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  1. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells. BioProject

    ID: PRJNA130421

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Though mitogen activated protein kinase kinases (MKK or
  2. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP PDB

    ID: PDB:3VVH

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  3. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:3EQB

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  4. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:3DY7

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  5. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P PDB

    ID: PDB:3EQC

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  6. Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) PDB

    ID: PDB:3W8Q

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  7. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP PDB

    ID: PDB:3E8N

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  8. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P PDB

    ID: PDB:3EQI

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  9. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P PDB

    ID: PDB:3EQF

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  10. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P PDB

    ID: PDB:3EQG

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  11. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P PDB

    ID: PDB:3EQH

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  12. Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP PDB

    ID: PDB:3MBL

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  13. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P PDB

    ID: PDB:3EQD

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  14. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:2P55

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  15. Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP PDB

    ID: PDB:3PP1

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  16. X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP PDB

    ID: PDB:1S9J

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  17. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells ArrayExpress

    ID: E-GEOD-23930

    Description: Though mitogen activated protein kinase kinases (MKK or

  18. MEK1 with PF-04622664 Bound PDB

    ID: PDB:3DV3

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  19. Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP PDB

    ID: PDB:3ORN

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  20. Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP PDB

    ID: PDB:3WIG

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  21. MEK1 IN COMPLEX WITH BI 847325 PDB

    ID: PDB:5EYM

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  22. CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP PDB

    ID: PDB:4ARK

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  23. Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP PDB

    ID: PDB:3OS3

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  24. Crystal structure of MEK1 in complex with fragment 3 PDB

    ID: PDB:3ZLW

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  25. Crystal Structure of MEK1 kinase bound to GDC0973 PDB

    ID: PDB:4LMN

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  26. Expression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901 ArrayExpress

    ID: E-GEOD-45758

    Description: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used m...

  27. Crystal structure of the BRAF:MEK1 complex PDB

    ID: PDB:4MNE

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  28. KSR2-MEK1 HETERODIMER PDB

    ID: PDB:2Y4I

    Description: KINASE SUPPRESSOR OF RAS 2, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN

  29. BTH treated mkk1, mkk2 and mkk1/2 knockout mutant BioProject

    ID: PRJNA107725

    Keywords: Transcriptome or Gene expression

    Access Type: download

  30. KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 PDB

    ID: PDB:5KKR

    Description: Kinase suppressor of Ras 2 (E.C.2.7.11.1), Dual specificity mitogen-activated

  31. Crystal structure of MEK1 in complex with fragment 6 PDB

    ID: PDB:3ZLS

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  32. Crystal structure of MEK1 in complex with fragment 18 PDB

    ID: PDB:3ZLX

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  33. Expression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040 ArrayExpress

    ID: E-GEOD-45757

    Description: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used m...

  34. Crystal structure of MEK1 in complex with fragment 8 PDB

    ID: PDB:3ZLY

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  35. Analysis of A375 and A375 clones that acquired resistance to GSK2118436 after treatment with GSK2118436 (GSK436), GSK1120212 (GSK212), or the combinat... BioProject

    ID: PRJNA152855

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: resistance clones acquired mutations in NRAS and MEK1. One clones, 16R6-4, acquired two mutations in NRAS – Q61K and A146T. Proliferation and western blot analyses demonstrated that these clones were insensitive to single agent GSK2118436 or GSK1120212 (an allosteric MEK inhibitor) but were sensitive to the combination of GSK2118436 and GSK1120212. To further characterize this combi...
  36. Crystal structure of MEK1 in complex with fragment 1 PDB

    ID: PDB:3ZM4

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  37. Transcription profiling by array of human MCF10A cells over-expressing HRas or MEK1 ArrayExpress

    ID: E-GEOD-12764

    Description: MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and ...

  38. Analysis of A375 and A375 clones that acquired resistance to GSK2118436 after treatment with GSK2118436 (GSK436), GSK1120212 (GSK212), or the combinat... ArrayExpress

    ID: E-GEOD-35230

    Description: resistance clones acquired mutations in NRAS and MEK1. One clones, 16R6-4, acquired two mutations in NRAS – Q61K and A146T. Proliferation and western blot analyses demonstrated that these clones were insensitive to single agent GSK2118436 or GSK1120212 (an allosteric MEK inhibitor) but were sensitive to the combination of GSK2118436 and GSK1120212. To further characterize this combi...

