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Displaying 20 of 559 results for "JAK3"
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  1. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukaemia by whole genome sequencing ArrayExpress

    ID: E-GEOD-28497

    Description: including IL7R, NRAS, KRAS, FLT3, BRAF, JAK1 and JAK3 in ETP ALL. Moreover, we identified multiple new targets of mutation in including GATA3, EP300, RUNX1, DNM2, ECT2L, HNRNPA1 and HNRNPR, as well as genes known to be mutated in T-ALL, including NOTCH1, PHF6, and WT1.. Five of 12 ETP ALL cases harboured novel chromosomal translocations, several of which accompanied complex multichromosomal rearrangements and resulted in the expression of chimeric in-frame fusion genes disrupting hematopoietic regulators, including ETV6-INO80D, NAP1L1-MLLT10 and RUNX1-EVX1. These results indicate that although ETP ALL is genetically heterogeneous, activation of Ras and cytokine receptor signalling distinguishes this disease from non-ETP ALL....

  2. Epigenetic Gene Regulation by Janus Kinase 1 in Diffuse Large B Cell Lymphoma (Agilent) BioProject

    ID: PRJNA341334

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Gene expression profiling in erythroid progenitors through ontogeny ArrayExpress

    ID: E-GEOD-37869

    Description: t has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early...

  4. Sequencing of ETP T-ALL dbGaP

    ID: phs000340.v2.p1

    Description: signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF), inactivating lesions disrupting haematopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1 and EP300) and histone-modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of recurrent mutation including DNM2, ECT2L and RELN. The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haematopoietic stem cells. These findings suggest that addition of myeloid-directed therapies might improve the poor outcome of ETP ALL....

  5. Transcription profiling of human Sez-4 cell line starved of IL2 for 16h, followed by addition of IL-2 activation and or JAK inhibition OmicsDI

    ID: E-GEOD-8687

    Date Released: 07-06-2011

    Description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...

  6. Sequencing of ETP T-ALL dbGaP

    ID: phs000340.v3.p1

    Description: signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF), inactivating lesions disrupting haematopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1 and EP300) and histone-modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of recurrent mutation including DNM2, ECT2L and RELN. The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haematopoietic stem cells. These findings suggest that addition of myeloid-directed therapies might improve the poor outcome of ETP ALL....

  7. Fragment based discovery of JAK-2 inhibitors PDB

    ID: PDB:3E64

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  8. Fragment based discovery of JAK-2 inhibitors PDB

    ID: PDB:3E62

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  9. IL13_0-12h_RAIA_et_al ArrayExpress

    ID: E-GEOD-23591

    Description: (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key d...

  10. Fragment based discovery of JAK-2 inhibitors PDB

    ID: PDB:3E63

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  11. Gene expression profiling in erythroid progenitors through ontogeny BioProject

    ID: PRJNA166911

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early...
  12. IL7R signaling mutations confer steroid resistance in T-ALL : IL-7 Receptor Mutations and Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic L... BioProject

    ID: PRJEB11453

    Keywords: Other

    Access Type: download

    dataset.description: her genes in this pathway, including IL7Ra, JAK1, JAK3, NF1, NRAS, KRAS, and AKT, in these 69 T-ALL patients and an additional 77 T-ALL patients. We identified mutations in 32% of patients, the majority of whom had a specific T-ALL subtype (ETP-ALL or TLX). Based on the outcome of these patients and their prednisolone responsiveness measured in vitro, we then confirmed that these mutations are associated with both steroid resistance and poor outcome. To functionally explore how these mutations cause steroid resistance and subsequent poor outcome, we expressed wild-type and mutant IL7R signaling molecules in two steroid-sensitive T-ALL cell lines (SUPT1 and P12 Ichikawa cells) using inducible lentiviral expression constructs. We found that expressing mutant IL7Ra, JAK1, or NRAS, wild-type NRAS, or wild-type AKT specifically induced steroid resistance in both lines without affecting sensitivity to vincristine or asparaginase. In contrast, wild-type IL7R, JAK1, and JAK3, as well as mutant JAK3 and mutant AKT, had no effect. We then performed a functional study to examine the mechanisms underlying steroid resistance and found that resistance was not due to a change in the steroid receptor’s ability to activate downstream targets. Rather, steroid resistance was associated with strong activation of MEK-ERK and AKT, downstream components of IL7R signaling pathway, thereby inducing a robust anti-apoptotic response by upregulating MCL1 and BCL-XL expression. Both the MEK-ERK and AKT pathways also inactivate BIM, an essential molecule for steroid-induced death, and inhibi...
  13. Transcription profiling of human CD4+ cutaneous T-cell lymphoma (CTCL) Sez-4 cell line activated with IL-2, IL-15 or IL-21. OmicsDI

    ID: E-GEOD-8685

    Date Released: 06-10-2011

    Description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...

