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Displaying 20 of 559 results for "JAK3"
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  1. Inhibition of the autocrine loop IL6-JAK2-STAT3-Calprotectin as targeted therapy for HR-/HER2+ breast cancers ArrayExpress

    ID: E-GEOD-62251

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  2. Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594 PDB

    ID: PDB:3UGC

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  3. The Jak1 kinase domain in complex with inhibitor PDB

    ID: PDB:4I5C

    Description: Tyrosine-protein kinase JAK1 (E.C.2.7.10.2)

  4. Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression BioProject

    ID: PRJNA379183

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ment and upregulation of gene targets for STAT1/2/3 and IRF1 in anti-PD-1 responding tumors. Therefore, these studies map the signaling pathway of interferon-inducible PD-1 ligand expression Overall design: Melanoma biopsies pre and on- anti-PD-1 treatment were sent for transcriptomic analysis by paired end RNAseq analysis...
  5. IL13_0-12h_RAIA_et_al OmicsDI

    ID: E-GEOD-23591

    Date Released: 03-27-2012

    Description: (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key d...

  6. WES Hodgkin Lymphoma cell lines : The mutational landscape of Hodgkin lymphoma cell lines determined by whole exome sequencing BioProject

    ID: PRJEB5699

    Keywords: Other

    Access Type: download

    dataset.description: Epstein Barr virus (EBV)-derived latent membrane protein 1 (LMP1). In addition, NF-κB activation is caused by diverse aberrations in multiple genes involved in the NF-κB pathway, such as amplifications of REL, gains of MAP3K14, mutations of TNFAIP3, NFKBIA and NFKBIE. A second pathway frequently altered in HRS cells is the JAK/STAT signaling pathway. Activation is caused by gains of JAK2 and inactivating mutations of SOCS1. In recent years, high-throughput sequencing technology has provided novel opportunities for the comprehensive identification of genetic aberrations involved in various types of cancer. To increase our understanding of the pathogenesis of HL, we perfor...
  7. Transcription profiling by array of livers from irradiated rats with or without pre-treatment of radioprotective Hong Shan Capsule (HSC) ArrayExpress

    ID: E-GEOD-57692

    Description: -cytokine receptor interaction, mitogen-activated protein kinase (MAPK) signaling pathway, peroxisomal proliferator-activated receptor (PPAR)signaling pathway, gonadotropin-releasing hormone (GnRH) signaling pathway, Wnt signaling pathway, janus kinase-signal transducers and activators of transcription (Jak-STAT) signaling pathway, Notch signaling pathway.Our analysis indicated that the pretreatment of rats with HSC attenuated radiation-induced these pathways, such as multiple MAPK pathways, suggesting that the protective effect of HSC acts mainly through the attenuation of these pathways. The rats were randomly assigned to one of the three following treatment groups (10-12 animals per group): normal ...

  8. Pathologic Immune Pathways in Psoriasis are Rapidly Attenuated by Tofacitinib Treatment: A Randomized Phase 2 Study in Patients with Moderate to Sever... BioProject

    ID: PRJNA287287

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. We sought to elucidate the molecular mechanisms underly...
  9. JAK2 Naive and Persitent Murine BaF3 cells infected with MPLW515L ArrayExpress

    ID: E-GEOD-38335

    Description: F3 MPLW515L mutants to JAK1/2 specific inhibitor. 3 condition experiment consiting of: 1) Naive cells treated with DMSO (Control) , 2) Naïve cells treated with 0.8 uM INCB18424 for 4 hours (Acute) and 3) Persistent cells treated with 0.8 uM INCB18424 for 4 hours (Persistent). Biological replicates: 3 DMSO control replicates, 3 Acute replicates, 3 Persistent replicates....

  10. Pathologic Immune Pathways in Psoriasis are Rapidly Attenuated by Tofacitinib Treatment: A Randomized Phase 2 Study in Patients with Moderate to Sever... ArrayExpress

    ID: E-GEOD-69967

    Description: e the molecular mechanism of tofacitinib, an oral Janus kinase inhibitor, in psoriasis. Tofacitinib exhibits a multi-tiered action, with early direct effects on keratinocytes and...