  39. Transcriptome of mkk1-mkk2 mutants ArrayExpress

    ID: E-GEOD-24516

    Description: au08-02_mkk1-mkk2 - mkk1-mkk2 - Functional redundancy of the two MAPKKs MKK1 and MKK2. - mkk1 and mkk2 k.o. plant...

  40. Microarray analysis of gene expression profiles in Map2k1+/-Map2k2+/- and Map2k1flox/-Map2k2+/-Tg+/Sox2Cre placentas ArrayExpress

    ID: E-GEOD-51644

    Description: The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, encoding dual-specificity kina...

  41. Expression profiling of medulloblastoma BioProject

    ID: PRJNA85081

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: alpha (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors. Immunohistochemical validation on an independent set of tumors shows significant overexpression of PDGFRA in M+ tumors compared to M0 tumors. Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and MAPK3 (p44 MAPK) phosphorylation in a dose-dependent manner. Neutralizing antibodies to PDGFRA blocks MAP2K1, MAP2K2 and MAPK1/3 phosphorylation, whereas U0126, a highly specific inhibitor of MAP2K1 and MAP2K2, also blocks MAPK1/3. Both inhibit migration and prevent PDGFA-stimulated m...
  42. Crystal Structure of the complex of human mitogen activated protein kinase PDB

    ID: PDB:2NPT

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2...

  43. Additional file 2: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D9

    Release Date: 12-15-2016

    Description: Is Table S2 presenting upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 19 kb)

  44. Mek1 adopts DFG-out conformation when bound to an analog of E6201. PDB

    ID: PDB:5HZE

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  45. Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms ArrayExpress

    ID: E-GEOD-74442

    Description: known, and recurrent cooperating mutations in non-MAP kinase pathways are undefined for the histiocytic neoplasms. Through combined whole exome and transcriptome sequencing, we identified recurrent kinase fusions involving BRAF, ALK, and NTRK1, as well as recurrent, activating MAP2K1 and ARAF mutations in BRAFV600E-wildtype, non-LCH patients. In addition to MAP kinase pathway lesions, recurrently altered genes involving diverse cellular pathways were identified. Treatment of MAP2K1- and ARAF-mutated, non-LCH patients using <...

  46. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V04

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  47. Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions. PDB

    ID: PDB:3V01

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  48. Additional file 3: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D5

    Release Date: 12-15-2016

    Description: Is Table S3 presenting the top enriched pathways in upregulated genes in sorted MSCs from MCF7 and BT-20 co-cultures. (XLSX 12 kb)

  49. Additional file 9: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D1

    Release Date: 12-15-2016

    Description: Is Table S5 presenting the top pathways for MCF7 versus HT-29. (XLSX 15 kb)

  50. Additional file 4: of CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3639467_D2

    Release Date: 12-15-2016

    Description: Is Table S4 presenting genes differentially expressed between positive and negative tumors. (XLSX 31 kb)

  51. MKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells. OmicsDI

    ID: E-GEOD-23930

    Date Released: 08-10-2015

    Description: Though mitogen activated protein kinase kinases (MKK or

  52. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array] BioProject

    ID: PRJNA217934

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit senescence by activating the expression of S-phase <...
  53. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array] ArrayExpress

    ID: E-GEOD-50517

    Description: e-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). Senescence induction leads to inhibition of self-renewal of tumor cells and blockage of tumor formation and growth. A signaling cascade was identified that acts downstream of Shp2 to counter senescence: Src, Focal adhesion kinase and Map kinase inhibit senescence by activating the expression of S-phase <...

  54. Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase PDB

    ID: PDB:2O2V

    Description: Dual specificity mitogen-activated protein kinase kinase 5 (E.C.2.7.12.2...

  55. Expression profiling of medulloblastoma GEMMA

    ID: 169

    Keywords: functional genomics

    Description: alpha (PDGFRA) and members of the downstream RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway are upregulated in M+ tumors. Immunohistochemical validation on an independent set of tumors shows significant overexpression of PDGFRA in M+ tumors compared to M0 tumors. Using in vitro assays, we show that platelet-derived growth factor alpha (PDGFA) enhances medulloblastoma migration and increases downstream MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK1 (p42 MAPK) and MAPK3 (p44 MAPK) phosphorylation in a dose-dependent manner. Neutralizing antibodies to PDGFRA blocks MAP2K1, MAP2K2 and MAPK1/3 phosphorylation, whereas U0126, a highly specific inhibitor of MAP2K1 and MAP2K2, also blocks MAPK1/3. Both inhibit migration and prevent PDGFA-stimulated m...

