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Displaying 20 of 559 results for "JAK3"
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  1. Expression data from Cerebral Cortex or Hippocampus of COX-1 or COX-2 null mice BioProject

    ID: PRJNA96197

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: BAergic neurotransmission genes (GABA transporter 3, GABA-A receptor subunit ?1) was altered in the cerebral cortex and hippocampus of COX-2 -/- mice. A COX isoform specific effect was observed in the expression of Janus Kinase (JAK) 1 and 2. COX-1 -/- mice exhibited an increase in JAK1 expression while COX-2 -/- mice exhibited a decrease in JAK2 expression, an observation consistent with a previously demonstrated COX isoform specific effect on the expression of NF-kB. In summary, this study demonstrates the wide ranging effects of genetic deletion of COX isoforms in the mouse brain and suggests that inhibition of COX activity may alter the profile of gene expression in specific areas of the brain. We u...
  2. Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain PDB

    ID: PDB:4GL9

    Description: Tyrosine-protein kinase (E.C.2.7.10.2), GP130, SOCS3

  3. IL13_0-12h_RAIA_et_al BioProject

    ID: PRJNA131727

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key d...
  4. Transcription profiling by array of Drosophila larvae infected with parasitoid wasps ArrayExpress

    ID: E-GEOD-8938

    Description: t this immune response. Leptopilina boulardi and L. heterotoma, two closely related, highly infectious natural parasitoids of Drosophila melanogaster, appear to use very different infection strategies at the cellular level. Here, we further characterize cellular level differences in the infection characteristics of these two wasp species using newly derived, virulent inbred strains, and then use whole geno...

  5. Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer ArrayExpress

    ID: E-GEOD-77987

    Description: CDK8 (cyclin-dependent kinase 8) is a kinase component of a multi - protein Mediator complex, involved in transcript...

  6. CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-7-[(DIMETHYL-1,3-THIAZOL-2-YL)AMINO]-10-ETHYL-3 PDB

    ID: PDB:5CF5

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  7. CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-[(2S)-2,3-DIHYDROXYPROPYL]-3-METHYL-7-(ME... PDB

    ID: PDB:5CF6

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  8. Supplementary Material for: Phosphorylation of STAT3 in Undifferentiated Pleomorphic Sarcoma Is Correlated with a Favorable Prognosis Figshare

    ID: doi:10.6084/M9.FIGSHARE.3843489.V1

    Release Date: 09-21-2016

    Description: Objective: The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a ro...

  9. Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion ArrayExpress

    ID: E-GEOD-32309

    Description: mycin (mTOR), or suppressor of cytokine signaling 3 (SOCS3), a negative regulator of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, in adult retinal ganglion cells (RGCs) individually promoted significant optic nerve regeneration, such regrowth tapered off around two weeks after the crush injury. Remarkably, we now find that simultaneous deletion of both PTEN and SOCS3 enable robust and sustained axon regeneration. We further show that PTEN and SOCS3 regulate two independent pathways tha...

  10. Supplementary Material for: Phosphorylation of STAT3 in Undifferentiated Pleomorphic Sarcoma Is Correlated with a Favorable Prognosis Figshare

    ID: doi:10.6084/M9.FIGSHARE.3843489

    Release Date: 09-21-2016

    Description: Objective: The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a ro...

  11. Janus Kinase 2 Inhibitors PDB

    ID: PDB:3JY9

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  12. JAK2 Naive and Persitent Murine BaF3 cells infected with MPLW515L BioProject

    ID: PRJNA167738

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nts to JAK1/2 specific inhibitor. Overall design: 3 condition experiment consiting of: 1) Naive cells treated with DMSO (Control) , 2) Naïve cells treated with 0.8 uM INCB18424 for 4 hours (Acute) and 3) Persistent cells treated with 0.8 uM INCB18424 for 4 hours (Persistent). Biological replicates: 3 DMSO control replicates, 3 Acute replicates, 3 Persistent replicates....
  13. Comparison of the expression profiles of wild-type (WT), Tyk2-deficient (Tyk2-/-) and kinase-inactive Tyk2 mutant (Tyk2K923E) NK cells OmicsDI

    ID: E-GEOD-68294

    Date Released: 05-02-2015

    Description: k2 and Tyk2K923E on the transcriptome of NK cells Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in...

