KIAA1549 | bioCADDIE Data Discovery Index
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Displaying 5 of 6 results for "KIAA1549"
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  1. Rosette-forming glioneuronal tumour arising in the spinal cord: a case report and molecular profiling BioProject

    ID: PRJNA272408

    Keywords: Variation

    Access Type: download

    dataset.description: 2) were identified. Additionally, we verified the KIAA1549-BRAF fusion, typically found in pilocytic astrocytomas, through aCGH, RT-PCR and FISH. Our comprehensive molecular profiling of a RGNT case suggests the existence of a unique genetic pathway for the development of these tumors: KIAA1549-BRAF fusion is a possible driver by constitutively activating MAPK pathway, and MLL2 mutation may lead to profound changes in the methylome. Taken together, these mechanisms may increase survival and/or tumorigenic capacity of cells, leading to the development of this rare entity. Overall design: Two-color Agilent 8x60K array CGH (aCGH) was performed in the rosette-forming glioneuronal tumour (CY3) and reference DNA (CY5 - DNA extracted from leucocytes of the patient)....

Displaying 5 of 6 results for "KIAA1549"