  11. JAK2 kinase (JH1 domain) in complex with compound 8 PDB

    ID: PDB:4HGE

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  12. Transcription profiling by array of livers from irradiated rats with or without pre-treatment of radioprotective Hong Shan Capsule (HSC) OmicsDI

    ID: E-GEOD-57692

    Date Released: 04-30-2015

    Description: -cytokine receptor interaction, mitogen-activated protein kinase (MAPK) signaling pathway, peroxisomal proliferator-activated receptor (PPAR)signaling pathway, gonadotropin-releasing hormone (GnRH) signaling pathway, Wnt signaling pathway, janus kinase-signal transducers and activators of transcription (Jak-STAT) signaling pathway, Notch signaling pathway.Our analysis indicated that the pretreatment of rats with HSC attenuated radiation-induced these pathways, such as multiple MAPK pathways, suggesting that the protective effect of HSC acts mainly through the attenuation of these pathways. The rats were randomly assigned to one of the three following treatment groups (10-12 animals per group): normal ...

  13. Prolactin stimulation of parathyroid adenomas ArrayExpress

    ID: E-GEOD-32387

    Description: on was associated with transcriptional changes in JAK/STAT, RIG-I like receptor and type II interferon signaling pathways as documented by gene expression profiling. Moreover, PRLR gene expression in parathyroid tumors was significantly inversely correlated with plasma total Ca2+ levels. In conclusion, the prolactin receptor was found highly abundant in human parathyroid gland, parathyroid tumours, correlated with patient Ca2+ levels and functionally responsive to physiological levels of prolactin. These findings suggest a role for the prolactin receptor in human parathyroid adenomas. Expression profiling was done in parathyroid adenomas subjected to prolactin treatment in culture. In addition, corresponding paraffin sections were obtained for verification of PRLr expression by immunohistochemistry. 200 mg/L prolactin (recombinant human prolactin, Cat. No. JM-4687-50, MBL Woburn, MA) was added to 1× 10^6 attached parathyroid tumour cells. Cells were harvested using RNAlater (QIAGEN) and homogenized with QIAshredder for RNA extraction after 3 h and 24 h in culture, respectively. Negative controls were col...

  14. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2 PDB

    ID: PDB:3IO7

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  15. A Novel Chemotype of Kinase Inhibitors PDB

    ID: PDB:3KCK

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  16. Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion BioProject

    ID: PRJNA147307

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: mycin (mTOR), or suppressor of cytokine signaling 3 (SOCS3), a negative regulator of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, in adult retinal ganglion cells (RGCs) individually promoted significant optic nerve regeneration, such regrowth tapered off around two weeks after the crush injury. Remarkably, we now find that simultaneous deletion of both PTEN and SOCS3 enable robust and sustained axon regeneration. We further show that PTEN and SOCS3 regulate two independent pathways tha...
  17. Pax5+/- murine model : Infection exposure is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility BioProject

    ID: PRJEB10678

    Keywords: Other

    Access Type: download

    dataset.description: d activating somatic, non-synonymous mutations of Jak3 as a second hit. Transplantation experiments and deep sequencing suggest that inactivating mutations in Pax5 promote leukemogenesis by creating an aberrant progenitor compartment that is susceptible to malignant transformation through accumulation of secondary Jak3 mutations. Thus, treatment of Pax5+/- leukemic cells with specific Jak1/3 inhibitors resulted in increased apoptosis. These results uncover the causal role of infection in pB-ALL development....
  18. Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells ArrayExpress

    ID: E-GEOD-17850

    Description: onse to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, regulating the transcription of its target genes...

  19. CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH A 9H-CARBAZOLE-1-CARBOXAMIDE INHIBITOR PDB

    ID: PDB:4ZIM

    Description: TYROSINE-PROTEIN KINASE JAK2 (E.C.2.7.1.112)

  20. Data from: A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: testing co-localization among outlier ma... Dryad

    DateIssued: 03-08-2017

    Description: ntified an overlapping subset of 17 outlier loci, 3 of which were also identified by BayeScan. Many outlier loci were near candidate genes and some were near published quantitative trait loci (QTLs) for growth, appetite, maturity, or disease-resistance. Parallel comparisons using a wild, non-founder population (Stewiacke River) yielded only one overlapping outlier locus as well as a known maturity QTL. We conclude that genome scans comparing a recently domesticated strain with its wild founder population can facilitate identification of candidate genes for traits known to have been under strong artificial selection....


Displaying 20 of 559 results for "JAK3"