  56. Transcription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) ... ArrayExpress

    ID: E-GEOD-7215

    Description: tivation of several MAPK pathways, including p38, MEK-ERK, and JNK. Inhibition of MEK1/2 by U0126 inhibited the induction of ER stress-response genes. In addition, knockdown of the MEK1/2 and JNK1/2 expression by short interfering RNA (siRNA) effectively inhibited the induction of apoptosis and activation of caspase-3 and cleavage of PARP by FOH. However, only MEK1/2 siRNAs reduced the expression of ER stress-related genes and inhibited phosphorylation of eIF2. Our results demonstrate that FOH-induced apoptosis is coupled to ER stress and that activation of MEK1/2 is an upstream event in the FOH-induced ER stress signaling cascade. Vehicle vs. 4h FOH Signature Gene lists (Replicates 1 & 2) are linked as supplementary files to the Series record. Experiment Overall Design: H460 cells were treated for 4 hours with 250 micromolar FOH or vehicle (DMSO) in duplicate experiments. Each FOH treated sample was compared to its matched Vehicle and dye-flips were performed, resulting in 4 arrays (2 replicate sets x 2 technical replicates)....

  57. Transcription profiling by array of Arabidopsis mutant for mkk1 and/or mkk2 after treatment with BTH ArrayExpress

    ID: E-GEOD-10646

    Description: Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase ...

  58. Gene profiles of pathway interference downstream neurofibromin signaling ArrayExpress

    ID: E-GEOD-39764

    Description: ow in an inoperable location. Neurofibromin, the protein coded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to constitutive activation of RAS and mitogen-activated protein kinase (MAPK) signaling in NF1 patients’ tumors. However, therapeutic targeting of RAS and MAPK have had limited success (Kalamarides, et al., 2012).  In this study, we modulated NRAS, MEK1/2 and neurofibromin levels in MPNST cell lines and determined the global gene expression changes that were associated with each experimental...

  59. Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP PDB

    ID: PDB:3SLS

    Description: Dual specificity mitogen-activated protein kinase kinase 1

  60. Reversible mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts ArrayExpress

    ID: E-GEOD-45222

    Description: tively active downstream kinases such as BRAF and MEK1. Using Affymetrix microarrays, we compared the transcriptional profiles of Rasless fibroblasts to those of K-Raslox (MEFs lacking only H-Ras and N-Ras). We also compared the transcriptional profile of Rasless cells with those of BRAF and MEK1-transfected Rasless cells which recovered proliferative ability. Re-entry of the Rasless cells into cell cycle progression through ectopic expression of activated BRAF or MEK1 resulted in full reversion ...

  61. Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase- BioProject

    ID: PRJNA275650

    Keywords: Transcriptome or Gene expression

    Access Type: download

  62. Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease ArrayExpress

    ID: E-GEOD-79596

    Description: eratins regulate Tslp expression in parts through MEK1/2 activation. The finding that 8 out of 17 EBS patients show elevated TSLP serum levels supports a major role of keratins in TSLP regulation. Our data identify a novel, keratin-dependent and cell-intrinsic regulation of Tslp. Elevated TSLP levels likely explain the high prevalence of pruritus in EBS and additional forms of EB, suggesting TSLP as novel biomarker for pruritus in EB. MEK1/2, in addition to calcineurin inhibitors, might be suitable drugs to treat itch in EB. Investigation was carried out using Keratin deficient keratinocytes isolated from typeI keratin mice....

  63. X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP PDB

    ID: PDB:1S9I

    Description: Dual specificity mitogen-activated protein kinase kinase 2 (E.C.2.7.1.-)...

