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Displaying 20 of 164 results for "KDM5B"
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  1. The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 [ChIP-Seq] ArrayExpress

    ID: E-GEOD-41172

    Description: ion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cranial nerves, defects in eye development and increased incidences of exencephaly. Moreover, in line with an overlap of Jarid1b and Polycomb targets genes, Jarid1b knockout embryos display homeotic skeletal transformations typical for Polycomb mutants. Genome-wide analysis ...

  2. KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation ArrayExpress

    ID: E-GEOD-53093

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  3. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression) ArrayExpress

    ID: E-GEOD-43920

    Description: Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irre...

  4. Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [RNA-seq] ArrayExpress

    ID: E-GEOD-70605

    Description: activation of two histone demethylases, Kdm4b and Kdm5b, accounts for the arrest of cloned embryos at 2-cell and 4-cell stage, respectively. Ectopic expression of Kdm4b and Kdm5b in SCNT can remove H3K9me3 barrier, restore the transcription profile and facilitate the blastocyst developmental efficiency over 95%. Moreover, these cloned embryos can further support full-term development and the derivation of SCNT-embryonic stem cells with greater efficiency. Our study reveals that histone methylation reset is crucial for the development of SCNT embryos, which provides a clue to further improve therapeutic ...

  5. Extended self-renewal and accelerated reprogramming in the absence of Kdm5b OmicsDI

    ID: E-GEOD-46893

    Date Released: 06-03-2014

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  6. KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation OmicsDI

    ID: E-GEOD-53093

    Date Released: 06-03-2014

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  7. Jarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq] ArrayExpress

    ID: E-GEOD-31966

    Description: We analyzed the genome-wide binding profile of Jarid1b in mouse ESCs. We find that Jarid1b localizes mainly to transcription start sites, of which mor...

  8. Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotin... PDB

    ID: PDB:5A3T

    Description: LYSINE-SPECIFIC DEMETHYLASE 5B (E.C.1.14.11.-)

    primaryPublication.title: Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
  9. Crystal structure of the catalytic domain of human JARID1B in complex with fumarate PDB

    ID: PDB:5FY5

    Description: LYSINE-SPECIFIC DEMETHYLASE 5B (E.C.1.14.11.-)

  10. Crystal structure of the catalytic domain of human JARID1B in complex with MC1648 PDB

    ID: PDB:5FYB

    Description: LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B (E.C.1.14.11.-)

  11. Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [RRBS] ArrayExpress

    ID: E-GEOD-70607

    Description: activation of two histone demethylases, Kdm4b and Kdm5b, accounts for the arrest of cloned embryos at 2-cell and 4-cell stage, respectively. Ectopic expression of Kdm4b and Kdm5b in SCNT can remove H3K9me3 barrier, restore the transcription profile and facilitate the blastocyst developmental efficiency over 95%. Moreover, these cloned embryos can further support full-term development and the derivation of SCNT-embryonic stem cells with greater efficiency. Our study reveals that histone methylation reset is crucial for the development of SCNT embryos, which provides a clue to further improve therapeutic ...

  12. The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 [Affymetrix] ArrayExpress

    ID: E-GEOD-41171

    Description: ion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cranial nerves, defects in eye development and increased incidences of exencephaly. Moreover, in line with an overlap of Jarid1b and Polycomb targets genes, Jarid1b knockout embryos display homeotic skeletal transformations typical for Polycomb mutants. Genome-wide analysis ...

  13. Jarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq] BioProject

    ID: PRJNA155275

    Keywords: Epigenomics

    Access Type: download

  14. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq) ArrayExpress

    ID: E-GEOD-43921

    Description: Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irre...

  15. PAX9_MOUSE UniProt:Swiss-Prot

    ID: P47242

    Description: Paired box protein Pax-9 Paired Interaction with KDM5B

  16. FOXG1_CHLPG UniProt:Swiss-Prot

    ID: Q1A1A5

    Description: Forkhead box protein G1 Fork-head Interaction with KDM5B His-rich Pro-rich Gly-rich

  17. Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [RNA-seq] OmicsDI

    ID: E-GEOD-70605

    Date Released: 05-22-2016

    Description: activation of two histone demethylases, Kdm4b and Kdm5b, accounts for the arrest of cloned embryos at 2-cell and 4-cell stage, respectively. Ectopic expression of Kdm4b and Kdm5b in SCNT can remove H3K9me3 barrier, restore the transcription profile and facilitate the blastocyst developmental efficiency over 95%. Moreover, these cloned embryos can further support full-term development and the derivation of SCNT-embryonic stem cells with greater efficiency. Our study reveals that histone methylation reset is crucial for the development of SCNT embryos, which provides a clue to further improve therapeutic ...

  18. Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [RRBS] OmicsDI

    ID: E-GEOD-70607

    Date Released: 05-22-2016

    Description: activation of two histone demethylases, Kdm4b and Kdm5b, accounts for the arrest of cloned embryos at 2-cell and 4-cell stage, respectively. Ectopic expression of Kdm4b and Kdm5b in SCNT can remove H3K9me3 barrier, restore the transcription profile and facilitate the blastocyst developmental efficiency over 95%. Moreover, these cloned embryos can further support full-term development and the derivation of SCNT-embryonic stem cells with greater efficiency. Our study reveals that histone methylation reset is crucial for the development of SCNT embryos, which provides a clue to further improve therapeutic ...

  19. Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [ChIP-seq] OmicsDI

    ID: E-GEOD-70606

    Date Released: 05-22-2016

    Description: activation of two histone demethylases, Kdm4b and Kdm5b, accounts for the arrest of cloned embryos at 2-cell and 4-cell stage, respectively. Ectopic expression of Kdm4b and Kdm5b in SCNT can remove H3K9me3 barrier, restore the transcription profile and facilitate the blastocyst developmental efficiency over 95%. Moreover, these cloned embryos can further support full-term development and the derivation of SCNT-embryonic stem cells with greater efficiency. Our study reveals that histone methylation reset is crucial for the development of SCNT embryos, which provides a clue to further improve therapeutic ...

  20. Crystal structure of the catalytic domain of human JARID1B in complex with MC3095 PDB

    ID: PDB:5FZI

    Description: LYSINE-SPECIFIC DEMETHYLASE 5B (E.C.1.14.11.-)


Displaying 20 of 164 results for "KDM5B"