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Displaying 20 of 559 results for "JAK3"
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  1. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2 PDB

    ID: PDB:3IOK

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  2. Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer BioProject

    ID: PRJNA312303

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: CDK8 (cyclin-dependent kinase 8) is a kinase component of a multi - protein Mediator complex, involved in transcript...
  3. Homo sapiens strain:iPS Cells : Allele Specific Targeting in Patient Derived iPSCs with CRISPR/Cas9 BioProject

    ID: PRJNA258262

    Keywords: genome sequencing

    Access Type: download

    dataset.description: This study compares the CRISPR/Cas9 and TALEN targeted nucleases in targeting 3 human genes: JAK2, SERPINA1, PPP1R12C.
  4. IL6 Related Cytokines Augment Angiogenesis in Nascent and Mature Human Endothelium Via JAK2 Signaling BioProject

    ID: PRJNA189473

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: hic factor receptor (CNTFR), and their downstream JAK/STAT signaling components in NRP1+CD34+ endothelial cells. When exposed to CNTF, angiogenic sprouting of NRP1+CD34+ was induced in Matrigel, which was abolished with JAK2 inhibition. Furthermore, we found evidence of JAK2 dependent cytokine signaling in more mature endothelium, highlighting the significance of the IL6R/JAK2 pathway, well known in hematopoiesis, in vascular biology. The findings identify a novel group of growth factor receptors and downstream signaling components that may be targeted to modulate angiogenesis and vasculogenesis. Overall design: 7 samples analyzed, 2 replicates for NRP1+CD34+, 3 replicates for NRP1+CD34-...
  5. GY118F downstream effect in EpiSCs OmicsDI

    ID: E-GEOD-36817

    Date Released: 05-11-2012

    Description: aper to be published in Nature Communications: “JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naïve pluripotency” by Anouk L. van Oosten, Yael Costa, Austin Smith & José C.R. Silva Gy0 a, gy0 b, gy0 c (triplicate samples for GY118F EpiS...

  6. Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells OmicsDI

    ID: E-GEOD-17850

    Date Released: 08-22-2013

    Description: onse to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, regulating the transcription of its target genes...

  7. Genetic landscape of Early T-cell precursor acute lymphoblastic leukaemia OmicsDI

    ID: EGAS00001000348

    Date Released:

    Description: signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF), inactivating lesions disrupting haematopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1 and EP300) and histone-modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of recurrent mutation including DNM2, ECT2L and RELN. The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haematopoietic stem cells. These findings suggest that additi...

  8. GY118F downstream effect in EpiSCs BioProject

    ID: PRJNA156855

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: aper to be published in Nature Communications: “JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naïve pluripotency” by Anouk L. van Oosten, Yael Costa, Austin Smith & José C.R. Silva Overall design: Gy0 a, gy0 b, gy0 c (triplicate samples...
  9. Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion OmicsDI

    ID: E-GEOD-32309

    Date Released: 11-14-2011

    Description: mycin (mTOR), or suppressor of cytokine signaling 3 (SOCS3), a negative regulator of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, in adult retinal ganglion cells (RGCs) individually promoted significant optic nerve regeneration, such regrowth tapered off around two weeks after the crush injury. Remarkably, we now find that simultaneous deletion of both PTEN and SOCS3 enable robust and sustained axon regeneration. We further show that PTEN and SOCS3 regulate two independent pathways tha...

  10. Affymetrix Genome-Wide Human SNP Array 6.0 data for Type II Enteropathy-associated T-cell lymphoma OmicsDI

    ID: E-GEOD-70653

    Date Released: 03-05-2016

    Description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Genome-wide DNA copy number profiling of Type II EATL tumors and matched normal samples was performed to determine copy-number changes in this disease. Affymetrix SNP6 arrays were performed according to the manufacturer's directions on gDNA extracted from 4 tumors and 4 matched whole blood samples....

  11. Transcription profiling by array of Drosophila larvae infected with parasitoid wasps OmicsDI

    ID: E-GEOD-8938

    Date Released: 04-30-2015

    Description: t this immune response. Leptopilina boulardi and L. heterotoma, two closely related, highly infectious natural parasitoids of Drosophila melanogaster, appear to use very different infection strategies at the cellular level. Here, we further characterize cellular level differences in the infection characteristics of these two wasp species using newly derived, virulent inbred strains, and then use whole geno...