  64. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN9

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  65. Regulation of Protein Phosphatase 4 by a MAP Kinase Cascade Controls Chemotaxis BioProject

    ID: PRJNA96885

    Keywords: Transcriptome or Gene expression

    Access Type: download

  66. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4ANB

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  67. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN3

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  68. Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum (ER) stress response BioProject

    ID: PRJNA98299

    Keywords: Transcriptome or Gene expression

    Access Type: download

  69. Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. PDB

    ID: PDB:4AN2

    Description: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1

  70. Transcription profiling by array of HaCat cells with or without over-expression of BCL-3 ArrayExpress

    ID: E-GEOD-60551

    Description: ratinocytes. KIAA1199 expression is enhanced upon human papillomavirus (HPV) infection and is aberrantly expressed in clinical cases of cervical (pre)neoplastic lesions. Mechanistically, KIAA1199 binds Plexin A2 and protects from Semaphorin 3A-mediated cell death by promoting EGFR stability and signaling. Moreover, KIAA1199 is an EGFR-binding protein and KIAA1199 deficiency impairs EGF-dependent Src,

  71. Gene profiles of pathway interference downstream neurofibromin signaling BioProject

    ID: PRJNA171610

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ow in an inoperable location. Neurofibromin, the protein coded by the Nf1 gene, functions as a GTPase activating protein (GAP) whose mutation leads to constitutive activation of RAS and mitogen-activated protein kinase (MAPK) signaling in NF1 patients’ tumors. However, therapeutic targeting of RAS and MAPK have had limited success (Kalamarides, et al., 2012).  In this study, we modulated NRAS, MEK1/2 and neurofibromin levels in MPNST cell lines and determined the global gene expression changes that were associated with each experimental...
  72. Gene regulation in a novel therapeutic approach that involves ceramide-induced apoptosis pathways BioProject

    ID: PRJNA118807

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We have used human umbilical vein endothelial cell line (HUVEC) as a model to investigate the effect of ultrasound (US) activated
  73. Extracellular Superoxide Dismutase Regulates the Expression of GTPase Guanine Nucleotide Exchange Factors (GEFs), GTPase-activating proteins (GAPs), a... BioProject

    ID: PRJNA243869

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: creased EGFR, RYK, ALK, FLT3, and EPHA10 tyrosine kinase receptor phosphorylation with consequent downstream SRC, FYN, YES, HCK, and LYN kinase activation. However, RAS pull-down experiment suggested lack of mitogen pathway stimulation that was confirmed by MEK1/2 and ERK1/2 Western blot. Interestingly, mRNA expression analysis indicated that SOD3 regulated in a dose dependent manner the expression of selected guanine nucleotide exchange factors (Rho GEF16, Ral GEF RGL1), GTPase activating proteins (ArfGAP ADAP2, Ras GAP RASAL1, RGS4), and Rho guanine nucleotide disassociation inhibitors (Rho GDI 2) therefore controlling the signal transduction through RAS GTPases to downstream signal transduction pathways. Our current data suggests a SOD3-induced activation of growth signal transduction is controlled in a dose dependent manner through GEF, GAP, and GDI. Overal...
  74. Crystal structure of mitogen-activated protein kinase kinase kinase 7 interacting protein 1 from Anopheles gambiae PDB

    ID: PDB:2IRM

    Description: mitogen-activated protein kinase kinase

  75. Raf/MEK signatures in zebrafish liver cells BioProject

    ID: PRJNA142819

    Keywords: Transcriptome or Gene expression

    Access Type: download

  76. Gene regulation in a novel therapeutic approach that involves ceramide-induced apoptosis pathways ArrayExpress

    ID: E-GEOD-17525

    Description: We have used human umbilical vein endothelial cell line (HUVEC) as a model to investigate the effect of ultrasound (US) activated

  77. CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION PDB

    ID: PDB:2C60

    Description: HUMAN MITOGEN-ACTIVATED PROTEIN KINASE

  78. Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1 PDB

    ID: PDB:5TCO

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

  79. Human Toll-Like Receptors Pathway Array Data ArrayExpress

    ID: E-GEOD-33449

    Description: ependent inflammatory signaling in HUVEC, primary human lung microvascular ECs and human monocytes. Additionally, we observed that whereas MEK1 negatively regulates TLR2 signaling in EC, MEK1 promotes TLR2 signaling in monocytes. We also noted that activation of TLR2 led to the upregulation of intracellularly expressed TLR2 and inflammatory mediators via NF-κB, JNK and p38-MAPK. Finally, we found that p38-MAPK, JNK, ERK5 and NF-κB promote the attachment of human neutrophils to lung microvascular EC that were pretreated with TLR2 agonists. This study newly ide...

  80. Deciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis BioProject

    ID: PRJNA170306

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: m of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is essentially required for eyelid closure. We used microarray to characterize the central role that MAP3K1 plays in embryonic eyelid closure. Overall design:...
  81. Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D) PDB

    ID: PDB:3FME

    Description: Dual specificity mitogen-activated protein kinase kinase 6 (E.C.2.7.12.2...