  14. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing BioProject

    ID: PRJNA138921

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF); alterations disrupting haemopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1, EP300); and inactivating mutations in histone modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of mutation including DNM2, ECT2L and RELN. Ten of 12 ETP ALL cases harboured chromosomal rearrangements, several of which complex and resulted in the expression of novel chimeric in-frame fusion genes disrupting haemopoietic regulators. Thus, similar to myeloid malignancies, mutations that drive proliferation, impair differentiation and disr...
  15. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukaemia by whole genome sequencing BioProject

    ID: PRJNA149299

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: including IL7R, NRAS, KRAS, FLT3, BRAF, JAK1 and JAK3 in ETP ALL. Moreover, we identified multiple new targets of mutation in including GATA3, EP300, RUNX1, DNM2, ECT2L, HNRNPA1 and HNRNPR, as well as genes known to be mutated in T-ALL, including NOTCH1, PHF6, and WT1.. Five of 12 ETP ALL cases harboured novel chromosomal translocations, several of which accompanied complex multichromosomal rearrangements and resulted in the expression of chimeric in-frame fusion genes disrupting hematopoietic regulators, including ETV6-INO80D, NAP1L1-MLLT10 and RUNX1-EVX1. These results indicate that although ETP ALL is genetically heterogeneous, activation of Ras and cytokine receptor signalling distinguishes this disease from non-ETP ALL....
  16. CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] - PDB

    ID: PDB:5CF4

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  17. Expression data from Cerebral Cortex or Hippocampus of COX-1 or COX-2 null mice GEMMA

    ID: 374

    Keywords: functional genomics

    Description: BAergic neurotransmission genes (GABA transporter 3, GABA-A receptor subunit ?1) was altered in the cerebral cortex and hippocampus of COX-2 -/- mice. A COX isoform specific effect was observed in the expression of Janus Kinase (JAK) 1 and 2. COX-1 -/- mice exhibited an increase in JAK1 expression while COX-2 -/- mice exhibited a decrease in JAK2 expression, an observation consistent with a previously demonstrated COX isoform specific effect on the expression of NF-kB. In summary, this study demonstrates the wide ranging effects of genetic deletion of COX isoforms in the mouse brain and suggests that inhibition of COX activity may alter the profile of gene expression in specific areas of the brain. We u...

  18. onal and signalling characteristics of the fusion protein in human cancers... ArrayExpress

    ID: E-MTAB-2102

    Description: , we demonstrate that the oncogenic FIP1L1-PDGFRa kinase exhibits a significantly different signaling pattern compared to PDGFRa wildtype: Interestingly, the conventional strong activation of PI3-kinase- and MAP-kinase- pathways is remarkably shifted towards a prominent activation of STAT factors. This diverging signaling patte...

  19. Gene expression profiling upon knockdown of JAK1 in IM9 cells ArrayExpress

    ID: E-GEOD-37012

    Description: particular, gene silencing of two members of the JAK family (JAK1 and JAK2) in a variety of tumor cell targets increased their susceptibility to NK-mediated lysis and induced increased secretion of interferon gamma (IFN-gamma by NK cells. Treatment of tumor cells with JAK inhibitors also induced increased susceptibility to NK cell activity. These findings may have important clinical implications and suggest that small molecule inhibitors of tyrosine kinases being developed as therapeutic anti-tumor agents may also have significant immunologic effects in vivo. IM9 cells were transduced with shRNA-encoding vectors and selected with Puromycin. Two vectors were specifically targeting JAK1 (JAK1-1 and JAK1-3) and one vector encoded an irrelevant control shRNA (CTRL-2). T...

  20. Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling BioProject

    ID: PRJNA315865

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 559 results for "JAK3"