-8, ANGPT2, TNFRSF12, MAPK3/7, MAPKBP1, and increased cell survival genes, suggesting activation of angiogenesis and MAPK/ERK pathways. Tumor lysate mRNA evaluated for murine gene expression to examine the contribution of host effects, indicated that tumor response was associated with downregulation of immune cell trafficking, cellular movement, and inflammatory response genes. During tumor escape, genes associated with cellular movement, inflammatory response, and immune cell trafficking were strongly induced, along with intra...

  15. Aberrant ERK signaling causes resistance to EGFR kinase inhibitors BioProject

    ID: PRJNA162711

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Expression data from BRAF-mutant melanoma cell lines ArrayExpress

    ID: E-GEOD-45558

    Description: een the lines sensitive and resistant to BRAF and MEK inhibitor drugs. 22 BRAF-mutant melanoma cell lines were assessed for response to BRAF and MEK inhibitors in a 3 day drug treatment dose response assay. Based on the IC50, 18 lines were found...

  17. Raf/MEK signatures in zebrafish liver cells ArrayExpress

    ID: E-GEOD-29308

    Description: ZFL-ΔRaf1-ER was established, in which oncogenic human Raf-1(ΔRaf1) can be activated in zebrafish liver cells by administration of 4-hydroxytamoxifen (4HT). Transcriptional p...

  18. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 4 PDB

    ID: PDB:5GJG

    Description: Mitogen-activated protein kinase kinase

  19. Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 12 PDB

    ID: PDB:5JGD

    Description: Mitogen-activated protein kinase kinase

  20. M3K1_HUMAN UniProt:Swiss-Prot

    ID: Q13233

    Description: Removed Mitogen-activated protein kinase kinase


Displaying 20 of 834 results for "MAP2K1"