  82. Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1 PDB

    ID: PDB:4O91

    Description: Mitogen-activated protein kinase kinase

  83. Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D) PDB

    ID: PDB:2DYL

    Description: Dual specificity mitogen-activated protein kinase kinase 7 (E.C.2.7.12.2...

  84. Induction of Senescence in Diterpene Ester-Treated Melanoma Cells via PKC-dependent Hyperactivation of the MAPK Pathway ArrayExpress

    ID: E-GEOD-3484

    Description: 5 and the diterpene ester TPA, observed in 20% of human melanoma cell lines. Primary cultures of normal human neonatal fibroblasts were uniformly resistant to growth arrest, indicating a potential for tumor selectivity. Sensitive cells were induced to senesce and exhibited a G1 and G2/M arrest. There was sustained expression of p21WAF1/CIP1, irreversi...

  85. Human p38 MAP Kinase in Complex with 2-amino-phenylamino-benzophenone PDB

    ID: PDB:3QUD

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

  86. Solution Structure of the N-terminal CUE Domain in the Human Mitogen-activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 (MAP3K7IP2) PDB

    ID: PDB:2DAE

    Description: KIAA0733 protein

  87. BRAF siRNA NHGRI_Liang_BRAF ArrayExpress

    ID: E-GEOD-5481

    Description: BRAF and CRAF), plays a major role in the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway, which mediates cellular responses to growth...

  88. Signaling pathways of HPAIV BioProject

    ID: PRJNA173422

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: infected cells and involves hyperinduction of p38 mitogen activated protein kinase (MAPK). Here we investigate the role of MAPK p38 signaling in the antiviral response against HPAIV in mice as well as in endothelial cells, the latter a primary source for cytokines during systemic infections. Global gene expression profiling of HPAIV infected endothelial cells in the presence of the MAP kinase p38-specific inhibitor SB202190 revealed, that inhibition of MAPK p38 leads to reduced expression of interferon (IFN) and other cytokines after A/Thailand/1
  89. Induction of Senescence in Diterpene Ester-Treated Melanoma Cells via PKC-dependent Hyperactivation of the MAPK Pathway BioProject

    ID: PRJNA93301

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 5 and the diterpene ester TPA, observed in 20% of human melanoma cell lines. Primary cultures of normal human neonatal fibroblasts were uniformly resistant to growth arrest, indicating a potential for tumor selectivity. Sensitive cells were induced to senesce and exhibited a G1 and G2/M arrest. There was sustained expression of p21WAF1/CIP1, irreversi...
  90. Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone PDB

    ID: PDB:3ZYA

    Description: MITOGEN-ACTIVATED PROTEIN KINASE 14 (E.C.2.7.11.24)

  91. Crystal structure of TL10-92 bound to TAK1-TAB1 PDB

    ID: PDB:5JH6

    Description: Mitogen-activated protein kinase kinase

  92. Transcriptional profiling of MKK4-depleted cells ArrayExpress

    ID: E-GEOD-19091

    Description: Mitogen-activated protein kinase kinase 4 (MKK4) is a d...

  93. Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate) PDB

    ID: PDB:4LOQ

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24), TGF-beta-

  94. Crystal structure of TL11-128 bound to TAK1-TAB1 PDB

    ID: PDB:5JK3

    Description: Mitogen-activated protein kinase kinase

  95. The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution PDB

    ID: PDB:3P4K

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24), MAP

  96. Targeting β-catenin overcomes resistance to MEK inhibitor in PIK3CA mutant colon cancer BioProject

    ID: PRJNA292658

    Keywords: Proteome

    Access Type: download

  97. Crystal structure of human p38alpha complexed with a MAPK docking peptide PDB

    ID: PDB:2Y8O

    Description: MITOGEN-ACTIVATED PROTEIN KINASE 14 (E.C.2.7.11.24), DUAL SPECIFICITY

  98. Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib PDB

    ID: PDB:5HES

    Description: Mitogen-activated protein kinase kinase

  99. ChIP-Seq for ERK2/MAPK1 and ELK1 in human embryonic stem cells BioProject

    ID: PRJEB1715

    Keywords: Other

    Access Type: download

  100. Human p38 MAP Kinase in Complex with Skepinone-L PDB

    ID: PDB:3QUE

    Description: Mitogen-activated protein kinase 14 (E.C.2.7.11.24)


Displaying 100 of 834 results for "MAP2K1"