  14. Hong Shan Capsule (HSC) offers radioprotection and modulates acute lethal total-body irradiation-induced alterations of gene expression in rats BioProject

    ID: PRJNA247730

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -cytokine receptor interaction, mitogen-activated protein kinase (MAPK) signaling pathway, peroxisomal proliferator-activated receptor (PPAR)signaling pathway, gonadotropin-releasing hormone (GnRH) signaling pathway, Wnt signaling pathway, janus kinase-signal transducers and activators of transcription (Jak-STAT) signaling pathway, Notch signaling pathway.Our analysis indicated that the pretreatment of rats with HSC attenuated radiation-induced these pathways, such as multiple MAPK pathways, suggesting that the protective effect of HSC acts mainly through the attenuation of these pathways. Overall design: The rats were randomly assigned to one of the three following treatment groups (10-12 animals per...
  15. IL6 Related Cytokines Augment Angiogenesis in Nascent and Mature Human Endothelium Via JAK2 Signaling ArrayExpress

    ID: E-GEOD-44328

    Description: hic factor receptor (CNTFR), and their downstream JAK/STAT signaling components in NRP1+CD34+ endothelial cells. When exposed to CNTF, angiogenic sprouting of NRP1+CD34+ was induced in Matrigel, which was abolished with JAK2 inhibition. Furthermore, we found evidence of JAK2 dependent cytokine signaling in more mature endothelium, highlighting the significance of the IL6R/JAK2 pathway, well known in hematopoiesis, in vascular biology. The findings identify a novel group of growth factor receptors and downstream signaling components that may be targeted to modulate angiogenesis and vasculogenesis. 7 samples analyzed, 2 replicates for NRP1+CD34+, 3 replicates for NRP1+CD34-...

  16. Inhibitors of Jak2 Kinase domain PDB

    ID: PDB:2XA4

    Description: TYROSINE-PROTEIN KINASE JAK2 (E.C.2.7.1.112, 2.7.10.2)

  17. Gene expression profiling upon knockdown of JAK1 in IM9 cells BioProject

    ID: PRJNA157535

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: particular, gene silencing of two members of the JAK family (JAK1 and JAK2) in a variety of tumor cell targets increased their susceptibility to NK-mediated lysis and induced increased secretion of interferon gamma (IFN-gamma by NK cells. Treatment of tumor cells with JAK inhibitors also induced increased susceptibility to NK cell activity. These findings may have important clinical implications and suggest that small molecule inhibitors of tyrosine kinases being developed as therapeutic anti-tumor agents may also have significant immunologic effects in vivo. Overall design: IM9 cells were transduced with shRNA-encoding vectors and selected with Puromycin. Two vectors were specifically targeting JAK1 (JAK1-1 and JAK1-3) and one vector encoded an irrelevant control s...
  18. Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. BioProject

    ID: PRJNA102357

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t this immune response. Leptopilina boulardi and L. heterotoma, two closely related, highly infectious natural parasitoids of Drosophila melanogaster, appear to use very different infection strategies at the cellular level. Here, we further characterize cellular level differences in the infection characteristics of these two wasp species using newly derived, virulent inbred strains, and then use whole geno...
  19. GY118F downstream effect in EpiSCs ArrayExpress

    ID: E-GEOD-36817

    Description: aper to be published in Nature Communications: “JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naïve pluripotency” by Anouk L. van Oosten, Yael Costa, Austin Smith & José C.R. Silva Gy0 a, gy0 b, gy0 c (triplicate samples for GY118F EpiS...

  20. CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] - PDB

    ID: PDB:5CF8

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)


Displaying 20 of 559 results for "JAK3"