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Displaying 50 of 834 results for "MAP2K1"
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  1. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells. BioProject

    ID: PRJNA130421

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Though mitogen activated protein kinase kinases (MKK or
  2. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP PDB

    ID: PDB:3VVH

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  3. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:3EQB

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  4. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:3DY7

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  5. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P PDB

    ID: PDB:3EQC

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  6. Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) PDB

    ID: PDB:3W8Q

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  7. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP PDB

    ID: PDB:3E8N

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  8. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P PDB

    ID: PDB:3EQI

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  9. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P PDB

    ID: PDB:3EQF

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  10. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P PDB

    ID: PDB:3EQG

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  11. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P PDB

    ID: PDB:3EQH

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  12. Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP PDB

    ID: PDB:3MBL

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  13. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P PDB

    ID: PDB:3EQD

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  14. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:2P55

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  15. Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP PDB

    ID: PDB:3PP1

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  16. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:1S9J

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  17. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells ArrayExpress

    ID: E-GEOD-23930

    Description: Though mitogen activated protein kinase kinases (MKK or

  18. MEK1 with PF-04622664 Bound PDB

    ID: PDB:3DV3

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  19. Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP PDB

    ID: PDB:3ORN

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  20. Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP PDB

    ID: PDB:3WIG

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  21. MEK1 IN COMPLEX WITH BI 847325 PDB

    ID: PDB:5EYM

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  22. CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP PDB

    ID: PDB:4ARK

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  23. Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP PDB

    ID: PDB:3OS3

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  24. Crystal structure of MEK1 in complex with fragment 3 PDB

    ID: PDB:3ZLW

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  25. Crystal Structure of MEK1 kinase bound to GDC0973 PDB

    ID: PDB:4LMN

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  26. Expression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901 ArrayExpress

    ID: E-GEOD-45758

    Description: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used m...

  27. Crystal structure of the BRAF:MEK1 complex PDB

    ID: PDB:4MNE

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  28. KSR2-MEK1 HETERODIMER PDB

    ID: PDB:2Y4I

    Description: KINASE SUPPRESSOR OF RAS 2, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN

  29. BTH treated mkk1, mkk2 and mkk1/2 knockout mutant BioProject

    ID: PRJNA107725

    Keywords: Transcriptome or Gene expression

    Access Type: download

  30. KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 PDB

    ID: PDB:5KKR

    Description: Kinase suppressor of Ras 2 (E.C.2.7.11.1), Dual specificity mitogen-activated

  31. Crystal structure of MEK1 in complex with fragment 6 PDB

    ID: PDB:3ZLS

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  32. Crystal structure of MEK1 in complex with fragment 18 PDB

    ID: PDB:3ZLX

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  33. Expression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040 ArrayExpress

    ID: E-GEOD-45757

    Description: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used m...

  34. Crystal structure of MEK1 in complex with fragment 8 PDB

    ID: PDB:3ZLY

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  35. Analysis of A375 and A375 clones that acquired resistance to GSK2118436 after treatment with GSK2118436 (GSK436), GSK1120212 (GSK212), or the combinat... BioProject

    ID: PRJNA152855

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: resistance clones acquired mutations in NRAS and MEK1. One clones, 16R6-4, acquired two mutations in NRAS – Q61K and A146T. Proliferation and western blot analyses demonstrated that these clones were insensitive to single agent GSK2118436 or GSK1120212 (an allosteric MEK inhibitor) but were sensitive to the combination of GSK2118436 and GSK1120212. To further characterize this combi...
  36. Crystal structure of MEK1 in complex with fragment 1 PDB

    ID: PDB:3ZM4

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  37. Transcription profiling by array of human MCF10A cells over-expressing HRas or MEK1 ArrayExpress

    ID: E-GEOD-12764

    Description: MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and ...

  38. Analysis of A375 and A375 clones that acquired resistance to GSK2118436 after treatment with GSK2118436 (GSK436), GSK1120212 (GSK212), or the combinat... ArrayExpress

    ID: E-GEOD-35230

    Description: resistance clones acquired mutations in NRAS and MEK1. One clones, 16R6-4, acquired two mutations in NRAS – Q61K and A146T. Proliferation and western blot analyses demonstrated that these clones were insensitive to single agent GSK2118436 or GSK1120212 (an allosteric MEK inhibitor) but were sensitive to the combination of GSK2118436 and GSK1120212. To further characterize this combi...

  39. Transcriptome of mkk1-mkk2 mutants ArrayExpress

    ID: E-GEOD-24516

    Description: au08-02_mkk1-mkk2 - mkk1-mkk2 - Functional redundancy of the two MAPKKs MKK1 and MKK2. - mkk1 and mkk2 k.o. plant...

  40. Microarray analysis of gene expression profiles in Map2k1+/-Map2k2+/- and Map2k1flox/-Map2k2+/-Tg+/Sox2Cre placentas ArrayExpress

    ID: E-GEOD-51644

    Description: The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, encoding dual-specificity kina...

  41. Expression profiling of medulloblastoma BioProject

    ID: PRJNA85081

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: alpha (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors. Immunohistochemical validation on an independent set of tumors shows significant overexpression of PDGFRA in M+ tumors compared to M0 tumors. Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and MAPK3 (p44 MAPK) phosphorylation in a dose-dependent manner. Neutralizing antibodies to PDGFRA blocks MAP2K1, MAP2K2 and MAPK1/3 phosphorylation, whereas U0126, a highly specific inhibitor of MAP2K1 and MAP2K2, also blocks MAPK1/3. Both inhibit migration and prevent PDGFA-stimulated m...
  42. Crystal Structure of the complex of human mitogen activated protein kinase PDB

    ID: PDB:2NPT

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2...

  43. Additional file 2: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D9

    Release Date: 12-15-2016

    Description: Is Table S2 presenting upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 19 kb)

  44. Mek1 adopts DFG-out conformation when bound to an analog of E6201. PDB

    ID: PDB:5HZE

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  45. Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms ArrayExpress

    ID: E-GEOD-74442

    Description: known, and recurrent cooperating mutations in non-MAP kinase pathways are undefined for the histiocytic neoplasms. Through combined whole exome and transcriptome sequencing, we identified recurrent kinase fusions involving BRAF, ALK, and NTRK1, as well as recurrent, activating MAP2K1 and ARAF mutations in BRAFV600E-wildtype, non-LCH patients. In addition to MAP kinase pathway lesions, recurrently altered genes involving diverse cellular pathways were identified. Treatment of MAP2K1- and ARAF-mutated, non-LCH patients using <...

  46. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V04

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  47. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V01

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  48. Additional file 3: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D5

    Release Date: 12-15-2016

    Description: Is Table S3 presenting the top enriched pathways in upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 12 kb)

  49. Additional file 9: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D1

    Release Date: 12-15-2016

    Description: Is Table S5 presenting the top pathways for MCF7 versus HT-29. (XLSX 15 kb)

  50. Additional file 4: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D2

    Release Date: 12-15-2016

    Description: Is Table S4 presenting genes differentially expressed between positive and negative tumors. (XLSX 31 kb)


Displaying 50 of 834 results for "MAP2K1"