  12. Homo sapiens : WES of patient derived pre-treatment metastatic melanoma on anti-PD-1 antibody treatment BioProject

    ID: PRJNA307199

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: erapy. Here we show that genetic mutations in the Janus kinases (JAK) controlling signalling downstream of the interferon receptor prevent PD-L1 upregulation on melanoma cells upon interferon exposure and result in innate resistance to PD-1 blockade in patients. Among 50 human melanoma cell lines tested for response to interferon gamma by PD-L1 surface e...
  13. Gene expression profiling of Type II Enteropathy-associated T-cell lymphoma OmicsDI

    ID: E-GEOD-70652

    Date Released: 03-05-2016

    Description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Here we performed gene expression profiling on four Type II EATL samples in order to better characterize this disease. As Type II EATL is suggested to arise from CD8+ IELs, we integrated our data with publicly available profile of CD8αα and CD8αβ T-cells from healthy donors (GSE33374). Gene expression profiling independently demonstrated strong en...

  14. Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells BioProject

    ID: PRJNA123545

    Keywords: Epigenomics

    Access Type: download

    dataset.description: onse to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, regulating the transcription of its target genes...
  15. Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with BMS-824171 AKA 6-[(3R)-3-(4-tert-bu tylbenzamido)piperidin-1-y... PDB

    ID: PDB:5BPY

    Description: Tyrosine-protein kinase BTK (E.C.2.7.10.2)

  16. Tight Junction Protein 1 is a Modulator and Biomarker of Proteasome Inhibitor Sensitivity in Multiple Myeloma ArrayExpress

    ID: E-GEOD-52369

    Description: We have identified expression of tight junction protein (TJP) 1 as being associated with sensitivity of plasma cells in vitro and in vivo to proteasome inhibitors. TJP1 suppressed expression of genes in the major histocompatibility class II region, including two catalytically active immunoproteasome subunits, thereby decreasing proteasome activity, a critic...

  17. Treatment of established mouse AA with topical JAK inhibitors BioProject

    ID: PRJNA194536

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. Phosphoproteomic analyses of IL-2 signaling reveals integrated JAK-dependent and independent phosphorylation networks that drive cytotoxic T cell fate OmicsDI

    ID: PXD004645

    Date Released: 01-01-1000

    Description: spectrometry analysis of Interleukin 2 (IL-2) and Janus kinase (JAK) controlled protein phosphorylations in cytotoxic T lymphocytes (CTL) reveale...

  19. Interferon alpha induced gene expression in SOCS1 and SOCS3 overexpressing melanoma and hepatoma cell lines. OmicsDI

    ID: E-GEOD-22801

    Date Released: 06-02-2014

    Description: receptors by masking its recognition site for the Janus kinases (JAK), by blocking the kinase activity of the JAKs and coincidentally hindering STAT molecules from binding to the kinases. They are also thought to ubiquitinate the JAKs resulting in their proteosomal degradation. The function of SOCS proteins in suppressing the interferon-alpha pathway has not yet been characterized exhaustively. This study should unveil links to understand the resistance in interferon-alpha therapy. As results we got almost complete silencing of JAK-STAT signaling in SOCS1 over-expressing cells and tissue-dependent partially suppressed gene induction in SOCS3 over-expressing cell lines. Two human cancer cell lines (ME-15, HuH-7) were stably transfected with pcDNA3.1-SOCS plasmids in presence of geneticin and daughter cell lines were generated after singularization of cells. Next, original cell line...

  20. INTERLEUKIN 15-DEPENDENT T CELL-LIKE INNATE INTRAEPITHELIAL LYMPHOCYTES DEVELOP IN THE INTESTINE AND TRANSFORM INTO LYMPHOMAS IN CELIAC DISEASE ArrayExpress

    ID: E-MTAB-4960

    Description: 3+ innate IELs with gain-of-function mutations in Janus kinase 1 or Signal transducer and activator of transcription 3 displayed enhanced response to IL-15 and acquired a selective advantage that favored clonal expansion and transformation into lymphoma. Overall we characterized gut T cell-like innate IELs, deciphered their pathway of differentiation, and showed their malignant transformation in celiac disease....


Displaying 20 of 559 results for "JAK3"